<SEC-DOCUMENT>0001213900-24-086724.txt : 20241010
<SEC-HEADER>0001213900-24-086724.hdr.sgml : 20241010
<ACCEPTANCE-DATETIME>20241010074002
ACCESSION NUMBER:		0001213900-24-086724
CONFORMED SUBMISSION TYPE:	6-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20241010
FILED AS OF DATE:		20241010
DATE AS OF CHANGE:		20241010

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PURPLE BIOTECH LTD.
		CENTRAL INDEX KEY:			0001614744
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		6-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37643
		FILM NUMBER:		241363835

	BUSINESS ADDRESS:	
		STREET 1:		4 OPPENHEIMER STREET
		STREET 2:		SCIENCE PARK
		CITY:			REHOVOT
		STATE:			L3
		ZIP:			7670104
		BUSINESS PHONE:		97239333121

	MAIL ADDRESS:	
		STREET 1:		4 OPPENHEIMER STREET
		STREET 2:		SCIENCE PARK
		CITY:			REHOVOT
		STATE:			L3
		ZIP:			7670104

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Kitov Pharma Ltd.
		DATE OF NAME CHANGE:	20180125

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Kitov Pharmaceuticals Holdings Ltd.
		DATE OF NAME CHANGE:	20140724
</SEC-HEADER>
<DOCUMENT>
<TYPE>6-K
<SEQUENCE>1
<FILENAME>ea0217294-6k_purple.htm
<DESCRIPTION>REPORT OF FOREIGN PRIVATE ISSUER
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Washington, D.C.&nbsp;20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>FORM 6-K</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Report of Foreign Private Issuer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Pursuant to Rule 13a-16 or 15d-16</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>of&nbsp;the Securities Exchange Act of 1934</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">For the month of October 2024</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Commission File Number: 001-37643</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>PURPLE BIOTECH LTD.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Translation of registrant&rsquo;s name into English)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>4 Oppenheimer Street, Science Park, Rehovot
7670104, Israel</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Address of principal executive offices)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Indicate by check mark whether the registrant files or will file annual
reports under cover Form 20-F or Form 40-F.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Form 20-F &#9746;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Form
40-F &#9744;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">On October 10, 2024, Purple Biotech Ltd. (the
&ldquo;Company&rdquo; or the &ldquo;Registrant&rdquo;) issued a press release titled &ldquo;<B><I>Purple Biotech to Present Data for its
Tri-Specific Antibody Platform&mdash;CAPTN-3&mdash;at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics</I></B>,&rdquo;
a copy of which is attached hereto as Exhibit 99.1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="border-bottom: black 1.5pt solid; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B><I>Exhibit</I></B></FONT></TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top; background-color: #CCEEFF">
    <TD STYLE="width: 8%; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B><I>99.1</I></B></FONT></TD>
    <TD STYLE="width: 1%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 91%; text-align: justify"><A HREF="ea021729401ex99-1_purple.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B><I>Press Release issued by Purple Biotech Ltd. on October 10, 2024</I></B></FONT></A></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B><I>&nbsp;</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Incorporation by Reference</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; background-color: white"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">This
Report on Form 6-K, including all exhibits attached hereto, is hereby incorporated by reference into each of the Registrant&rsquo;s Registration
Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000114420416103812/v440298_s8.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
S-8</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on May 20, 2016 (Registration file number 333-211478), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390017006184/fs82017_kitovpharma.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
S-8</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on June 6, 2017 (Registration file number 333-218538), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390018009254/ff32018_kitovpharma.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-3</FONT></A><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">, as amended, originally filed with the Securities
and Exchange Commission on July 16, 2018 (Registration file number 333-226195), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390019005134/fs82019_kitovpharmaltd.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
S-8</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on March 28, 2019 (Registration file number 333-230584), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390019018149/ff32019_kitovpharma.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-3</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on September 16, 2019 (Registration file number 333-233795), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390019027099/ff12019_kitovpharma.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-1</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on December 27, 2019 (Registration file number 333-235729), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390020012007/ea121429-f3_kitovpharma.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-3</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on May 13, 2020 (Registration file number 333-238229), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390020012852/ea122048-s8_kitovpharma.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
S-8</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on May 18, 2020 (Registration file number 333-238481), each of the Registrant&rsquo;s Registration Statements on </FONT><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-3</FONT> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on July 10, 2020 (Registration file numbers <A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390020017224/ea123998-f3_kitovpharma.htm">333-239807</A> and <A HREF="https://www.sec.gov/Archives/edgar/data/1614744/000121390020017228/ea124005-posam_kitovpharma.htm">333-233793</A>), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390022017815/ea157934-s8_purplebiotech.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
S-8</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on April 4, 2022 (Registration file number 333-264107) and the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390023022248/ea175634-f3_purplebiotech.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-3</FONT></A> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">filed with the Securities and Exchange Commission
on March 23, 2023 (Registration file number 333-270769), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390022078317/ea169732-f3_purplebiotech.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-3</FONT></A><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">, as amended, originally filed with the Securities
and Exchange Commission on December 8, 2022 (Registration file number 333-268710), the Registrant&rsquo;s Registration Statement on </FONT><A HREF="http://www.sec.gov/Archives/edgar/data/1614744/000121390023081556/ea187369-f1_purplebio.htm"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Form
F-1</FONT></A><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><U>,</U> as amended, originally filed with the
Securities and Exchange Commission on October 30, 2023 (Registration file number 333-275216) and the Registrant&rsquo;s Registration Statement
on <A HREF="https://www.sec.gov/Archives/edgar/data/1614744/000101376224000516/ea0209789-f1_purplebio.htm">Form F-1</A><U>,</U> filed with the Securities and Exchange Commission on July 22, 2024 (Registration file number 333-</FONT> <FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">280947</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">),
to be a part thereof from the date on which this report is submitted, to the extent not superseded by documents or reports subsequently
filed or furnished.</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">Pursuant to the requirements
of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto
duly authorized.&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">October 10, 2024</FONT></TD>
    <TD COLSPAN="2" STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>PURPLE BIOTECH LTD.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 60%; text-align: justify">&nbsp;</TD>
    <TD STYLE="width: 4%; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; width: 36%; text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><I>/s/ Lior Fhima</I></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Lior Fhima</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD>
    <TD STYLE="text-align: justify"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Chief Financial Officer</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

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<P STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">2</P>

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<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ea021729401ex99-1_purple.htm
<DESCRIPTION>PRESS RELEASE ISSUED BY PURPLE BIOTECH LTD. ON OCTOBER 10, 2024
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit 99.1</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>Purple Biotech to Present Data for its Tri-Specific
Antibody Platform&mdash;CAPTN-3&mdash;at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B><I>CAPTN-3 is a conditionally activated tri-specific
antibody platform that features novel dual engagement of T cells and NK cells to mount an optimal anti-tumoral immune response against
cancer</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">REHOVOT, Israel, Oct. 10, 2024 (GLOBE NEWSWIRE) -- Purple Biotech
Ltd. (&ldquo;Purple Biotech&rdquo; or &ldquo;the Company&rdquo;) (NASDAQ/TASE: PPBT), a clinical-stage company developing first-in-class therapies
that overcome tumor immune evasion and drug resistance, today announced it has been selected for a poster presentation at the 36<SUP>th</SUP>
European Organization for Research and Treatment of Cancer, National Cancer Institute, American Association for Cancer Research (EORTC-NCI-AACR)
Symposium on Molecular Targets and Cancer Therapeutics (the &ldquo;Triple Meeting&rdquo;) held October 23-25, 2024 in Barcelona, Spain.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Purple Biotech&rsquo;s poster titled &ldquo;CAPTN-3:
A novel platform of conditionally activated T cell and NK cell engagers&rdquo; (Abstract # 450, poster board number: PB438) will be presented
by Dr. Hadas Reuveni, VP R&amp;D of Purple Biotech, during a &lsquo;New therapies in immuno oncology&rsquo; poster session on Friday,
25 October 2024.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">CAPTN-3 is a First-in-class platform of conditionally
activated tri-specific antibodies engaging both T cells and NK cells with the tumor to create an immune synapse with enhanced anti-tumor
efficacy. The NK engager arm (<FONT STYLE="font-family: Symbol">a</FONT>NKG2A) of our lead compound also acts as a checkpoint inhibitor
for both NK cells and highly cytotoxic T cell subsets, unleashing both innate and adaptive immune subsets against the tumor.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Purple Biotech&rsquo;s lead CAPTN-3 platform candidate,
IM1240, targets 5T4 as a tumor associated antigen (TAA), which is overexpressed in a variety of solid tumors and is correlated with advanced
disease, increased invasiveness, and poor clinical outcome. 5T4, also known as trophoblast glycoprotein (TPBG), is an oncofetal surface
protein that is not found on adult healthy tissues but is abnormally expressed in several cancer types. This specific expression pattern
as well as the correlation with poor prognosis in different cancer diseases such as lung, gastric, head and neck and other cancers makes
it an ideal TAA for various therapeutic approaches.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>About Purple Biotech</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Purple Biotech Ltd. (NASDAQ/TASE: PPBT) is a clinical-stage
company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance. The Company&rsquo;s oncology pipeline
includes CM24, NT219 and IM1240. CM24 is a humanized monoclonal antibody that blocks CEACAM1, that supports tumor immune evasion and survival
through multiple pathways. CEACAM1 on tumor cells, immune cells and neutrophils extracellular traps is a novel target for the treatment
of multiple cancer indications. As a proof of concept of these novel pathways, the Company is advancing CM24 as a combination therapy
with anti-PD-1 checkpoint inhibitors in a Phase 2 study for the treatment of pancreatic ductal adenocarcinoma (PDAC). The Company has
entered into a clinical collaboration agreement with Bristol Myers Squibb for the Phase 2 clinical trials to evaluate the combination
of CM24 with the PD-1 inhibitor nivolumab in addition to chemotherapy. NT219 is a dual inhibitor, novel small molecule that simultaneously
targets IRS1/2 and STAT3. A Phase 1 dose escalation study was concluded as a monotherapy and in combination with cetuximab in which NT219
demonstrated anti-tumor activity in combination with cetuximab in second line patients with recurrent and/or metastatic SCCHN (R/N SCCHN).
The Company is advancing CAPTN-3, a preclinical platform of conditionally-activated tri-specific antibody that engages both T cells and
NK cells to induce a strong, localized immune response within the tumor microenvironment. The cleavable capping technology confines the
compound&rsquo;s therapeutic activity to the local tumor microenvironment, and thereby potentially increases the anticipated therapeutic window
in patients. The third arm specifically targets the Tumor Associated Antigen (TAA). The technology presents a novel mechanism of action
by unleashing both innate and adaptive immune systems to mount an optimal anti-tumoral immune response. IM1240 is the first tri-specific
antibody in development that targets 5T4 expressed in a variety of solid tumors and is correlated with advanced disease, increased invasiveness
and poor clinical outcomes. The Company&rsquo;s corporate headquarters are located in Rehovot, Israel. For more information, please visit&nbsp;https://purple-biotech.com/.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white"><B>Forward-Looking Statements and Safe Harbor
Statement</B></P>

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<P STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; background-color: white">Certain statements in this press release that
are forward-looking and not statements of historical fact are forward-looking statements within the meaning of the safe harbor provisions
of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include, but are not limited to, statements that
are not statements of historical fact, and may be identified by words such as &ldquo;believe&rdquo;, &ldquo;expect&rdquo;, &ldquo;intend&rdquo;,
&ldquo;plan&rdquo;, &ldquo;may&rdquo;, &ldquo;should&rdquo;, &ldquo;could&rdquo;, &ldquo;might&rdquo;, &ldquo;seek&rdquo;, &ldquo;target&rdquo;, &ldquo;will&rdquo;,
&ldquo;project&rdquo;, &ldquo;forecast&rdquo;, &ldquo;continue&rdquo; or &ldquo;anticipate&rdquo; or their negatives or variations of these words
or other comparable words or by the fact that these statements do not relate strictly to historical matters. You should not place undue
reliance on these forward-looking statements, which are not guarantees of future performance. Forward-looking statements reflect our current
views, expectations, beliefs or intentions with respect to future events, and are subject to a number of assumptions, involve known and
unknown risks, many of which are beyond our control, as well as uncertainties and other factors that may cause our actual results, performance
or achievements to be significantly different from any future results, performance or achievements expressed or implied by the forward-looking
statements. Important factors that could cause or contribute to such differences include, among others, risks relating to: the plans,
strategies and objectives of management for future operations; product development for NT219, CM24 and IM1240; the process by which such
early stage therapeutic candidates could potentially lead to an approved drug product is long and subject to highly significant risks,
particularly with respect to a joint development collaboration; the fact that drug development and commercialization involves a lengthy
and expensive process with uncertain outcomes; our ability to successfully develop and commercialize our pharmaceutical products; the
expense, length, progress and results of any clinical trials; the impact of any changes in regulation and legislation that could affect
the pharmaceutical industry; the difficulty in receiving the regulatory approvals necessary in order to commercialize our products; the
difficulty of predicting actions of the U.S. Food and Drug Administration or any other applicable regulator of pharmaceutical products;
the regulatory environment and changes in the health policies and regimes in the countries in which we operate; the uncertainty surrounding
the actual market reception to our pharmaceutical products once cleared for marketing in a particular market; the introduction of competing
products; patents obtained by competitors; dependence on the effectiveness of our patents and other protections for innovative products;
our ability to obtain, maintain and defend issued patents; the commencement of any patent interference or infringement action against
our patents, and our ability to prevail, obtain a favorable decision or recover damages in any such action; and the exposure to litigation,
including patent litigation, and/or regulatory actions, and other factors that are discussed in our Annual Report on Form 20-F for the
year ended December 31, 2023 and in our other filings with the U.S. Securities and Exchange Commission (&ldquo;SEC&rdquo;), including our
cautionary discussion of risks and uncertainties under &ldquo;Risk Factors&rdquo; in our Registration Statements and Annual Reports. These
are factors that we believe could cause our actual results to differ materially from expected results. Other factors besides those we
have listed could also adversely affect us. Any forward-looking statement in this press release speaks only as of the date which it is
made. We disclaim any intention or obligation to publicly update or revise any forward-looking statement or other information contained
herein, whether as a result of new information, future events or otherwise, except as required by applicable law. You are advised, however,
to consult any additional disclosures we make in our reports to the SEC, which are available on the SEC&rsquo;s website, https://www.sec.gov.</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>CONTACTS:</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Company Contact:</B><BR>
Lior Fhima<BR>
Chief Financial Officer<BR>
IR@purple-biotech.com</P>

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