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Related Party Transactions - Additional Information (Detail) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2015 | Feb. 19, 2021
Related Party Transaction [Line Items] |  |  |  |
Research and development | $ 49,643,000 | $ 52,696,000 |  |
M.D. Anderson Cancer Center |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Payment | 100,000 | 0 |  |
MD Anderson License and the Research and Development Agreement Member [Member] |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Cash resources on hand | 0 | 8,100,000 |  |
License Agreement | M.D. Anderson Cancer Center |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Issuance of common stock in licensing agreement (in shares) |  |  | 11,722,163 |
Research and development |  |  | $ 67,300,000 |
Vineti Inc [Member] | Collaborative Arrangement |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Expenses From Transactions With Related Party | 400,000 | $ 29,000,000 |  |
Watermill And Robert W Postma [Member] |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Amount due to related party, current |  |  |  | $ 400,000
Fees and Expenses, Related Party | 650,000 |  |  |
Eden BioCell [Member] |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Payments to Fund Long-term Loans to Related Parties | 10,000,000.0 |  |  |
Additional Loans Committed | $ 25,000,000.0 |  |  |

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