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Income Taxes - Significant Component of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Net operating loss carryforwards | $ 164,486 | $ 147,004
Deferred tax assets: |  |
Start-up and organizational costs | 21,705 | 25,909
Research and development credit carryforwards | 39,817 | 37,183
Stock compensation | 706 | 1,478
Capitalized acquisition costs | 2,946 | 3,691
Lease liability | 1,278 | 1,225
Depreciation | 102 | 71
Other | 156 | 135
Deferred Tax Assets Gross | 231,196 | 216,696
Less valuation allowance | (230,119) | (215,513)
Total deferred tax assets | 1,077 | 1,183
Deferred tax liabilities: |  |
Right of use asset | (1,077) | (1,183)
Total deferred tax liabilities | (1,077) | (1,183)
Net deferred taxes | $ 0 | $ 0

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