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Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021
Income Taxes [Line Items] |  |
Net operating loss carryforwards | $ 171,070 | $ 164,486
Deferred tax assets operating loss carryforwards without expire date | 323,800 |
Research and development credit carryforwards | 40,116 | 39,817
Uncertain Tax Positions Adjustment | 0 | $ 0
Increase (decrease) in deferred tax assets | 6,700 |
Domestic Tax Authority [Member] |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards | $ 665,500 |
Net operating loss carryforwards, expiration date | 2037 |
Federal and State [Member] |  |
Income Taxes [Line Items] |  |
Deferred tax assets operating loss carryforwards with expire date | $ 341,700 |
Net operating loss carryforwards, expiration date | 2042 |
Federal and State [Member] | Research Tax Credit Carryforward |  |
Income Taxes [Line Items] |  |
Research and development credit carryforwards | $ 40,100 |
State and Local Jurisdiction [Member] |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards | $ 497,900 |

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