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Commitments and Contingencies - Additional Information (Detail) - USD ($) |  |  |  | 3 Months Ended | 12 Months Ended |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
May 28, 2019 | Aug. 17, 2015 | Jan. 13, 2015 | Mar. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Oct. 22, 2019 | Feb. 19, 2019 | Oct. 05, 2018 | Aug. 24, 2004
Accrued Payments |  |  |  |  |  |  |  |  |  |
Royalty amount |  |  |  |  | $ 0 | $ 0 |  |  |  |
Research and development expense |  |  |  |  | 25,018,000 | 49,643,000 |  |  |  |
Collaboration revenue |  |  |  |  | 2,922,000 | 398,000 |  |  |  |
Md Anderson Warrant [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Number of Warrants |  |  |  |  |  |  | 3,333,333 |  |  |
Warrant exercise per share |  |  |  |  |  |  | $ 0.001 |  |  |
Warrant Expiry date |  |  |  |  |  |  | Dec. 31, 2026 |  |  |
MD Anderson License and the Research and Development Agreement [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Reimbursement of historical costs |  |  |  |  |  |  | $ 20,000,000.0 |  |  |
Payments due prior to the first marketing approval |  |  |  |  |  |  | 3,000,000.0 |  |  |
Quarterly expense incurred |  |  |  |  | 800,000 | 300,000 |  |  |  |
Aggregate potential benchmark payments |  |  |  |  |  |  | $ 36,500,000 |  |  |
CRADA Agreement [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Contribution payable on per annum basis |  |  |  | $ 1,000,000.0 |  |  |  |  |  |
Obligations due under contract |  |  |  |  |  |  |  | $ 5,000,000.0 |  |
Annual expense incurred |  |  |  |  | 0 | 1,300,000 |  |  |  |
Quarterly payments under contract |  |  |  |  | 3,800,000 |  |  |  |  |
MD Anderson Agreement and Worldwide License [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
License agreement commencing date |  |  | Jan. 13, 2015 |  |  |  |  |  |  |
C A R Products [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Maximum royalty amount |  |  |  |  |  |  |  |  | $ 100,000,000.0 |
The University of Texas MD Anderson Cancer Center and The Texas A & M University System [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Milestone maximum payment |  |  |  |  |  |  |  |  |  | $ 4,500,000
One time milestone payment |  |  |  |  | 2,500,000 |  |  |  |  |
Payment under license agreement |  |  |  |  |  | 100,000 |  |  |  |
The University of Texas MD Anderson Cancer Center and The Texas A & M University System [Member] | Royalty [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Payment under license agreement |  |  |  |  | 2,000 | 0 |  |  |  |
Collaboration Agreement with Solasia Pharma K.K. [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Collaboration revenue |  |  |  |  | 2,900,000 | 400,000 |  |  |  |
License Agreement with the National Cancer Institute [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
License Expense |  |  |  |  | 700,000 | $ 500,000 |  |  |  |
License Agreement with the National Cancer Institute [Member] | One Time Benchmark Payments [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
First benchmark payment |  |  |  |  | $ 100,000 |  |  |  |  |
Ziop License Agreement With The National Cancer Institute [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Minimum royalties amount payable | $ 300,000 |  |  |  |  |  |  |  |  |
Aggregate minimum annual royalties paid | 1,500,000 |  |  |  |  |  |  |  |  |
Royalties amount payable thereafter | $ 100,000 |  |  |  |  |  |  |  |  |
Description Of First Benchmark Payable | The first benchmark payment of $0.1 million was paid during the year ended December 31, 2022 upon the initiation of the Company's TCR-T Library Phase 1/2 Trial, which was a qualifying Phase 1 clinical trial under the terms of the Patent License. |  |  |  |  |  |  |  |  |
Description Of option To terminate Agreement | The NCI may terminate or modify the Patent License in the event of a material breach, including if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event. |  |  |  |  |  |  |  |  |
Agreement termination, notice period | 60 days |  |  |  |  |  |  |  |  |
Ziop License Agreement With The National Cancer Institute [Member] | Performance Based Payments [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Aggregate Benchmark Payments Payable | $ 4,300,000 |  |  |  |  |  |  |  |  |
Ziop License Agreement With The National Cancer Institute [Member] | One Time Benchmark Payments [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Potential Benchmark Payments Payable | 12,000,000.0 |  |  |  |  |  |  |  |  |
Ziop License Agreement With The National Cancer Institute [Member] | Post Marketing Approval [Member] | Performance Based Payments [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Aggregate Benchmark Payments Payable | 3,000,000.0 |  |  |  |  |  |  |  |  |
Ziop License Agreement With The National Cancer Institute [Member] | Licensed Products [Member] | One Time Benchmark Payments [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Maximum Sales Revenue On Which Benchmark Payments Payable | 1,000,000,000.0 |  |  |  |  |  |  |  |  |
Minimum sales revenue on which benchmark payments payable | $ 250,000,000.0 |  |  |  |  |  |  |  |  |
Intrexon Corporation [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Annual License fee |  |  |  |  |  |  |  |  | 100,000 |
Expected additional milestones payable |  |  |  |  |  |  |  |  | 52,500,000 |
Intrexon Corporation [Member] | T-Cell Receptor [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Maximum royalty amount |  |  |  |  |  |  |  |  | $ 100,000,000.0 |
Portion of income payable to related party |  |  |  |  |  |  |  |  | 20.00% |
Minimum [Member] | MD Anderson License and the Research and Development Agreement [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Research and development expense |  | $ 15,000,000.0 |  |  |  |  |  |  |  |
Maximum [Member] | MD Anderson License and the Research and Development Agreement [Member] |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |
Research and development expense |  | $ 20,000,000.0 |  |  |  |  |  |  |  |

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