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v3.22.4

Income Taxes - Significant Component of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Net operating loss carryforwards | $ 171,070 | $ 164,486
Deferred tax assets: |  |
Start-up and pre-clinical studies | 17,204 | 21,705
Research and development credit carryforwards | 40,116 | 39,817
Stock-based compensation | 698 | 706
Capitalized acquisition costs | 2,180 | 2,946
Lease liability | 618 | 1,278
Depreciation | 239 | 102
Capitalized research expenses | 5,156 | 0
Other | 27 | 156
Deferred Tax Assets Gross | 237,308 | 231,196
Less valuation allowance | (236,827) | (230,119)
Total deferred tax assets | 481 | 1,077
Deferred tax liabilities: |  |
Right of use asset | (481) | (1,077)
Total deferred tax liabilities | (481) | (1,077)
Net deferred taxes | $ 0 | $ 0

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