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Income Taxes - Significant Component of Deferred Tax Assets (Detail) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
--- | --- | ---
Net operating loss carryforwards | $ 148,009 | $ 171,070
Deferred tax assets: |  |
Start-up and pre-clinical studies | 13,754 | 17,204
Research and development credit carryforwards | 39,838 | 40,116
Stock-based compensation | 681 | 698
Capitalized acquisition costs | 1,570 | 2,180
Lease liability | 0 | 618
Depreciation | 1 | 239
Capitalized research expenses | 7,176 | 5,156
Other | 2 | 27
Deferred Tax Assets Gross | 211,031 | 237,308
Less valuation allowance | (211,031) | (236,827)
Total deferred tax assets | 0 | 481
Deferred tax liabilities: |  |
Right of use asset | 0 | (481)
Total deferred tax liabilities | 0 | (481)
Net deferred taxes | $ 0 | $ 0

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