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Commitments and Contingencies - Additional Information (Details) - USD ($) |  |  |  |  |  | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Oct. 20, 2023 | Mar. 17, 2023 | Jan. 09, 2017 | Aug. 17, 2015 | Jan. 13, 2015 | Dec. 31, 2024 | Dec. 31, 2023 | Apr. 03, 2023 | Dec. 31, 2022 | Oct. 22, 2019 | Oct. 05, 2018 | Aug. 24, 2004
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  |  |  | $ 362,000 | $ 16,279,000 |  |  |  |  |
Revenue |  |  |  |  |  | $ 10,000 | $ 5,000 |  |  |  |  |
Warrant exercise per share |  |  |  |  |  | $ 28.5 | $ 268.5 |  | $ 863.25 |  |  |
Loss contingency, name of plaintiff |  | KBI Biopharma |  |  |  |  |  |  |  |  |  |
Unspecified monetary damages |  | $ 3,200,000 |  |  |  |  |  |  |  |  |  |
Litigation expense | $ 1,000,000 |  |  |  |  |  |  |  |  |  |  |
Md Anderson Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Number of warrants |  |  |  |  |  |  |  |  |  | 22,222 |  |
Warrant exercise per share |  |  |  |  |  |  |  |  |  | $ 0.15 |  |
Warrant expiry date |  |  |  |  |  |  |  |  |  | Dec. 31, 2026 |  |
MD Anderson Related to the 2015 R&D Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Clinical expenses |  |  |  |  |  | $ 0 | $ 0.1 |  |  |  |  |
MD Anderson License and the Research and Development Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Reimbursement of historical costs |  |  |  |  |  |  |  |  |  | $ 20,000,000 |  |
Clinical expenses |  |  |  |  |  | 0 | 800,000 |  |  |  |  |
Aggregate potential benchmark payments |  |  |  |  |  |  |  |  |  | 36,500,000 |  |
Payments due prior to the first marketing approval |  |  |  |  |  |  |  |  |  | $ 3,000,000 |  |
CRADA Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Agreement termination date |  |  | Oct. 13, 2023 |  |  |  |  |  |  |  |  |
Annual expense incurred |  |  |  |  |  | 0 | 500,000 |  |  |  |  |
MD Anderson Agreement and Worldwide License [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
License agreement commencing date |  |  |  |  | Jan. 13, 2015 |  |  |  |  |  |  |
The University of Texas MD Anderson Cancer Center and The Texas A & M University System [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Milestone maximum payment |  |  |  |  |  |  |  |  |  |  |  | $ 4,500,000
The University of Texas MD Anderson Cancer Center and The Texas A & M University System [Member] | Royalty [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Payment under license agreement |  |  |  |  |  | $ 0 | 1,000 |  |  |  |  |
License Agreement with the National Cancer Institute [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Agreement termination effective date |  |  |  |  |  | Dec. 26, 2023 |  |  |  |  |  |
License expense |  |  |  |  |  | $ 0 | 400,000 |  |  |  |  |
Collaboration Agreement with Solasia Pharma KK [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | 0 | 0 |  |  |  |  |
Collaboration Agreement with Solasia Pharma KK [Member] | Royalty [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  |  | $ 10,000 | $ 5,000 |  |  |  |  |
Intrexon Corporation [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Annual license fee |  |  |  |  |  |  |  | $ 75,000 |  |  | $ 100,000 |
Expected additional milestones payable |  |  |  |  |  |  |  |  |  |  | 52,500,000 |
Intrexon Corporation [Member] | T-Cell Receptor [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Maximum royalty amount |  |  |  |  |  |  |  |  |  |  | $ 100,000,000 |
Portion of income payable to related party |  |  |  |  |  |  |  |  |  |  | 20.00% |
Minimum [Member] | MD Anderson License and the Research and Development Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  | $ 15,000,000 |  |  |  |  |  |  |  |
Maximum [Member] | MD Anderson License and the Research and Development Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Accrued Payments |  |  |  |  |  |  |  |  |  |  |  |
Research and development expense |  |  |  | $ 20,000,000 |  |  |  |  |  |  |  |

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