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Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023
Income Taxes [Line Items] |  |
Net operating loss carryforwards | $ 154,634 | $ 148,009
Deferred tax assets operating loss carryforwards without expire date | 395,000 |
Research and development credit carryforwards | 40,486 | 39,838
Reduced credits carryforward | 0 |
Uncertain tax positions adjustment | 0 | $ 0
Increase (decrease) in deferred tax assets | 2,250 |
Interest and penalties | 0 |
Domestic Tax Authority [Member] |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards | $ 737,000 |
Net operating loss carryforwards, expiration date | 2037 |
Federal and State [Member] |  |
Income Taxes [Line Items] |  |
Deferred tax assets operating loss carryforwards with expire date | $ 342,000 |
Net operating loss carryforwards, expiration date | 2043 |
Federal and State [Member] | Research Tax Credit Carryforward |  |
Income Taxes [Line Items] |  |
Research and development credit carryforwards | $ 40,500 |
State and Local Jurisdiction [Member] |  |
Income Taxes [Line Items] |  |
Net operating loss carryforwards | 498,000 |
Increase (decrease) in deferred tax assets | $ 0 |

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- Definition Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 740 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 6 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482685/740-10-50-6 + Details
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