<SEC-DOCUMENT>0001209191-21-035149.txt : 20210521
<SEC-HEADER>0001209191-21-035149.hdr.sgml : 20210521
<ACCEPTANCE-DATETIME>20210521210855
ACCESSION NUMBER:		0001209191-21-035149
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20210520
FILED AS OF DATE:		20210521
DATE AS OF CHANGE:		20210521

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Muralidhar Bali
		CENTRAL INDEX KEY:			0001784138

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39594
		FILM NUMBER:		21950915

	MAIL ADDRESS:	
		STREET 1:		C/O EXICURE, INC.
		STREET 2:		8045 LAMON AVENUE, SUITE 410
		CITY:			SKOKIE
		STATE:			IL
		ZIP:			60077

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SPRUCE BIOSCIENCES, INC.
		CENTRAL INDEX KEY:			0001683553
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				812154263
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2001 JUNIPERO SERRA BLVD., SUITE 640
		CITY:			DALY CITY
		STATE:			CA
		ZIP:			94104
		BUSINESS PHONE:		(415) 294-1687

	MAIL ADDRESS:	
		STREET 1:		2001 JUNIPERO SERRA BLVD., SUITE 640
		CITY:			DALY CITY
		STATE:			CA
		ZIP:			94104
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>doc4.xml
<DESCRIPTION>FORM 4 SUBMISSION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2021-05-20</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001683553</issuerCik>
        <issuerName>SPRUCE BIOSCIENCES, INC.</issuerName>
        <issuerTradingSymbol>SPRB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001784138</rptOwnerCik>
            <rptOwnerName>Muralidhar Bali</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ABINGWORTH BIOVENTURES</rptOwnerStreet1>
            <rptOwnerStreet2>38 JERMYN STREET</rptOwnerStreet2>
            <rptOwnerCity>LONDON</rptOwnerCity>
            <rptOwnerState>X0</rptOwnerState>
            <rptOwnerZipCode>SW1Y6DN</rptOwnerZipCode>
            <rptOwnerStateDescription>UNITED KINGDOM</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>15.24</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2021-05-20</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness>
                <value></value>
            </transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>10000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0.00</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2031-05-19</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>10000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>10000</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2022 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the &quot;Plan&quot;)) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan).</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>Samir Gharib, Attorney-in-Fact</signatureName>
        <signatureDate>2021-05-21</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
