    <SEC-DOCUMENT>0000950170-24-042287-index.html : 20240405
    <SEC-HEADER>0000950170-24-042287.hdr.sgml : 20240405
    <ACCEPTANCE-DATETIME>20240405162644
    ACCESSION NUMBER:		0000950170-24-042287
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20231231
    FILED AS OF DATE:		20240405
    DATE AS OF CHANGE:		20240405
    EFFECTIVENESS DATE:		20240405

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			SPRUCE BIOSCIENCES, INC.
    		CENTRAL INDEX KEY:			0001683553
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		IRS NUMBER:				812154263
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-39594
    		FILM NUMBER:		24826863

    	BUSINESS ADDRESS:
    		STREET 1:		611 GATEWAY BOULEVARD, SUITE 740
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    		BUSINESS PHONE:		(415) 655-4168

    	MAIL ADDRESS:
    		STREET 1:		611 GATEWAY BOULEVARD, SUITE 740
    		CITY:			SOUTH SAN FRANCISCO
    		STATE:			CA
    		ZIP:			94080
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>sprb-ars-10k-2023.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: sprb-ars-10k-2023.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>