<SEC-DOCUMENT>0001193125-26-163919-index.html : 20260420
<SEC-HEADER>0001193125-26-163919.hdr.sgml : 20260420
<ACCEPTANCE-DATETIME>20260420160233
ACCESSION NUMBER:		0001193125-26-163919
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20260420
DATE AS OF CHANGE:		20260420

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SPRUCE BIOSCIENCES, INC.
		CENTRAL INDEX KEY:			0001683553
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				812154263
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-291152
		FILM NUMBER:		26875012

	BUSINESS ADDRESS:	
		STREET 1:		611 GATEWAY BOULEVARD, SUITE 740
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		(415) 655-4168

	MAIL ADDRESS:	
		STREET 1:		611 GATEWAY BOULEVARD, SUITE 740
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>sprb-424b5-2026-april.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: sprb-424b5-2026-april.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>img215082687_0.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: img215082687_0.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>img215082687_1.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: img215082687_1.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>img215082687_2.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: img215082687_2.jpg

</DOCUMENT>
</SEC-DOCUMENT>