    <SEC-DOCUMENT>0001213900-22-005856-index.html : 20220208
    <SEC-HEADER>0001213900-22-005856.hdr.sgml : 20220208
    <ACCEPTANCE-DATETIME>20220208124410
    ACCESSION NUMBER:		0001213900-22-005856
    CONFORMED SUBMISSION TYPE:	S-1/A
    PUBLIC DOCUMENT COUNT:		26
    FILED AS OF DATE:		20220208
    DATE AS OF CHANGE:		20220208

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Blue Water Vaccines Inc.
    		CENTRAL INDEX KEY:			0001782107
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-260137
    		FILM NUMBER:		22600156

    	BUSINESS ADDRESS:
    		STREET 1:		2041 COURTLAND AVENUE
    		CITY:			CINCINNATI
    		STATE:			OH
    		ZIP:			45212
    		BUSINESS PHONE:		646-303-0737

    	MAIL ADDRESS:
    		STREET 1:		2041 COURTLAND AVENUE
    		CITY:			CINCINNATI
    		STATE:			OH
    		ZIP:			45212
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-1/A
    <SEQUENCE>1
    <FILENAME>fs12022a6_bluewater.htm
    <DESCRIPTION>REGISTRATION STATEMENT
    <TEXT>
    Document 1 - file: fs12022a6_bluewater.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-1.1
    <SEQUENCE>2
    <FILENAME>fs12022a6ex1-1_bluewater.htm
    <DESCRIPTION>FORM OF UNDERWRITING AGREEMENT
    <TEXT>
    Document 2 - file: fs12022a6ex1-1_bluewater.htm

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    <DOCUMENT>
    <TYPE>EX-4.2
    <SEQUENCE>3
    <FILENAME>fs12022a6ex4-2_bluewater.htm
    <DESCRIPTION>FORM OF REPRESENTATIVE'S WARRANT*
    <TEXT>
    Document 3 - file: fs12022a6ex4-2_bluewater.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>4
    <FILENAME>fs12022a6ex5-1_bluewater.htm
    <DESCRIPTION>OPINION OF ELLENOFF GROSSMAN & SCHOLE LLP
    <TEXT>
    Document 4 - file: fs12022a6ex5-1_bluewater.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>5
    <FILENAME>fs12022a6ex23-1_bluewater.htm
    <DESCRIPTION>CONSENT OF MAYER HOFFMAN MCCANN P.C
    <TEXT>
    Document 5 - file: fs12022a6ex23-1_bluewater.htm

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    <DOCUMENT>
    <TYPE>EX-FILING FEES
    <SEQUENCE>6
    <FILENAME>fs12022a6ex-fee_bluewater.htm
    <DESCRIPTION>FILING FEE TABLE
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    Document 6 - file: fs12022a6ex-fee_bluewater.htm

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    <SEQUENCE>7
    <FILENAME>tblue_logo.jpg
    <DESCRIPTION>GRAPHIC
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    Document 7 - file: tblue_logo.jpg

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    <FILENAME>timage_001.jpg
    <DESCRIPTION>GRAPHIC
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    Document 8 - file: timage_001.jpg

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    <DESCRIPTION>GRAPHIC
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    Document 9 - file: timage_002.jpg

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    <SEQUENCE>10
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    <DESCRIPTION>GRAPHIC
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    Document 10 - file: timage_003.jpg

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    <SEQUENCE>11
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: timage_004.jpg

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    <SEQUENCE>12
    <FILENAME>timage_005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: timage_005.jpg

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    <SEQUENCE>13
    <FILENAME>timage_006.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: timage_006.jpg

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    <SEQUENCE>14
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: timage_007a.jpg

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    <SEQUENCE>15
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    <DESCRIPTION>GRAPHIC
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    Document 15 - file: timage_007b.jpg

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    <SEQUENCE>16
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    <DESCRIPTION>GRAPHIC
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    Document 16 - file: timage_0013a.jpg

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    <SEQUENCE>17
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    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: timage_008.jpg

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    <SEQUENCE>18
    <FILENAME>timage_009.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: timage_009.jpg

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    <SEQUENCE>19
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    <DESCRIPTION>GRAPHIC
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    Document 19 - file: timage_010.jpg

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    <DESCRIPTION>GRAPHIC
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    Document 20 - file: timage_0101.jpg

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    Document 21 - file: timage_011.jpg

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    <SEQUENCE>22
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    <DESCRIPTION>GRAPHIC
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    Document 22 - file: ttable_003.jpg

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    <DESCRIPTION>GRAPHIC
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    Document 23 - file: timage_012.jpg

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    <SEQUENCE>24
    <FILENAME>ex5-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 24 - file: ex5-1_001.jpg

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    <SEQUENCE>25
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    Document 25 - file: ex23-1_001.jpg

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    <SEQUENCE>26
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    <TEXT>
    Document 26 - file: ex23-1_002.jpg

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