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        <link:definition>109 - Disclosure - Property and Equipment</link:definition>

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        <link:definition>111 - Disclosure - Agreement with Sanofi-Aventis SA</link:definition>

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        <link:definition>112 - Disclosure - Comprehensive Income (Loss)</link:definition>

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        <link:definition>113 - Disclosure - Iloperidone Sublicense to Novartis Pharma AG</link:definition>

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        <link:definition>117 - Disclosure - Warrant Liability</link:definition>

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        <link:definition>124 - Disclosure - Organization and Summary of Significant Accounting Policies (Policies)</link:definition>

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        <link:definition>125 - Disclosure - Organization and Summary of Significant Accounting Policies (Tables)</link:definition>

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        <link:definition>126 - Disclosure - Property and Equipment (Tables)</link:definition>

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        <link:definition>128 - Disclosure - Warrant Liability (Tables)</link:definition>

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        <link:definition>129 - Disclosure - Stockholders&#8217; Equity (Tables)</link:definition>

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        <link:definition>130 - Disclosure - Stock Plans (Tables)</link:definition>

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      <link:roleType roleURI="http://www.titanpharm.com/role/IncomeTaxesTables" id="IncomeTaxesTables">
        <link:definition>131 - Disclosure - Income Taxes (Tables)</link:definition>

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        <link:definition>132 - Disclosure - Quarterly Financial Data (Unaudited) (Tables)</link:definition>

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      <link:roleType roleURI="http://www.titanpharm.com/role/OrganizationAndSummaryOfSignificantAccountingPoliciesDetails" id="OrganizationAndSummaryOfSignificantAccountingPoliciesDetails">
        <link:definition>133 - Disclosure - Organization and Summary of Significant Accounting Policies (Details)</link:definition>

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        <link:definition>134 - Disclosure - Organization and Summary of Significant Accounting Policies (Details 1)</link:definition>

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        <link:definition>135 - Disclosure - Organization and Summary of Significant Accounting Policies (Details 2)</link:definition>

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        <link:definition>137 - Disclosure - Organization and Summary of Significant Accounting Policies (Details Textual)</link:definition>

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      <link:roleType roleURI="http://www.titanpharm.com/role/PropertyAndEquipmentDetails" id="PropertyAndEquipmentDetails">
        <link:definition>138 - Disclosure - Property and Equipment (Details)</link:definition>

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        <link:definition>139 - Disclosure - Property and Equipment (Details Textual)</link:definition>

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        <link:definition>140 - Disclosure - Research and License Agreements (Details Textual)</link:definition>

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        <link:definition>143 - Disclosure - Braeburn License (Details Textual)</link:definition>

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        <link:definition>145 - Disclosure - Commitments and Contingencies (Details Textual)</link:definition>

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        <link:definition>146 - Disclosure - Royalty Liability (Details Textual)</link:definition>

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        <link:definition>147 - Disclosure - Warrant Liability (Details)</link:definition>

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        <link:definition>148 - Disclosure - Warrant Liability (Details Textual)</link:definition>

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        <link:definition>149 - Disclosure - Stockholders&#39; Equity (Deficit) (Details)</link:definition>

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        <link:usedOn>link:definitionLink</link:usedOn>

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        <link:definition>150 - Disclosure - Stockholders&#8217; Equity (Deficit) (Details 1)</link:definition>

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        <link:definition>151 - Disclosure - Stockholders&#8217; Equity (Deficit) (Details Textual)</link:definition>

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        <link:definition>152 - Disclosure - Stock Plans (Details)</link:definition>

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        <link:definition>154 - Disclosure - Stock Plans (Details 2)</link:definition>

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        <link:definition>155 - Disclosure - Stock Plans (Details 3)</link:definition>

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        <link:definition>156 - Disclosure - Stock Plans (Details 4)</link:definition>

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      <link:roleType roleURI="http://www.titanpharm.com/role/StockPlansDetailsTextual" id="StockPlansDetailsTextual">
        <link:definition>157 - Disclosure - Stock Plans (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.titanpharm.com/role/IncomeTaxesDetails" id="IncomeTaxesDetails">
        <link:definition>158 - Disclosure - Income Taxes (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.titanpharm.com/role/IncomeTaxesDetails1" id="IncomeTaxesDetails1">
        <link:definition>159 - Disclosure - Income Taxes (Details 1)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.titanpharm.com/role/IncomeTaxesDetailsTextual" id="IncomeTaxesDetailsTextual">
        <link:definition>160 - Disclosure - Income Taxes (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.titanpharm.com/role/QuarterlyFinancialDataUnauditedDetails" id="QuarterlyFinancialDataUnauditedDetails">
        <link:definition>161 - Disclosure - Quarterly Financial Data (Unaudited) (Details)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:roleType roleURI="http://www.titanpharm.com/role/SubsequentEventsDetailsTextual" id="SubsequentEventsDetailsTextual">
        <link:definition>162 - Disclosure - Subsequent events (Details Textual)</link:definition>

        <link:usedOn>link:presentationLink</link:usedOn>

        <link:usedOn>link:definitionLink</link:usedOn>

        <link:usedOn>link:calculationLink</link:usedOn>
      </link:roleType>

      <link:linkbaseRef xlink:type="simple" xlink:href="ttnp-20140630_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />

      <link:linkbaseRef xlink:type="simple" xlink:href="ttnp-20140630_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />

      <link:linkbaseRef xlink:type="simple" xlink:href="ttnp-20140630_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />

      <link:linkbaseRef xlink:type="simple" xlink:href="ttnp-20140630_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" />
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  <import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" />

  <import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />

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  <import namespace="http://xbrl.sec.gov/country/2013-01-31" schemaLocation="http://xbrl.sec.gov/country/2013/country-2013-01-31.xsd" />

  <import namespace="http://xbrl.sec.gov/currency/2014-01-31" schemaLocation="http://xbrl.sec.gov/currency/2014/currency-2014-01-31.xsd" />

  <import namespace="http://xbrl.sec.gov/exch/2014-01-31" schemaLocation="http://xbrl.sec.gov/exch/2014/exch-2014-01-31.xsd" />

  <import namespace="http://xbrl.sec.gov/naics/2011-01-31" schemaLocation="http://xbrl.sec.gov/naics/2011/naics-2011-01-31.xsd" />

  <import namespace="http://xbrl.sec.gov/sic/2011-01-31" schemaLocation="http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd" />

  <import namespace="http://xbrl.sec.gov/stpr/2011-01-31" schemaLocation="http://xbrl.sec.gov/stpr/2011/stpr-2011-01-31.xsd" />

  <import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />

  <import namespace="http://www.xbrl.org/2009/role/net" schemaLocation="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd" />

  <import namespace="http://www.xbrl.org/2009/arcrole/fact-explanatoryFact" schemaLocation="http://www.xbrl.org/lrr/arcrole/factExplanatory-2009-12-16.xsd" />

  <import namespace="http://xbrl.sec.gov/dei/2014-01-31" schemaLocation="http://xbrl.sec.gov/dei/2014/dei-2014-01-31.xsd" />

  <import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd" />

  <import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />

  <import namespace="http://fasb.org/us-types/2014-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2014/elts/us-types-2014-01-31.xsd" />

  <element name="NoncashGainOnTerminationOfRoyaltyPurchaseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_NoncashGainOnTerminationOfRoyaltyPurchaseAgreement" />

  <element name="NonCashGainLossOnChangesInFairValueOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_NonCashGainLossOnChangesInFairValueOfWarrants" />

  <element name="ProceedsFromSaleOfRoyalty" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_ProceedsFromSaleOfRoyalty" />

  <element name="SettlementOfLongtermDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_SettlementOfLongtermDebt" />

  <element name="WarrantLiabilityDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantLiabilityDisclosureTextBlock" />

  <element name="CompanyPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_CompanyPolicyTextBlock" />

  <element name="BasisOfPresentationPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_BasisOfPresentationPolicyTextBlock" />

  <element name="WarrantsIssuedInConnectionWithEquityFinancingPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantsIssuedInConnectionWithEquityFinancingPolicyTextBlock" />

  <element name="CashAndCashEquivalentsAndMarketableSecuritiesPolicyTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_CashAndCashEquivalentsAndMarketableSecuritiesPolicyTextBlock" />

  <element name="RangeOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_RangeOneMember" />

  <element name="RangeTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_RangeTwoMember" />

  <element name="RangeThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_RangeThreeMember" />

  <element name="RangeFourMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_RangeFourMember" />

  <element name="ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeAbstract" />

  <element name="ShareBasedGoodsAndNonemployeeServicesTransactionValuationMethodWeightedAverageVolatilityFactor" type="xbrli:decimalItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedGoodsAndNonemployeeServicesTransactionValuationMethodWeightedAverageVolatilityFactor" />

  <element name="EstimatedForfeitureRatesForOptionsGrantedToManagement" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_EstimatedForfeitureRatesForOptionsGrantedToManagement" />

  <element name="EstimatedForfeitureRatesForOptionsGrantedToNonManagement" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_EstimatedForfeitureRatesForOptionsGrantedToNonManagement" />

  <element name="NonEmployeeDirectorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_NonEmployeeDirectorMember" />

  <element name="TwoThousandTwoPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_TwoThousandTwoPlanMember" />

  <element name="TwoThousandOneNonQualifiedPlanMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_TwoThousandOneNonQualifiedPlanMember" />

  <element name="StockPlansAdditionalTextualAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockPlansAdditionalTextualAbstract" />

  <element name="StockPlansTextualAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockPlansTextualAbstract" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAmendedNumberOfSharesAuthorized" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardAmendedNumberOfSharesAuthorized" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodOfAward" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardPeriodOfAward" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfFairMarketValueOfCommonStockForCalculatingExercisePrice" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfFairMarketValueOfCommonStockForCalculatingExercisePrice" />

  <element name="OptionsToPurchaseCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="ttnp_OptionsToPurchaseCommonStock" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardRemainingPeriodOfAward" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardRemainingPeriodOfAward" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfFairMarketValueOfCommonStockForCalculatingExercisePriceUnderShareholderGrantee" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardPercentageOfFairMarketValueOfCommonStockForCalculatingExercisePriceUnderShareholderGrantee" />

  <element name="RoyaltyLiabilityTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_RoyaltyLiabilityTextBlock" />

  <element name="ClassOfWarrantsFairValueDisclosure" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantsFairValueDisclosure" />

  <element name="WarrantsIssued" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_WarrantsIssued" />

  <element name="ExcerciseOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_ExcerciseOfWarrants" />

  <element name="ChangeInFairValueOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_ChangeInFairValueOfWarrants" />

  <element name="DeerfieldWarrantMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_DeerfieldWarrantMember" />

  <element name="CommitmentsAndContingenciesTextualAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_CommitmentsAndContingenciesTextualAbstract" />

  <element name="WarrantsTerm" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantsTerm" />

  <element name="PercentageOfPrincipleAmountDueInYearOne" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfPrincipleAmountDueInYearOne" />

  <element name="PercentageOfPrincipleAmountDueInYearTwo" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfPrincipleAmountDueInYearTwo" />

  <element name="PercentageOfPrincipleAmountDueInYearThree" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfPrincipleAmountDueInYearThree" />

  <element name="PrincipleAmountRepaymentPercentage" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PrincipleAmountRepaymentPercentage" />

  <element name="DebtInstrumentCashDiscount" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_DebtInstrumentCashDiscount" />

  <element name="RoyaltyLiabilityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_RoyaltyLiabilityTable" />

  <element name="RoyaltyLiabilityLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_RoyaltyLiabilityLineItems" />

  <element name="RoyaltyLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_RoyaltyLiability" />

  <element name="PercentageOfAggregateRoyaltiesOnNetSales" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfAggregateRoyaltiesOnNetSales" />

  <element name="PercentageOfRoyaltyOnNetSalesToThirdParty" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfRoyaltyOnNetSalesToThirdParty" />

  <element name="PercentageOfRoyaltiesAboveThreshold" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfRoyaltiesAboveThreshold" />

  <element name="PercentageOfRetainRoyaltiesOnNetSalesAboveThreshold" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfRetainRoyaltiesOnNetSalesAboveThreshold" />

  <element name="ScheduleOfOrganizationAndSummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_ScheduleOfOrganizationAndSummaryOfSignificantAccountingPoliciesTable" />

  <element name="ScheduleOfOrganizationAndSummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ScheduleOfOrganizationAndSummaryOfSignificantAccountingPoliciesLineItems" />

  <element name="LicenseAndServicesRevenueNet" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_LicenseAndServicesRevenueNet" />

  <element name="MaximumAmountEligibleToBeReceivedOnAchievementOfSalesMilestone" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_MaximumAmountEligibleToBeReceivedOnAchievementOfSalesMilestone" />

  <element name="MaximumAmountEligibleToBeReceivedOnAchievementOfRegulatoryMilestone" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_MaximumAmountEligibleToBeReceivedOnAchievementOfRegulatoryMilestone" />

  <element name="SeriesWarrantsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SeriesWarrantsMember" />

  <element name="WeightedAverageFairValueAssumptionsOfWarrants" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WeightedAverageFairValueAssumptionsOfWarrants" />

  <element name="StockIssuedDuringPeriodValueExerciseOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_StockIssuedDuringPeriodValueExerciseOfWarrants" />

  <element name="StockIssuedDuringPeriodSharesExerciseOfWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockIssuedDuringPeriodSharesExerciseOfWarrants" />

  <element name="ResearchAndLicenseAgreementsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ResearchAndLicenseAgreementsAbstract" />

  <element name="ResearchAndLicenseAgreementsTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ResearchAndLicenseAgreementsTextBlock" />

  <element name="AgreementAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_AgreementAbstract" />

  <element name="AgreementTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_AgreementTextBlock" />

  <element name="SublicenseAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SublicenseAbstract" />

  <element name="SublicenseTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SublicenseTextBlock" />

  <element name="ExpenseIncurredUnderResearchAndLicenseAgreements" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_ExpenseIncurredUnderResearchAndLicenseAgreements" />

  <element name="NovartisMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_NovartisMember" />

  <element name="PercentageOfNextSlabOfAnnualSalesForCalculatingNetRoyalty" type="num:percentItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PercentageOfNextSlabOfAnnualSalesForCalculatingNetRoyalty" />

  <element name="OperatingLeasesFutureMinimumPaymentsDueInThreeYearsAndThereafter" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_OperatingLeasesFutureMinimumPaymentsDueInThreeYearsAndThereafter" />

  <element name="ClassOfWarrantOrRightIssuedDateOneMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightIssuedDateOneMember" />

  <element name="ClassOfWarrantOrRightIssuedDateTwoMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightIssuedDateTwoMember" />

  <element name="ClassOfWarrantOrRightIssuedDateThreeMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightIssuedDateThreeMember" />

  <element name="ClassOfWarrantOrRightIssuedDateFourMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightIssuedDateFourMember" />

  <element name="ClassOfWarrantOrRightAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightAbstract" />

  <element name="ClassOfWarrantsOrRightsIssueDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantsOrRightsIssueDate" />

  <element name="ClassOfWarrantsOrRightsExpirationDate" type="xbrli:dateItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantsOrRightsExpirationDate" />

  <element name="ScheduleOfSharesReservedForFutureIssuanceAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ScheduleOfSharesReservedForFutureIssuanceAbstract" />

  <element name="ScheduleOfSharesReservedForFutureIssuanceTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ScheduleOfSharesReservedForFutureIssuanceTableTextBlock" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsReleasedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsReleasedInPeriod" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsReleasedInPeriodWeightedAverageExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsReleasedInPeriodWeightedAverageExercisePrice" />

  <element name="ScheduleOfIncomeTaxesTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_ScheduleOfIncomeTaxesTable" />

  <element name="IncomeTaxReconciliationBookGainsLossesNotCurrentlyBenefited" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxReconciliationBookGainsLossesNotCurrentlyBenefited" />

  <element name="IncomeTaxReconciliationDisallowedInterestExpense" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxReconciliationDisallowedInterestExpense" />

  <element name="IncomeTaxReconciliationIncomeFromDebtRestructuring" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxReconciliationIncomeFromDebtRestructuring" />

  <element name="IncomeTaxReconciliationRevaluationOfWarrantLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxReconciliationRevaluationOfWarrantLiability" />

  <element name="IncomeTaxesLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxesLineItems" />

  <element name="OperatingLossCarryForwardsRelatedToStockOptionPlan" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_OperatingLossCarryForwardsRelatedToStockOptionPlan" />

  <element name="TaxCreditResearchGeneratedDuringPeriod" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_TaxCreditResearchGeneratedDuringPeriod" />

  <element name="AccruedRoyaltiesNoncurrent" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_AccruedRoyaltiesNoncurrent" />

  <element name="LicenseRightsDisclosureAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_LicenseRightsDisclosureAbstract" />

  <element name="LicenseRightsDisclosureTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_LicenseRightsDisclosureTextBlock" />

  <element name="NonRefundableUpFrontLicenseFeeTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_NonRefundableUpFrontLicenseFeeTable" />

  <element name="NonRefundableUpFrontLicenseFeeLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_NonRefundableUpFrontLicenseFeeLineItems" />

  <element name="EstimatedRevenueRecognitionPeriodForUpfrontPayment" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_EstimatedRevenueRecognitionPeriodForUpfrontPayment" />

  <element name="RevenuesToBeRecognizedPerMonthForUpfrontPayment" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_RevenuesToBeRecognizedPerMonthForUpfrontPayment" />

  <element name="MaximumReceiptTimeForMilestonePayment" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_MaximumReceiptTimeForMilestonePayment" />

  <element name="SubsequentEventsTextualsAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SubsequentEventsTextualsAbstract" />

  <element name="FairValueOfWarrantLiabilityTableTextBlock" type="nonnum:textBlockItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_FairValueOfWarrantLiabilityTableTextBlock" />

  <element name="IncrementalCommonSharesAttributableToAssumedExerciseOfOptions" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_IncrementalCommonSharesAttributableToAssumedExerciseOfOptions" />

  <element name="IncrementalCommonSharesAttributableToAssumedExerciseOfWarrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_IncrementalCommonSharesAttributableToAssumedExerciseOfWarrants" />

  <element name="ResearchAndLicenseAgreementsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_ResearchAndLicenseAgreementsTable" />

  <element name="GainsLossesOnExtinguishmentOfRoyaltyLiability" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_GainsLossesOnExtinguishmentOfRoyaltyLiability" />

  <element name="ScheduleOfQuarterlyFinancialInformationTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_ScheduleOfQuarterlyFinancialInformationTable" />

  <element name="DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_DocumentAndEntityInformationAbstract" />

  <element name="WarrantsToPurchaseCommonStockShares" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantsToPurchaseCommonStockShares" />

  <element name="ClassOfWarrantOrRightExercisedDuringPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightExercisedDuringPeriod" />

  <element name="ClassOfWarrantOrRightSubjectToExpiry" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightSubjectToExpiry" />

  <element name="ClassOfWarrantOrRightExpiryTerm" type="xbrli:stringItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightExpiryTerm" />

  <element name="ClassOfWarrantOrRightExpiredDuringPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ClassOfWarrantOrRightExpiredDuringPeriod" />

  <element name="SeriesBWarrantsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SeriesBWarrantsMember" />

  <element name="InstitutionalInvestorMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_InstitutionalInvestorMember" />

  <element name="StockPurchasePricePerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockPurchasePricePerShare" />

  <element name="PremiumAllocatedToFairValueOptionAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_PremiumAllocatedToFairValueOptionAgreement" />

  <element name="TypeOfAgreementAxis" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:dimensionItem" id="ttnp_TypeOfAgreementAxis" />

  <element name="TypeOfAgreementDomain" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_TypeOfAgreementDomain" />

  <element name="StockPurchaseAndOptionAgreementWithAffiliateMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockPurchaseAndOptionAgreementWithAffiliateMember" />

  <element name="LicenseRevenueMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_LicenseRevenueMember" />

  <element name="OxfordMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_OxfordMember" />

  <element name="SeriesAndSeriesBWarrantsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SeriesAndSeriesBWarrantsMember" />

  <element name="PremiumPerShareUnderOptionAgreement" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="ttnp_PremiumPerShareUnderOptionAgreement" />

  <element name="ShareBasedCompensationExpenseImpactOnBasicEarningsPerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationExpenseImpactOnBasicEarningsPerShare" />

  <element name="ShareBasedCompensationExpenseImpactOnDilutedEarningsPerShare" type="num:perShareItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationExpenseImpactOnDilutedEarningsPerShare" />

  <element name="ResearchAndLicenseAgreementsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ResearchAndLicenseAgreementsLineItems" />

  <element name="QuarterlyFinancialInformationLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_QuarterlyFinancialInformationLineItems" />

  <element name="InvestmentAmountAgreedToInvest" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="instant" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_InvestmentAmountAgreedToInvest" />

  <element name="WarrantsToPurchaseCommonstock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantsToPurchaseCommonstock" />

  <element name="WarrantsExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantsExercisePrice" />

  <element name="OxfordCapitalFinancingMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_OxfordCapitalFinancingMember" />

  <element name="DeerfieldPromissoryNotesMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_DeerfieldPromissoryNotesMember" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForGrants" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForGrants" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForIssue" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForIssue" />

  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForExpirations" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesAvailableForExpirations" />

  <element name="StockAwardsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockAwardsMember" />

  <element name="DebtInstrumentPeriodicPaymentNumberOfYears" type="xbrli:durationItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_DebtInstrumentPeriodicPaymentNumberOfYears" />

  <element name="ScheduleOfStockOptionsTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_ScheduleOfStockOptionsTable" />

  <element name="StockOptionsLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_StockOptionsLineItems" />

  <element name="WarrantsAdjustedExercisePrice" type="num:perShareItemType" abstract="false" xbrli:periodType="instant" nillable="true" substitutionGroup="xbrli:item" id="ttnp_WarrantsAdjustedExercisePrice" />

  <element name="IncentivePlan2014Member" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_IncentivePlan2014Member" />

  <element name="IncomeTaxReconciliationNoncashGainFromTerminationOfRoyaltyPurchaseAgreement" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxReconciliationNoncashGainFromTerminationOfRoyaltyPurchaseAgreement" />

  <element name="IncomeTaxReconciliationNoncashGainOnSettlementOfLongtermDebt" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="credit" substitutionGroup="xbrli:item" id="ttnp_IncomeTaxReconciliationNoncashGainOnSettlementOfLongtermDebt" />

  <element name="FairValueOfWarrants" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" nillable="true" xbrli:balance="debit" substitutionGroup="xbrli:item" id="ttnp_FairValueOfWarrants" />

  <element name="ComprehensiveIncomeLossTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem" id="ttnp_ComprehensiveIncomeLossTable" />

  <element name="ComprehensiveIncomeLossLineItems" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_ComprehensiveIncomeLossLineItems" />

  <element name="SanofiaventisSaMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_SanofiaventisSaMember" />

  <element name="OptionToPurchaseOfCommonStock" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item" id="ttnp_OptionToPurchaseOfCommonStock" />
</schema>

