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Commitments and Contingencies (Details Textual) (USD $) | 3 Months Ended | 6 Months Ended | 12 Months Ended | 3 Months Ended |  | 1 Months Ended |
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Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 | Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2011 | Jun. 30, 2014 Sanofi-Aventis SA [Member] | Jun. 30, 2013 Sanofi-Aventis SA [Member] | Dec. 31, 2013 Sanofi-Aventis SA [Member] | Nov. 14, 2011 Deerfield Promissory Notes [Member] | Apr. 05, 2011 Deerfield Promissory Notes [Member] | Mar. 15, 2011 Deerfield Promissory Notes [Member] | Apr. 30, 2012 Deerfield Promissory Notes [Member]
Commitments and Contingencies |  |  |  |  |  |  |  |  |  |  |  |  |  |
Debt Instrument, Face Amount |  |  |  |  |  |  |  |  |  |  | $ 20,000,000 |  | $ 20,000,000 |
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid |  |  |  |  |  |  |  |  |  |  |  | 480,000 |  |
Warrants, Term |  |  |  |  |  |  |  |  |  |  |  |  | 6 years |
Repayments of Long-term Debt, Total |  |  | 0 | 2,500,000 | 2,500,000 | 393,000 | 7,564,000 |  |  |  |  | 7,600,000 |  |
Debt Instrument, Interest Rate, Stated Percentage |  |  |  |  |  |  |  |  |  |  |  |  | 8.50% |
Percentage of principle amount due in year one |  |  |  |  |  |  |  |  |  |  |  |  | 10.00% |
Percentage of principle amount due in year two |  |  |  |  |  |  |  |  |  |  |  |  | 15.00% |
Percentage of principle amount due on each of the next three anniversaries |  |  |  |  |  |  |  |  |  |  |  |  | 25.00% |
Principle amount repayment percentage |  |  |  |  |  |  |  |  |  |  |  |  | 110.00% |
Royalty revenue | 0 | 0 | 0 | 1,424,000 | 1,424,000 | 4,750,000 | 3,585,000 | 15,700,000 | 16,700,000 |  |  |  |  |
Debt Instrument, Cash Discount |  |  |  |  |  |  |  |  |  |  |  |  | 3,000,000 |
Accrued Royalties |  |  |  |  |  |  |  |  |  |  | 5,000,000 |  |  | 3,000,000
Long-term Debt, Gross |  |  |  |  |  |  |  |  |  |  | 10,000,000 |  |  |
Repayments of Debt |  |  |  |  |  | 2,500,000 |  |  |  |  |  |  |  |
Gains (Losses) on Extinguishment of Debt, Total |  |  | 0 | 1,860,000 | 1,860,000 | 0 | 0 |  |  |  |  |  |  |
Debt Instrument, Fee Amount |  |  |  |  |  |  |  |  |  |  |  |  | 500,000 |
Warrants To Purchase Common Stock |  |  |  |  |  |  |  |  |  |  |  |  | 6,000,000 |
Warrants, Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.57 |
Adjustments to Additional Paid in Capital, Warrant Issued |  |  |  |  |  |  |  |  |  |  |  |  | 5,500,000 |
Debt Instrument, Unamortized Discount |  |  |  |  |  |  |  |  |  |  |  |  | 9,000,000 |
Extinguishment of Debt, Amount |  |  |  |  |  | 7,500,000 |  |  |  |  | 10,000,000 |  |  |
Debt Instrument, Periodic Payment, Principal |  |  |  |  |  |  |  |  |  |  | 2,500,000 |  |  |
Debt Instrument Periodic Payment Number of Years |  |  |  |  |  |  |  |  |  |  | 4 years |  |  |
Warrants, Adjusted Exercise Price |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.25
Operating Leases, Rent Expense |  |  |  |  | 210,000 | 203,000 | 214,000 |  |  |  |  |  |  |
Accrued Royalties, Current |  |  |  |  |  |  |  | $ 2,400,000 |  | $ 3,100,000 |  |  |  |

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- Definition Amount of long-term debt before deduction of unamortized discount or premium. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt, with initial maturities beyond one year or the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 20 -Article 5 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.22) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 22 -Article 5 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 03 -Paragraph 16 -Article 9 + Details
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