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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail)
9 Months Ended
Sep. 30, 2022
USD ($)
$ / shares
shares
Share-Based Payment Arrangement [Abstract]  
Shares Subject to Outstanding, Beginning Balance | shares 1,422,195
Shares Subject to Outstanding, Options granted | shares 1,320,322
Shares Subject to Outstanding, Options exercised | shares 0
Shares Subject to Outstanding, Options Forfeited | shares (266,347)
Shares Subject to Outstanding, Options Expired | shares (74,436)
Shares Subject to Outstanding, Ending Balance | shares 2,401,734
Shares Subject to Outstanding, Vested and expected to vest | shares 2,115,782
Shares Subject to Outstanding, Exercisable | shares 873,633
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance | $ / shares $ 5.28
Weighted-Average Exercise Price Per Share, Options granted | $ / shares 1.11
Weighted-Average Exercise Price Per Share, Options exercised | $ / shares 0
Weighted-Average Exercise Price Per Share, Options forfeited | $ / shares 2.29
Weighted-Average Exercise Price Per Share, Options expired | $ / shares 6.04
Weighted Average Exercise Price Per Share, Outstanding Ending Balance | $ / shares 3.29
Weighted Average Exercise Price Per Share, Vested and expected to vest | $ / shares 3.55
Weighted Average Exercise Price Per Share, Exercisable | $ / shares $ 6.59
Aggregate Intrinsic Value, Beginning Balance | $ $ 0
Aggregate Intrinsic Value, Options Granted | $ 297,000.00
Aggregate Intrinsic Value, Ending Balance | $ $ 0