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Stock-Based Compensation and Employee Stock Purchase Program (Tables) | 12 Months Ended
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Dec. 31, 2022
Share-Based Payment Arrangement [Abstract] |
Summary of Activity Under Stock Incentive Plans | The following is a summary of stock option information and weighted average exercise prices under the Company’s stock incentive plans (in thousands, except share data and price per share):
|  | Shares Subject to Outstanding Options |  |  | Weighted- Average Exercise Price Per Share |  |  | Aggregate Intrinsic Value |
Outstanding — Balance at December 31, 2020 |  |  | 22,243 |  |  | $ | 578.40 |  |  | $ | 9,600 |
Options granted |  |  | 30,676 |  |  |  | 110.40 |  |  |  | — |
Options exercised |  |  | — |  |  |  | — |  |  |  | — |
Options forfeited |  |  | (11,004 | ) |  |  | 123.60 |  |  |  | 43,440 |
Options expired |  |  | (6,361 | ) |  |  | 1,160.80 |  |  |  | — |
Outstanding — Balance at December 31, 2021 |  |  | 35,554 |  |  |  | 211.20 |  |  |  | — |
Options granted |  |  | 33,408 |  |  |  | 44.00 |  |  |  | 11,880 |
Options exercised |  |  | — |  |  |  | — |  |  |  | — |
Options forfeited |  |  | (6,658 | ) |  |  | 91.60 |  |  |  | — |
Options expired |  |  | (2,302 | ) |  |  | 644.80 |  |  |  | — |
Outstanding — Balance at December 31, 2022 |  |  | 60,002 |  |  |  | 114.80 |  |  |  | — |
Vested and expected to vest — December 31, 2022 |  |  | 54,018 |  |  |  | 121.60 |  |  |  | — |
Exercisable —December 31, 2022 |  |  | 22,456 |  |  | $ | 215.20 |  |  | $ | — |
Weighted-Average Fair Value Assumption of Stock Option Awards | The fair value of stock option awards was estimated at the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumption:
|  | Year Ended December 31, |
Assumptions |  | 2022 |  |  | 2021 |
Expected term (years) |  |  | 6.40 |  |  |  | 6.31 |
Expected volatility |  |  | 122 | % |  |  | 121 | %
Risk-free interest rate |  |  | 2.61 | % |  |  | 0.86 | %
Expected dividend yield |  |  | — |  |  |  | — |

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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