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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail) - USD ($)
 3 Months Ended
Mar. 31, 2023
Mar. 31, 2022
Share-Based Payment Arrangement [Abstract]    
Shares Subject to Outstanding, Beginning Balance 60,002  
Shares Subject to Outstanding, Options granted 2,700  
Shares Subject to Outstanding, Options exercised 0  
Shares Subject to Outstanding, Options Forfeited (858)  
Shares Subject to Outstanding, Options Expired 0  
Shares Subject to Outstanding, Ending Balance 61,844  
Shares Subject to Outstanding, Vested and expected to vest 56,615  
Shares Subject to Outstanding, Exercisable 25,725  
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance $ 114.80  
Weighted-Average Exercise Price Per Share, Options granted 11.17  
Weighted-Average Exercise Price Per Share, Options exercised 0  
Weighted-Average Exercise Price Per Share, Options forfeited 47.06  
Weighted-Average Exercise Price Per Share, Options expired 0  
Weighted Average Exercise Price Per Share, Outstanding Ending Balance 110.91  
Weighted Average Exercise Price Per Share, Vested and expected to vest 116.59  
Weighted Average Exercise Price Per Share, Exercisable $ 194.30  
Aggregate Intrinsic Value, Beginning Balance $ 0  
Aggregate Intrinsic Value, Options Granted 0  
Aggregate Intrinsic Value, Options Exercised 0 $ 0
Aggregate Intrinsic Value, Options Forfeited 39,054,000.00  
Aggregate Intrinsic Value, Options Expired 0  
Aggregate Intrinsic Value, Ending Balance 0  
Aggregate Intrinsic Value, Vested and expected to vest 0  
Aggregate Intrinsic Value, Exercisable $ 0