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Stock-Based Compensation and Employee Stock Purchase Program (Tables) | 6 Months Ended
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Jun. 30, 2023
Share-Based Payment Arrangement [Abstract] |
Summary of Activity Under Stock Incentive Plans | The following is a summary of stock option information and weighted average exercise prices under the Company’s stock incentive plans (in thousands, except share data and price per share):
|  | Shares Subject to Outstanding Options |  |  | Weighted- Average Exercise Price Per Share |  |  | Aggregate Intrinsic Value |
Outstanding — Balance at December 31, 2022 |  |  | 60,002 |  |  | $ | 114.80 |  |  | $ | — |
Options granted |  |  | 26,021 |  |  |  | 6.38 |  |  |  | — |
Options exercised |  |  | — |  |  |  | — |  |  |  | — |
Options forfeited |  |  | (1,058 | ) |  |  | 39.05 |  |  |  | 39,062 |
Options expired |  |  | (210 | ) |  |  | 118.35 |  |  |  | — |
Outstanding — Balance at June 30, 2023 |  |  | 84,755 |  |  | $ | 82.21 |  |  | $ | — |
Vested and expected to vest — June 30, 2023 |  |  | 76,998 |  |  | $ | 87.98 |  |  | $ | — |
Exercisable — June 30, 2023 |  |  | 35,364 |  |  | $ | 155.85 |  |  | $ | — |
Weighted-Average Fair Value Assumption of Stock Option Awards | The fair value of stock option awards was estimated at the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumption:
|  | Three Months Ended June 30, |  |  | Six Months Ended June 30, |
|  | 2023 |  |  | 2022 |  |  | 2023 |  |  | 2022 |
Expected term (years) |  |  | 7.20 |  |  |  | 6.85 |  |  |  | 7.06 |  |  |  | 6.61 |
Expected volatility |  |  | 124 | % |  |  | 123 | % |  |  | 124 | % |  |  | 122 | %
Risk-free interest rate |  |  | 3.59 | % |  |  | 2.85 | % |  |  | 3.61 | % |  |  | 2.48 | %
Dividend yield |  |  | — |  |  |  | — |  |  |  | — |  |  |  | — |

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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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