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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail)
$ / shares in Units, $ in Thousands
 6 Months Ended
Jun. 30, 2023
USD ($)
$ / shares
shares
Share-Based Payment Arrangement [Abstract]  
Shares Subject to Outstanding, Beginning Balance | shares 60,002
Shares Subject to Outstanding, Options granted | shares 26,021
Shares Subject to Outstanding, Options exercised | shares 0
Shares Subject to Outstanding, Options Forfeited | shares (1,058)
Shares Subject to Outstanding, Options Expired | shares (210)
Shares Subject to Outstanding, Ending Balance | shares 84,755
Shares Subject to Outstanding, Vested and expected to vest | shares 76,998
Shares Subject to Outstanding, Exercisable | shares 35,364
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance | $ / shares $ 114.80
Weighted-Average Exercise Price Per Share, Options granted | $ / shares 6.38
Weighted-Average Exercise Price Per Share, Options exercised | $ / shares 0
Weighted-Average Exercise Price Per Share, Options forfeited | $ / shares 39.05
Weighted-Average Exercise Price Per Share, Options expired | $ / shares 118.35
Weighted Average Exercise Price Per Share, Outstanding Ending Balance | $ / shares 82.21
Weighted Average Exercise Price Per Share, Vested and expected to vest | $ / shares 87.98
Weighted Average Exercise Price Per Share, Exercisable | $ / shares $ 155.85
Aggregate Intrinsic Value, Beginning Balance | $ $ 0
Aggregate Intrinsic Value, Options Granted | $ 0
Aggregate Intrinsic Value, Options Exercised | $ 0
Aggregate Intrinsic Value, Options Forfeited | $ 39,062
Aggregate Intrinsic Value, Options Expired | $ 0
Aggregate Intrinsic Value, Ending Balance | $ 0
Aggregate Intrinsic Value, Vested and expected to vest | $ 0
Aggregate Intrinsic Value, Exercisable | $ $ 0