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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail)
$ / shares in Units, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2023
USD ($)
$ / shares
shares
Sep. 30, 2023
USD ($)
$ / shares
shares
Share-Based Payment Arrangement [Abstract]    
Shares Subject to Outstanding, Beginning Balance | shares   60,002
Shares Subject to Outstanding, Options granted | shares 0 26,021
Shares Subject to Outstanding, Options exercised | shares   0
Shares Subject to Outstanding, Options Forfeited | shares   (1,755)
Shares Subject to Outstanding, Options Expired | shares   (210)
Shares Subject to Outstanding, Ending Balance | shares 84,058 84,058
Shares Subject to Outstanding, Vested and expected to vest | shares 76,998 76,998
Shares Subject to Outstanding, Exercisable | shares 35,364 35,364
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance | $ / shares   $ 114.80
Weighted-Average Exercise Price Per Share, Options granted | $ / shares   6.38
Weighted-Average Exercise Price Per Share, Options exercised | $ / shares   0
Weighted-Average Exercise Price Per Share, Options forfeited | $ / shares   32.02
Weighted-Average Exercise Price Per Share, Options expired | $ / shares   118.35
Weighted Average Exercise Price Per Share, Outstanding Ending Balance | $ / shares $ 82.71 82.71
Weighted Average Exercise Price Per Share, Vested and expected to vest | $ / shares 87.65 87.65
Weighted Average Exercise Price Per Share, Exercisable | $ / shares $ 143.59 $ 143.59
Aggregate Intrinsic Value, Beginning Balance | $   $ 0
Aggregate Intrinsic Value, Options Granted | $   0
Aggregate Intrinsic Value, Options Exercised | $   0
Aggregate Intrinsic Value, Options Forfeited | $   39,062
Aggregate Intrinsic Value, Options Expired | $   0
Aggregate Intrinsic Value, Ending Balance | $ $ 0 0
Aggregate Intrinsic Value, Vested and expected to vest | $ 0 0
Aggregate Intrinsic Value, Exercisable | $ $ 0 $ 0