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Stock-Based Compensation and Employee Stock Purchase Program - Summary of Activity Under Stock Incentive Plans (Detail) - USD ($)
$ / shares in Units, $ in Thousands
12 Months Ended
Dec. 31, 2023
Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]    
Shares Subject to Outstanding, Beginning Balance 60,002 35,554
Shares Subject to Outstanding, Options granted 26,021 33,408
Shares Subject to Outstanding, Options exercised 0 0
Shares Subject to Outstanding, Options Forfeited (5,644) (6,658)
Shares Subject to Outstanding, Options Expired (301) (2,302)
Shares Subject to Outstanding, Ending Balance 80,078 60,002
Shares Subject to Outstanding, Vested and expected to vest 74,608  
Shares Subject to Outstanding, Exercisable 41,735  
Weighted-Average Exercise Price Per Share, Outstanding Beginning Balance $ 114.8 $ 211.2
Weighted-Average Exercise Price Per Share, Options granted 6.38 44
Weighted-Average Exercise Price Per Share, Options exercised 0 0
Weighted-Average Exercise Price Per Share, Options forfeited 29.58 91.6
Weighted-Average Exercise Price Per Share, Options expired 121.05 644.8
Weighted Average Exercise Price Per Share, Outstanding Ending Balance 85.3 $ 114.8
Weighted Average Exercise Price Per Share, Vested and expected to vest 89.85  
Weighted Average Exercise Price Per Share, Exercisable $ 139.82  
Aggregate Intrinsic Value, Beginning Balance $ 0 $ 0
Aggregate Intrinsic Value, Options Granted 0 11,880
Aggregate Intrinsic Value, Options Exercised 0 0
Aggregate Intrinsic Value, Options Forfeited 39,062 0
Aggregate Intrinsic Value, Options Expired 0 0
Aggregate Intrinsic Value, Ending Balance 0 $ 0
Aggregate Intrinsic Value, Vested and expected to vest 0  
Aggregate Intrinsic Value, Exercisable $ 0