<SEC-DOCUMENT>0001683168-25-002939-index.html : 20250429
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<ACCEPTANCE-DATETIME>20250429170010
ACCESSION NUMBER:		0001683168-25-002939
CONFORMED SUBMISSION TYPE:	10-K/A
PUBLIC DOCUMENT COUNT:		16
CONFORMED PERIOD OF REPORT:	20241231
FILED AS OF DATE:		20250429
DATE AS OF CHANGE:		20250429

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Xenetic Biosciences, Inc.
		CENTRAL INDEX KEY:			0001534525
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				452952962
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		10-K/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37937
		FILM NUMBER:		25888934

	BUSINESS ADDRESS:	
		STREET 1:		945 CONCORD ST.
		CITY:			FRAMINGHAM
		STATE:			MA
		ZIP:			01701
		BUSINESS PHONE:		781-778-7720

	MAIL ADDRESS:	
		STREET 1:		945 CONCORD ST.
		CITY:			FRAMINGHAM
		STATE:			MA
		ZIP:			01701

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	General Sales & Leasing, Inc.
		DATE OF NAME CHANGE:	20130227

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GENERAL AIRCRAFT INC.
		DATE OF NAME CHANGE:	20111108
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<TYPE>10-K/A
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<FILENAME>xenetic_10ka1-123124.htm
<DESCRIPTION>AMENDMENT NO. 1 TO FORM 10-K
<TEXT>
Document 1 - file: xenetic_10ka1-123124.htm

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<DOCUMENT>
<TYPE>EX-31.3
<SEQUENCE>2
<FILENAME>xenetic_ex3103.htm
<DESCRIPTION>CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
<TEXT>
Document 2 - file: xenetic_ex3103.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-31.4
<SEQUENCE>3
<FILENAME>xenetic_ex3104.htm
<DESCRIPTION>CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER
<TEXT>
Document 3 - file: xenetic_ex3104.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>4
<FILENAME>xbio-20241231.xsd
<DESCRIPTION>XBRL SCHEMA FILE
<TEXT>
Document 4 - file: xbio-20241231.xsd

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<FILENAME>xbio-20241231_def.xml
<DESCRIPTION>XBRL DEFINITION FILE
<TEXT>
Document 5 - file: xbio-20241231_def.xml

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<TYPE>EX-101.LAB
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<DESCRIPTION>XBRL LABEL FILE
<TEXT>
Document 6 - file: xbio-20241231_lab.xml

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<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>7
<FILENAME>xbio-20241231_pre.xml
<DESCRIPTION>XBRL PRESENTATION FILE
<TEXT>
Document 7 - file: xbio-20241231_pre.xml

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<FILENAME>R1.htm
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<TEXT>
Document 9 - file: R1.htm

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<TYPE>EXCEL
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<FILENAME>Financial_Report.xlsx
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 10 - file: Financial_Report.xlsx

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<TYPE>XML
<SEQUENCE>11
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<TEXT>
Document 11 - file: Show.js

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<TYPE>XML
<SEQUENCE>12
<FILENAME>report.css
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 12 - file: report.css

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<TYPE>XML
<SEQUENCE>14
<FILENAME>FilingSummary.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 14 - file: FilingSummary.html

Document 14 - RAW XML: FilingSummary.xml

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<DOCUMENT>
<TYPE>JSON
<SEQUENCE>16
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 16 - file: MetaLinks.json

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<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>17
<FILENAME>0001683168-25-002939-xbrl.zip
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 17 - file: 0001683168-25-002939-xbrl.zip

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<DOCUMENT>
<TYPE>XML
<SEQUENCE>18
<FILENAME>xenetic_10ka1-123124_htm.xml
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<TEXT>
Document 18 - file: xenetic_10ka1-123124_htm.html

Document 18 - RAW XML: xenetic_10ka1-123124_htm.xml

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