<SEC-DOCUMENT>0001493152-22-025244.txt : 20220907
<SEC-HEADER>0001493152-22-025244.hdr.sgml : 20220907
<ACCEPTANCE-DATETIME>20220907160538
ACCESSION NUMBER:		0001493152-22-025244
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20220829
FILED AS OF DATE:		20220907
DATE AS OF CHANGE:		20220907

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Senanayake Chris
		CENTRAL INDEX KEY:			0001945766

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41488
		FILM NUMBER:		221231240

	MAIL ADDRESS:	
		STREET 1:		SHUTTLE PHARMACEUTICALS HOLDINGS, INC.
		STREET 2:		ONE RESEARCH COURT, SUITE 450
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shuttle Pharmaceuticals Holdings, Inc.
		CENTRAL INDEX KEY:			0001757499
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		ONE RESEARCH COURT
		STREET 2:		SUITE 450
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
		BUSINESS PHONE:		2404034212

	MAIL ADDRESS:	
		STREET 1:		ONE RESEARCH COURT
		STREET 2:		SUITE 450
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>ownership.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-08-29</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001757499</issuerCik>
        <issuerName>Shuttle Pharmaceuticals Holdings, Inc.</issuerName>
        <issuerTradingSymbol>SHPH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001945766</rptOwnerCik>
            <rptOwnerName>Senanayake Chris</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SHUTTLE PHARMACEUTICALS HOLDINGS</rptOwnerStreet1>
            <rptOwnerStreet2>ONE RESEARCH COURT, SUITE 450</rptOwnerStreet2>
            <rptOwnerCity>ROCKVILLE</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20850</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>COMMON STOCK</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>3843</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">The undersigned became a Reporting Person subject to Section 16 reporting on August 29, 2022 at the time Shuttle Pharmaceuticals Holdings, Inc (&quot;Company&quot;) completed its initial public offering (&quot;IPO&quot;). At the time of the IPO, the Reporting Person was the beneficial owner of 3,843 shares of common stock of the Company, consisting of 3,834 restricted stock units (&quot;RSUs&quot;), of which 2,562 have fully vested and 1,281 RSUs remain subject to vesting.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Chris H. Senanayake</signatureName>
        <signatureDate>2022-09-07</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
