    <SEC-DOCUMENT>0001493152-22-023497-index.html : 20220819
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    <ACCEPTANCE-DATETIME>20220818190200
    ACCESSION NUMBER:		0001493152-22-023497
    CONFORMED SUBMISSION TYPE:	S-1/A
    PUBLIC DOCUMENT COUNT:		23
    FILED AS OF DATE:		20220819
    DATE AS OF CHANGE:		20220818

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Shuttle Pharmaceuticals Holdings, Inc.
    		CENTRAL INDEX KEY:			0001757499
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-265429
    		FILM NUMBER:		221178528

    	BUSINESS ADDRESS:
    		STREET 1:		ONE RESEARCH COURT
    		STREET 2:		SUITE 450
    		CITY:			ROCKVILLE
    		STATE:			MD
    		ZIP:			20850
    		BUSINESS PHONE:		2404034212

    	MAIL ADDRESS:
    		STREET 1:		ONE RESEARCH COURT
    		STREET 2:		SUITE 450
    		CITY:			ROCKVILLE
    		STATE:			MD
    		ZIP:			20850
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    <SEQUENCE>1
    <FILENAME>forms-1a.htm
    <TEXT>
    Document 1 - file: forms-1a.htm

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    <TYPE>EX-1.1
    <SEQUENCE>2
    <FILENAME>ex1-1.htm
    <TEXT>
    Document 2 - file: ex1-1.htm

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    <SEQUENCE>3
    <FILENAME>ex4-2.htm
    <TEXT>
    Document 3 - file: ex4-2.htm

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    <SEQUENCE>4
    <FILENAME>ex4-3.htm
    <TEXT>
    Document 4 - file: ex4-3.htm

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    <TYPE>EX-4.4
    <SEQUENCE>5
    <FILENAME>ex4-4.htm
    <TEXT>
    Document 5 - file: ex4-4.htm

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    <SEQUENCE>6
    <FILENAME>ex5-1.htm
    <TEXT>
    Document 6 - file: ex5-1.htm

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    <FILENAME>ex10-32.htm
    <TEXT>
    Document 7 - file: ex10-32.htm

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    <SEQUENCE>8
    <FILENAME>ex10-33.htm
    <TEXT>
    Document 8 - file: ex10-33.htm

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    <SEQUENCE>9
    <FILENAME>ex10-34.htm
    <TEXT>
    Document 9 - file: ex10-34.htm

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    <FILENAME>ex23-1.htm
    <TEXT>
    Document 10 - file: ex23-1.htm

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    <TYPE>EX-FILING FEES
    <SEQUENCE>11
    <FILENAME>ex107.htm
    <DESCRIPTION>CALCULATION OF FILING FEE TABLES
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    Document 12 - file: ex5-1_001.jpg

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    <FILENAME>formdrs_007.jpg
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    Document 13 - file: formdrs_007.jpg

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    Document 14 - file: forms-1_009.jpg

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    <FILENAME>formdrs_008.jpg
    <TEXT>
    Document 15 - file: formdrs_008.jpg

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    <FILENAME>formdrs_003.jpg
    <TEXT>
    Document 16 - file: formdrs_003.jpg

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    <FILENAME>formdrs_004.jpg
    <TEXT>
    Document 17 - file: formdrs_004.jpg

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    Document 18 - file: formdrs_005.jpg

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    Document 19 - file: formdrs_006.jpg

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    <FILENAME>coverlogo.jpg
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    Document 20 - file: coverlogo.jpg

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    Document 21 - file: image_002.jpg

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    Document 22 - file: image_003.jpg

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    Document 23 - file: image_004.jpg

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