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    <element id="SHPH_ConvertibleNotePolicyTextBlock" name="ConvertibleNotePolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantsPolicyTextBlock" name="WarrantsPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleOfErrorCorrectionsAndPriorPeriodAdjustmentsTableTextBlock" name="ScheduleOfErrorCorrectionsAndPriorPeriodAdjustmentsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleofWarrantLiabilitiesTableTextBlock" name="ScheduleofWarrantLiabilitiesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleOfUsefulLivesForPropertyPlantEquipmentTableTextBlock" name="ScheduleOfUsefulLivesForPropertyPlantEquipmentTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleOfDerivativeOfSettlementValuationTableTextBlock" name="ScheduleOfDerivativeOfSettlementValuationTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleofDerivativeKeyValuationInputsTableTextBlock" name="ScheduleofDerivativeKeyValuationInputsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleOfPretaxIncomeFromContinuingOperationsTableTextBlock" name="ScheduleOfPretaxIncomeFromContinuingOperationsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleofQuarterlyFinancialDataTableTextBlock" name="ScheduleofQuarterlyFinancialDataTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeemedDividendOnExtinguishmentOfSeriesPreferredStock" name="DeemedDividendOnExtinguishmentOfSeriesPreferredStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeemedDividendOnModificationOfEquityclassifiedWarrantsAsRestated" name="DeemedDividendOnModificationOfEquityclassifiedWarrantsAsRestated" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_WarrantsExercisedForCash" name="WarrantsExercisedForCash" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_GainOnInterestReliefOnConversionOfNotesPayable" name="GainOnInterestReliefOnConversionOfNotesPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_CommonStockIssuedUponConversionOfConvertibleDebt" name="CommonStockIssuedUponConversionOfConvertibleDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInIssuanceCost" name="IncreaseDecreaseInIssuanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInWarrants" name="IncreaseDecreaseInWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInWarrantsFromLiability" name="IncreaseDecreaseInWarrantsFromLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInFairValueOfWarrants" name="IncreaseDecreaseInFairValueOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInNetIncomeLoss" name="IncreaseDecreaseInNetIncomeLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInPreferredStock" name="IncreaseDecreaseInPreferredStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInDividendLiability" name="IncreaseDecreaseInDividendLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityWarrants" name="DerivativeLiabilityWarrants" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityAcceleratedFeature" name="DerivativeLiabilityAcceleratedFeature" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantsEstimatedFairValue" name="WarrantsEstimatedFairValue" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantLiabilities" name="WarrantLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantLiabilitiesIssued" name="WarrantLiabilitiesIssued" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantLiabilitiesExercised" name="WarrantLiabilitiesExercised" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_GainOnChangeInFairValue" name="GainOnChangeInFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ReclassificationsToStockholdersEquity" name="ReclassificationsToStockholdersEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ShareBasedCompensations" name="ShareBasedCompensations" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_OtherInformationAbstract" name="OtherInformationAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_RentVariableRate1" name="RentVariableRate1" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EstimatedMonthlyCommonAreaMaintenanceCost" name="EstimatedMonthlyCommonAreaMaintenanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_CommonAreaMaintenanceCost" name="CommonAreaMaintenanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_PaymentForPlacementAgent" name="PaymentForPlacementAgent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_InterestFeeAmount" name="InterestFeeAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IssuanceOfWarrantsShares" name="IssuanceOfWarrantsShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_SharebasedCompensationArrangementBySharebasedPaymentAwardNonOptionsOutstandingWeightedAverageRemainingContractualTerm1" name="SharebasedCompensationArrangementBySharebasedPaymentAwardNonOptionsOutstandingWeightedAverageRemainingContractualTerm1" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ShareBasedCompensationArrangementByShareBasedPaymetAwardNonOptionGrandInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymetAwardNonOptionGrandInPeriodWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_SharebasedCompensationArrangementBySharebasedPaymentAwardNonOptionsGrantedInPeriodWeightedAverageRemainingContractualTerm" name="SharebasedCompensationArrangementBySharebasedPaymentAwardNonOptionsGrantedInPeriodWeightedAverageRemainingContractualTerm" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ShareBasedCompensationArrangementByShareBasedPaymetAwardNonOptionExercisedInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymetAwardNonOptionExercisedInPeriodWeightedAverageExercisePrice" nillable="true" xbrli:periodType="duration" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_CommonStockVestingOfRestrictedStockUnit" name="CommonStockVestingOfRestrictedStockUnit" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedUponCompletionShares" name="StockIssuedUponCompletionShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedUponCompletion" name="StockIssuedUponCompletion" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedDuringPeriodSharesConversionOfPreferredShares" name="StockIssuedDuringPeriodSharesConversionOfPreferredShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedDuringPeriodSharesConversionOfDividends" name="StockIssuedDuringPeriodSharesConversionOfDividends" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedDuringPeriodValueDividendsPayable" name="StockIssuedDuringPeriodValueDividendsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_CumulativeDividendsPercentage" name="CumulativeDividendsPercentage" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeemedContributionOfConversionOfPreferredStockAndSettlementOfPreferredStockDividends" name="DeemedContributionOfConversionOfPreferredStockAndSettlementOfPreferredStockDividends" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_WarrantSharePrice" name="WarrantSharePrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantLiability" name="WarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantObligationLiability" name="WarrantObligationLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_AdditionOfNewDerivativesRecognizedAsDebtDiscounts" name="AdditionOfNewDerivativesRecognizedAsDebtDiscounts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityOfAcceleration" name="DerivativeLiabilityOfAcceleration" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityOfCarringValueMeasurementDate" name="DerivativeLiabilityOfCarringValueMeasurementDate" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityOfProbabilityAcceleration" name="DerivativeLiabilityOfProbabilityAcceleration" nillable="true" xbrli:periodType="instant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityMeasurementDuration" name="DerivativeLiabilityMeasurementDuration" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityDiscoutRate" name="DerivativeLiabilityDiscoutRate" nillable="true" xbrli:periodType="instant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityOfDiscountRate" name="DerivativeLiabilityOfDiscountRate" nillable="true" xbrli:periodType="instant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeGainLossOnDerivativeWarrants" name="DerivativeGainLossOnDerivativeWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRightsValue" name="ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRightsValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_PaymentsToInvoicesInResearchAndDevelopment" name="PaymentsToInvoicesInResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationProvisionAdjustments" name="IncomeTaxReconciliationProvisionAdjustments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesAbstract" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDerivativeDebtDiscountAmortization" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDerivativeDebtDiscountAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesChangeInFMVOfWarrantLiability" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesChangeInFMVOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesLossOnConvertibleNote" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesLossOnConvertibleNote" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesOther" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeferredTaxAssetsLeaseLiabilities" name="DeferredTaxAssetsLeaseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeferredTaxLiabilitiesFairMarketValue" name="DeferredTaxLiabilitiesFairMarketValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowances" name="DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowances" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_EffectiveIncomeTaxRateReconciliationReturnToProvisionAdjustments" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionAdjustments" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesDerivativeChangeInFMVOfWarrantLiability" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesDerivativeChangeInFMVOfWarrantLiability" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesLossOnConvertibleNoteConversion" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesLossOnConvertibleNoteConversion" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_EffectiveIncomeTaxRateReconciliationShortFallOfStockCompensationExpense" name="EffectiveIncomeTaxRateReconciliationShortFallOfStockCompensationExpense" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeferredTaxAssetsOperatingLossCarriedForwardFutureFederalIncome" name="DeferredTaxAssetsOperatingLossCarriedForwardFutureFederalIncome" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_AdditionalEscrowDeposit" name="AdditionalEscrowDeposit" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_InitialPublicOfferingDescription" name="InitialPublicOfferingDescription" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDifferencesChangeInFMVOfWarrantLiability" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDifferencesChangeInFMVOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
</schema>
