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    <element id="SHPH_ReclassificationOfFairValueOfWarrantLiabilityToEquityUponInitialPublicOffering" name="ReclassificationOfFairValueOfWarrantLiabilityToEquityUponInitialPublicOffering" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DisclosureNotesPayablerelatedPartyAbstract" name="DisclosureNotesPayablerelatedPartyAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DisclosureQuarterlyFinancialDataUnauditedAndRestatedAbstract" name="DisclosureQuarterlyFinancialDataUnauditedAndRestatedAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ReverseStockSplitPolicyTextBlock" name="ReverseStockSplitPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantsPolicyTextBlock" name="WarrantsPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeferredOfferingCostsPolicyTextBlock" name="DeferredOfferingCostsPolicyTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ScheduleOfErrorCorrectionsAndPriorPeriodAdjustmentsTableTextBlock" name="ScheduleOfErrorCorrectionsAndPriorPeriodAdjustmentsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ScheduleOfUsefulLivesForPropertyPlantEquipmentTableTextBlock" name="ScheduleOfUsefulLivesForPropertyPlantEquipmentTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleOfBalanceSheetInformationRelatedToOperatingLeasesTableTextBlock" name="ScheduleOfBalanceSheetInformationRelatedToOperatingLeasesTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ScheduleofDerivativeKeyValuationInputsTableTextBlock" name="ScheduleofDerivativeKeyValuationInputsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ScheduleOfPretaxIncomeFromContinuingOperationsTableTextBlock" name="ScheduleOfPretaxIncomeFromContinuingOperationsTableTextBlock" nillable="true" xbrli:periodType="duration" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeemedDividendOnExtinguishmentOfSeriesPreferredStock" name="DeemedDividendOnExtinguishmentOfSeriesPreferredStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_GainOnInterestReliefOnConversionOfNotesPayable" name="GainOnInterestReliefOnConversionOfNotesPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_IncreaseDecreaseInWarrantsFromLiability" name="IncreaseDecreaseInWarrantsFromLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInFairValueOfWarrants" name="IncreaseDecreaseInFairValueOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInNetIncomeLoss" name="IncreaseDecreaseInNetIncomeLoss" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncreaseDecreaseInPreferredStock" name="IncreaseDecreaseInPreferredStock" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DerivativeLiabilityAcceleratedFeature" name="DerivativeLiabilityAcceleratedFeature" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_RentVariableRate1" name="RentVariableRate1" nillable="true" xbrli:periodType="instant" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_PercentageOfRentAbatement" name="PercentageOfRentAbatement" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EstimatedMonthlyCommonAreaMaintenanceCost" name="EstimatedMonthlyCommonAreaMaintenanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_CommonAreaMaintenanceCost" name="CommonAreaMaintenanceCost" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_PaymentForPlacementAgent" name="PaymentForPlacementAgent" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_InterestFeeAmount" name="InterestFeeAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ConvertibleNotesPayableCurrentNonCurrent" name="ConvertibleNotesPayableCurrentNonCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionEquityInstrumentsOutstandingWeightedAverageExercisePrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsOutstandingIntrinsicValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNonOptionsOutstandingIntrinsicValue" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_CommonStockVestingOfRestrictedStockUnit" name="CommonStockVestingOfRestrictedStockUnit" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedUponCompletionShares" name="StockIssuedUponCompletionShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedUponCompletion" name="StockIssuedUponCompletion" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedDuringPeriodSharesConversionOfPreferredShares" name="StockIssuedDuringPeriodSharesConversionOfPreferredShares" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedDuringPeriodSharesConversionOfDividends" name="StockIssuedDuringPeriodSharesConversionOfDividends" nillable="true" xbrli:periodType="duration" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_StockIssuedDuringPeriodValueDividendsPayable" name="StockIssuedDuringPeriodValueDividendsPayable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeemedContributionOfConversionOfPreferredStockAndSettlementOfPreferredStockDividends" name="DeemedContributionOfConversionOfPreferredStockAndSettlementOfPreferredStockDividends" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_WarrantSharePrice" name="WarrantSharePrice" nillable="true" xbrli:periodType="instant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantLiability" name="WarrantLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_WarrantObligationLiability" name="WarrantObligationLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_AdditionOfNewDerivativesRecognizedAsDebtDiscounts" name="AdditionOfNewDerivativesRecognizedAsDebtDiscounts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeGainLossOnDerivativeWarrants" name="DerivativeGainLossOnDerivativeWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeSettlementsOnDerivativeWarrants" name="DerivativeSettlementsOnDerivativeWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRightsValue" name="ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRightsValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_PaymentsToInvoicesInResearchAndDevelopment" name="PaymentsToInvoicesInResearchAndDevelopment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_WarrantLiabilitiesIssued" name="WarrantLiabilitiesIssued" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_GainOnChangeInFairValue" name="GainOnChangeInFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ReclassificationsToStockholdersEquity" name="ReclassificationsToStockholdersEquity" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DerivativeLiabilityOfCarringValueMeasurementDate" name="DerivativeLiabilityOfCarringValueMeasurementDate" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityOfProbabilityAcceleration" name="DerivativeLiabilityOfProbabilityAcceleration" nillable="true" xbrli:periodType="instant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityMeasurementDuration" name="DerivativeLiabilityMeasurementDuration" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityDiscoutRate" name="DerivativeLiabilityDiscoutRate" nillable="true" xbrli:periodType="instant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DerivativeLiabilityOfDiscountRate" name="DerivativeLiabilityOfDiscountRate" nillable="true" xbrli:periodType="instant" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDerivativeDebtDiscountAmortization" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDerivativeDebtDiscountAmortization" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesChangeInFMVOfWarrantLiability" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesChangeInFMVOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesLossOnConvertibleNote" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesLossOnConvertibleNote" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesOther" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesOther" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
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    <element id="SHPH_DeferredTaxLiabilitiesFairMarketValue" name="DeferredTaxLiabilitiesFairMarketValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeferredTaxLiabilitiesFiniteLivedAssets" name="DeferredTaxLiabilitiesFiniteLivedAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowances" name="DeferredTaxAssetsLiabilitiesNetBeforeValuationAllowances" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationChangeInTaxRate" name="EffectiveIncomeTaxRateReconciliationChangeInTaxRate" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationReturnToProvisionAdjustments" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionAdjustments" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesAbstract" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesAbstract" abstract="true" nillable="true" xbrli:periodType="duration" type="xbrli:stringItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesDerivativeDebtDiscountAmortization" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesDerivativeDebtDiscountAmortization" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesDerivativeChangeInFMVOfWarrantLiability" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesDerivativeChangeInFMVOfWarrantLiability" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesLossOnConvertibleNoteConversion" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesLossOnConvertibleNoteConversion" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationPermanentDifferencesOther" name="EffectiveIncomeTaxRateReconciliationPermanentDifferencesOther" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_EffectiveIncomeTaxRateReconciliationShortFallOfStockCompensationExpense" name="EffectiveIncomeTaxRateReconciliationShortFallOfStockCompensationExpense" nillable="true" xbrli:periodType="duration" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ReverseCommonStockSharesOutstanding" name="ReverseCommonStockSharesOutstanding" nillable="true" xbrli:periodType="instant" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeferredTaxAssetsOperatingLossCarriedForward" name="DeferredTaxAssetsOperatingLossCarriedForward" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_DeferredTaxAssetsOperatingLossCarriedForwardFutureFederalIncome" name="DeferredTaxAssetsOperatingLossCarriedForwardFutureFederalIncome" nillable="true" xbrli:periodType="duration" type="xbrli:durationItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ConvertibleNotePayableCurrent" name="ConvertibleNotePayableCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_ChangeInFairValueOfDerivativeLiability" name="ChangeInFairValueOfDerivativeLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDifferencesChangeInFMVOfWarrantLiability" name="IncomeTaxReconciliationForeignIncomeTaxPermanentDifferencesDifferencesChangeInFMVOfWarrantLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" />
    <element id="SHPH_AltoOpportunityMasterFundSPCMember" name="AltoOpportunityMasterFundSPCMember" nillable="true" xbrli:periodType="duration" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" />
</schema>
