<SEC-DOCUMENT>0001493152-25-004733.txt : 20250203
<SEC-HEADER>0001493152-25-004733.hdr.sgml : 20250203
<ACCEPTANCE-DATETIME>20250203193007
ACCESSION NUMBER:		0001493152-25-004733
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20241231
FILED AS OF DATE:		20250203
DATE AS OF CHANGE:		20250203

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Schafer Joshua
		CENTRAL INDEX KEY:			0001945557
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-41488
		FILM NUMBER:		25584384

	MAIL ADDRESS:	
		STREET 1:		SHUTTLE PHARMACEUTICALS HOLDINGS, INC.
		STREET 2:		ONE RESEARCH COURT, SUITE 450
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Shuttle Pharmaceuticals Holdings, Inc.
		CENTRAL INDEX KEY:			0001757499
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		401 PROFESSIONAL DRIVE
		STREET 2:		SUITE 260
		CITY:			GAITHERSBURG
		STATE:			MD
		ZIP:			20879
		BUSINESS PHONE:		(240) 403-4212

	MAIL ADDRESS:	
		STREET 1:		401 PROFESSIONAL DRIVE
		STREET 2:		SUITE 260
		CITY:			GAITHERSBURG
		STATE:			MD
		ZIP:			20879
</SEC-HEADER>
<DOCUMENT>
<TYPE>5
<SEQUENCE>1
<FILENAME>ownership.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>5</documentType>

    <periodOfReport>2024-12-31</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <form3HoldingsReported>0</form3HoldingsReported>

    <form4TransactionsReported>0</form4TransactionsReported>

    <issuer>
        <issuerCik>0001757499</issuerCik>
        <issuerName>Shuttle Pharmaceuticals Holdings, Inc.</issuerName>
        <issuerTradingSymbol>SHPH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001945557</rptOwnerCik>
            <rptOwnerName>Schafer Joshua</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SHUTTLE PHARMACEUTICALS HOLDINGS</rptOwnerStreet1>
            <rptOwnerStreet2>401 PROFESSIONAL DRIVE, SUITE 260</rptOwnerStreet2>
            <rptOwnerCity>GAITHERSBURG,</rptOwnerCity>
            <rptOwnerState>MD</rptOwnerState>
            <rptOwnerZipCode>20879</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2024-12-31</value>
            </transactionDate>
            <deemedExecutionDate></deemedExecutionDate>
            <transactionCoding>
                <transactionFormType>5</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionTimeliness></transactionTimeliness>
            <transactionAmounts>
                <transactionShares>
                    <value>209790</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>210004</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Represents 209,790 restricted stock units (&quot;RSUs&quot;) issued to the Reporting Person under the Shuttle Pharmaceuticals Holdings, Inc. 2018 Equity Incentive Plan. The 209,790 RSUs which are scheduled to vest in one third increments on each of 12/31/2025, 12/31/2026 and 12/31/2027.</footnote>
        <footnote id="F2">Consists of (1) 214 shares of common stock and (2) 209,790 RSUs which remain subject to vesting.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Joshua Schafer</signatureName>
        <signatureDate>2025-02-03</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
