v3.23.1

Note 15 - Common Stock Reserved for Issuance - Common Stock Reserved for Issuance (Details) - $ / shares | Dec. 31, 2022 | Dec. 31, 2021
--- | --- | ---
Outstanding stock options and RSUs (in dollars per share) | $ 13,130,144 | $ 5,977,179
Shares reserved for future option grants and RSUs (in shares) | 376,201 | 589,064
Total common stock reserved for issuance (in shares) | 95,674,634 | 40,931,857
Lincoln Park [Member] |  |
Total common stock reserved for issuance (in shares) | 15,814,471 | 5,222,867
Madryn Noteholders [Member] |  |
Total common stock reserved for issuance (in shares) | 8,215,706 | 8,213,880
Non-Voting Preferred Stock [Member] |  |
Shares reserved for conversion of future preferred share issuance (in shares) | 1,209,245 | 1,209,245
Voting Preferred Stock [Member] |  |
Shares reserved for conversion of future preferred share issuance (in shares) | 9,150,000 | 0
Common Stock [Member] |  |
Outstanding common stock warrants (in shares) | 15,928,867 | 15,928,867
Preferred Stock [Member] |  |
Preferred shares (in shares) | 31,850,000 | 3,790,755

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