v3.25.1

Note 15 - Stockholders Equity (Details Textual) |  |  |  |  |  |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended | 24 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Mar. 03, 2025 $ / shares | Feb. 14, 2025 | Feb. 27, 2024 USD ($) | Feb. 22, 2024 $ / shares shares | Oct. 20, 2023 USD ($) shares | Oct. 04, 2023 $ / shares shares | Sep. 08, 2023 USD ($) shares | Jul. 12, 2023 USD ($) shares | May 15, 2023 USD ($) shares | May 11, 2023 | May 10, 2023 | Jul. 12, 2022 USD ($) $ / shares shares | Nov. 30, 2022 USD ($) $ / shares shares | Nov. 30, 2017 | Nov. 30, 2010 | Dec. 31, 2024 USD ($) $ / shares shares | Dec. 31, 2023 USD ($) $ / shares shares | Dec. 31, 2022 USD ($) shares | Jun. 30, 2022 USD ($) $ / shares shares | Sep. 26, 2024 shares | May 24, 2024 USD ($) shares | Feb. 07, 2024 $ / shares shares | May 31, 2023 USD ($) $ / shares | Jun. 16, 2020 USD ($) $ / shares shares
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.0001 | $ 0.0001 |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 10,000 | $ 816,000 |  |  |  |  |  |  |
Proceeds from Issuance of Private Placement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 977,000 | $ 6,261,000 |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,934,233 | 1,717,111 |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 | $ 0 |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7.81 | $ 30.91 |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,152,000 | $ 1,552,000 |  |  |  |  |  |  |
The 2010 Share Option Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  |  |  |  |  |  |  |  |  |  | 10 years | 7 years |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,155 | 2,566 |  |  |  |  |  |  |
The 2019 Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,939 | 6,351 |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,728 |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Increase in Authorized Shares, Percentage of Outstanding Stock Maximum |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 4.00% |  |  |  |  |  |  |  |
The 2024 Investor Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  | $ 14.74 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrants and Rights Outstanding, Term (Year) |  |  |  | 5 years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Voting Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Liquidation Preference Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 330 |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  |  |  |  |  |  |  |  |  |  |  |  | 0.0606 |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Volume Weighted Average Price Per Common Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  | $ 206.25 |  |  |  |  |  |  |  |  |  |  |
Senior Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  |  |  |  |  |  |  |  | 0.2424 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Liquidation Preference, Multiplier |  |  |  |  |  |  |  |  | 2.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion Price, Benchmark, Multiplier |  |  |  |  |  |  |  |  | 2.75 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series X Convertible Preferred Stock [Member][ |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  |  |  |  | $ 221.1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  |  |  |  |  | 0.9091 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  | $ 0.0001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Shares Authorized (in shares) | shares |  |  |  |  |  | 400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Dividend Rate, Percentage |  |  |  |  |  | 12.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series Y Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Convertible, Conversion Ratio |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9.0909 |  |  |
Preferred Stock, Shares Authorized (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 900,000 | 600,000 |  |  |
Preferred Stock, Convertible, Minimum Proceeds From Conversion |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 30,000,000 |  |  |
Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 758 | 31,210 |  |  |  |  |  |  |
H.C. Wainwright & Co., LLC [Member] | Placement Agent Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 20.1438 |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,204 |  |
Equity Purchase Agreement [Member] | Lincoln Park [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity Purchase Agreement, Maximum Offering Amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 31,000,000
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.0001
Equity Purchase Agreement, Maximum Shares Issuable (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 47,050
Equity Agreement, Maximum Percentage of Stock Outstanding |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 19.99%
Equity Agreement, Minimum Average Purchase Price (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 655.9575
Maximum Percentage of Outstanding Stock, Beneficial Ownership |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9.99%
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,425 | 20,831 |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 445.5 |  |  |  |  |
Stock Issued During Period, Shares, Commitment Fee (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,271 |  |  |  |  |
Stock Issued During Period, Value, Commitment Fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 620,000 |  |  |  |  |
Deferred Offering Costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0 | $ 123,000 |  |  |  |  |
Proceeds from Issuance of Common Stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 272,000 |  |  |  |  |  |
LPC Purchase Agreement 2022 [Member] | Lincoln Park [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity Purchase Agreement, Maximum Offering Amount |  |  |  |  |  |  |  |  |  |  |  | $ 11,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  | $ 0.0001 |  |  |  |  |  |  |  |  |  |  |  |
Equity Purchase Agreement, Maximum Shares Issuable (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  | 78,020 |  |  |  |  |  |  |  |  |  |  |  |
Equity Agreement, Maximum Percentage of Stock Outstanding |  |  |  |  |  |  |  |  |  |  |  | 19.99% |  |  |  |  |  |  |  |  |  |  |  |
Maximum Percentage of Outstanding Stock, Beneficial Ownership |  |  |  |  |  |  |  |  |  |  |  | 9.99% |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 12.76 | $ 43.626 |  |  |  |  |  |  |
Stock Issued During Period, Shares, Commitment Fee (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  | 4,155 |  |  |  | 758 | 70,587 |  |  |  |  |  |  |
Stock Issued During Period, Value, Commitment Fee |  |  |  |  |  |  |  |  |  |  |  | $ 330,000 |  |  |  | $ 10,000 | $ 3,080,000 |  |  |  |  |  |  |
The 2022 Private Placement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Private Placement |  |  |  |  |  |  |  |  |  |  |  |  | $ 6,720,000 |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs |  |  |  |  |  |  |  |  |  |  |  |  | $ 202,000 |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement [Member] | Convertible Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  | 3,185,000 |  |  |  |  |  |  |  |  |  |  |
The 2022 Private Placement [Member] | Common Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  |  |  |  |  |  |  |  |  |  | 10,608 |  |  |  |  |  |  |  |  |  |  |
Multi-Tranche Private Placement 2023 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Equity Purchase Agreement, Maximum Offering Amount |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 9,000,000 |
Equity Purchase Agreement, Minimum Aggregate Purchase Amount Per Tranche |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 500,000 |
Multi-Tranche Private Placement 2023 [Member] | Senior Preferred Stock [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  |  | 502,513 |  | 292,398 | 500,000 | 280,899 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.0001 |
Proceeds from Issuance of Preferred Stock and Preference Stock |  |  |  |  | $ 2,000,000 |  | $ 1,000,000 | $ 2,000,000 | $ 2,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Registered Direct Offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum Percentage of Outstanding Stock, Beneficial Ownership |  |  |  | 4.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues (in shares) | shares |  |  |  | 74,342 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share (in dollars per share) | $ / shares |  |  |  | $ 16.115 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments of Stock Issuance Costs |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 222,000 |  |  |  |  |  |  |  |
Proceeds from Issuance or Sale of Equity |  |  | $ 1,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Registered Direct Offering [Member] | H.C. Wainwright & Co., LLC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Placement Agent Fee, Percentage of Gross Proceeds |  |  | 7.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Management Fee, Percentage of Gross Proceeds |  |  | 1.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares | $ 0.0001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum [Member] | Registered Direct Offering [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum Percentage of Outstanding Stock, Beneficial Ownership |  |  |  | 9.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  |  |  |  |  |  |  |  |  | 15 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio | 11 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  |  |  |  |  |  |  |  |  |  | 5 |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] | Minimum [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  | 5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  |  |  |  |  |  |  |  |  |  | 15 |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse Stock Split [Member] | Maximum [Member] | Subsequent Event [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stockholders' Equity Note, Stock Split, Conversion Ratio |  | 16 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

X
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