v3.25.1

Note 15 - Stockholders Equity (Details Textual)													1 Months Ended			12 Months Ended			24 Months Ended
	Mar. 03, 2025 $ / shares	Feb. 14, 2025	Feb. 27, 2024 USD ($)	Feb. 22, 2024 $ / shares shares	Oct. 20, 2023 USD ($) shares	Oct. 04, 2023 $ / shares shares	Sep. 08, 2023 USD ($) shares	Jul. 12, 2023 USD ($) shares	May 15, 2023 USD ($) shares	May 11, 2023	May 10, 2023	Jul. 12, 2022 USD ($) $ / shares shares	Nov. 30, 2022 USD ($) $ / shares shares	Nov. 30, 2017	Nov. 30, 2010	Dec. 31, 2024 USD ($) $ / shares shares	Dec. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) shares	Jun. 30, 2022 USD ($) $ / shares shares	Sep. 26, 2024 shares	May 24, 2024 USD ($) shares	Feb. 07, 2024 $ / shares shares	May 31, 2023 USD ($) $ / shares	Jun. 16, 2020 USD ($) $ / shares shares
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares																$ 0.0001	$ 0.0001
Proceeds from Issuance of Common Stock																$ 10,000	$ 816,000
Proceeds from Issuance of Private Placement																$ 977,000	$ 6,261,000
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares																8,934,233	1,717,111
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Payments																$ 0
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value																$ 0	$ 0
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) | $ / shares																$ 7.81	$ 30.91
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value																$ 1,152,000	$ 1,552,000
The 2010 Share Option Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)														10 years	7 years
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares																3,155	2,566
The 2019 Plan [Member]
Common Stock, Capital Shares Reserved for Future Issuance (in shares) | shares																25,939	6,351
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares) | shares																2,728
Share-based Compensation Arrangement by Share-based Payment Award, Increase in Authorized Shares, Percentage of Outstanding Stock Maximum																4.00%
The 2024 Investor Warrants [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares				$ 14.74
Warrants and Rights Outstanding, Term (Year)				5 years
Voting Preferred Stock [Member]
Preferred Stock, Liquidation Preference Per Share (in dollars per share) | $ / shares													$ 330
Preferred Stock, Convertible, Conversion Ratio													0.0606
Preferred Stock, Convertible, Volume Weighted Average Price Per Common Share (in dollars per share) | $ / shares													$ 206.25
Senior Preferred Stock [Member]
Preferred Stock, Convertible, Conversion Ratio									0.2424
Liquidation Preference, Multiplier									2.5
Conversion Price, Benchmark, Multiplier									2.75
Series X Convertible Preferred Stock [Member][
Shares Issued, Price Per Share (in dollars per share) | $ / shares						$ 221.1
Preferred Stock, Convertible, Conversion Ratio						0.9091
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares						$ 0.0001
Preferred Stock, Shares Authorized (in shares) | shares						400,000
Preferred Stock, Dividend Rate, Percentage						12.50%
Series Y Convertible Preferred Stock [Member]
Preferred Stock, Convertible, Conversion Ratio																					9.0909
Preferred Stock, Shares Authorized (in shares) | shares																				900,000	600,000
Preferred Stock, Convertible, Minimum Proceeds From Conversion																					$ 30,000,000
Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares																758	31,210
H.C. Wainwright & Co., LLC [Member] | Placement Agent Warrants [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares																						$ 20.1438
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | shares																						5,204
Equity Purchase Agreement [Member] | Lincoln Park [Member]
Equity Purchase Agreement, Maximum Offering Amount																								$ 31,000,000
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares																								$ 0.0001
Equity Purchase Agreement, Maximum Shares Issuable (in shares) | shares																								47,050
Equity Agreement, Maximum Percentage of Stock Outstanding																								19.99%
Equity Agreement, Minimum Average Purchase Price (in dollars per share) | $ / shares																								$ 655.9575
Maximum Percentage of Outstanding Stock, Beneficial Ownership																								9.99%
Stock Issued During Period, Shares, New Issues (in shares) | shares																		2,425	20,831
Shares Issued, Price Per Share (in dollars per share) | $ / shares																			$ 445.5
Stock Issued During Period, Shares, Commitment Fee (in shares) | shares																			1,271
Stock Issued During Period, Value, Commitment Fee																			$ 620,000
Deferred Offering Costs																		$ 0	$ 123,000
Proceeds from Issuance of Common Stock																		$ 272,000
LPC Purchase Agreement 2022 [Member] | Lincoln Park [Member]
Equity Purchase Agreement, Maximum Offering Amount												$ 11,000,000
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares												$ 0.0001
Equity Purchase Agreement, Maximum Shares Issuable (in shares) | shares												78,020
Equity Agreement, Maximum Percentage of Stock Outstanding												19.99%
Maximum Percentage of Outstanding Stock, Beneficial Ownership												9.99%
Shares Issued, Price Per Share (in dollars per share) | $ / shares																$ 12.76	$ 43.626
Stock Issued During Period, Shares, Commitment Fee (in shares) | shares												4,155				758	70,587
Stock Issued During Period, Value, Commitment Fee												$ 330,000				$ 10,000	$ 3,080,000
The 2022 Private Placement [Member]
Proceeds from Issuance of Private Placement													$ 6,720,000
Payments of Stock Issuance Costs													$ 202,000
The 2022 Private Placement [Member] | Convertible Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares													3,185,000
The 2022 Private Placement [Member] | Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares													10,608
Multi-Tranche Private Placement 2023 [Member]
Equity Purchase Agreement, Maximum Offering Amount																							$ 9,000,000
Equity Purchase Agreement, Minimum Aggregate Purchase Amount Per Tranche																							$ 500,000
Multi-Tranche Private Placement 2023 [Member] | Senior Preferred Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares) | shares					502,513		292,398	500,000	280,899
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares																							$ 0.0001
Proceeds from Issuance of Preferred Stock and Preference Stock					$ 2,000,000		$ 1,000,000	$ 2,000,000	$ 2,000,000
Registered Direct Offering [Member]
Maximum Percentage of Outstanding Stock, Beneficial Ownership				4.99%
Stock Issued During Period, Shares, New Issues (in shares) | shares				74,342
Shares Issued, Price Per Share (in dollars per share) | $ / shares				$ 16.115
Payments of Stock Issuance Costs																$ 222,000
Proceeds from Issuance or Sale of Equity			$ 1,200,000
Registered Direct Offering [Member] | H.C. Wainwright & Co., LLC [Member]
Placement Agent Fee, Percentage of Gross Proceeds			7.00%
Management Fee, Percentage of Gross Proceeds			1.00%
Subsequent Event [Member]
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares	$ 0.0001
Maximum [Member] | Registered Direct Offering [Member]
Maximum Percentage of Outstanding Stock, Beneficial Ownership				9.99%
Reverse Stock Split [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio										15
Reverse Stock Split [Member] | Subsequent Event [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio	11
Reverse Stock Split [Member] | Minimum [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio											5
Reverse Stock Split [Member] | Minimum [Member] | Subsequent Event [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio		5
Reverse Stock Split [Member] | Maximum [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio											15
Reverse Stock Split [Member] | Maximum [Member] | Subsequent Event [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio		16

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