<SEC-DOCUMENT>0001144204-12-005602.txt : 20120203
<SEC-HEADER>0001144204-12-005602.hdr.sgml : 20120203
<ACCEPTANCE-DATETIME>20120202193122
ACCESSION NUMBER:		0001144204-12-005602
CONFORMED SUBMISSION TYPE:	8-K/A
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20111118
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20120203
DATE AS OF CHANGE:		20120202

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ADEONA PHARMACEUTICALS, INC.
		CENTRAL INDEX KEY:			0000894158
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133808303
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-12584
		FILM NUMBER:		12567571

	BUSINESS ADDRESS:	
		STREET 1:		3930 VARSITY DRIVE
		CITY:			ANN ARBOR
		STATE:			MI
		ZIP:			48108
		BUSINESS PHONE:		734-332-7800

	MAIL ADDRESS:	
		STREET 1:		3930 VARSITY DRIVE
		CITY:			ANN ARBOR
		STATE:			MI
		ZIP:			48108

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20061214

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19970730

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHEFFIELD MEDICAL TECHNOLOGIES INC
		DATE OF NAME CHANGE:	19940606
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K/A
<SEQUENCE>1
<FILENAME>v301090_8ka.htm
<DESCRIPTION>FORM 8-K/A
<TEXT>
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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>FORM 8-K/A</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>CURRENT REPORT</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Pursuant to Section 13 or 15(d) of
the Securities Exchange Act of 1934</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">Date of Report (date of earliest event
reported): <B>November18, 2011</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 18pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Adeona Pharmaceuticals, Inc.</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">(Exact name of registrant as specified
in charter)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Nevada</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">(State or other jurisdiction of incorporation)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; padding-right: 0.8pt; line-height: 115%; font-size: 10pt; font-weight: bold; text-align: center"><B>01-12584</B></TD>
    <TD STYLE="width: 50%; padding-right: 0.8pt; line-height: 115%; font-size: 10pt; font-weight: bold; text-align: center"><B>13-3808303</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; font-size: 10pt; text-align: center">(Commission File Number)</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; font-size: 10pt; text-align: center">(IRS Employer Identification No.)</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>3985 Research Park Drive, Suite 200</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Ann Arbor, MI 48108</B></P>

<P STYLE="font: 10pt/0.75pt Times New Roman, Times, Serif; margin: 8.5pt 158.3pt 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">(Address of principal executive
offices and zip code)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(734) 332-7800</B></P>

<P STYLE="font: 10pt/0.75pt Times New Roman, Times, Serif; margin: 8.5pt 158.3pt 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">&nbsp; &nbsp; (Registrant&rsquo;s
telephone number including area code)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>N/A</B></P>

<P STYLE="font: 10pt/0.75pt Times New Roman, Times, Serif; margin: 8.5pt 158.3pt 0; text-align: center; background-color: black">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 8.5pt 0 0; text-align: center">&nbsp; &nbsp; (Former Name and
Former Address)</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">Check the appropriate box below if the
Form 8-K filing is intended to simultaneously satisfy the filing obligation of registrant under any of the following provisions:</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
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    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 88%; padding-right: 0.8pt; line-height: 115%">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 88%; padding-right: 0.8pt; line-height: 115%">Soliciting material pursuant to Rule 14a-12(b) under the Exchange Act (17 CFR 240.14a-12)</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 88%; padding-right: 0.8pt; line-height: 115%">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 6%; padding-right: 0.8pt; line-height: 115%"><FONT STYLE="font-family: Wingdings 2">&#163;</FONT></TD>
    <TD STYLE="width: 88%; padding-right: 0.8pt; line-height: 115%; text-align: justify">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0"><B>Explanatory Note</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0pt">On November 21, 2011, Adeona Pharmaceuticals, Inc.
(the &ldquo;Company&rdquo;) filed a Current Report on Form 8-K (the &ldquo;Original Form 8-K&rdquo;) concerning, in part, the
agreement the Company entered into with Intrexon Corporation. This Current Report on Form 8-K/A (the &ldquo;Amendment&rdquo;)
is being filed solely to refile Exhibit 10.1 of the Original Form 8-K to include additional terms of the Intrexon Corporation
agreement previously redacted. Except as disclosed in this Amendment, the Company has not otherwise modified the disclosures presented
in the Original <FONT STYLE="background-color: White">Form</FONT> 8-K. This Amendment should be read in conjunction with the Original
<FONT STYLE="background-color: White">Form</FONT> 8-K. The changes in this exhibit were made in response to comments received
from the Securities and Exchange Commission.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0 0 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; padding-right: 0.8pt; line-height: 115%; font-weight: bold"><B>Item 9.01</B></TD>
    <TD STYLE="width: 88%; padding-right: 0.8pt; line-height: 115%; font-weight: bold; text-align: justify"><B>Financial Statements and Exhibits.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 3%; padding-right: 0.8pt; line-height: 115%">(d)</TD>
    <TD STYLE="width: 94%; padding-right: 0.8pt; line-height: 115%; text-align: justify">Exhibits</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 13%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; line-height: 115%; font-weight: bold"><B>Exhibit&nbsp;No.</B></TD>
    <TD STYLE="width: 2%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 85%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; line-height: 115%; font-weight: bold"><B>Description</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">10.1</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">Exclusive Channel Collaboration Agreement by and between Adeona Pharmaceuticals, Inc. and Intrexon Corporation dated as of November 18, 2011 **</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">**. Certain Confidential Information contained in this Exhibit
was omitted by means of redacting a portion of the text and replacing it with an asterisk. This Exhibit has been filed separately
with the Secretary of the Securities and Exchange Commission without the redaction pursuant to a Confidential Treatment Request
under Rule 24b-2 of the Securities Exchange Act of 1934, as amended.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">Pursuant to the requirements of the Securities Exchange Act
of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">Dated:&nbsp;&nbsp;February 2, 2012</TD>
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%">ADEONA PHARMACEUTICALS, INC.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%">(Registrant)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 49%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 7%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 44%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">By:</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding-right: 0.8pt; line-height: 115%">/s/ James S. Kuo</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%">Name: James S. Kuo</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-right: 1.8pt; line-height: 115%">Title: President and Chief Executive Officer</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

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<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0; text-align: center"><B><U>INDEX OF EXHIBITS</U></B></P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 13%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; line-height: 115%; font-weight: bold"><B>Exhibit&nbsp;No.</B></TD>
    <TD STYLE="width: 2%; padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="width: 85%; border-bottom: black 1.5pt solid; padding-right: 0.8pt; line-height: 115%; font-weight: bold"><B>Description</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.8pt; line-height: 115%; text-align: center">10.1</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">&nbsp;</TD>
    <TD STYLE="padding-right: 0.8pt; line-height: 115%">Exclusive Channel Collaboration Agreement by and between Adeona Pharmaceuticals, Inc. and Intrexon Corporation dated as of November 18, 2011 **</TD></TR>
</TABLE>
<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp; &nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">&nbsp;** Previously filed and herein incorporated by reference
in, the Company&rsquo;s Current Report on Form 8-K filed with Securities and Exchange Commission on November 21, 2011. Certain
Confidential Information contained in this Exhibit was omitted by means of redacting a portion of the text and replacing it with
an asterisk. This Exhibit has been filed separately with the Secretary of the Securities and Exchange Commission</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 0">without the redaction pursuant to a Confidential Treatment
Request under Rule 24b-2 of the Securities Exchange Act of 1934, as amended.&nbsp;</P>

<P STYLE="font: 10pt/normal Times New Roman, Times, Serif; margin: 8.5pt 0 0">&nbsp;</P>

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<P STYLE="font: 10pt/0.05pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>



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<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>v301090_ex10-1.htm
<DESCRIPTION>EXHIBIT 10.1
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><B>Portions herein identified by [*****] have
been omitted pursuant to a request for confidential treatment under Rule 24b-2 of the Securities Exchange Act of 1934, as amended.&nbsp;&nbsp;A
complete copy of this document has been filed separately with the Securities and Exchange Commission.</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: left"><FONT STYLE="font-variant: small-caps">&nbsp;</FONT></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps">Exclusive
Channel Collaboration Agreement</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps"><B>This
Exclusive Channel Collaboration Agreement </B></FONT>(the &ldquo;<B>Agreement</B>&rdquo;) is made and entered into effective as
of November 18, 2011 (the &ldquo;<B>Effective Date</B>&rdquo;) by and between <FONT STYLE="font-variant: small-caps"><B>Intrexon
Corporation</B></FONT>, a Virginia corporation, through its Human Therapeutics Division with offices at 20358 Seneca Meadows Parkway,
Germantown, MD 20876 (&ldquo;<B>Intrexon</B>&rdquo;), and <FONT STYLE="font-variant: small-caps"><B>Adeona Pharmaceuticals, Inc.</B></FONT>,
a Nevada corporation having its principal place of business at 3985 Research Park Drive, Suite 200, Ann Arbor, MI 48108 (&ldquo;<B>Adeona</B>&rdquo;).
Intrexon and Adeona may be referred to herein individually as a &ldquo;<B>Party</B>&rdquo;, and collectively as the &ldquo;<B>Parties</B>.&rdquo;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps"><B>Recitals</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps"><B>Whereas</B></FONT><B>,
</B>Intrexon has expertise in and owns or controls proprietary technology relating to the design and production of DNA vectors
or their <I>in vivo</I> expression or the control of expression, as well as control over cell function; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps"><B>Whereas,</B></FONT>
Adeona now desires to become Intrexon&rsquo;s exclusive channel collaborator with respect to such technology for the purpose of
developing the PAH Program (as defined herein), and Intrexon is willing to appoint Adeona as a channel collaborator in such field
under the terms and conditions of this Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps"><B>Now
Therefore,</B></FONT> in consideration of the foregoing and the covenants and promises contained herein, the Parties agree as follows:</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
1<BR>
<BR>
</B></FONT><B>Definitions</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">As used in this
Agreement, the following capitalized terms shall have the following meanings:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.1 </B>&ldquo;<B>Adeona
Indemnitees</B>&rdquo; has the meaning set forth in Section 9.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.2 </B>&ldquo;<B>Adeona
Product</B>&rdquo; means any product in the Field that is created, produced, developed, or identified directly or indirectly by
or on behalf of Adeona during the Term whether through use or practice of Intrexon Channel Technology or the Intrexon Materials
or otherwise.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.3 </B>&ldquo;<B>Adeona
Program Patent</B>&rdquo; has the meaning set forth in Section 6.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.4
</B></FONT>&ldquo;<B>Adeona Termination IP</B>&rdquo; means all Patents or other intellectual property that Adeona or any of its
Affiliates Controls as of the Effective Date or during the Term that Cover, or is otherwise necessary or useful for, the development,
manufacture or commercialization of a Reverted Product or necessary or useful for Intrexon to operate in the Field.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.5
</B></FONT>&ldquo;<B>Affiliate</B>&rdquo; means, with respect to a particular Party, any other person or entity that directly or
indirectly controls, is controlled by, or is in common control with such Party. As used in this Section 1.1, the term &ldquo;controls&rdquo;
(with correlative meanings for the terms &ldquo;controlled by&rdquo; and &ldquo;under common control with&rdquo;) means the ownership,
directly or indirectly, of more than fifty percent (50%) of the voting securities or other ownership interest of an entity, or
the possession, directly or indirectly, of the power to direct the management or policies of an entity, whether through the ownership
of voting securities, by contract, or otherwise. Notwithstanding the foregoing, except as set forth in Section 2.3(a), Third Security
shall be deemed not to be an Affiliate of Intrexon, and any other person, corporation, partnership, or other entity that would
be an Affiliate of Intrexon solely because it and Intrexon are under common control by Randal J. Kirk or by investment funds managed
by Third Security or an affiliate of Third Security<B> </B>shall also be deemed not to be an Affiliate of Intrexon.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.6
</B></FONT>&ldquo;<B>Allowable Expenses</B>&rdquo; means any of the following expenses incurred by Adeona or an Affiliate of Adeona
after the First Commercial Sale in the Territory of an Adeona Product, in each case to the extent specifically attributable to
such Adeona Product and specifically attributable to the Commercialization of such Adeona Product: (a) Cost of Goods Sold, (b)
Marketing Expenses, (c) Distribution Expenses, (d) Post-Launch Product R&amp;D Expenses, and (e) Additional Commercialization Expenses,
in each case as such terms are defined and calculated in this Article 1 and in Exhibit A.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.7
</B></FONT>&ldquo;<B>Applicable Laws</B>&rdquo; has the meaning set forth in Section 8.2(d)(xiii).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.8
</B></FONT>&ldquo;<B>Authorizations</B>&rdquo; has the meaning set forth in Section 8.2(d)(xiii).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.9
</B></FONT>&ldquo;<B>Blocking Third Party IP</B>&rdquo; has the meaning set forth in Section 3.7(a).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.10
</B></FONT>&ldquo;<B>CC</B>&rdquo; has the meaning set forth in Section 2.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.11 </B>&ldquo;<B>Channel-Related
Program IP</B>&rdquo; has the meaning set forth in Section 6.1(c).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.12
</B></FONT>&ldquo;<B>Claims</B>&rdquo; has the meaning set forth in Section 9.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.13
</B></FONT>&ldquo;<B>CMCC</B>&rdquo; has the meaning set forth in Section 2.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.14
</B></FONT>&ldquo;<B>Committees</B>&rdquo; has the meaning set forth in Section 2.2(a).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.15
</B></FONT>&ldquo;<B>Commercialize</B>&rdquo; or &ldquo;<B>Commercialization</B>&rdquo; means any activities directed to marketing,
promoting, distributing, importing for sale, offering to sell and/or selling Adeona Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.16 </B>&ldquo;<B>Confidential
Information</B>&rdquo; means each Party&rsquo;s confidential information, inventions, non-public know-how or non-public data disclosed
pursuant to this Agreement or any other confidentiality agreement between the Parties and shall include, without limitation, manufacturing,
marketing, financial, personnel and other business information and plans, whether in oral, written, graphic or electronic form.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.17 </B>&ldquo;<B>Control</B>&rdquo;
means, with respect to a Patent or other intellectual property right, that a Party owns or has a license to such right and has
the ability to grant a license or sublicense as provided for in this Agreement under such right without violating the terms of
any agreement or other arrangement with any Third Party.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.18 </B>&ldquo;<B>CRC</B>&rdquo;
has the meaning set forth in Section 2.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.19 </B>&ldquo;<B>Diligent
Efforts</B>&rdquo; means, with respect to a Party&rsquo;s obligation under this Agreement, the level of efforts and resources reasonably
required to diligently develop, manufacture, and/or commercialize (as applicable) a Adeona Product in a sustained manner, consistent
with the efforts and resources a similarly situated company working in the Field would typically devote to a product of similar
market potential, profit potential, strategic value and/or proprietary protection, based on market conditions then prevailing.
With respect to a particular task or obligation, Diligent Efforts requires that the applicable Party promptly assign responsibility
for such task and consistently make and implement decisions and allocate resources designed to advance progress with respect to
such task or obligation.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.20 </B>&ldquo;<B>Equity
Agreements</B>&rdquo; has the meaning set forth in Section 5.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.21 </B>&ldquo;<B>Excess
Product Liability Costs</B>&rdquo; has the meaning set forth in Section 9.3.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.22 </B>&ldquo;<B>Executive
Officer</B>&rdquo; means the Chief Executive Officer of the applicable Party, or another senior executive officer of such Party
who has been duly appointed by the Chief Executive Officer to act as the representative of the Party to resolve, as the case may
be, (a) a Committee dispute, provided that such officer is not a member of the applicable Committee and occupies a position senior
to the positions occupied by the applicable Party&rsquo;s members of the applicable Committee, or (b) a dispute described in Section
11.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.23 </B>&ldquo;<B>FDA</B>&rdquo;
has the meaning set forth in Section 8.2(d)(xiii).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.24 </B>&ldquo;<B>Field
Infringement</B>&rdquo; has the meaning set forth in Section 6.3(b)</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.25 </B>&ldquo;<B>Field</B>&rdquo;
means the production of prostaglandin synthase (PGIS) through the use of an <I>in vivo</I> conditionally regulated embedded controllable
bioreactor for the treatment of PAH in humans.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.26 </B>&ldquo;<B>First
Commercial Sale</B>&rdquo; means, with respect to an Adeona Product and country, the first sale to a Third Party of such Adeona
Product in such country after regulatory approval (and any pricing or reimbursement approvals, if necessary) has been obtained
in such country.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.27 </B>&ldquo;<B>Fully
Loaded Cost</B>&rdquo; means the direct cost of the applicable good, product or service plus indirect charges and overheads reasonably
allocable to the provision of such good, product or service in accordance with US GAAP. Intrexon will bill for its internal direct
costs incurred through the use of annualized FTE; such rate shall be based upon the actual fully loaded costs of those personnel
directly involved in the provision of such good, product or service. Intrexon may, from time to time, adjust such FTE rate based
on changes to its actual fully loaded costs and will review the accuracy of its FTE rate at least quarterly. Intrexon shall provide
Adeona with reasonable documentation indicating the basis for any such adjustment.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.28 </B>&ldquo;<B>Information</B>&rdquo;
means information, results and data of any type whatsoever, in any tangible or intangible form whatsoever, including without limitation,
databases, inventions, practices, methods, techniques, specifications, formulations, formulae, knowledge, know-how, skill, experience,
test data including pharmacological, biological, chemical, biochemical, toxicological and clinical test data, analytical and quality
control data, stability data, studies and procedures, and patent and other legal information or descriptions.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.29 </B>&ldquo;<B>Infringement</B>&rdquo;
has the meaning set forth in Section 6.3(a).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.30 </B><FONT STYLE="color: black">&ldquo;<B>Intrexon
Channel Technology</B>&rdquo; means Intrexon&rsquo;s technology directed towards </FONT>the production of prostaglandin synthase
(PGIS) through the use of an <I>in vivo</I> conditionally regulated embedded controllable bioreactor for the treatment of PAH in
humans, including without limitation the technology embodied in the Intrexon Materials and the Intrexon IP<FONT STYLE="color: black">.</FONT></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.31 </B>&ldquo;<B>Intrexon
Indemnitees</B>&rdquo; has the meaning set forth in Section 9.2.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.32 </B>&ldquo;<B>Intrexon
IP</B>&rdquo; means the Intrexon Patents and Intrexon Know-How.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.33 </B>&ldquo;<B>Intrexon
Know-How</B>&rdquo; means all Information (other than Intrexon Patents) that (a) is Controlled by Intrexon as of the Effective
Date or during the Term and (b) is <FONT STYLE="color: black">reasonably required or useful for Adeona to conduct the PAH Program.
For the avoidance of doubt, the Intrexon Know-How shall include any Information (other than Intrexon Patents) in the Channel-Related
Program IP.</FONT></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.34 </B>&ldquo;<B>Intrexon
Materials</B>&rdquo; means the genetic code and associated gene constructs used alone or in combination and such other proprietary
reagents including but not limited to plasmid vectors, virus stocks, cells and cell lines, and ligand-related chemistry, in each
case that are reasonably required or provided to Adeona to conduct the PAH Program.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.35 </B>&ldquo;<B>Intrexon
Patents</B>&rdquo; means all Patents that (a) are Controlled by Intrexon as of the Effective Date or during the Term; and (b) are
reasonably required or useful for Adeona to conduct the PAH Program. For the avoidance of doubt, the Intrexon Patents shall include
any Patent in the <FONT STYLE="color: black">Channel-Related</FONT> Program IP.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.36 </B>&ldquo;<B>Intrexon
Trademarks</B>&rdquo; means those trademarks related to the Intrexon Channel Technology that are established from time to time
by Intrexon for use across its channel partnerships or collaborations.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.37 </B>&ldquo;<B>Inventions</B>&rdquo;
has the meaning set forth in Section 6.1(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.38 </B>&ldquo;<B>IPC</B>&rdquo;
has the meaning set forth in Section 2.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.39 </B>&ldquo;<B>JSC</B>&rdquo;
has the meaning set forth in Section 2.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.40 </B>&ldquo;<B>Losses</B>&rdquo;
has the meaning set forth in Section 9.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.41 </B>&ldquo;<B>Net
Sales</B>&rdquo; means, with respect to any Adeona Product, the net sales of such Adeona Product by Adeona or an Affiliate of Adeona
(including without limitation net sales of Adeona Product to a non-Affiliate sublicensee but not including net sales by such non-Affiliate
sublicensee), as determined in accordance with US GAAP.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.42
</B></FONT>&ldquo;<B>NYSE Amex Approval</B>&rdquo; means receipt by Adeona of the issuance of securities to Intrexon pursuant to
the Equity Agreements.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.43
</B></FONT>&ldquo;<B>PAH</B>&rdquo; means pulmonary arterial hypertension.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.44
</B></FONT>&ldquo;<B>PAH Program</B>&rdquo; has the meaning set forth in Section 2.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.45 </B>&ldquo;<B>Patents</B>&rdquo;
means (a) all patents and patent applications (including provisional applications), (b) any substitutions, divisions, continuations,
continuations-in-part, reissues, renewals, registrations, requests for continued examination, confirmations, re-examinations, extensions,
supplementary protection certificates and the like of the foregoing, and (c) any foreign or international equivalents of any of
the foregoing.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.46 </B>&ldquo;<B>Product
Profit</B>&rdquo; means Net Sales less Allowable Expenses.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.47 </B>&ldquo;<B>Product-Specific
Program Patent</B>&rdquo; means any issued Intrexon Patent where all the claims are directed to Inventions that relate solely and
specifically to Adeona Products. In the event of a disagreement between the Parties as to whether a particular Intrexon Patent
is or is not a Product-Specific Program Patent, the Parties shall seek to resolve the issue through discussions at the IPC, provided
that if the Parties are unable to resolve the disagreement, the issue shall be submitted to arbitration pursuant to Section 11.2.
Any Intrexon Patent that is subject to such a dispute shall be deemed not to be a Product-Specific Program Patent unless and until
(a) Intrexon agrees in writing that such Patent is a Product-Specific Program Patent or (b) an arbitrator or arbitration panel
determines, pursuant to Article 11, that such Intrexon Patent is a Product-Specific Program Patent.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.48 </B>&ldquo;<B>Proposed
Terms</B>&rdquo; has the meaning set forth in Section 11.2.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.49 </B>&ldquo;<B>Prosecuting
Party</B>&rdquo; has the meaning set forth in Section 6.2(c).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.50 </B>&ldquo;<B>Recovery</B>&rdquo;
has the meaning set forth in Section 6.3(f).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.51 </B>&ldquo;<B>Required
Third Party IP</B>&rdquo; has the meaning set forth in Section 3.7(a).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.52 </B>&ldquo;<B>Retained
Product</B>&rdquo; has the meaning set forth in Section 10.4(a).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.53 </B>&ldquo;<B>Reverted
Product</B>&rdquo; has the meaning set forth in Section 10.4(c).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.54 </B>&ldquo;<B>SEC</B>&rdquo;
means the United States Securities and Exchange Commission.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.55 </B>&ldquo;<B>Sublicensing
Revenue</B>&rdquo; means any cash consideration (including upfront payments, milestone payments, and royalties), and the cash equivalent
of all other consideration, actually received by Adeona or its Affiliate from a Third Party in consideration for a grant of a sublicense
under the Intrexon IP or any rights to develop or commercialize Adeona Products, but excluding: (a) any amounts paid as bona fide
reimbursement for research and development costs to the extent incurred following such grant; (b) bona fide loans or any payments
in consideration for a grant of equity of Adeona to the extent that such consideration is equal to or less than fair market value
(i.e. any amounts in excess of fair market value shall be Sublicensing Revenue); or (c) amounts received from sublicensees in respect
of any Adeona Product sales that are included in Net Sales.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.56 </B>&ldquo;<B>Superior
Therapy</B>&rdquo; means a therapy in the Field that, based on the data then available, (a) demonstrably appears to offer either
superior efficacy or safety or significantly lower cost of therapy, as compared with both (i) those therapies that are marketed
(either by Adeona or others) at such time for the indication and (ii) those therapies that are being actively developed by Adeona
for such indication; (b) demonstrably appears to represent a substantial improvement over such existing therapies; and (c) has
intellectual property protection and a regulatory approval pathway that, in each case, would not present a significant barrier
to commercial development.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.57 </B>&ldquo;<B>Support
Memorandum</B>&rdquo; has the meaning set forth in Section 11.2.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.58 </B>&ldquo;<B>Term</B>&rdquo;
has the meaning set forth in Section 10.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.59 </B>&ldquo;<B>Third
Party</B>&rdquo; means any individual or entity other than the Parties or their respective Affiliates.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.60 </B>&ldquo;<B>Third
Party IP</B>&rdquo; has the meaning set forth in Section 3.7(a).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.61 </B>&ldquo;<B>Third
Security</B>&rdquo; means Third Security, LLC.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.62 </B>&ldquo;<B>Territory</B>&rdquo;
means the entire world.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.63 </B>&ldquo;<B>US
GAAP</B>&rdquo; means generally accepted accounting principles in the United States.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><B>1.64 </B>&ldquo;<B>Working
Group</B>&rdquo; has the meaning set forth in Section 2.3(d).</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
2<BR>
<BR>
</B></FONT><B>Scope of Channel Collaboration; Management</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.1
</B></FONT><B>General</B>. The general purpose of the channel collaboration described in this Agreement will be to use the Intrexon
Channel Technology to research, develop and commercialize products for use in the Field (collectively, the &ldquo;<B>PAH Program</B>&rdquo;).
As provided below, the JSC shall establish projects for the PAH Program. Either Party may propose potential projects in the Field
for review and consideration by the JSC.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.2
</B></FONT><B>Committees</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT><B>Generally</B>. The Parties desire to establish several committees (collectively, &ldquo;<B>Committees</B>&rdquo;)
to oversee the PAH Program and to facilitate communications between the Parties with respect thereto. Each of such Committees shall
have the responsibilities and authority allocated to it in this Article 2. Each of the Committees shall have the obligation to
exercise its authority consistent with the respective purpose for such Committee as stated herein and any such decisions shall
be made in good faith.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT><B>Formation and Purpose</B>. Promptly following the Effective Date, the Parties shall create the Committees listed
in the chart below, each of which shall have the purpose indicated in the chart.</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; border-top: black 1pt solid; border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; font-weight: bold; text-align: center">Committee</TD>
    <TD STYLE="width: 50%; border: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; font-weight: bold; text-align: center">Purpose</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Joint Steering Committee (&ldquo;<B>JSC</B>&rdquo;)</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Establish projects for the PAH Program and establish the priorities, as well as approve budgets for such projects.&nbsp; Approve all subcommittee projects and plans.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Chemistry, Manufacturing and Controls Committee (&ldquo;<B>CMCC</B>&rdquo;)</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Establish project plans and review and approve activities and budgets for chemistry, manufacturing, and controls under the PAH Program.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Clinical/Regulatory Committee (&ldquo;<B>CRC</B>&rdquo;)</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Review and approve all research and development plans, clinical projects and publications, and regulatory filings and correspondence under the PAH Program; review and approve itemized budgets with respect to the foregoing.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Commercialization Committee (&ldquo;<B>CC</B>&rdquo;)</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Establish project plans and review and approve activities and budgets for commercialization activities under the PAH Program.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Intellectual Property Committee (&ldquo;<B>IPC</B>&rdquo;)</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Evaluate intellectual property issues in connection with the PAH Program; review and approve itemized budgets with respect to the foregoing.</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.3
</B></FONT><B>General Committee Membership and Procedure</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT><B>Membership</B>. For each Committee, each Party shall designate an equal number of representatives who are employees
of such Party or an Affiliate of such Party (not to exceed four (4) for each Party) with appropriate expertise to serve as members
of such Committee (and Third Security shall be deemed to be an Affiliate of Intrexon solely for purposes of this Section 2.3).
Each representative may serve on more than one Committee as appropriate in view of the individual&rsquo;s expertise. Each Party
may replace its Committee representatives at any time upon written notice to the other Party. Each Committee shall have a chairperson;
the chairperson of each committee shall serve for a two-year term and the right to designate which representative to the Committee
will act as chairperson shall alternate between the Parties, with Adeona selecting the chairperson first for the JSC, CRC and CC,
and Intrexon selecting the chairperson first for the CMCC and IPC. The chairperson of each Committee shall be responsible for calling
meetings, preparing and circulating an agenda in advance of each meeting of such Committee, and preparing and issuing minutes of
each meeting within fifteen (15) days thereafter.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT><B>Meetings</B>. Each Committee shall hold meetings at such times as it elects to do so, but in no event shall such
meetings be held less frequently than once every six (6) months. Meetings of any Committee may be held in person or by means of
telecommunication (telephone, video, or web conferences). To the extent that a Committee holds any meetings in person, the Parties
will alternate in designating the location for such in-person meetings, with Adeona selecting the first meeting location for each
Committee. A reasonable number of additional representatives of a Party may attend meetings of a Committee in a non-voting capacity.
Each Party shall be responsible for all of its own expenses of participating in any Committee (including without limitation in
any Working Group).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT><B>Meeting Agendas</B>. Each Party will disclose to the other proposed agenda items along with appropriate information
at least three (3) business days in advance of each meeting of the applicable Committee; provided, that a Party may provide its
agenda items to the other Party within a lesser period of time in advance of the meeting, or may propose that there not be a specific
agenda for a particular meeting, so long as such other Party consents to such later addition of such agenda items or the absence
of a specific agenda for such Committee meeting.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT><B>Working Groups</B>. From time to time, each Committee may establish and delegate duties to other committees, sub-committees
or directed teams (each, a &ldquo;<B>Working Group</B>&rdquo;) on an &ldquo;as-needed&rdquo; basis to oversee particular projects
or activities. Each such Working Group shall be constituted and shall operate as the applicable Committee determines; provided,
that each Working Group shall have equal representation from each Party. Each Working Group and its activities shall be subject
to the oversight, review and approval of, and shall report to, the Committee that established such Working Group. In no event shall
the authority of the Working Group exceed that specified for the relevant Committee in this Article 2. As of the Effective Date,
the following Working Groups shall be established by the Parties:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; border: black 1pt solid; border-right-color: windowtext; border-right-style: solid; border-right-width: 1pt; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; font-weight: bold; text-align: center">Working Group</TD>
    <TD STYLE="width: 50%; border: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; font-weight: bold; text-align: center">Purpose</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Discovery Project Team</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Develop and execute integrated project plans, including milestones, timelines and preliminary budget, for early-stage Product development</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Preclinical Project Team</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Develop and execute integrated project plans, including milestones, timelines and preliminary budget, for pre-clinical stage Product development</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: windowtext 1pt solid; border-bottom: black 1pt solid; border-left: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Clinical Project Team</TD>
    <TD STYLE="border-right: black 1pt solid; border-bottom: black 1pt solid; padding-right: 5.75pt; padding-bottom: 12pt; padding-left: 5.75pt; text-align: justify">Develop and execute integrated project plans, including milestones, timelines and preliminary budget, for clinical stage Product development</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT><B>Limitations of Committee Powers</B>. Each Committee shall have only such powers as are specifically delegated to
it hereunder or from time to time as agreed to by the mutual consent of the Parties and shall not be a substitute for the rights
of the Parties. Without limiting the generality of the foregoing, no Committee shall have any power to amend this Agreement. Any
amendment to the terms and conditions of this Agreement shall be implemented pursuant to Section 12.7 below.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.4
</B></FONT><B>Committee Decision-Making</B>. If a Committee is unable to reach unanimous consent on a particular matter within
thirty (30) days of its initial consideration of such matter, then either Party may provide written notice of such dispute to the
Executive Officer of the other Party. The Executive Officers of each of the Parties will meet at least once in person or by means
of telecommunication (telephone, video, or web conferences) to discuss the dispute and use their good faith efforts to resolve
the dispute within thirty (30) days after submission of such dispute to the Executive Officers. If any such dispute is not resolved
by the Executive Officers within thirty (30) days after submission of such dispute to such officers, then the Executive Officer
of the Party specified in the applicable subsection below shall have the authority to finally resolve such dispute acting in good
faith.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT><B>Casting Vote at JSC</B>. If a dispute at the JSC is not resolved pursuant to Section 2.4 above, then the Executive
Officer of Adeona shall have the authority to finally resolve such dispute</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT><B>Casting Vote at CMCC</B>. If a dispute at the CMCC is not resolved pursuant to Section 2.4 above, then (i) in the
case of any disputes relating to the Intrexon Materials, the manufacture of an Adeona Product active pharmaceutical ingredient,
or the manufacturing of other components of Adeona Products contracted for or manufactured by Intrexon, the Executive Officer of
Intrexon shall have the authority to finally resolve such dispute; and (ii) in the case of any other disputes, the Executive Officer
of Adeona shall have the authority to finally resolve such dispute.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT><B>Casting Vote at CRC</B>. If a dispute at the CRC is not resolved pursuant to Section 2.4 above, then the Executive
Officer of Adeona shall have the authority to finally resolve such dispute.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT><B>Casting Vote at CC</B>. If a dispute at the CC is not resolved pursuant to Section 2.4 above, then the Executive
Officer of Adeona shall have the authority to finally resolve such dispute.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT><B>Casting Vote at IPC</B>. If a dispute at the IPC is not resolved pursuant to Section 2.4 above, then the Executive
Officer of Intrexon shall have the authority to finally resolve such dispute, provided that such authority shall be shared by the
Parties with respect to Product-Specific Program Patents (i.e. neither Party shall have the casting vote on such matters, and any
such disputes shall be resolved pursuant to Article 11).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(f)
</B></FONT><B>Other Committees</B>. If any additional Committee is formed, then the Parties shall, at the time of such formation,
agree on which Party shall have the authority to finally resolve a dispute that is not resolved pursuant to Section 2.4 above.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(g)
</B></FONT><B>Restrictions</B>. Neither Party shall exercise its right to finally resolve a dispute at a committee in accordance
with this Section 2.4 in a manner that (i) excuses such Party from any of its obligations specifically enumerated under this Agreement;
(ii) expands the obligations of the other Party under this Agreement; (iii) negates any consent rights or other rights specifically
allocated to the other Party under this Agreement; (iv) purports to resolve any dispute involving the breach or alleged breach
of this Agreement; (v) resolves a matter if the provisions of this Agreement specify that mutual agreement is required for such
matter; or (vi) would require the other Party to perform any act that is inconsistent with applicable law.</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
3<BR>
<BR>
</B></FONT><B>License Grants</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.1
</B></FONT><B>Licenses to Adeona</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Subject to the terms and conditions of this Agreement, Intrexon hereby grants to Adeona a license under the Intrexon
IP to research, develop, use, import, make, have made, sell, and offer for sale Adeona Products in the Field in the Territory.
Such license shall be exclusive (even as to Intrexon) with respect to any clinical development, selling, offering for sale or other
Commercialization of Adeona Products in the Field, and shall be otherwise non-exclusive.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>Subject to the terms and conditions of this Agreement, Intrexon hereby grants to Adeona a non-exclusive, royalty-free
license to use and display the Intrexon Trademarks, solely in connection with the Commercialization of Adeona Products, in the
promotional materials, packaging, and labeling for Adeona Products, as provided under and in accordance with Section 4.9.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.2
</B></FONT><B>Sublicensing</B>. Except as provided below, Adeona shall not sublicense the rights granted under Section 3.1 to any
Third Party, or transfer the Intrexon Materials to any Third Party, or otherwise grant any Third Party the right to research, develop,
use, or commercialize Adeona Products, in each case except with Intrexon&rsquo;s written consent, which written consent may be
withheld in Intrexon&rsquo;s sole discretion. Notwithstanding the foregoing, Adeona may transfer, to the extent reasonably necessary,
Intrexon Materials to a Third Party contractor performing post-API fill/finish responsibilities for Adeona Products, and may grant
any sublicenses necessary to enable such Third Party to perform such activities. In addition, Adeona shall not sublicense the rights
granted under Section 3.1 to an Affiliate, or transfer the Intrexon Materials to any Affiliate, or otherwise grant any Affiliate
the right to research, develop, use, or commercialize Adeona Products, in each case except with Intrexon&rsquo;s written consent,
which written consent shall not be unreasonably withheld or delayed. In the event that Intrexon consents to any such grant or transfer
to an Affiliate, Adeona shall remain responsible for, and be guarantor of, the performance by any such Affiliate and shall cause
such Affiliate to comply with the provisions of this Agreement in connection with such performance (as though such Affiliate were
Adeona), including any payment obligations owed to Intrexon hereunder. None of the enforcement rights under the Intrexon Patents
that are granted to Adeona pursuant to Section 6.3 shall be transferred to, or exercised by, a sublicensee except with Intrexon&rsquo;s
prior written consent, which may be withheld in Intrexon&rsquo;s sole discretion.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.3
</B></FONT><B>No Non-Permitted Use</B>. Adeona hereby covenants that it shall not, nor shall it permit any Affiliate or, if applicable,
(sub)licensee, to use or practice, directly or indirectly, any Intrexon IP, Intrexon Channel Technology, or Intrexon Materials
for any purposes other than those expressly permitted by this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.4
</B></FONT><B>Exclusivity</B>. Intrexon and Adeona mutually agree that, under the channel collaboration established by this Agreement,
it is intended that the Parties will be exclusive to each other in the Field. To this end, neither Intrexon nor its Affiliates
shall make the Intrexon Channel Technology or Intrexon Materials available to any Third Party for the purpose of developing or
commercializing products in the Field, and neither Intrexon nor any Affiliate shall pursue (either by itself or with a Third Party
or Affiliate) the research, development or commercialization of any product for purpose of sale in the Field, outside of the PAH
Program. Further, neither Adeona nor its Affiliates shall pursue (either by itself or with a Third Party or Affiliate) the research,
development or commercialization of any product for purpose of sale in the Field, outside of the PAH Program.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.5
</B></FONT><B>Off Label Use</B>. For purpose of clarity, (a) following the First Commercial Sale of an Adeona Product, the use
by direct or indirect purchasers or other users of Adeona Products outside the Field (i.e. &ldquo;off label use&rdquo;) shall not
constitute a breach by Adeona of the terms of Section 3.3 or 3.4, provided that neither Adeona nor its Affiliate (nor any Third
Party under contract with either of them) marketed or promoted Adeona Products for such off-label use; and (b) following the first
commercial sale of a product by Intrexon, an Intrexon Affiliate, or a Third Party sublicensee, collaborator, or partner of Intrexon,
the use by direct or indirect purchasers or other users of such products in the Field (i.e. &ldquo;off label use&rdquo;) shall
not constitute a breach by Intrexon of the terms of Section 3.4, provided that neither Intrexon nor its Affiliate (nor any Third
Party under contract with either of them) marketed or promoted such products for such off-label use.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.6
</B></FONT><B>No Prohibition on Intrexon</B>. Except as explicitly set forth in Sections 3.1 and 3.4, nothing in this Agreement
shall prevent Intrexon from practicing or using the Intrexon Materials, Intrexon Channel Technology, and Intrexon IP for any purpose,
and to grant to Third Parties the right to do the same. Without limiting the generality of the foregoing, Adeona acknowledges that
Intrexon has all rights, in Intrexon&rsquo;s sole discretion, to make the Intrexon Materials, Intrexon Channel Technology (including
any active pharmaceutical ingredient used in an Adeona Product), and Intrexon IP available to Third Party channel partners or collaborators
for use in fields outside the Field.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.7
</B></FONT><B>Third Party Licenses</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>[*****] shall obtain, [*****], any licenses from Third Parties that are required in order to practice the Intrexon Channel
Technology in the Field where the licensed intellectual property is directed towards conditional <I>in vivo</I> expression for
embedded bioreactors (but excluding intellectual property directed to any specific effector molecules) (&ldquo;<B>Required Third
Party IP</B>&rdquo;). Other than with respect to Required Third Party IP, [*****] shall be solely responsible for obtaining, [*****],
any licenses from Third Parties that [*****] determines, in its sole discretion, are required in order to lawfully make, use, sell,
offer for sale, or import Adeona Products (&ldquo;<B>Blocking Third Party IP</B>&rdquo;). Required Third Party IP and Blocking
Third Party IP are collectively referred to as &ldquo;<B>Third Party IP</B>&rdquo;.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>In the event that either Party desires to license from a Third Party any Required Third Party IP or Blocking Third Party
IP, such Party shall so notify the other Party in writing, and the IPC shall discuss such Third Party IP and its applicability
to the Adeona Products and to the Field. As provided above in Section 3.7(a), [*****] shall have the sole right and responsibility
to pursue a license under Required Third Party IP, and [*****] hereby covenants that it shall not itself directly license such
Required Third Party IP at any time, <U>provided</U> <U>that</U> [*****] may (but shall not be obligated to) obtain such a license
directly if the Third Party owner or licensee of such Required Third Party IP brings an infringement action against [*****] or
its Affiliates and, after written notice to [*****]of such action, [*****]fails to obtain a license to such Required Third Party
IP within ninety (90) days after such notice. Following the IPC&rsquo;s discussion of any Blocking Third Party IP, subject to Section
3.7(c), [*****]shall have the right to pursue a license under Blocking Third Party IP, [*****]. For the avoidance of doubt, [*****]
may at any time obtain a license under Blocking Third Party IP outside the Field, [*****], <U>provided</U> <U>that</U> if [*****]
decides to seek to obtain such a license, it shall use reasonable efforts to coordinate its licensing activities in this regard
with [*****].</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>[*****] shall provide the proposed terms of any license under Blocking Third Party IP and the final version of the definitive
license agreement for any Blocking Third Party IP to the IPC for review and discussion prior to signing, and shall consider Intrexon&rsquo;s
comments thereto in good faith. To the extent that Adeona obtains a license under Required Third Party IP, Adeona shall provide
the final version of the definitive license agreement for such Required Third Party IP to the IPC. If Adeona acquires rights under
any Third Party IP outside the Field, it will do so on a non-exclusive basis unless it obtains the prior written consent of Intrexon
for such license outside the Field to be exclusive.<BR STYLE="mso-special-character: line-break">
<BR STYLE="mso-special-character: line-break">
</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">[<B>*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify"><B></B></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">Any Party that is pursuing a
license to any Third Party IP with respect to the Field under this Section 3.7 shall keep the other Party reasonably informed of
the status of any negotiations relating thereto. For purposes of clarity, (i) any costs incurred by [*****] in obtaining and maintaining
licenses to Required Third Party IP shall be borne solely by [*****], and (ii) any costs incurred by [*****] in obtaining and maintaining
licenses to Blocking Third Party IP (and, to the limited extent provided in subsection (b), Required Third Party IP) shall be treated
[*****].</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT>For any Third Party license under which Adeona or its Affiliates obtain a license under Patents claiming inventions
or know-how specific to or used or incorporated into the development, manufacture, and/or commercialization of Adeona Products,
Adeona shall use commercially reasonable efforts to ensure that Adeona will have the ability, pursuant to Section 10.4(h), to assign
such agreement to Intrexon or grant a sublicense to Intrexon thereunder (having the scope set forth in Section 10.4(h)).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>The licenses granted to Adeona under Section 3.1 may include sublicenses under Intrexon IP that has been licensed to
Intrexon by one or more Third Parties. Any such sublicenses are subject to the terms and conditions set forth in the applicable
upstream license agreement, subject to the cost allocation set forth in Section 3.7(c), <U>provided</U> <U>that</U> Intrexon shall
either provide unredacted copies of such upstream license agreements to Adeona or shall disclose in writing to Adeona all of such
terms and conditions that are applicable to Adeona. Adeona shall not be responsible for complying with any provisions of such upstream
license agreements unless, and to the extent that, such provisions have been disclosed to Adeona as provided in the preceding sentence.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.8
</B></FONT><B>Licenses to Intrexon.</B> Subject to the terms and conditions of this Agreement, Adeona hereby grants to Intrexon
a non-exclusive, worldwide, fully-paid, royalty-free license, under any applicable Patents or other intellectual property Controlled
by Adeona or its Affiliates, solely to the extent necessary for Intrexon to conduct those responsibilities assigned to it under
this Agreement, which license shall be sublicensable solely to Intrexon&rsquo;s Affiliates or to any of Intrexon&rsquo;s subcontractors.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>3.9
</B></FONT><B>Restrictions Relating to Intrexon Materials</B>. Adeona shall use the Intrexon Materials solely for purposes of the
PAH Program and not for any other purpose without the prior written consent of Intrexon. With respect to the Intrexon Materials
comprising Intrexon&rsquo;s vector assembly technology, Adeona shall not, and shall ensure that Adeona personnel do not (a) distribute,
sell, lend or otherwise transfer such Intrexon Materials to any Third Party; (b) co-mingle such Intrexon Materials with any other
proprietary biological or chemical materials without Intrexon&rsquo;s written consent; or (c) analyze such Intrexon Materials or
in any way attempt to reverse engineer or sequence such Intrexon Materials.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">[<B>*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify"><B></B></P>

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<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
4<BR>
<BR>
</B></FONT><B>Other Rights and Obligations</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.1
</B></FONT><B>Development and Commercialization</B>. Subject to Sections 4.6 and 4.7, Adeona shall be solely responsible for the
performance of the PAH Program and the development and commercialization of Adeona Products in the Field. Adeona shall be responsible
for all costs incurred in connection with the PAH Program except that Intrexon shall be responsible for the following: (a) costs
of establishing manufacturing capabilities and facilities in connection with Intrexon&rsquo;s manufacturing obligation under Section
4.6 (provided, however, that Intrexon may include an allocable portion of such costs, through depreciation and amortization, when
calculating the Fully Loaded Cost of manufacturing Adeona Product, to the extent such allocation, depreciation, and amortization
is permitted by US GAAP, it being recognized that the majority of non-facilities scale-up costs cannot be capitalized and amortized
under US GAAP); (b) costs of basic research with respect to the Intrexon Channel Technology and Intrexon Materials (i.e., platform
improvements) but, for clarity, excluding research described in Section 4.7 or research requested by the JSC for the development
of an Adeona Product (which research costs shall be reimbursed by Adeona); (c) [*****]; and (d) costs of filing, prosecution and
maintenance of Intrexon Patents. The costs encompassed within subsection (a) above shall include the scale-up of Intrexon Materials
and API for clinical trials and commercialization of Adeona Products undertaken pursuant to Section 4.6, which shall be at Intrexon&rsquo;s
cost whether it elects to conduct such efforts internally or through Third Party contractors retained by either Intrexon or Adeona
(with Intrexon&rsquo;s consent).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.2
</B></FONT><B>Transfer of PAH Technology Information</B>. No later than sixty (60) days after the Effective Date (or as soon thereafter
as practicable), Intrexon shall provide to Adeona copies of the relevant portions of all material reports and information, including
concepts and preliminary vector designs, obtained or generated by or on behalf of Intrexon or its Affiliates in connection with
the PAH Program, and general data related to embedded controllable bioreactors. Thereafter, as additional projects are included
in the PAH Program, the JSC shall develop a plan and protocol for each such project relating to the transfer of relevant data and
Intrexon Materials.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.3
</B></FONT><B>Information and Reporting</B>. Adeona will keep Intrexon informed about Adeona&rsquo;s efforts to develop and commercialize
Adeona Products, including reasonable and accurate summaries of Adeona&rsquo;s (and its Affiliates&rsquo; and, if applicable, (sub)licensees&rsquo;)
global development plans (as updated), including preclinical, clinical and regulatory plans, global marketing plans (as updated),
progress towards meeting the goals and milestones in such plans and explanations of any material deviations, and significant developments
in the development and/or commercialization of the Adeona Products, including initiation or completion of a clinical trial, submission
of a United States or international regulatory filing, receipt of a response to such United States or international regulatory
filing, clinical safety event, receipt of Regulatory Approval, or commercial launch.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify"><B>[*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify"><B></B></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">Intrexon will keep Adeona informed
about Intrexon&rsquo;s efforts (a) to establish manufacturing capabilities and facilities for Adeona Products (and Intrexon Materials
relevant thereto) and otherwise perform its manufacturing responsibilities under Section 4.6 and (b) to undertake discovery-stage
research for the PAH Program with respect to the Intrexon Channel Technology and Intrexon Materials. Such disclosures by Adeona
and Intrexon will be made in the course of JSC meetings at least once every six (6) months while Adeona Products are being developed
or commercialized anywhere in the world, and shall be reflected in the minutes of such meetings.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.4
</B></FONT><B>Regulatory Matters</B>. At all times after the Effective Date, Adeona shall own and maintain, at its own cost, all
regulatory filings and Regulatory Approvals for Adeona Products that Adeona is developing or Commercializing pursuant to this Agreement.
As such, Adeona shall be responsible for reporting all adverse events related to such Adeona Products to the appropriate regulatory
authorities in the relevant countries, in accordance with the applicable laws and regulations of such countries. The decision to
list or not list Patents in any regulatory filing for a Adeona Product (for example, as required by 21 C.F.R. &sect; 314.53(b)),
or add or delete a Patent from a regulatory filing shall be determined by Intrexon, after consultation with Adeona, except with
respect to Product Specific Program Patents, which will be mutually determined by the Parties.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.5
</B></FONT><B>Diligence</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Adeona shall use Diligent Efforts to develop and commercialize Adeona Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>Without limiting the generality of the foregoing, Intrexon may, from time to time, notify Adeona that it believes it
has identified a Superior Therapy, and in such case shall provide to Adeona its then-available information about such therapy.
Adeona shall have the following obligations with respect to such proposed Superior Therapy: (i) within sixty (60) days after such
notification, Adeona shall prepare and deliver to the JSC for review and approval a development plan detailing how Adeona will
pursue the Superior Therapy (including a proposed budget); (ii) Adeona shall revise the development plan as directed by the JSC;
and (iii) following approval of the development plan by the JSC, Adeona shall use Diligent Efforts to pursue the development of
the Superior Therapy under the PAH Program in accordance with such development plan. If Adeona fails to comply with the foregoing
obligations, or if Adeona exercises its casting vote at the JSC to either (x) prevent the approval of a development plan for a
Superior Therapy; (y) delay such approval more than sixty (60) days after delivery of the development plan to the JSC; or (z) approve
a development plan that is insufficient in view of the nature and magnitude of the opportunity presented by the Superior Therapy,
then Intrexon shall have the termination right set forth in Section 10.2(c) (subject to the limitation set forth therein). For
clarity, any dispute arising under this 4.5, including any dispute as to whether a proposed project constitutes a Superior Therapy
(as with any other dispute under this Agreement) shall be subject to dispute resolution in accordance with Article 11.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>The activities of Adeona&rsquo;s Affiliates and any permitted sublicensees shall be attributed to Adeona for the purposes
of evaluating Adeona&rsquo;s fulfillment of the obligations set forth in this Section 4.5.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.6
</B></FONT><B>Manufacturing</B>. Intrexon shall have the option and, in the event it so elects, shall use Diligent Efforts, to
perform any manufacturing activities in connection with the PAH Program that relate to the Intrexon Materials, the manufacture
of bulk drug product, the manufacturing of bulk quantities of other components of Adeona Products, or any earlier steps in the
manufacturing process for Adeona Products. Except as provided in Section 4.1, any manufacturing undertaken by Intrexon pursuant
to the preceding sentence shall be performed in exchange for cash payments equal to Intrexon&rsquo;s Fully Loaded Cost in connection
with such manufacturing, on terms to be negotiated by the Parties in good faith. In the event that Intrexon does not manufacture
Intrexon Materials, bulk drug product or bulk quantities of other components of Adeona Products, then Intrexon shall provide to
Adeona or a contract manufacturer selected by Adeona and approved by Intrexon all Information Controlled by Intrexon that is related
to the manufacturing of such Intrexon Materials, bulk drug product or bulk qualities of other components of Adeona Products, for
use in the Field and is reasonably necessary to enable Adeona or such contract manufacturer (as appropriate) for the sole purpose
of manufacturing such Intrexon Materials, bulk drug product or bulk quantities of other components of Adeona Products, in each
case as manufactured by Intrexon. The costs and expenses incurred by Intrexon in carrying out such transfer shall be borne by Intrexon.
Any manufacturing Information transferred hereunder to Adeona or its contract manufacturer shall not be further transferred to
any Third Party or Adeona Affiliate without the prior written consent of Intrexon; provided, however, that Intrexon shall not unreasonably
withhold such consent if necessary to permit Adeona to switch manufacturers.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.7
</B></FONT><B>Support Services</B>. From time to time, on an ongoing basis, Adeona shall request, or Intrexon may propose, that
Intrexon perform certain support services with respect to the PAH Program. To the extent that the Parties mutually agree that Intrexon
should perform such services, the Parties shall negotiate in good faith the terms under which services would be performed, it being
understood that Intrexon would be compensated for such services by cash payments equal to Intrexon&rsquo;s Fully Loaded Cost in
connection with such services.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.8
</B></FONT><B>Compliance with Law</B>. Each Party shall comply, and shall ensure that its Affiliates, (sub)licensees and Third
Party contractors comply, with all applicable laws, regulations, and guidelines applicable to the PAH Program, including without
limitation those relating to the transport, storage, and handling of Intrexon Materials and Adeona Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.9
</B></FONT><B>Trademarks. </B>To the extent permitted by applicable law and regulations, Adeona shall, and shall ensure that the
packaging, promotional materials, and labeling for Adeona Products shall carry, in a conspicuous location, the applicable Intrexon
Trademark(s), subject to Adeona&rsquo;s reasonable approval of the size, position, and location thereof. Adeona shall provide Intrexon
with copies of any materials containing the Intrexon Trademarks prior to using or disseminating such materials, in order to obtain
Adeona&rsquo;s approval thereof . Adeona&rsquo;s use of the Intrexon Trademarks shall be subject to prior review and approval of
the IPC. Adeona acknowledges Intrexon&rsquo;s sole ownership of the Intrexon Trademarks and agrees not to take any action inconsistent
with such ownership. Adeona covenants that it shall not use any trademark confusingly similar to any Intrexon Trademarks in connection
with any products (including any Adeona Product). From time to time during the Term, Intrexon shall have the right to obtain from
Adeona samples of Adeona Product sold by Adeona or its Affiliates or sublicensees for the purpose of inspecting the quality of
such Adeona Products and use of the Intrexon Trademark(s). In the event that Intrexon inspects the quality of such Adeona Products
and use of the Intrexon Trademark, Intrexon shall notify the result of such inspection to Adeona in writing thereafter. Adeona
shall comply with reasonable policies provided by Intrexon from time-to-time to maintain the goodwill and value of the Intrexon
Trademarks.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
5<BR>
<BR>
</B></FONT><B>Compensation</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.1
</B></FONT><B>Equity</B>. In partial consideration for Adeona&rsquo;s appointment as an exclusive channel collaborator and the
other rights granted to Adeona hereunder, Adeona has agreed to issue to Intrexon certain shares of Adeona&rsquo;s common stock,
in accordance with the terms and conditions of that certain Stock Purchase Agreement and Registration Rights Agreement, each of
even date herewith (the &ldquo;<B>Equity Agreements</B>&rdquo;). Pursuant to the Equity Agreements, Intrexon shall also have the
right to purchase certain shares of the Company&rsquo;s common stock for cash consideration, subject to the terms and conditions
therein. Provided that all closing conditions for the First Tranche Closing (as defined in the Equity Agreements) that are within
the reasonable control of Intrexon have been satisfied or waived, the issuance of the First Tranche Shares (as defined in the Equity
Agreements) is a condition subsequent to the effectiveness of this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.2
</B></FONT><B>Profit-Share</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>No later than thirty (30) days after each calendar quarter in which there is positive Product Profit arising from the
sale of Adeona Product in the Field in the Territory, Adeona shall pay to Intrexon fifty percent (50%) of such Product Profit,
on a Adeona Product-by-Adeona Product basis. In the event of negative Product Profit for a particular Adeona Product in any calendar
quarter, neither Adeona nor Intrexon shall owe any payments hereunder with respect to such Adeona Product. Any negative Product
Profit that results from Excess Product Liability Costs, and [*****] (as defined in Exhibit A) may be carried forward to future
quarters and offset against positive Product Profit in such future quarters for the same Adeona Product. Except as set forth in
the preceding sentence, Adeona shall not be permitted to carry forward any negative Product Profits to subsequent quarters.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>No later than thirty (30) days after each calendar quarter in which Adeona or any Adeona Affiliate receives Sublicensing
Revenue, Adeona shall pay to Intrexon fifty percent (50%) of such Sublicensing Revenue. As set forth in Section 3.2, sublicensing
shall require Intrexon&rsquo;s prior written consent.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify"><B>[*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">Nevertheless, this Section 5.2(b)
shall apply to Sublicensing Revenue received by Adeona or any Adeona Affiliate, even if rights were granted to the applicable sublicensee
in violation of this Agreement. For purposes of clarity, sales of Adeona Products by approved sublicensees shall not constitute
Net Sales.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.3
</B></FONT><B>Method of Payment</B>. All payments due to Intrexon under this Agreement shall be paid in United States dollars by
wire transfer to a bank in the United States designated in writing by Intrexon. All references to &ldquo;dollars&rdquo; or &ldquo;$&rdquo;
herein shall refer to United States dollars.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.4
</B></FONT><B>Payment Reports and Records Retention</B>. Within thirty (30) days after the end of each calendar quarter during
which Net Sales have been generated or Allowable Expenses been incurred, Adeona shall deliver to Intrexon a written report that
shall contain at a minimum for the applicable calendar quarter:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>gross sales of each Adeona Product (on a country-by-country basis);</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>itemized calculation of Net Sales, showing all applicable deductions;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>itemized calculation of Allowable Expenses and Sublicensing Revenue;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT>the amount of the payment (if any) due pursuant to Section 5.2(a) and/or 5.2(b);</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>the amount of taxes, if any, withheld to comply with any applicable law; and</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(f)
</B></FONT>the exchange rates used in any of the foregoing calculations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">For three (3) years after each sale
of Adeona Product or the incurring of an item included in Allowable Expenses, Adeona shall keep (and shall ensure that its Affiliates
and, if applicable, (sub)licensees shall keep) complete and accurate records of such sales or Allowable Expenses (as the case may
be) in sufficient detail to confirm the accuracy of the payment calculations hereunder.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.5
</B></FONT><B>Audits</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Upon the written request of Intrexon, Adeona shall permit an independent certified public accounting firm of internationally
recognized standing selected by Intrexon, and reasonably acceptable to Adeona, to have access to and to review, during normal business
hours and upon no less than thirty (30) days prior written notice, the applicable records of Adeona and its Affiliates to verify
the accuracy and timeliness of the reports and payments made by Adeona under this Agreement. Such review may cover the records
for sales made in any calendar year ending not more than three (3) years prior to the date of such request. The accounting firm
shall disclose to both Parties whether the royalty reports and/or know-how reports conform to the provisions of this Agreement
and/or US GAAP, as applicable, and the specific details concerning any discrepancies. Such audit may not be conducted more than
once in any calendar year.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>If such accounting firm concludes that additional amounts were owed during such period, Adeona shall pay additional
amounts, with interest from the date originally due as set forth in Section 5.7, within thirty (30) days of receipt of the accounting
firm&rsquo;s written report. If the amount of the underpayment is greater than five percent (5%) of the total amount actually owed
for the period audited, then Adeona shall in addition reimburse Intrexon for all costs related to such audit; otherwise, Intrexon
shall pay all costs of the audit. In the event of overpayment, any amount of such overpayment shall be fully creditable against
amounts payable for the immediately succeeding calendar quarter(s); provided, however,<I> </I>that<I> </I>such credit cannot be
applied to reduce the amounts payable by Adeona to Intrexon for any particular calendar quarter by more than [*****] of the amount
otherwise due to Intrexon.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>Intrexon shall (i) treat all information that it receives under this Section 5.5 in accordance with the confidentiality
provisions of Article 7 and (ii) cause its accounting firm to enter into an acceptable confidentiality agreement with Adeona obligating
such firm to retain all such financial information in confidence pursuant to such confidentiality agreement, in each case except
to the extent necessary for Intrexon to enforce its rights under this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.6
</B></FONT><B>Taxes</B>. The Parties will cooperate in good faith to obtain the benefit of any relevant tax treaties to minimize
as far as reasonably possible any taxes which may be levied on any amounts payable hereunder. Adeona shall deduct or withhold from
any payments any taxes that it is required by applicable law to deduct or withhold. Notwithstanding the foregoing, if Intrexon
is entitled under any applicable tax treaty to a reduction of the rate of, or the elimination of, applicable withholding tax, it
may deliver to Adeona or the appropriate governmental authority (with the assistance of Adeona to the extent that this is reasonably
required and is expressly requested in writing) the prescribed forms necessary to reduce the applicable rate of withholding or
to relieve Adeona of its obligation to withhold tax, and Adeona shall apply the reduced rate of withholding tax, or dispense with
withholding tax, as the case may be, provided that Adeona has received evidence of Intrexon&rsquo;s delivery of all applicable
forms (and, if necessary, its receipt of appropriate governmental authorization) at least fifteen (15) days prior to the time that
the payment is due. If, in accordance with the foregoing, Adeona withholds any amount, it shall make timely payment to the proper
taxing authority of the withheld amount, and send to Intrexon proof of such payment within forty-five (45) days following that
latter payment.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>5.7
</B></FONT><B>Late Payments</B>. Any amount owed by Adeona to Intrexon under this Agreement that is not paid within the applicable
time period set forth herein shall accrue interest at the lower of (a) two percent (2%) per month, compounded, or (b) the highest
rate permitted under applicable law.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">[<B>*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify"><B></B></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
6<BR>
<BR>
</B></FONT><B>Intellectual Property</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>6.1
</B></FONT><B>Ownership</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Subject to the license granted under Section 3.1, all rights in the Intrexon IP shall remain with Intrexon.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>Adeona and/or Intrexon may solely or jointly conceive, reduce to practice or develop discoveries, inventions, processes,
techniques, and other technology, whether or not patentable, in the course of performing the PAH Program (collectively &ldquo;<B>Inventions</B>&rdquo;).
Each Party shall promptly provide the other Party with a detailed written description of any such Inventions that relate to the
Field. Inventorship shall be determined in accordance with United States patent laws.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>Intrexon shall solely own all right, title and interest in all Inventions related to Intrexon Channel Technology, together
with all Patent rights and other intellectual property rights therein (the &ldquo;<B>Channel-Related Program IP</B>&rdquo;). Adeona
hereby assigns all of its right, title and interest in and to the Channel-Related Program IP to Intrexon. Adeona agrees to execute
such documents and perform such other acts as Intrexon may reasonably request to obtain, perfect and enforce its rights to the
Channel-Related Program IP and the assignment thereof.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT>Notwithstanding anything to the contrary in this Agreement, any discovery, invention, process, technique, or other technology,
whether or not patentable, that is conceived, reduced to practice or developed by Adeona solely or jointly through the use of the
Intrexon Channel Technology, Intrexon IP, or Intrexon Materials in breach of the terms and conditions of this Agreement, together
with all patent rights and other intellectual property rights therein, shall be solely owned by Intrexon and shall be included
in the Channel-Related Program IP.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>All information regarding Channel-Related Program IP shall be Confidential Information of Intrexon. Adeona shall be
under appropriate written agreements with each of its employees or agents working on the PAH Program, pursuant to which such person
shall grant all rights in the Inventions to Adeona (so that Adeona may convey certain of such rights to Intrexon, as provided herein).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>6.2
</B></FONT><B>Patent Prosecution</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Intrexon shall have the sole right, but not the obligation, to conduct and control the filing, prosecution and maintenance
of the Intrexon Patents. At the reasonable request of Intrexon, Adeona shall cooperate with Intrexon in connection with such filing,
prosecution, and maintenance, at Intrexon&rsquo;s expense. U<FONT STYLE="color: black">nder no circumstances shall Adeona (a) file,
attempt to file, or assist anyone else in filing, or attempting to file, any Patent application, either in the United States or
elsewhere, that claims or uses or purports to claim or use or relies for support upon an Invention owned by Intrexon or use, attempt
to use, or assist anyone else in using or attempting to use, the Intrexon Know-How, Intrexon Materials, or any Confidential Information
of Intrexon to support the filing of a Patent application, either in the United States or elsewhere, that contains claims directed
to the Intrexon IP, Intrexon Materials, or the Intrexon Channel Technology.</FONT></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>Adeona shall have the sole right, but not the obligation, to conduct and control the filing, prosecution and maintenance
of any Patents claiming Inventions that are owned by Adeona or its Affiliates and not assigned to Intrexon under Section 6.1(c)
( &ldquo;<B>Adeona Program Patents</B>&rdquo;). At the reasonable request of Adeona, Intrexon shall cooperate with Adeona in connection
with such filing, prosecution, and maintenance, at Adeona&rsquo;s expense.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>The Prosecuting Party shall be entitled to use patent counsel selected by it and reasonably acceptable to the non-Prosecuting
Party (including in-house patent counsel as well as outside patent counsel) for the prosecution of the Intrexon Patents and Adeona
Program Patents, as applicable. The Prosecuting Party shall:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(i)
</FONT>regularly provide the other Party in advance with reasonable information relating to the Prosecuting Party&rsquo;s prosecution
of Patents hereunder, including by providing copies of substantive communications, notices and actions submitted to or received
from the relevant patent authorities and copies of drafts of filings and correspondence that the Prosecuting Party proposes to
submit to such patent authorities (it being understood that, to the extent that any such information is readily accessible to the
public, the Prosecuting Party may, in lieu of directly providing copies of such information to such other Party, provide such other
Party with sufficient information that will permit such other Party to access such information itself directly);</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(ii)
</FONT>consider in good faith and consult with the non-Prosecuting Party regarding its timely comments with respect to the same;
provided, however, that if, within fifteen (15) days after providing any documents to the non-Prosecuting Party for comment, the
Prosecuting Party does not receive any written communication from the non-Prosecuting Party indicating that it has or may have
comments on such document, the Prosecuting Party shall be entitled to assume that the non-Prosecuting Party has no comments thereon;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(iii)
</FONT>consult with the non-Prosecuting Party before taking any action that would reasonably be expected to have a material adverse
impact on the scope of claims within the Intrexon Patents and Adeona Program Patents, as applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">As used above &ldquo;<B>Prosecuting
Party</B>&rdquo; means Intrexon in the case of Intrexon Patents and Adeona in the case of Adeona Program Patents.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>6.3
</B></FONT><B>Infringement of Patents by Third Parties</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Except as expressly provided in the remainder of this Section 6.3, Intrexon shall have the sole right to take appropriate
action against any person or entity directly or indirectly infringing any Intrexon Patent (or asserting that a Intrexon Patent
is invalid or unenforceable) (collectively, &ldquo;<B>Infringement</B>&rdquo;), either by settlement or lawsuit or other appropriate
action.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>Notwithstanding the foregoing, Adeona shall have the first right, but not the obligation, to take appropriate action
to enforce Product-Specific Program Patents against any Infringement that involves a commercially material amount of allegedly
infringing activities in the Field (&ldquo;<B>Field Infringement</B>&rdquo;), either by settlement or lawsuit or other appropriate
action. If Adeona fails to take the appropriate steps to enforce Product-Specific Program Patents against any Field Infringement
within one hundred eighty (180) days of the date one Party has provided notice to the other Party pursuant to Section 6.3(g) of
such Field Infringement, then Intrexon shall have the right (but not the obligation), at its own expense, to enforce Product-Specific
Program Patents against such Field Infringement, either by settlement or lawsuit or other appropriate action.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>With respect to any Field Infringement that cannot reasonably be abated through the enforcement of Product-Specific
Program Patents pursuant to Section 6.3(b) but can reasonable be abated through the enforcement of Intrexon Patent(s) (other than
the Product-Specific Program Patents), Intrexon shall be obligated to choose one of the following courses of action: (i) enforce
one or more of the applicable Intrexon Patent(s) in a commercially reasonable manner against such Field Infringement, or (ii) [*****].
Intrexon and Adeona shall bear the costs and expenses of such enforcement equally. The determination of which Intrexon Patent(s)
to assert shall be made by Intrexon in its sole discretion; provided, however, that Intrexon shall consult in good faith with Adeona
on such determination. For the avoidance of doubt, Intrexon has no obligations under this Agreement to enforce any Intrexon Patents
against, or otherwise abate, any Infringement that is not a Field Infringement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT>In the event a Party pursues an action under this Section 6.3, the other Party shall reasonably cooperate with the enforcing
Party with respect to the investigation and prosecution of any alleged, threatened, or actual Infringement, at the enforcing Party&rsquo;s
expense (except with respect to an action under Section 6.3(c), where all costs and expenses will be shared equally in accordance
with terms thereof).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>Adeona shall not settle or otherwise compromise any action under this Section 6.3 in a way that diminishes the rights
or interests of Intrexon outside the Field or adversely affects any Intrexon Patent without Intrexon&rsquo;s prior written consent,
which consent shall not be unreasonably withheld. Intrexon shall not settle or otherwise compromise any action under this Section
6.3 in a way that diminishes the rights or interests of Adeona in the Field or adversely affects any Intrexon Patent with respect
to the Field without Adeona&rsquo;s prior written consent, which consent shall not be unreasonably withheld.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(f)
</B></FONT>Except as otherwise agreed to by the Parties in writing, any settlements, damages or other monetary awards recovered
pursuant to a suit, proceeding, or action brought pursuant to Section 6.3 will be allocated first to the costs and expenses of
the Party controlling such action, and second, to the costs and expenses (if any) of the other Party (to the extent not otherwise
reimbursed), and any remaining amounts (the <B>&ldquo;Recovery&rdquo;</B>) will be shared by the Parties as follows: In any action
initiated by Intrexon pursuant to Section 6.3(a) that does not involve Field Infringement, or in any action initiated by Intrexon
pursuant to Section 6.3(b),</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">[<B>*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify"><B></B></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">Intrexon shall retain one hundred
percent (100%) of any Recovery. In any action initiated by Adeona pursuant to Section 6.3(b), Adeona shall retain one hundred percent
(100%) of any Recovery, [*****]. In any action initiated by Intrexon or Adeona pursuant to Section 6.3(c), the Parties shall share
the Recovery equally, and such Recovery shall not be deemed to constitute Sublicensing Revenue.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(g)
</B></FONT>Adeona shall promptly notify Intrexon in writing of any alleged, threatened, or actual Infringement of which it becomes
aware, and Intrexon shall promptly notify Adeona in writing of any alleged, threatened, or actual Field Infringement of which it
becomes aware.</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
7<BR>
<BR>
</B></FONT><B>Confidentiality</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>7.1
</B></FONT><B>Confidentiality</B>. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing by
the Parties, each Party agrees that it shall keep confidential and shall not publish or otherwise disclose and shall not use for
any purpose other than as provided for in this Agreement any Confidential Information disclosed to it by the other Party pursuant
to this Agreement, except to the extent that the receiving Party can demonstrate by competent evidence that specific Confidential
Information:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>was already known to the receiving Party, other than under an obligation of confidentiality, at the time of disclosure
by the other Party;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>was generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving
Party;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>became generally available to the public or otherwise part of the public domain after its disclosure and other than
through any act or omission of the receiving Party in breach of this Agreement;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT>was disclosed to the receiving Party, other than under an obligation of confidentiality to a Third Party, by a Third
Party who had no obligation to the disclosing Party not to disclose such information to others; or</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>was independently discovered or developed by the receiving Party without the use of Confidential Information belonging
to the disclosing Party, as documented by the receiving Party&rsquo;s written records.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">The foregoing non-use
and non-disclosure obligation shall continue (i) indefinitely, for all Confidential Information that qualifies as a trade secret
under applicable law; or (ii) for the Term of this Agreement and for seven (7) years thereafter, in all other cases.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">[<B>*****] - <FONT STYLE="font-size: 10pt">redacted
pursuant to a confidentiality request with the United States Securities and Exchange Commission</FONT></B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify"><B></B></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify"><B>&nbsp;</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>7.2
</B></FONT><B>Authorized Disclosure</B>. <FONT STYLE="color: black">Notwithstanding the limitations in this Article 7, either Party
</FONT>may disclose the Confidential Information belonging to the other Party to the extent such disclosure is reasonably necessary
in the following instances:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>complying with applicable laws or regulations<FONT STYLE="color: black"> or valid court orders</FONT>, <I>provided that</I>
the Party making such disclosure provides the other Party with reasonable prior written notice of such disclosure and makes a reasonable
effort to obtain, or to assist the other Party in obtaining, a protective order preventing or limiting the disclosure and/or requiring
that the terms and conditions of this Agreement be used only for the purposes for which the law or regulation required, or for
which the order was issued;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>to regulatory authorities in order to seek or obtain approval to conduct clinical trials, or to gain regulatory approval,
of Adeona Products or any products being developed by Intrexon or its other licensees and/or channel partners or collaborators,
provided that the Party making such disclosure (i) provides the other Party with reasonable opportunity to review any such disclosure
in advance and to suggest redactions or other means of limiting the disclosure of such other Party&rsquo;s Confidential Information
and (ii) does not unreasonably reject any such suggestions;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>disclosure to investors and potential investors, acquirers, or merger candidates who agree to maintain the confidentiality
of such information, <I>provided that</I> such disclosure is used solely for the purpose of evaluating such investment, acquisition,
or merger (as the case may be);</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT>disclosure on a need-to-know basis to Affiliates, licensees, sublicensees, employees, consultants or agents (such as
CROs and clinical investigators) who agree to be bound by obligations of confidentiality and non-use at least equivalent in scope
to those set forth in this Article 7; and</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>disclosure of the terms of this Agreement by Intrexon to collaborators and other channel partners or collaborators who
agree to be bound by obligations of confidentiality and non-use at least equivalent in scope to those set forth in this Article
7.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>7.3
</B></FONT><B>Publicity; Publications</B>. The Parties agree that the public announcement of the execution of this Agreement shall
be substantially in the form of the press release attached as Exhibit B. Each Party will provide the other Party with the opportunity
to review and comment, prior to submission or presentation, on external publications and presentations (abstracts, posters, manuscripts
and oral presentations) that refer to the PAH Program or programs that are approved by the JSC. For abstracts, posters and oral
presentations, the disclosing Party will provide the other Party at least fifteen (15) calendar days for review of the proposed
submission or presentation. For manuscripts, the disclosing Party will provide the other Party at least thirty (30) calendar days
for review of the manuscript. The presenting Party will act in good faith to incorporate the comments of the other Party and shall,
in any event, redact any Confidential Information of the other Party.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>7.4
</B></FONT><B>Terms of the Agreement</B>. Each Party shall treat the terms of this Agreement as the Confidential Information of
other Party, subject to the exceptions set forth in Section 7.2. Notwithstanding the foregoing, each Party acknowledges that the
other Party may be obligated to file a copy of this Agreement with the SEC, either as of the Effective Date or at some point during
the Term. Each Party shall be entitled to make such a required filing, provided that it requests confidential treatment of certain
commercial terms and sensitive technical terms hereof to the extent such confidential treatment is reasonably available to it.
In the event of any such filing, the filing Party shall provide the other Party with a copy of the Agreement marked to show provisions
for which the filing Party intends to seek confidential treatment and shall reasonably consider and incorporate the other Party&rsquo;s
comments thereon to the extent consistent with the legal requirements governing redaction of information from material agreements
that must be publicly filed. The other Party shall promptly provide any such comments.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>7.5
</B></FONT><B>Proprietary Information Audits.</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>For the purpose of confirming compliance with the Field-limited licenses granted in Article 3 and the confidentiality
obligations under Article 7, Adeona acknowledges that Intrexon&rsquo;s authorized representative(s), during regular business hours
may (i) examine and inspect Adeona&rsquo;s facilities and (ii) inspect all data and work products relating to this Agreement. Any
examination or inspection hereunder shall require five (5) business days written notice from Intrexon to Adeona. Adeona will make
itself and the pertinent employees and/or agents available, on a reasonable basis, to Intrexon for the aforementioned compliance
review.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>In view of the Intrexon Confidential Information, Intrexon Know-How, and Intrexon Materials transferred to Adeona hereunder,
Intrexon from time-to-time, but no more than quarterly, may request that Adeona confirm the status of the Intrexon Materials at
Company (i.e. how much used, how much shipped, to whom and any unused amounts destroyed (by whom, when) as well as any amounts
returned to Intrexon or destroyed). Within ten (10) business days of Adeona&rsquo;s receipt of any such written request, Adeona
shall provide the written report to Intrexon.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>7.6
</B></FONT><B>Intrexon Commitment</B>. Intrexon shall use reasonable efforts to obtain an agreement with its other licensees and
channel partners or collaborators to enable Adeona to disclose confidential information of such licensees and channel partners
or collaborators to regulatory authorities in order to seek or obtain approval to conduct clinical trials, or to gain regulatory
approval of, Adeona Products, in a manner consistent with the provisions of Section 7.2(b).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
8<BR>
<BR>
</B></FONT><B>Representations And Warranties</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>8.1
</B></FONT><B>Representations and Warranties of Adeona</B>. Adeona hereby represents and warrants to Intrexon that, as of the Effective
Date:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT><B>Corporate Power</B>. Adeona is duly organized and validly existing under the laws of Nevada and has corporate full
power and authority to enter into this Agreement and to carry out the provisions hereof.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT><B>Due Authorization</B>. Adeona is duly authorized to execute and deliver this Agreement and to perform its obligations
hereunder, and the person executing this Agreement on Adeona&rsquo;s behalf has been duly authorized to do so by all requisite
corporate action.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT><B>Binding Agreement</B>. This Agreement is a legal and valid obligation binding upon Adeona and enforceable in accordance
with its terms, except as such enforcement may be limited by applicable bankruptcy, insolvency, reorganization, arrangement, moratorium
or other similar laws affecting creditors&rsquo; rights, and subject to general equity principles and to limitations on availability
of equitable relief, including specific performance. The execution, delivery and performance of this Agreement by Adeona does not
conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it may be bound.
Adeona is aware of no action, suit or inquiry or investigation instituted by any governmental agency which questions or threatens
the validity of this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>8.2
</B></FONT><B>Representations and Warranties of Intrexon</B>. Intrexon hereby represents and warrants to Adeona that, as of the
Effective Date:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT><B>Corporate Power</B>. Intrexon is duly organized and validly existing under the laws of Virginia and has full corporate
power and authority to enter into this Agreement and to carry out the provisions hereof.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT><B>Due Authorization</B>. Intrexon is duly authorized to execute and deliver this Agreement and to perform its obligations
hereunder, and the person executing this Agreement on Intrexon&rsquo;s behalf has been duly authorized to do so by all requisite
corporate action.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT><B>Binding Agreement</B>. This Agreement is a legal and valid obligation binding upon Intrexon and enforceable in accordance
with its terms, except as such enforcement may be limited by applicable bankruptcy, insolvency, reorganization, arrangement, moratorium
or other similar laws affecting creditors&rsquo; rights, and subject to general equity principles and to limitations on availability
of equitable relief, including specific performance. The execution, delivery and performance of this Agreement by Intrexon does
not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it may be bound.
Intrexon is aware of no action, suit or inquiry or investigation instituted by any governmental agency which questions or threatens
the validity of this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT><B>Additional Intellectual Property Representations</B>.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(i)
</FONT>Intrexon possesses sufficient rights to enable Intrexon to grant all rights and licenses it purports to grant to Adeona
with respect to the Intrexon Patents under this Agreement;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(ii)
</FONT>The Intrexon Patents existing as of the Effective Date constitute all of the Patents Controlled by Intrexon as of such date
that are necessary for the development, manufacture or Commercialization of Adeona Products;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(iii)
</FONT>Intrexon has not granted, and during the Term Intrexon will not grant, any right or license, to any Third Party under the
Intrexon IP that conflicts with the rights or licenses granted or to be granted to Adeona hereunder;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(iv)
</FONT>There is no pending litigation, and Intrexon has not received any written notice of any claims or litigation, seeking to
invalidate or otherwise challenge the Intrexon Patents or Intrexon&rsquo;s rights therein;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(v)
</FONT>None of the Intrexon Patents is subject to any pending re-examination, opposition, interference or litigation proceedings;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(vi)
</FONT>All of the Intrexon Patents have been filed and prosecuted in accordance with all applicable laws and have been maintained,
with all applicable fees with respect thereto (to the extent such fees have come due) having been paid;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(vii)
</FONT>Intrexon has entered into agreements with each of its current and former officers, employees and consultants involved in
research and development work, including development of the Intrexon&rsquo;s products and technology providing Intrexon, to the
extent permitted by law, with title and ownership to patents, patent applications, trade secrets and inventions conceived, developed,
reduced to practice by such person, solely or jointly with other of such persons, during the period of employment by Intrexon (except
where the failure to have entered into such an agreement would not have a material adverse effect on the rights granted to Adeona
herein), and Intrexon is not aware that any of its employees or consultants is in material violation thereof;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(viii)
</FONT>To Intrexon&rsquo;s knowledge, there is no infringement, misappropriation or violation by third parties of any Intrexon
Channel Technology in the Field;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(ix)
</FONT>There is no pending or, to Intrexon&rsquo;s knowledge, threatened action, suit, proceeding or claim by others against Intrexon
that Intrexon infringes, misappropriates or otherwise violates any intellectual property or other proprietary rights of others
in connection with the use of the Intrexon Channel Technology, and Intrexon has not received any written notice of such claim;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(x)
</FONT>To Intrexon&rsquo;s knowledge, no employee of Intrexon is the subject of any claim or proceeding involving a violation of
any term of any employment contract, patent disclosure agreement, invention assignment agreement, non-competition agreement, non-solicitation
agreement, non-disclosure agreement or any restrictive covenant to or with a former employer (A) where the basis of such violation
relates to such employee&rsquo;s employment with Intrexon or actions undertaken by the employee while employed with Intrexon and
(B) where such violation is relevant to the use of the Intrexon Channel Technology in the Field;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(xi)
</FONT>None of the Intrexon Patents owned by Intrexon or its Affiliates, and, to Intrexon&rsquo;s knowledge, the Intrexon Patents
licensed to Intrexon or its Affiliates, have been adjudged invalid or unenforceable by a court of competent jurisdiction or applicable
government agency, in whole or in part, and there is no pending or, to Intrexon&rsquo;s knowledge, threatened action, suit, proceeding
or claim by others challenging the validity or scope of any such Intrexon Patents; and</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(xii) </FONT>Except
as otherwise disclosed in writing to Adeona, Intrexon: (A) is in material compliance with all statutes, rules or regulations
applicable to the ownership, testing, development, manufacture, packaging, processing, use, distribution,
marketing, labeling, promotion, sale, offer for sale, storage, import, export or disposal of any product that is under
development, manufactured or distributed by Intrexon in the Field (&ldquo;<B>Applicable Laws</B>&rdquo;); (B) has not
received any FDA Form 483, notice of adverse finding, warning letter, untitled letter or other correspondence or notice from
the United States Food and Drug Administration (the &ldquo;<B>FDA</B>&rdquo;) or any other federal, state, local or foreign
governmental or regulatory authority alleging or asserting material noncompliance with any Applicable Laws or any licenses,
certificates, approvals, clearances, authorizations, permits and supplements or amendments thereto required by any such
Applicable Laws (&ldquo;<B>Authorizations</B>&rdquo;), which would not, individually or in the aggregate, result in a
material adverse effect; (C) possesses all material Authorizations necessary for the operation of its business as described
in the Field and such Authorizations are valid and in full force and effect and Intrexon is not in material violation of any
term of any such Authorizations; and (D) since January 1, 2008, (1) has not received notice of any claim, action, suit,
proceeding, hearing, enforcement, investigation, arbitration or other action from the FDA or any other federal, state, local
or foreign governmental or regulatory authority or third party alleging that any product operation or activity is in material
violation of any Applicable Laws or Authorizations and has no knowledge that the FDA or any other federal, state, local or
foreign governmental or regulatory authority or third party is considering any such claim, litigation, arbitration, action,
suit investigation or proceeding; (2) has not received notice that the FDA or any other federal, state, local or
foreign governmental or regulatory authority has taken, is taking or intends to take action to limit, suspend, modify or
revoke any material Authorizations and has no knowledge that the FDA or any other federal, state, local or foreign
governmental or regulatory authority is considering such action; (3) has filed, obtained, maintained or submitted all
material reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as
required by any Applicable Laws or Authorizations and that all such reports, documents, forms, notices, applications,
records, claims, submissions and supplements or amendments were materially complete and correct on the date filed (or were
corrected or supplemented by a subsequent submission); and (4) has not, either voluntarily or involuntarily, initiated,
conducted, or issued or caused to be initiated, conducted or issued, any recall, market withdrawal or replacement, safety
alert, post sale warning, &ldquo;dear doctor&rdquo; letter, or other notice or action relating to the alleged lack of safety
or efficacy of any product or any alleged product defect or violation and, to Intrexon&rsquo;s knowledge, no third party has
initiated, conducted or intends to initiate any such notice or action. Except to the extent disclosed in writing to Adeona,
since January 1, 2008, Intrexon has not received any notices or correspondence from the FDA or any other federal, state,
local or foreign governmental or regulatory authority requiring the termination, suspension or material modification of any
studies, tests or preclinical or clinical trials conducted by or on behalf of Intrexon. except, in each of (ix) through
(xiii), for any instances which would not, individually or in the aggregate, result in a material adverse effect on the
rights granted to Adeona hereunder or Intrexon&rsquo;s ability to perform its obligations hereunder.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>8.3
</B></FONT><B>Warranty Disclaimer</B>. EXCEPT FOR THE EXPRESS WARRANTIES PROVIDED IN THIS ARTICLE 8 OR IN THE EQUITY AGREEMENTS,
EACH PARTY HEREBY DISCLAIMS ANY AND ALL OTHER WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES
OF TITLE, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR <FONT STYLE="color: black">NONINFRINGEMENT OF THE INTELLECTUAL
PROPERTY RIGHTS OF THIRD PARTIES.</FONT></P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
9<BR>
<BR>
</B></FONT><B>Indemnification</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>9.1
</B></FONT><B>Indemnification by Intrexon</B>. Intrexon agrees to indemnify, hold harmless, and defend Adeona and its Affiliates
and their respective directors, officers, employees, and agents (collectively, the &ldquo;<B>Adeona Indemnitees</B>&rdquo;) from
and against any and all liabilities, damages, costs, expenses, or losses (including reasonable legal expenses and attorneys&rsquo;
fees) (collectively, &ldquo;<B>Losses</B>&rdquo;) resulting from any claims, suits, actions, demands, or other proceedings brought
by a Third Party (collectively, &ldquo;<B>Claims</B>&rdquo;) to the extent arising from (a) the gross negligence or willful misconduct
of Intrexon or any of its Affiliates, or their respective employees or agents, (b) the use, handling, storage or transport of Intrexon
Materials by or on behalf of Intrexon or its Affiliates, licensees (other than Adeona) or sublicensees; or (c) breach by Intrexon
of any representation, warranty or covenant in this Agreement. Notwithstanding the foregoing, Intrexon shall not have any obligation
to indemnify the Adeona Indemnitees to the extent that a Claim arises from (i) the gross negligence or willful misconduct of Adeona
or any of its Affiliates, licensees, or sublicensees, or their respective employees or agents; or (ii) a breach by Adeona of a
representation, warranty, or covenant of this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>9.2
</B></FONT><B>Indemnification by Adeona</B>. Adeona agrees to indemnify, hold harmless, and defend Intrexon, its Affiliates and
Third Security, and their respective directors, officers, employees, and agents (and any Third Parties which have licensed to Intrexon
intellectual property rights within Intrexon IP on or prior to the Effective Date, to the extent required by the relevant upstream
license agreement) (collectively, the &ldquo;<B>Intrexon Indemnitees</B>&rdquo;) from and against any Losses resulting from Claims,
to the extent arising from any of the following: (a) the gross negligence or willful misconduct of Adeona or any of its Affiliates
or their respective employees or agents; (b) the use, handling, storage, or transport of <FONT STYLE="color: black">Intrexon Materials</FONT>
by or on behalf of Adeona or its Affiliates, licensees, or sublicensees; (c) breach by Adeona of any material representation, warranty
or covenant in this Agreement; or (d) the design, development, manufacture, regulatory approval, handling, storage, transport,
distribution, sale or other disposition of any Adeona Product by or on behalf of Adeona or its Affiliates, licensees, or sublicensees.
Notwithstanding the foregoing, Adeona shall not have any obligation to indemnify the Intrexon Indemnitees to the extent that a
Claim arises from (i) the gross negligence or willful misconduct of Intrexon or any of its Affiliates, or their respective employees
or agents; or (ii) a breach by Intrexon of a representation, warranty, or covenant of this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>9.3
</B></FONT><B>Product Liability Claims</B>. Notwithstanding the provisions of Section 9.2, any Losses arising out of any Third
Party claim, suit, action, proceeding, liability or obligation involving any actual or alleged death or bodily injury arising out
of or resulting from the development, manufacture or commercialization of any Adeona Products for use or sale in the Field, to
the extent that such Losses exceed the amount (if any) covered by the applicable Party&rsquo;s product liability insurance (&ldquo;<B>Excess
Product Liability Costs</B>&rdquo;), shall be paid by Adeona and shared by the Parties as Allowable Expenses for purposes of calculating
Cumulative Product Profit, except to the extent such Losses arise out of any Third-Party Claim based on the gross negligence or
willful misconduct of a Party, its Affiliates, its or its Affiliates&rsquo; Sublicensees, or any of the respective officers, directors,
employees and agents of each of the foregoing entities, in the performance of obligations or exercise of rights under this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>9.4
</B></FONT><B>Control of Defense</B>. As a condition precedent to any indemnification obligations hereunder, any entity entitled
to indemnification under this Article 9 shall give written notice to the indemnifying Party of any Claims that may be subject to
indemnification, promptly after learning of such Claim. If such Claim falls within the scope of the indemnification obligations
of this Article 9, then the indemnifying Party shall assume the defense of such Claim with counsel reasonably satisfactory to the
indemnified Party. The indemnified Party shall cooperate with the indemnifying Party in such defense. The indemnified Party may,
at its option and expense, be represented by counsel of its choice in any action or proceeding with respect to such Claim. The
indemnifying Party shall not be liable for any litigation costs or expenses incurred by the indemnified Party without the indemnifying
Party&rsquo;s written consent, such consent not to be unreasonably withheld. The indemnifying Party shall not settle any such Claim
if such settlement (a) does not fully and unconditionally release the indemnified Party from all liability relating thereto or
(b) adversely impacts the exercise of the rights granted to the indemnified Party under this Agreement, unless the indemnified
Party otherwise agrees in writing.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>9.5
</B></FONT><B>Insurance</B>. Immediately prior to, and during marketing, Adeona shall maintain in effect and good standing a product
liability insurance policy issued by a reputable insurance company in amounts considered standard for the industry. At Intrexon&rsquo;s
reasonable request, Adeona shall provide Intrexon with all details regarding such policy, including without limitation copies of
the applicable liability insurance contracts. Adeona shall use reasonable efforts to include Intrexon as an additional insured
on any such policy.</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
10<BR>
<BR>
</B></FONT><B>Term; Termination</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>10.1
</B></FONT><B>Term</B>. The term of this Agreement shall commence upon the Effective Date and shall continue until terminated pursuant
to Section 10.2 or 10.3 (the &ldquo;<B>Term</B>&rdquo;).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>10.2
</B></FONT><B>Termination for Material Breach; Termination Under Section 4.5(b)</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>Either Party shall have the right to terminate this Agreement upon written notice to the other Party if the other Party
commits any material breach of this Agreement that such breaching Party fails to cure within sixty (60) days following written
notice from the nonbreaching Party specifying such breach.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>Intrexon shall have the right to terminate this Agreement, at its sole discretion, if the NYSE Amex Approval has not
been obtained, and the First Tranche Shares (as defined in the Equity Agreements) have not been issued, within sixty (60) days
following the execution of this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT>Intrexon shall have the right to terminate this Agreement under the circumstances set forth in Section 4.5(b) upon written
notice to Adeona, such termination to become effective sixty (60) days following such written notice unless Adeona remedies the
circumstances giving rise to such termination within such sixty (60) day period.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT> Intrexon shall have the right to terminate this Agreement under the circumstances set forth in Section 12.8 upon written
notice to Adeona, such termination to become effective immediately upon such written notice.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT>Notwithstanding the foregoing, during the eighteen (18) month period commencing on the Effective Date, neither Party
shall have the right to terminate this Agreement under Section 10.2(a) based on the failure of the other Party to use Diligent
Efforts or to comply with any other diligence obligations hereunder (including Section 4.5), nor shall Intrexon have the right
to terminate this Agreement under Section 10.2(c).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>10.3
</B></FONT><B>Termination by Adeona</B>. Adeona shall have the right to voluntarily terminate this Agreement in its entirety upon
ninety (90) days written notice to Intrexon at any time, provided that such notice may not be given during the eighteen (18) month
period commencing on the Effective Date.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>10.4
</B></FONT><B>Effect of Termination</B>. In the event of termination of this Agreement pursuant to Section 10.2 or Section 10.3,
the following shall apply:</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT><B>Retained Products</B>. Adeona shall be permitted to continue the development and commercialization of any Adeona
Product that, at the time of termination, satisfies at least one of the following criteria (a &ldquo;<B>Retained Product</B>&rdquo;):</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(i)
</FONT> is being Commercialized by Adeona,</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(ii)
</FONT>has received regulatory approval,</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(iii)
</FONT>is a subject of an application for regulatory approval in the Field that is pending before the applicable regulatory authority,</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"><FONT STYLE="color: black">(iv)
</FONT>is the subject of at least</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in">(A) an ongoing Phase
2 clinical trial in the Field (in the case of a termination by Intrexon due to a Adeona uncured breach pursuant to Section 10.2(a)
or a termination by Adeona pursuant to Section 10.3), or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in">(B) an ongoing Phase
1 clinical trial in the Field (in the case of a termination by Adeona due to an Intrexon uncured breach pursuant to Section 10.2(a)
or a termination by Intrexon pursuant to Section 10.2(c) or 10.2(d)), or</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1.5in">(v) Adeona has spent
at least $4.5 million developing.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">Such right to continue development and
commercialization shall be subject to Adeona&rsquo;s full compliance with the payment provisions in Article 5 and all other provisions
of this Agreement that survive termination.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT><B>Termination of Licenses</B>. Except as necessary for Adeona to continue to develop and commercialize the Retained
Products as permitted by Section 10.4(a), all rights and licenses granted by Intrexon to Adeona under this Agreement shall terminate
and shall revert to Intrexon without further action by either Intrexon or Adeona. Adeona&rsquo;s license with respect to Retained
Products shall be exclusive or non-exclusive, as the case may be, on the same terms as set forth in Section 3.1.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(c)
</B></FONT><B>Reverted Products</B>. All Adeona Products other than the Retained Products shall be referred to herein as the &ldquo;<B>Reverted
Products</B>.&rdquo; Adeona shall immediately cease, and shall cause its Affiliates and, if applicable, (sub)licensees to immediately
cease, all development and commercialization of the Reverted Products, and Adeona shall not use or practice, nor shall it cause
or permit any of its Affiliates or, if applicable, (sub)licensees to use or practice, directly or indirectly, any Intrexon IP with
respect to the Reverted Products. Adeona shall immediately discontinue making any representation regarding its status as a licensee
or channel collaborator of Intrexon with respect to the Reverted Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(d)
</B></FONT><B>Intrexon Materials</B>. Adeona shall promptly return, or at Intrexon&rsquo;s request, destroy, any Intrexon Materials
in Adeona&rsquo;s possession or control at the time of termination, or other than any Intrexon Materials necessary for the continued
development and commercialization of the Retained Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(e)
</B></FONT><B>Licenses to Intrexon</B>. Adeona is automatically deemed to grant to Intrexon a worldwide, fully paid, royalty-free,
exclusive (even as to Adeona and its Affiliates), irrevocable, license (with full rights to sublicense) under the Adeona Termination
IP, to make, have made, import, use, offer for sale and sell Reverted Products and to use the Intrexon Channel Technology, the
Intrexon Materials, and/or the Intrexon IP in the Field, subject to any exclusive rights held by Adeona in Reverted Products pursuant
to Section 10.4(c). Adeona shall also take such actions and execute such other instruments and documents as may be necessary to
document such license to Intrexon.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(f)
</B></FONT><B>Regulatory Filings</B>. Adeona shall promptly assign to Intrexon, and will provide full copies of, all regulatory
approvals and regulatory filings that relate specifically and solely to Reverted Products. Adeona shall also take such actions
and execute such other instruments, assignments and documents as may be necessary to effect the transfer of rights thereunder to
Intrexon. To the extent that there exist any regulatory approvals and regulatory filings that relate both to Reverted Products
and other products, Adeona shall provide copies of the portions of such regulatory filings that relate to Reverted Products and
shall reasonably cooperate to assist Intrexon in obtaining the benefits of such regulatory approvals with respect to the Reverted
Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 1in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(g)
</B></FONT><B>Data Disclosure</B>. Adeona shall provide to Intrexon copies of the relevant portions of all material reports and
data, including clinical and non-clinical data and reports, obtained or generated by or on behalf of Adeona or its Affiliates to
the extent that they relate to Reverted Products, within sixty (60) days of such termination unless otherwise agreed, and Intrexon
shall have the right to use any such Information in developing and commercializing Reverted Products and to license any Third Parties
to do so.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(h)
</B></FONT><B>Third-Party Licenses</B>. At Intrexon&rsquo;s request, Adeona shall promptly provide to Intrexon copies of all Third-Party
agreements under which Adeona or its Affiliates obtained a license under Patents claiming inventions or know-how specific to or
used or incorporated into the development, manufacture and/or commercialization of the Reverted Products. At Intrexon&rsquo;s request,
Adeona shall promptly: (x) with respect to such Third Party licenses relating solely to the applicable Reverted Products, immediately
assign (or cause to be assigned), such agreements to Intrexon, and (y) with respect to all other Third Party licenses, at Adeona&rsquo;s
option either assign the agreement or grant (or cause to be granted) to Intrexon a sublicense thereunder of a scope equivalent
to that described in Section 10.4(e), provided Adeona has the ability to assign such agreement to Intrexon or grant a sublicense
to Intrexon thereunder. In any case, thereafter Intrexon shall be fully responsible for all obligations due for its actions under
the Third Party agreements. Notwithstanding the above, if Intrexon does not wish to assume any financial or other obligations associated
with a particular assignment or sublicense, then Intrexon shall so notify Adeona and Adeona shall not make such assignment or grant
such sublicense (or cause it to be made or granted).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(i)
</B></FONT><B>Remaining Materials</B>. At the request of Intrexon, Adeona shall transfer to Intrexon, all quantities of Reverted
Product (including API or work-in-process) in the possession of Adeona or its Affiliates. Adeona shall transfer to Intrexon all
such quantities of Reverted Products without charge, except that Intrexon shall pay the reasonable costs of shipping.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(j)
</B></FONT><B>Third Party Vendors</B>. At Intrexon&rsquo;s request, Adeona shall promptly provide to Intrexon copies of all agreements
between Adeona or its Affiliates and Third Party suppliers, vendors, or distributors that relate to the supply, sale, or distribution
of Reverted Products in the Territory. At Intrexon&rsquo;s request, Adeona shall promptly: (x) with respect to such Third Party
agreements relating solely to the applicable Reverted Products, immediately assign (or cause to be assigned), such agreements to
Intrexon, and (y) with respect to all other such Third Party agreements, Adeona shall reasonably cooperate to assist Intrexon in
obtaining the benefits of such agreements. Adeona shall be liable for any costs associated with assigning a Third Party agreement
to Intrexon or otherwise obtaining the benefits of such agreement for Intrexon, to the extent such costs are directly related to
Adeona&rsquo;s breach. For the avoidance of doubt, Intrexon shall have no obligation to assume any of Adeona&rsquo;s obligations
under any Third Party agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(k)
</B></FONT><B>Commercialization</B>. Intrexon shall have the right to develop and commercialize the Reverted Products itself or
with one or more Third Parties, and shall have the right, without obligation to Adeona, to take any such actions in connection
with such activities as Intrexon (or its designee), at its discretion, deems appropriate.</P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(l)
</B></FONT><B>Confidential Information</B>. Each Party shall promptly return, or at the other <FONT STYLE="color: black">Party</FONT>&rsquo;s
request destroy, any Confidential Information of the other Party in such Party&rsquo;s possession or control at the time of termination;
provided, however, that each Party shall be permitted to retain (i) a single copy of each item of Confidential Information of the
other Party in its confidential legal files for the sole purpose of monitoring and enforcing its compliance with Article 7, (ii)
Confidential Information of the other Party that is maintained as archive copies on the recipient Party&rsquo;s disaster recovery
and/or information technology backup systems, or (iii) Confidential Information of the other Party necessary to exercise such Party&rsquo;s
rights in Retained Products (in the case of Adeona) or Reverted Products (in the case of Intrexon). The recipient of Confidential
Information shall continue to be bound by the terms and conditions of this Agreement with respect to any such Confidential Information
retained in accordance with this Section 10.4(l).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>10.5
</B></FONT><B>Surviving Obligations</B>. Termination or expiration of this Agreement shall not affect any rights of either <FONT STYLE="color: black">Party</FONT>
arising out of any event or occurrence prior to termination, including, without limitation, any obligation of Adeona to pay any
amount which became due and payable under the terms and conditions of this Agreement prior to expiration or such termination. The
following portions of this Agreement shall survive termination or expiration of this Agreement: Sections 5.5, 5.7, 6.1, 6.2 (with
subsection (c) surviving only to the extent relating to Intrexon Patents that are relevant to Retained Products that, to Intrexon&rsquo;s
knowledge, are being developed or commercialized at such time, if any), 10.4, and 10.5; Articles 7, 9, 11, and 12; and any relevant
definitions in Article 1.</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
11<BR>
<BR>
</B></FONT><B>Dispute Resolution</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.1
</B></FONT><B>Disputes</B>. It is the objective of the Parties to establish procedures to facilitate the resolution of disputes
arising under this Agreement in an expedient manner by mutual cooperation and without resort to litigation. In the event of any
disputes, controversies or differences which may arise between the Parties out of or in relation to or in connection with this
Agreement (other than disputes arising from a Committee), including, without limitation, any alleged failure to perform, or breach,
of this Agreement, or any issue relating to the interpretation or application of this Agreement, then upon the request of either
Party by written notice, the Parties agree to meet and discuss in good faith a possible resolution thereof, which good faith efforts
shall include at least one in-person meeting between the Executive Officers of each Party. If the matter is not resolved within
thirty (30) days following the written request for discussions, either Party may then invoke the provisions of Section 11.2. For
the avoidance of doubt, any disputes, controversies or differences arising from a Committee pursuant to Article 2 shall be resolved
solely in accordance with Section 2.4.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.2
</B></FONT><B>Arbitration</B>. Any dispute, controversy, difference or claim which may arise between the Parties and not from a
Committee, out of or in relation to or in connection with this Agreement (including, without limitation, arising out of or relating
to the validity, construction, interpretation, enforceability, breach, performance, application or termination of this Agreement)
that is not resolved pursuant to Section 11.1 shall, subject to Section 11.10, be settled by binding &ldquo;baseball arbitration&rdquo;
as follows. Either Party, following the end of the thirty (30) day period referenced in Section 11.1, may refer such issue to arbitration
by submitting a written notice of such request to the other Party. Promptly following receipt of such notice, the Parties shall
meet and discuss in good faith and seek to agree on an arbitrator to resolve the issue, which arbitrator shall be neutral and independent
of both Parties and all of their respective Affiliates, shall have significant experience and expertise in licensing and partnering
agreements in the pharmaceutical and biotechnology industries, and shall have some experience in mediating or arbitrating issues
relating to such agreements. If the Parties cannot agree on a single arbitrator within fifteen (15) days of request by a Party
for arbitration, then each Party shall select an arbitrator meeting the foregoing criteria and the two (2) arbitrators so selected
shall select a third arbitrator meeting the foregoing criteria. Within fifteen (15) days after an arbitrator(s) is selected (in
the case of the three-person panel, when the third arbitrator is selected), each Party will deliver to both the arbitrator(s) and
the other Party a detailed written proposal setting forth its proposed terms for the resolution for the matter at issue (the &ldquo;<B>Proposed
Terms</B>&rdquo; of the Party) and a memorandum (the &ldquo;<B>Support Memorandum</B>&rdquo;) in support thereof. The Parties will
also provide the arbitrator(s) a copy of this Agreement, as it may be amended at such time. Within fifteen (15) days after receipt
of the other Party&rsquo;s Proposed Terms and Support Memorandum, each Party may submit to the arbitrator(s) (with a copy to the
other Party) a response to the other Party&rsquo;s Support Memorandum. Neither Party may have any other communications (either
written or oral) with the arbitrator(s) other than for the sole purpose of engaging the arbitrator or as expressly permitted in
this Section 11.2; provided that, the arbitrator(s) may convene a hearing if the arbitrator(s) so chooses to ask questions of the
Parties and hear oral argument and discussion regarding each Party&rsquo;s Proposed Terms. Within sixty (60) days after the arbitrator&rsquo;s
appointment, the arbitrator(s) will select one of the two Proposed Terms (without modification) provided by the Parties that he
or she believes is most consistent with the intention underlying and agreed principles set forth in this Agreement. The decision
of the arbitrator(s) shall be final, binding, and unappealable. For clarity, the arbitrator(s) must select as the only method to
resolve the matter at issue one of the two sets of Proposed Terms, and may not combine elements of both Proposed Terms or award
any other relief or take any other action.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.3
</B></FONT><B>Governing Law</B>. This Agreement shall be governed by and construed under the substantive laws of the State of New
York, excluding any conflicts or choice of law rule or principle that might otherwise refer construction or interpretation of this
Agreement to the substantive law of another jurisdiction.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.4
</B></FONT><B>Award</B>. Any award to be paid by one Party to the other Party as determined by the arbitrator(s) as set forth above
under Section 11.2 shall be promptly paid in United States dollars free of any tax, deduction or offset; and any costs, fees or
taxes incident to enforcing the award shall, to the maximum extent permitted by law, be charged against the losing Party.<FONT STYLE="color: black">
Each Party agrees to abide by the award rendered in any arbitration conducted pursuant to this Article 11, and agrees that, subject
to the United States Federal Arbitration Act, 9 U.S.C. &sect;&sect; 1-16, judgment may be entered upon the final award in any United
States District Court located in </FONT>New York<FONT STYLE="color: black"> and that other courts may award full faith and credit
to such judgment in order to enforce such award. The award shall include interest from the date of any damages incurred for breach
of the Agreement, and from the date of the award until paid in full, at a rate fixed by the arbitrator</FONT>(s)<FONT STYLE="color: black">.
With respect to money damages, nothing contained herein shall be construed to permit the arbitrator</FONT>(s)<FONT STYLE="color: black">
or any court or any other forum to award consequential, incidental, special, punitive or exemplary damages. By entering into this
agreement to arbitrate, the Parties expressly waive any claim for consequential, incidental, special, punitive or exemplary damages.
The only damages recoverable under this Agreement are direct compensatory damages.</FONT></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.5
</B></FONT><B>Costs</B>. Each Party shall bear its own legal fees. The arbitrator(s) shall assess his or her costs, fees and expenses
against the Party losing the arbitration.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.6
</B></FONT><B>Injunctive Relief</B>. Nothing in this Article 11 will preclude either Party from seeking equitable relief or interim
or provisional relief from a court of competent jurisdiction, including a temporary restraining order, preliminary injunction or
other interim equitable relief, concerning a dispute either prior to or during any arbitration if necessary to protect the interests
of such Party or to preserve the status quo pending the arbitration proceeding. <FONT STYLE="color: black">Specifically, the Parties
agree that a material breach by either Party of its obligations in 3.4 of this Agreement may cause irreparable harm to the other
Party, for which damages may not be an adequate remedy. Therefore, in addition to its rights and remedies otherwise available at
law, including, without limitation, the recovery of damages for breach of this Agreement, upon an adequate showing of material
breach of such Section 3.4, and without further proof of irreparable harm other than this acknowledgement, such non-breaching Party
shall be entitled to seek (a) immediate equitable relief, specifically including, but not limited to, both interim and permanent
restraining orders and injunctions, and (b) such other and further equitable relief as the court may deem proper under the circumstances.
For the avoidance of doubt, nothing in this Section 11.6 shall otherwise limit a breaching Party&rsquo;s opportunity to cure a
material breach as permitted in accordance with Section 10.2.</FONT></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.7
</B></FONT><B>Confidentiality</B>. The arbitration proceeding shall be confidential and the arbitrator(s) shall issue appropriate
protective orders to safeguard each Party&rsquo;s Confidential Information. Except as required by law, no Party shall make (or
instruct the arbitrator(s) to make) any public announcement with respect to the proceedings or decision of the arbitrator(s) without
prior written consent of the other Party. The existence of any dispute submitted to arbitration, and the award, shall be kept in
confidence by the Parties and the arbitrator(s), except as required in connection with the enforcement of such award or as otherwise
required by applicable law.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.8
</B></FONT><B>Survivability</B>. Any duty to arbitrate under this Agreement shall remain in effect and be enforceable after termination
of this Agreement for any reason.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.9
</B></FONT><B>Jurisdiction</B>. For the purposes of this Article 11, the Parties acknowledge their diversity and agree to accept
the jurisdiction of any <FONT STYLE="color: black">United States District Court located in </FONT>New York for the purposes of
enforcing or appealing any awards entered pursuant to this Article 11 and for enforcing the agreements reflected in this Article
11 and agree not to commence any action, suit or proceeding related thereto except in such courts.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>11.10
</B></FONT><B>Patent Disputes</B>. Notwithstanding any other provisions of this Article 11, and subject to the provisions of Section
6.2, any dispute, controversy or claim relating to the scope, validity, enforceability or infringement of any Intrexon Patents
shall be submitted to a court of competent jurisdiction in the country in which such Patent was filed or granted.</P>

<P STYLE="font: normal italic 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><FONT STYLE="font-variant: small-caps; color: black"><B>ARTICLE
12<BR>
<BR>
</B></FONT><B>General Provisions</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.1
</B></FONT><B>Use of Name</B>. No right, express or implied, is granted by this Agreement to either Party to use in any manner
the name of the other or any other trade name or trademark of the other in connection with the performance of this Agreement, except
that either Party may use the name of the other Party as required by regulations and in press releases accompanying quarterly and
annual earnings reports approved by the Audit Committee of the issuer&rsquo;s Board of Directors.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.2
</B></FONT><B>LIMITATION OF LIABILITY</B>. NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL,
PUNITIVE, OR INDIRECT DAMAGES ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY
OF SUCH DAMAGES. NOTWITHSTANDING THE FOREGOING, NOTHING IN THIS PARAGRAPH IS INTENDED TO LIMIT OR RESTRICT THE INDEMNIFICATION
RIGHTS OR OBLIGATIONS OF ANY PARTY UNDER ARTICLE 9, OR DAMAGES AVAILABLE FOR BREACHES OF THE OBLIGATIONS SET FORTH IN ARTICLE 7.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.3
</B></FONT><B>Independent Parties</B>. The Parties are not employees or legal representatives of the other Party for any purpose.
Neither Party shall have the authority to enter into any contracts in the name of or on behalf of the other Party. <FONT STYLE="color: black">This
Agreement shall not constitute, create, or in any way be interpreted as a joint venture, partnership, or business organization
of any kind.</FONT></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.4
</B></FONT><B>Notice</B>. All notices, including notices of address change, required or permitted to be given under this Agreement
shall be in writing and deemed to have been given when delivered if personally delivered or sent by facsimile (provided that the
party providing such notice promptly confirms receipt of such transmission with the other party by telephone), on the business
day after dispatch if sent by a nationally-recognized overnight courier and on the third business day following the date of mailing
if sent by certified mail, postage prepaid, return receipt requested. All such communications shall be sent to the address or facsimile
number set forth below (or any updated addresses or facsimile number communicated to the other Party in writing):</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; margin-left: 37.25pt; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 38%; padding-right: 5.75pt; padding-left: 5.75pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">If to Intrexon:</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">with a copy to:</P></TD>
    <TD STYLE="width: 62%; padding-right: 5.75pt; padding-left: 5.75pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Intrexon Corporation</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">20358 Seneca Meadows Parkway</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Germantown, MD 20876</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Attention: President, Human Therapeutics Division</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">Fax: (301) 556-9901</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Intrexon Corporation</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">20358 Seneca Meadows Parkway</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Germantown, MD 20876</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Attention: Legal Department</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">Fax: (301) 556-9902</P></TD></TR>
</TABLE>

<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0">&nbsp;</P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 5.75pt; padding-left: 5.75pt; width: 38%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">If to Adeona:</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">with a copy to:</P></TD>
    <TD STYLE="padding-right: 5.75pt; padding-left: 5.75pt; width: 62%">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Adeona Pharmaceuticals, Inc.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">3985 Research Park Drive, Suite 200</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Ann Arbor, MI 48108</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Attention: Chief Executive Officer</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">Fax: (734) 332-7878</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Gracin &amp; Marlow, LLP</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">405 Lexington Avenue</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">New York, NY 10174</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Attn: Leslie Marlow, Esq.</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Fax: (212) 208-4657</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt">&nbsp;</P></TD></TR>
</TABLE>
<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 12pt 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.5
</B></FONT><B>Severability</B>. In the event any provision of this Agreement is held to be invalid or unenforceable, the valid
or enforceable portion thereof and the remaining provisions of this Agreement will remain in full force and effect.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.6
</B></FONT><B>Waiver</B>. Any waiver (express or implied) by either Party of any breach of this Agreement shall not constitute
a waiver of any other or subsequent breach.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.7
</B></FONT><B>Entire Agreement; Amendment</B>. This Agreement and the exhibits attached hereto constitute the entire, final, complete
and exclusive agreement between the Parties and supersede all previous agreements or representations, written or oral, with respect
to the subject matter of this Agreement (including any prior confidentiality agreement between the Parties). All information of
Intrexon or Adeona to be kept confidential by the other Party under any prior confidentiality agreement, as of the Effective Date,
shall be maintained as Confidential Information by such other Party under the obligations set forth in Article 7 of this Agreement.
This Agreement may not be modified or amended except in a writing signed by a duly authorized representative of each Party.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.8
</B></FONT><B>Nonassignability; Binding on Successors</B>. Any attempted assignment of the rights or delegation of the obligations
under this Agreement shall be void without the prior written consent of the nonassigning or nondelegating Party; provided, however,
that either <FONT STYLE="color: black">Party</FONT> may assign its rights or delegate its obligations under this Agreement without
such consent (a) to an Affiliate of such <FONT STYLE="color: black">Party</FONT> or (b) to its successor in interest in connection
with any merger, acquisition, consolidation, corporate reorganization, or similar transaction, or sale of all or substantially
all of its assets, provided that such assignee agrees in writing to assume and be bound by the assignor&rsquo;s obligations under
this Agreement. This Agreement shall be binding upon, and inure to the benefit of, the successors, executors, heirs, representatives,
administrators and permitted assigns of the Parties hereto. Notwithstanding the foregoing, in the event that either Party assigns
this Agreement to its successor in interest by way of merger, acquisition, or sale of all or substantially all of its assets (whether
this Agreement is actually assigned or is assumed by such successor in interest or its affiliate by operation of law (e.g., in
the context of a reverse triangular merger)), (a) the intellectual property rights of such successor in interest or any of its
affiliates shall be automatically excluded from the rights licensed to the other Party under this Agreement, and (b) such successor
in interest may elect by written notice to have the restrictions set forth in Section 3.4 not apply to the activities of such successor
in interest (but, for purposes of clarity, such restriction shall in any event continue to apply to the applicable Party and all
other Affiliates of such Party not related to such successor in interest). In the event that a successor in interest to Adeona
elects to have the restrictions set forth in Section 3.4 not apply to the activities of such successor in interest, Intrexon shall
have the termination right set forth in Section 10.2(d).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; font-variant: normal; font-variant: normal; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.9
</B></FONT><B>Force Majeure</B>. Neither Party shall be liable to the other for its failure to perform any of its obligations under
this Agreement, except for payment obligations, during any period in which such performance is delayed because rendered impracticable
or impossible due to circumstances beyond its reasonable control, including without limitation earthquakes, governmental regulation,
fire, flood, labor difficulties, civil disorder, acts of terrorism and acts of God, provided that the Party experiencing the delay
promptly notifies the other Party of the delay.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.10
</B></FONT><B>No Other Licenses</B>. Neither Party grants to the other Party any rights or licenses in or to any intellectual property,
whether by implication, estoppel, or otherwise, except to the extent expressly provided for under this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.11
</B></FONT><B>Non-Solicitation</B>. During the Term and for a period of one (1) year following the end of the Term, neither Adeona
nor Intrexon may directly or indirectly solicit, in order to offer to employ, any employee of the other Party without the prior
approval of such other Party. General employment solicitations or advertisements or employment discussions initiated by such an
employee, shall not be considered direct or indirect solicitations, and are not prohibited under this Agreement.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.12
</B></FONT><B>Legal Compliance</B>. The Parties shall review in good faith and cooperate in taking such actions to ensure compliance
of this Agreement with all applicable laws.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>12.13
</B></FONT><B>Counterparts</B>. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original
and all of which shall constitute together the same instrument.</P>

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blank.]</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="font-variant: small-caps"><B>In
Witness Whereof,</B></FONT> the Parties hereto have duly executed this Exclusive Channel Collaboration Agreement.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding: 0; text-align: justify; font-weight: bold">Intrexon Corporation</TD>
    <TD STYLE="padding: 0; text-align: justify; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0; text-align: justify; font-weight: bold">Adeona Pharmaceuticals, Inc.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; text-align: justify; font-weight: bold; width: 2%">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify; font-weight: bold; width: 30%">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify; font-weight: bold; width: 16%">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify; font-weight: bold; width: 2%">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify; font-weight: bold; width: 30%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; text-align: justify">By:</TD>
    <TD STYLE="padding: 0; text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">By:</TD>
    <TD STYLE="padding: 0; text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; text-align: justify">Name:</TD>
    <TD STYLE="padding: 0; text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">Name:</TD>
    <TD STYLE="padding: 0; text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0; text-align: left">Title:</TD>
    <TD STYLE="padding: 0; text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: left">&nbsp;</TD>
    <TD STYLE="padding: 0; text-align: left">Title:</TD>
    <TD STYLE="padding: 0; text-align: justify; border-bottom: Black 1pt solid">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><B>EXHIBIT A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><B>Financial Terms for Calculating Allowable
Expenses</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify">As used herein, the term &ldquo;operating
unit&rdquo; shall mean the smallest operating unit in which an operating profit and loss statement is prepared for management accounting
purposes in the applicable Party&rsquo;s normal accounting procedures, consistently applied within and across its operating units.
To the extent certain cost or expense items below are incurred with respect to multiple products and some of such products are
not Adeona Products, then such cost or expense items shall be allocated on a <I>pro rata </I>basis based upon net sales of each
respective product by the applicable operating unit during the most recent quarter.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt"><FONT STYLE="font-variant: small-caps; color: black"><B>1.
</B></FONT><B>Cost of Goods Sold</B></P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">&ldquo;<B>Cost
of Goods Sold</B>&rdquo;<I> </I>means all Manufacturing Costs that are directly and reasonably attributable to manufacturing of
Adeona Product for commercial sale in the countries where such Adeona Product has been launched.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>1.1
</B></FONT>&ldquo;<B>Manufacturing Costs</B>&rdquo; means, with respect to Adeona Products, the FTE costs (under a reasonable accounting
mechanism to be agreed upon by the Parties and out-of-pocket costs of a Party or any of its Affiliates incurred in manufacturing
such Adeona Products, including costs and expenses incurred in connection with (1) the development or validation of any manufacturing
process, formulations or delivery systems, or improvements to the foregoing; (2) manufacturing scale-up; (3) in-process testing,
stability testing and release testing; (4) quality assurance/quality control development; (5) internal and Third Party costs and
expenses incurred in connection with qualification and validation of Third Party contract manufacturers, including scale up, process
and equipment validation, and initial manufacturing licenses, approvals and inspections; (6) packaging development and final packaging
and labeling; (7) shipping configurations and shipping studies; and (8) overseeing the conduct of any of the foregoing. &ldquo;Manufacturing
Costs&rdquo; shall further include:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(a)
</B></FONT>to the extent that any such Adeona Product is Manufactured by a Third Party manufacturer, the out-of-pocket costs incurred
by such Party or any of its Affiliates to the Third Party for the manufacture and supply (including packaging and labeling) thereof,
and any reasonable out-of-pocket costs and direct labor costs incurred by such Party or any of its Affiliates in managing or overseeing
the Third Party relationship determined in accordance with the books and records of such Party or its Affiliates maintained in
accordance with US GAAP; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 1in"><FONT STYLE="color: black"><B>(b)
</B></FONT>to the extent that any such Adeona Product is manufactured by such Party or any of its Affiliates, direct material and
direct labor costs attributable to such Adeona Product, as well as reasonably allocable overhead expenses, determined in accordance
with the books and records of such Party or its Affiliates maintained in accordance with US GAAP.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt"><FONT STYLE="color: black"><B>2. </B></FONT><B><FONT STYLE="font-variant: small-caps">Marketing
Expenses</FONT></B>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">&ldquo;<B>Marketing
Expenses</B>&rdquo; means the sum of reasonable Selling Expenses, Marketing Management Expenses, Market and Consumer Research Expenses,
Advertising Expenses, Trade Promotion Expenses, and Consumer Promotion Expenses, each of which is specified below, in each case
to the extent directly and reasonably attributable to the sale, promotion or marketing of the applicable Adeona Products in the
countries where such Adeona Product has been launched.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.1
</B></FONT>&ldquo;<B>Selling Expenses</B>&rdquo; shall mean all reasonable costs and expenses directly associated with the efforts
of field sales representatives with respect to Adeona Products in the Territory. The costs of detailing sales calls shall be allocated
based on field force time at an accounting charge rate reasonably and consistently applied within and across its operating units
and which is no less favorable to the Adeona Products than the internal charge rate used by Adeona for its own internal cost accounting
purposes for products other than Adeona Products (excluding internal profit margins and markups).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.2
</B></FONT>&ldquo;<B>Marketing Management Expenses</B>&rdquo; means all reasonable product management and sales promotion management
compensation (including customary bonuses and benefits but excluding stock-based compensation) and departmental expenses, including
product related public relations, relationships with opinion leaders and professional societies, health care economics studies,
contract pricing and administration, market information systems, governmental affairs activities for reimbursement, formulary acceptance
and other activities directly related to the Adeona Products in the Territory, management and administration of managed care and
national accounts and other activities associated with developing overall sales and marketing strategies and planning for Adeona
Products in the Territory.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.3
</B></FONT>&ldquo;<B>Market and Consumer Research Expenses</B>&rdquo; means all reasonable compensation (including customary bonuses
and benefits but excluding stock-based compensation) and departmental expenses for market and consumer research personnel and payments
to Third Parties related to and to the extent use for conducting and monitoring professional and consumer appraisals of existing,
new or proposed Adeona Products in the Territory such as market share services (e.g., IMS data), special research testing and focus
groups.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.4
</B></FONT>&ldquo;<B>Advertising Expenses</B>&rdquo; shall mean all reasonable costs reasonably incurred for the advertising and
promotion of Adeona Products in the Territory.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.5
</B></FONT>&ldquo;<B>Trade Promotion Expenses</B>&rdquo; means the actual and reasonable allowances given to retailers, brokers,
distributors, hospital buying groups, etc. for purchasing, promoting, and distribution of Adeona Products in the Territory. This
shall include purchasing, advertising, new distribution, and display allowances as well as free goods, wholesale allowances and
reasonable field sales samples (at the out of pocket cost).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>2.6
</B></FONT>&ldquo;<B>Consumer Promotion Expenses</B>&rdquo; means all reasonable expenses associated with programs to promote Adeona
Products directly to the end user in the Territory. This category shall include expenses associated with promoting products directly
to the professional community such as professional samples, professional literature, promotional material costs, patient aids and
detailing aids.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 0.5in; text-align: justify">&nbsp;</P>

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<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt 0.5in; font-variant: normal; text-align: justify">&nbsp;</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt"><FONT STYLE="color: black"><B>3. </B></FONT><B><FONT STYLE="font-variant: small-caps">Distribution
Expenses</FONT></B>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><I>&ldquo;</I><B>Distribution
Expenses</B><I>&rdquo;</I><B> </B>means the reasonable costs, excluding overhead, incurred by Adeona that are directly and reasonably
allocable to the distribution of a Adeona Product with respect to a particular country where such Adeona Product has been launched,
excluding any costs included as a deduction in calculating Net Sales.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt"><FONT STYLE="color: black"><B>4. </B></FONT><B><FONT STYLE="font-variant: small-caps">Additional
Commercialization Expenses</FONT></B>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">&ldquo;<B>Additional
Commercialization Expenses</B>&rdquo; means the sum of Regulatory and Related Costs, Third Party Blocking IP Costs, Patent and
Trademark Costs, Product Liability Costs, and Additional Approved Expenses, each of which is specified below, in each case to the
extent directly and reasonably attributable to the commercialization of the applicable Adeona Products.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.1
</B></FONT>&ldquo;<B>Regulatory and Related Costs</B>&rdquo; means all reasonable costs and expenses associated with the preparation
and filing of marketing and pricing approval applications, and the maintenance of marketing approvals, for Adeona Products, including
(i) fees paid to regulatory authorities directly related to NDAs and Marketing Approvals in the Field, (ii) costs of any regulatory
interactions with respect to Adeona Products, (iii) costs incurred in securing reimbursement approvals from public and private
payers, and (iv) costs to establish and maintain a global safety database.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.2
</B></FONT>&ldquo;<B>Third Party Blocking IP Costs</B>&rdquo; means royalties, license fees or other payments, as applicable, reasonably
allocable to the development, manufacture or Commercialization of Adeona Products paid or payable to Third Parties to license Blocking
Third Party IP owned or controlled by such Third Parties.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.3
</B></FONT>&ldquo;<B>Patent and Trademark Costs</B>&rdquo; means all reasonable costs and expenses incurred by Adeona or its Affiliates
in connection with (i) the preparation, filing, prosecution, maintenance and enforcement of Adeona Program Patents, and (ii) establishing,
maintaining and enforcing the Patents and trademarks for Adeona Products in the Territory.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.4
</B></FONT>&ldquo;<B>Product Liability Costs</B>&rdquo; means the reasonable costs associated with (i) any recall in the Territory,
including the cost of any investigations or corrective actions, (ii) any Excess Product Liability Costs, and (iii) product liability
insurance premiums for policies covering the development, manufacture or Commercialization of Adeona Products (as described in
Section 9.5).</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in"><FONT STYLE="color: black"><B>4.5
</B></FONT>&ldquo;<B>Additional Approved Expenses</B>&rdquo; means any additional costs and/or expenses that are incurred in connection
with the commercialization of Adeona Products and that are approved in advance, in writing, by the Intrexon representatives on
the CC.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt"><FONT STYLE="color: black"><B>5. </B></FONT><B><FONT STYLE="font-variant: small-caps">Post-Launch
Product R&amp;D Expenses</FONT></B>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify; text-indent: 0.5in">&ldquo;<B>Post-Launch
Product R&amp;D Expenses</B>&rdquo; means the reasonable costs, excluding administrative expenses and costs that are included within
Costs of Goods Sold, of Phase 4 clinical trials and ongoing product support (including manufacturing and quality assurance technical
support, and laboratory and clinical efforts directed toward the further understanding of product safety and efficacy) and medical
affairs (including regulatory support necessary for product maintenance), in each case that are (a) specifically attributable to
a Adeona Product in the countries of the Territory where such Adeona Product has been launched and (b) approved by both Parties
in writing.</P>

<P STYLE="font: normal 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: justify"><FONT STYLE="color: black"><B>6.
</B></FONT><B><FONT STYLE="font-variant: small-caps">No Duplication</FONT></B><FONT STYLE="font-variant: small-caps">. </FONT>No
item of cost shall be duplicated in any of the categories comprising Allowable Expenses or in the deductions permitted under Net
Sales or Sublicensing Revenue.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0"><B>&nbsp;EXHIBIT B</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; text-align: center; margin-bottom: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><B>Press Release</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"><I>[See Attached]</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 12pt; text-align: center">&nbsp;</P>



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