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License, Collaborative and Employment Agreements and Commitments (Details Textual) (USD $) | 12 Months Ended |  | 12 Months Ended | 1 Months Ended | 12 Months Ended |  | 12 Months Ended |  | 12 Months Ended |
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Dec. 31, 2013 | Dec. 31, 2012 | Dec. 31, 2009 | Dec. 31, 2013 Mark Pimentel [Member] | Dec. 31, 2013 Option Agreement [Member] | Dec. 31, 2013 Non Refundable Option [Member] | Dec. 31, 2013 Non Refundable Extension [Member] | Dec. 31, 2013 Licensing Agreements [Member] | Dec. 31, 2013 Patents [Member] | Feb. 29, 2012 Jeffrey Riley [Member] | Feb. 29, 2012 C. Evan Ballantyne [Member] | Sep. 30, 2005 Research and Development Arrangement [Member] | Dec. 31, 2012 Intrexon [Member] | Dec. 31, 2011 Intrexon [Member] | Dec. 31, 2013 Intrexon [Member] | Dec. 31, 2013 Intrexon [Member] Research and Development Arrangement [Member] | Dec. 31, 2012 Prev Abr Llc [Member] | Dec. 31, 2013 Cedars-Sinai Medical Center [Member] | Dec. 31, 2012 Office Space In Ann Arbor [Member] | Dec. 31, 2012 Office Space In Rockville [Member] | Dec. 31, 2012 December 31, 2014 [Member] | Dec. 31, 2012 December 31, 2015 [Member] | Dec. 31, 2012 Phase I Clinical Trials [Member] | Dec. 31, 2012 Phase Iii Clinical Trials [Member] | Dec. 31, 2012 Nda Submission In Us [Member] | Dec. 31, 2012 European Medicines Agency Approval [Member] | Dec. 31, 2012 Regulatory Approval In Asian Country [Member] | Dec. 31, 2012 IND Milestone Event [Member] | Dec. 31, 2012 Approval Milestone Event [Member] | Dec. 31, 2012 Field Expansion Fee [Member] | Dec. 31, 2013 First Year [Member] | Dec. 31, 2013 Second Year [Member] | Dec. 31, 2013 Third Year [Member]
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Line of Credit Facility, Periodic Payment |  |  | $ 197,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Line of Credit Facility, Periodic Payment, Interest |  |  | 5,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense | 6,507,000 | 12,287,000 |  |  |  |  |  |  |  |  |  | 460,000 | 7,800,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Rent Expense | 68,000 | 123,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value |  |  |  |  |  |  |  |  |  | 1,700,000 | 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Officers Compensation |  |  |  |  |  |  |  |  |  | 348,000 | 298,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | 222,500 |  |  |  |  |  |  |  |  | 750,000 | 425,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Future Minimum Payments, Due in Two Years |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 33,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Lease Leasing Term |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | extend the term of the lease to December 31, 2014 | one year operating lease that may be renewed for two additional terms of one year |  |  |  |  |  |  |  |  |  |  |  |  |
Partial Consideration for Execution |  |  |  |  |  |  |  |  |  |  |  |  |  | Intrexon a number of shares of our common stock equal to 9.995% of the number of shares of the Companys common stock issued |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Registration Payment Arrangement, Settlement Alternatives |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | The Company also agreed upon the filing of an IND application with the FDA for a Synthetic Product, or alternatively the filing of the first equivalent regulatory filing with a foreign regulatory agency (both as applicable, the IND Milestone Event), to pay Intrexon either (i) $2.0 million in cash, or (ii) that number of shares of Common Stock (the IND Milestone Shares) having a fair market value equaling $2.0 million where such fair market value is determined using published market data of the share price for Common Stock at the close of market on the business day immediately preceding the date of public announcement of attainment of the IND Milestone Event | Upon the first to occur of either first commercial sale of a Synthetic Product in a country or the granting of the regulatory approval of that Synthetic Product (both as applicable, the Approval Milestone Event), the Company agreed to pay to Intrexon either (i) $3.0 million in cash, or (ii) that number of shares of Common Stock (the Approval Milestone Shares) having a fair market value equaling $3.0 million where such fair market value is determined using published market data of the share price for Common Stock at the close of market on the business day immediately preceding the date of public announcement of attainment of the Approval Milestone Event | The Field Expansion Fee must be paid completely in either Common Stock or cash, and will comprise either (i) $2.0 million in cash for each target in excess of three total that the Company elects, or (ii) that number of shares of Common Stock (the Field Expansion Fee Shares) having a fair market value equaling $2.0 million for each such target that the Company elects in excess of three where such fair market value is determined using published market data establishing the volume-weighted average price for a share of Common Stock over the 30 day period immediately preceding the date of the Field Expansion Fee Closing. |  |  |
Registration Payment Arrangement, Term |  | In connection with the transactions contemplated by the Stock Purchase Agreement, and pursuant to the Registration Rights Agreement executed and delivered by the Company to Intrexon, the Company agreed to file a resale registration statement registering the resale of the First Tranche Shares within 120 days of the closing date of such issuance. |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 42,000 | 50,000 | 25,000 |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 303,287 | 316,438 | 328,758
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 | 100,000 | 250,000 | 100,000 | 100,000 |  |  |  |  |  |
Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 135,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unregistered Shares Issued to License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 625,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Consideration Payable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50% in cash and 50% in our stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Acquisitions |  |  |  |  |  |  |  |  |  |  |  |  | 3,552,210 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Development Stage Entities, Equity Issuance, Per Share Amount |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Prepaid Expense and Other Assets, Current | 1,591,000 | 2,509,000 |  |  |  |  |  |  |  |  |  |  |  |  | 2,500,000 | 1,400,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Fees |  |  |  |  |  | 50,000 | 25,000 | 150,000 | 220,000 |  |  |  |  |  |  |  |  | 50,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  | 43,342 |  |  | 291,569 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments to Acquire in Process Research and Development | 1,000,000 | 87,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Market Value |  |  |  |  | 110.00% |  |  |  |  |  |  |  |  |  |  |  |  | 110.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock Outstanding Percentage |  |  |  | 8.50% |  |  |  |  |  |  |  |  |  |  |  |  |  | 11.50% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange percentage of unregistered common stock | 50.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from (Repurchase of) Equity, Total | $ 3,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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