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Consolidated Statements of Equity (USD $) In Thousands, except Share data | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Noncontrolling Interest [Member]
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2011 | $ 7,059 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest | $ 31 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | $ 58,901 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | $ (51,873)us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | $ 0 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance (in shares) at Dec. 31, 2011 |  | 31,292,520 us-gaap_SharesOutstanding / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Stock-based compensation | 1,852 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 1,852 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for exclusive channel collaboration agreement | 7,814 syn_StockIssuedDuringPeriodValueForExclusiveChannelCollaborationAgreement | 3 syn_StockIssuedDuringPeriodValueForExclusiveChannelCollaborationAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 7,811 syn_StockIssuedDuringPeriodValueForExclusiveChannelCollaborationAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 syn_StockIssuedDuringPeriodValueForExclusiveChannelCollaborationAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 syn_StockIssuedDuringPeriodValueForExclusiveChannelCollaborationAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for exclusive channel collaboration agreement (in shares) |  | 3,552,210 syn_StockIssuedDuringPeriodSharesForExclusiveChannelCollaborationAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock for acquisition of program assets | 1,169 us-gaap_StockIssuedDuringPeriodValueAcquisitions | 1 us-gaap_StockIssuedDuringPeriodValueAcquisitions / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 1,168 us-gaap_StockIssuedDuringPeriodValueAcquisitions / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_StockIssuedDuringPeriodValueAcquisitions / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockIssuedDuringPeriodValueAcquisitions / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for acquisition of program assets (in shares) |  | 625,000 us-gaap_StockIssuedDuringPeriodSharesAcquisitions / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock for stock options and warrants exercised | 2,082 syn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised | 2 syn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 2,080 syn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 syn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 syn_StockIssuedDuringPeriodValueStockOptionsAndWarrantsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for stock options and warrants exercised (in shares) |  | 2,143,018 syn_StockIssuedDuringPeriodSharesStockOptionsAndWarrantsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock, net of issuance costs | 10,120 us-gaap_StockIssuedDuringPeriodValueNewIssues | 7 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 10,113 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock, net of issuance costs (in shares) |  | 6,750,000 us-gaap_StockIssuedDuringPeriodSharesNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Net loss | (17,068)us-gaap_ProfitLoss | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | (17,068)us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance at Dec. 31, 2012 | 13,028 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest | 44 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 81,925 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | (68,941)us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance (in shares) at Dec. 31, 2012 |  | 44,362,748 us-gaap_SharesOutstanding / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Stock-based compensation | 1,669 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 1,669 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock, net of issuance costs | 12,193 us-gaap_StockIssuedDuringPeriodValueNewIssues | 13 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 12,180 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock, net of issuance costs (in shares) |  | 13,225,000 us-gaap_StockIssuedDuringPeriodSharesNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock for exercise of stock options | 232 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised | 1 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 231 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for exercise of stock options (in shares) |  | 291,667 us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock for license agreement | 425 syn_StockIssuedDuringPeriodValueLicenseAgreement | 0 syn_StockIssuedDuringPeriodValueLicenseAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 425 syn_StockIssuedDuringPeriodValueLicenseAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 syn_StockIssuedDuringPeriodValueLicenseAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 syn_StockIssuedDuringPeriodValueLicenseAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for license agreement (in shares) |  | 334,911 syn_StockIssuedDuringPeriodSharesLicenseAgreement / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of stock | 1 syn_StockIssuedOfDuringPeriodValueNewIssues | 0 syn_StockIssuedOfDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 0 syn_StockIssuedOfDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 syn_StockIssuedOfDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 1 syn_StockIssuedOfDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of stock (in shares) |  | 0 us-gaap_StockIssuedDuringPeriodSharesOther / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Net loss | (12,318)us-gaap_ProfitLoss | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | (12,317)us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | (1)us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance at Dec. 31, 2013 | 15,230 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest | 58 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 96,430 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | (81,258)us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance (in shares) at Dec. 31, 2013 |  | 58,214,326 us-gaap_SharesOutstanding / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Stock-based compensation | 2,459 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 2,459 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensationStockOptionsRequisiteServicePeriodRecognition / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock, net of issuance costs | 11,647 us-gaap_StockIssuedDuringPeriodValueNewIssues | 14 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 11,633 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockIssuedDuringPeriodValueNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock, net of issuance costs (in shares) |  | 14,059,616 us-gaap_StockIssuedDuringPeriodSharesNewIssues / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock for exercise of stock options | 4 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised | 0 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 4 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for exercise of stock options (in shares) |  | 6,583 us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Issuance of common stock for cashless exercise of warrants | 0 syn_IssuanceValueOfCommonStockUponExerciseOfWarrants | 0 syn_IssuanceValueOfCommonStockUponExerciseOfWarrants / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 0 syn_IssuanceValueOfCommonStockUponExerciseOfWarrants / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | 0 syn_IssuanceValueOfCommonStockUponExerciseOfWarrants / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 syn_IssuanceValueOfCommonStockUponExerciseOfWarrants / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Issuance of common stock for cashless exercise of warrants (in shares) |  | 232,619 syn_IssuanceOfCommonStockUponExerciseSharesOfWarrants / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |
Net loss | (19,784)us-gaap_ProfitLoss | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | (19,784)us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | 0 us-gaap_ProfitLoss / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance at Dec. 31, 2014 | $ 9,556 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest | $ 72 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember | $ 110,526 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_AdditionalPaidInCapitalMember | $ (101,042)us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_RetainedEarningsMember | $ 0 us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest / us-gaap_StatementEquityComponentsAxis = us-gaap_NoncontrollingInterestMember
Balance (in shares) at Dec. 31, 2014 |  | 72,513,144 us-gaap_SharesOutstanding / us-gaap_StatementEquityComponentsAxis = us-gaap_CommonStockMember |  |  |

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