<SEC-DOCUMENT>0000930413-15-000655.txt : 20150218
<SEC-HEADER>0000930413-15-000655.hdr.sgml : 20150216
<ACCEPTANCE-DATETIME>20150217103704
ACCESSION NUMBER:		0000930413-15-000655
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20150217
DATE AS OF CHANGE:		20150217

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Synthetic Biologics, Inc.
		CENTRAL INDEX KEY:			0000894158
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133808303
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-50777
		FILM NUMBER:		15619048

	BUSINESS ADDRESS:	
		STREET 1:		617 DETROIT STREET, SUITE 100
		CITY:			ANN ARBOR
		STATE:			MI
		ZIP:			48104
		BUSINESS PHONE:		(734) 332-7800

	MAIL ADDRESS:	
		STREET 1:		155 GIBBS STREET
		STREET 2:		SUITE 412
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADEONA PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20081027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20061214

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19970730

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>c80307_sc13ga.htm
<TEXT>
<HTML>
<HEAD>
<TITLE></TITLE>
</HEAD>
<BODY>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES<BR>
SECURITIES AND EXCHANGE COMMISSION<BR>
Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Schedule 13G/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Amendment No. 1)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Under the Securities Exchange Act of 1934</B></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: Black 1px solid"><B>Synthetic Biologics Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: Black 1px solid">Common Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: Black 1px solid">87164U102</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: Black 1px solid">December 31, 2014</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Date of Event which Requires Filing of this
Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left">Check the appropriate box to designate the rule
pursuant to which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; text-align: left"><FONT STYLE="font: 10pt Wingdings">&#0111;</FONT></TD>
    <TD STYLE="width: 95%; text-align: left"><FONT STYLE="font-size: 10pt">Rule 13d-1(b)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font: 10pt Wingdings">&#0253;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Rule 13d-1(c)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font: 10pt Wingdings">&#0111;</FONT></TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Rule 13d-1(d)</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">*The remainder of this cover
page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">The information required in the remainder of
this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of 1934
(&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: left"><B>Persons who respond to the collection of
information contained in this form are not required to respond unless the form displays a currently valid OMB control number.</B></P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<!-- Field: Page; Sequence: 1; Options: NewSection -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 23%; border: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 12pt; text-align: left; vertical-align: top"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 59%; border-right: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 16pt; text-align: center"><FONT STYLE="font: 16pt Arial, Helvetica, Sans-Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; text-align: left; vertical-align: top"><FONT STYLE="font: 10pt Arial, Helvetica, Sans-Serif">Page 2 of 9 Pages</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>



<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>1.</B></TD>
    <TD COLSPAN="2"><B>NAMES OF REPORTING PERSONS</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">Great Point Partners, LLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">37-1475292</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>2.</B></TD>
    <TD COLSPAN="2"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 5%; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%">(a)</TD>
    <TD STYLE="width: 90%"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">(b)</TD>
    <TD><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>3.</B></TD>
    <TD COLSPAN="2"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>4.</B></TD>
    <TD COLSPAN="2"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">USA</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="8" STYLE="width: 20%; text-align: center; vertical-align: middle; padding-bottom: 5pt"><B>NUMBER
    OF SHARES<BR>
<BR>
 BENEFICIALLY<BR>
<BR>
 OWNED BY EACH<BR>
<BR>
 REPORTING PERSON<BR>
<BR>
 WITH</B></TD>
    <TD STYLE="width: 5%; text-align: center; padding-bottom: 5pt"><B>5.</B></TD>
    <TD STYLE="width: 75%; padding-bottom: 5pt; text-align: left"><B>SOLE
    VOTING POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">0</TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>6.</B></TD>
    <TD STYLE="padding-bottom: 5pt; text-align: left"><B>SHARED
    VOTING POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">7,588,341<SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>7.</B></TD>
    <TD STYLE="padding-bottom: 5pt; text-align: left"><B>SOLE DISPOSITIVE POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">0</TD></TR>

<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>8.</B></TD>
    <TD STYLE="padding-bottom: 5pt; text-align: left"><B>SHARED
    DISPOSITIVE POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">7,588,341<SUP>1</SUP></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="text-align: left"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED
    BY EACH REPORTING PERSON</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 5%; text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 90%; text-align: left; padding-left: 36pt">7,588,341<SUP>1</SUP></TD>
    <TD STYLE="vertical-align: bottom; width: 5%; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: left">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><B>10.</B></TD>
    <TD STYLE="vertical-align: top; text-align: left"><B>CHECK BOX IF THE AGGREGATE
    AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B> (See Instructions)</TD>
    <TD STYLE="vertical-align: middle; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: top; text-align: left">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>11.</B></TD>
    <TD COLSPAN="2" STYLE="text-align: left"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT
    IN ROW (9)</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; padding-left: 36pt">9.97%<SUP>2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>12.</B></TD>
    <TD COLSPAN="2" STYLE="text-align: left"><B>TYPE OF REPORTING PERSON</B> (See
    Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; padding-left: 36pt">IA</TD></TR>
</TABLE>
<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</P>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"></P>
<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif"><TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="width: 3%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD><TD STYLE="text-align: justify; width: 97%; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Includes
                                       warrants to purchase an aggregate of 3,589,400 shares underlying warrants, owned by Biomedical
                                       Value Fund, LP, Biomedical Offshore Value Fund, Ltd., Biomedical Institutional Value Fund,
                                       LP, GEF-SMA, LP and Class D Series of GEF-PS, LP.</FONT></TD></TR>             <TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
<TD STYLE="font: 10pt Times New Roman, Times, Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><SUP>2</SUP></FONT></TD><TD STYLE="text-align: justify; font: 10pt Times New Roman, Times, Serif"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0; text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Based
                                                     on a total of 72,513,144 shares of Common Stock outstanding, as reported
                                                     by the Issuer on a Form 10-Q filed with the SEC on November 14, 2014.</FONT></P>


</TD></TR>
</TABLE>


<!-- Field: Page; Sequence: 2 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="border: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 12pt; text-align: left; width: 23%; vertical-align: top"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 59%; border-right: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 16pt; text-align: center"><FONT STYLE="font: 16pt Arial, Helvetica, Sans-Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; text-align: left; vertical-align: top"><FONT STYLE="font: 10pt Arial, Helvetica, Sans-Serif">Page 3 of 9 Pages</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>



<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><B>1.</B></TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom"><B>NAMES OF REPORTING PERSONS</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">Dr. Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center"><B>2.</B></TD>
    <TD COLSPAN="2"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 5%">(a)</TD>
    <TD STYLE="width: 90%"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>(b)</TD>
    <TD><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center"><B>3.</B></TD>
    <TD COLSPAN="2"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center"><B>4.</B></TD>
    <TD COLSPAN="2"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">USA</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="8" STYLE="width: 20%; text-align: center; padding-bottom: 5pt; vertical-align: middle"><B>NUMBER OF SHARES<BR><BR>BENEFICIALLY<BR><BR>
OWNED BY EACH<BR><BR>REPORTING PERSON<BR><BR>WITH</B></TD>
    <TD STYLE="width: 5%; text-align: center; padding-bottom: 5pt"><B>5.</B></TD>
    <TD STYLE="width: 75%; padding-bottom: 5pt"><B>SOLE VOTING POWER</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 5pt; text-align: center">0</TD>
</TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>6.</B></TD>
    <TD STYLE="padding-bottom: 5pt"><B>SHARED VOTING POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 5pt; text-align: center">7,588,341<SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>7.</B></TD>
    <TD STYLE="padding-bottom: 5pt"><B>SOLE DISPOSITIVE POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 5pt; text-align: center">0</TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>8.</B></TD>
    <TD STYLE="padding-bottom: 5pt"><B>SHARED DISPOSITIVE POWER</B></TD></TR>
<TR STYLE="vertical-align: top">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="padding-bottom: 5pt; text-align: center">7,588,341<SUP>1</SUP></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>9.</B></TD>
    <TD COLSPAN="2"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 5%; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 90%; padding-left: 36pt">7,588,341<SUP>1</SUP></TD>
    <TD STYLE="vertical-align: bottom; width: 5%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center"><B>10.</B></TD>
    <TD STYLE="vertical-align: top"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES </B>(See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; font-family: Wingdings">&#111;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>11.</B></TD>
    <TD COLSPAN="2"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt">9.97%<SUP>2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>12.</B></TD>
    <TD COLSPAN="2"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt">IN</TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 3 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="width: 23%; border: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 12pt; text-align: left; vertical-align: top"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="vertical-align: top; width: 59%; border-right: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 16pt; text-align: center"><FONT STYLE="font: 16pt Arial, Helvetica, Sans-Serif"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 5.4pt; padding-left: 5.4pt; font-size: 10pt; text-align: left; vertical-align: top"><FONT STYLE="font: 10pt Arial, Helvetica, Sans-Serif">Page 4 of 9 Pages</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>1.</B></TD>
    <TD COLSPAN="2"><B>NAMES OF REPORTING PERSONS</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">Mr. David Kroin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>2.</B></TD>
    <TD COLSPAN="2"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 5%">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%">(a)</TD>
    <TD STYLE="width: 90%"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">(b)</TD>
    <TD STYLE="font-family: Webdings"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>3.</B></TD>
    <TD COLSPAN="2"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>4.</B></TD>
    <TD COLSPAN="2"><B>CITIZENSHIP OR PLACE OF ORGANIZATION </B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">USA</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD ROWSPAN="8" STYLE="vertical-align: middle; width: 20%; text-align: center; padding-bottom: 5pt"><B>NUMBER
    OF SHARES <BR>
<BR>
BENEFICIALLY <BR>
<BR>
OWNED BY EACH <BR>
<BR>
REPORTING PERSON <BR>
<BR>
WITH</B></TD>
    <TD STYLE="vertical-align: bottom; width: 5%; text-align: center; padding-bottom: 5pt"><B>5.</B></TD>
    <TD STYLE="vertical-align: bottom; width: 75%; text-align: left; padding-bottom: 5pt"><B>SOLE
    VOTING POWER</B></TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">0</TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>6.</B></TD>
    <TD STYLE="text-align: left; padding-bottom: 5pt"><B>SHARED VOTING POWER</B></TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">7,588,341<SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>7.</B></TD>
    <TD STYLE="text-align: left; padding-bottom: 5pt"><B>SOLE DISPOSITIVE POWER</B></TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">0</TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt"><B>8.</B></TD>
    <TD STYLE="text-align: left; padding-bottom: 5pt"><B>SHARED DISPOSITIVE POWER</B></TD></TR>
<TR STYLE="vertical-align: bottom">

    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD STYLE="text-align: center; padding-bottom: 5pt">7,588,341<SUP>1</SUP></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="text-align: left"><B>AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
    PERSON</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; text-align: left">7,588,341<SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 5%; text-align: center"><B>10.</B></TD>
    <TD STYLE="vertical-align: top; width: 90%"><B>CHECK BOX IF THE AGGREGATE AMOUNT
    IN ROW (9) EXCLUDES CERTAIN SHARES</B> (See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; width: 5%"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>11.</B></TD>
    <TD COLSPAN="2" STYLE="text-align: left"><B>PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; text-align: left">9.97%<SUP>2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>12.</B></TD>
    <TD COLSPAN="2" STYLE="text-align: left"><B>TYPE OF REPORTING PERSON</B> (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; text-align: left">IN</TD></TR>
</TABLE>



<!-- Field: Page; Sequence: 4 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="width: 23%; border: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 12pt">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="width: 59%; border-right: black 1px solid; font: bold 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 16pt">13G/A</FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top">Page
    5  of 9 Pages</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman,serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; font: 10pt Times New Roman,serif">

 <FONT STYLE="font-size: 10pt"><B>Item 1.</B></FONT></TD>
    <TD STYLE="width: 4%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 4%; font-family: Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="width: 70%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 5%; font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="width: 8%; font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Name of Issuer</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt">Synthetic Biologics Inc.</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Address of Issuer&rsquo;s Principal Executive Offices</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">155 Gibbs Street, Suite 412, Rockville, MD 20850</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt"><B>Item 2.</B></FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Name of Person Filing</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Tahoma,sans-serif; text-align: left">&nbsp;</TD>
    <TD>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 10pt">Great Point Partners, LLC<BR>
        Dr. Jeffrey R. Jay, M.D.</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 10pt">Mr. David Kroin</P></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Tahoma,sans-serif; text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-family: Times New Roman,serif; text-align: left">The Reporting Persons have entered into a Joint Filing Agreement, dated February 17, 2015, a copy of which
is filed with this Schedule 13G/A as Exhibit A, pursuant to which the Reporting Persons have agreed to file this statement jointly
in accordance with the provisions of Rule 13d-1(k)(1) under the Act.


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Address of Principal Business Office, or if none, Residence</FONT></TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="4" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">The address of the principal business office of each of the Reporting Persons is</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2">
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0 0 0 0pt">165 Mason Street, 3rd Floor</P>
        <P STYLE="font: 10pt Times New Roman,serif; margin: 0">Greenwich, CT 06830</P></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(c)</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Citizenship</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font-family: Times New Roman,serif"><FONT STYLE="font-size: 10pt">Great Point Partners, LLC is a limited liability company organized under the laws of the State of Delaware.  Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Mr. David Kroin is a citizen of the United States.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(d)</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Title of Class of Securities</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Common Stock</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(e)</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Tahoma,sans-serif; text-align: left; padding-left: 5pt"><FONT STYLE="font: 10pt Times New Roman,serif">CUSIP Number</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Tahoma,sans-serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">87164U102</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt"><B>Item 3.</B></FONT></TD>
    <TD COLSPAN="5" STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt"><B>If this statement is filed pursuant to &sect;240.13d-1(b) or 240.13d.2(b) or (c), check whether the person
filing is a:</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="5" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-family: Times New Roman,serif; text-align: left; padding-left: 5pt"><FONT STYLE="font-size: 10pt">Not Applicable.</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o)</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(<FONT STYLE="font-family: Times New Roman,serif">c</FONT>)</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(d)</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman,serif">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">(e)</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman,serif; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD COLSPAN="3" STYLE="font: 10pt Times New Roman,serif"><FONT STYLE="font-size: 10pt">An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E).</FONT></TD></TR>
</TABLE>

<!-- Field: Page; Sequence: 5 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="width: 23%; border: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 12pt">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="width: 59%; border-right: black 1px solid; font: bold 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 16pt">13G/A</FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top">Page
    6  of 9  Pages</TD></TR>
</TABLE>



<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 9%; font-weight: bold">&nbsp;</TD>
    <TD STYLE="width: 4%">(f)</TD>
    <TD STYLE="width: 4%; text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD STYLE="width: 83%">An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F).


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>(g)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD>A parent holding company or control person in accordance with &sect;240.13d-1(b)(1)(ii)(G).


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>(h)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD>A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>(i)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD>A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the
Investment Company Act of 1940 (15 U.S.C. 80a-3).


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD>(j)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">&#0111;</FONT></TD>
    <TD>Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold"><B>Item 4.</B></TD>
    <TD COLSPAN="3" STYLE="font-weight: bold">Ownership</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Tahoma; font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: left">Biomedical Value Fund, L.P. (&ldquo;BVF&rdquo;) is the record owner of 1,184,618 shares of Common Stock (the
&ldquo;BVF Shares&rdquo;). Great Point Partners, LLC (&ldquo;Great Point&rdquo;) is the investment manager of BVF, and by virtue
of such status may be deemed to be the beneficial owner of the BVF Shares. Each of Dr. Jeffrey R. Jay, M.D. (&ldquo;Dr. Jay&rdquo;),
as senior managing member of Great Point, and Mr. David Kroin (&ldquo;Mr. Kroin&rdquo;), as special managing member of Great Point,
has voting and investment power with respect to the BVF Shares, and therefore may be deemed to be the beneficial owner of the BVF
Shares. In addition, BVF is the record owner of warrants to purchase 1,063,300 shares of Common Stock.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><P STYLE="margin: 0; text-align: left">Biomedical Offshore Value Fund, Ltd. (&ldquo;BOVF&rdquo;) is the record owner of 1,443,756 shares of Common
Stock (the &ldquo;BOVF Shares&rdquo;). Great Point is the investment manager of BOVF, and by virtue of such status may be deemed
to be the beneficial owner of the BOVF Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special
managing member of Great Point, has voting and investment power with respect to the BOVF Shares, and therefore may be deemed to
be the beneficial owner of the BOVF Shares. In addition, BOVF is the record owner of warrants to purchase 1,295,897 shares of Common
Stock.</P>


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><P STYLE="margin: 0; text-align: left">Biomedical Institutional Value Fund, L.P. (&ldquo;BIVF&rdquo;) is the record owner of 259,136 shares of Common
Stock (the &ldquo;BIVF Shares&rdquo;). Great Point is the investment manager of BIVF, and by virtue of such status may be deemed
to be the beneficial owner of the BIVF Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special
managing member of Great Point, has voting and investment power with respect to the BIVF Shares, and therefore may be deemed to
be the beneficial owner of the BIVF Shares. In addition, BIVF is the record owner of warrants to purchase 232,597 shares of Common
Stock.</P>


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><P STYLE="margin: 0; text-align: left">GEF-SMA, LP (&ldquo;GEF-SMA&rdquo;) is the record owner of 814,429 shares of Common Stock (the &ldquo;GEF-SMA
Shares&rdquo;). Great Point is the investment manager of GEF-SMA, and by virtue of such status may be deemed to be the beneficial
owner of the GEF-SMA Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member
of Great Point, has voting and investment power with respect to the GEF-SMA Shares, and therefore may be deemed to be the beneficial
owner of the GEF-SMA Shares. In addition, GEF-SMA is the record owner of warrants to purchase 731,019 shares of Common Stock.</P>


</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="font-weight: bold">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="text-align: justify"><P STYLE="margin: 0; text-align: left">Class D Series of GEF-PS, LP (&ldquo;GEF-PS&rdquo;) is the record owner of 297,002 shares of Common Stock
(the &ldquo;GEF-PS Shares&rdquo;). Great Point is the investment manager of GEF-PS, and by virtue of such status may be deemed
to be the beneficial owner of the GEF-PS Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special
managing member of Great Point, has voting and investment power with respect to the GEF-PS Shares, and therefore may be deemed
to be the beneficial owner of the GEF-PS Shares. In addition, GEF-PS is the record owner of warrants to purchase 266,587 shares
of Common Stock.</P>


</TD></TR>
</TABLE>


<!-- Field: Page; Sequence: 6 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="width: 23%; border: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 12pt">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="width: 59%; border-right: black 1px solid; font: bold 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 16pt">13G/A</FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top">Page
    7       of 9  Pages</TD></TR>
</TABLE>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left">The provisions of the warrants described above restrict the exercise of such warrants to the extent that, after giving effect to such exercise, the holder of the warrants and its affiliates and any other person or entities with which such holder would constitute a group would beneficially own in excess of 9.97% of the number of shares of Common Stock of the Issuer outstanding immediately after giving effect to such exercise (the &ldquo;Ownership Cap&rdquo;). Therefore, the reporting persons could be deemed to beneficially own such number of shares underlying such warrants as would result in total beneficial ownership by such reporting persons up to the Ownership Cap.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left">Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BOVF Shares, the BIVF Shares, the GEF-SMA Shares, the GEF-PS Shares, and the shares of Common Stock underlying warrants described above, except to the extent of their respective pecuniary interests.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold; width: 9%">&nbsp;</TD>
<TD STYLE="width: 4%">&nbsp;</TD>
<TD STYLE="width: 4%">&nbsp;</TD>
<TD STYLE="width: 83%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD>
<TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">1.</FONT></TD>
<TD COLSPAN="2" STYLE="font-weight: bold">Great Point Partners, LLC</TD></TR>
<TR STYLE="vertical-align: top">
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2" STYLE="font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(a)</TD>
<TD COLSPAN="2">Amount beneficially owned: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(b)</TD>
<TD COLSPAN="2" STYLE="font-size: 10pt">Percent of class: 9.97%<SUP>4</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2" STYLE="font-size: 12pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(c)</TD>
<TD COLSPAN="2">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(i)</TD>
<TD>Sole power to vote or to direct the vote:  0.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(ii)</TD>
<TD>Shared power to vote or to direct the vote: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(iii)</TD>
<TD>Sole power to dispose or to direct the disposition of:  0.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(iv)</TD>
<TD>Shared power to dispose or to direct the disposition of: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
<TD><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold"><FONT STYLE="font-size: 10pt"><B>Dr. Jeffrey R. Jay, M.D.</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2" STYLE="font-family: Tahoma; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(a)</TD>
<TD COLSPAN="2">Amount beneficially owned: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(b)</TD>
<TD COLSPAN="2">Percent of class: 9.97%<SUP>4</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(c)</TD>
<TD COLSPAN="2">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(i)</TD>
<TD>Sole power to vote or to direct the vote: 0.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(ii)</TD>
<TD>Shared power to vote or to direct the vote: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(iii)</TD>
<TD>Sole power to dispose or to direct the disposition of: 0.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(iv)</TD>
<TD>Shared power to dispose or to direct the disposition of: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">3.</FONT></TD>
<TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; font-weight: bold"><B>Mr. David Kroin</B></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD COLSPAN="2" STYLE="font-family: Tahoma; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="font-weight: bold">&nbsp;</TD>
<TD>(a)</TD>
<TD COLSPAN="2">Amount beneficially owned: 7,588,341<SUP>3</SUP></TD></TR>
</TABLE>



<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman Bold">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 3%"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><SUP>3</SUP></FONT></TD><TD STYLE="text-align: justify; width: 97%"><FONT STYLE="font: normal 10pt Times New Roman, Times, Serif">Includes
                                                                                                     warrants to purchase an aggregate
                                                                                                     of 3,589,400 shares underlying
                                                                                                     warrants, owned by Biomedical
                                                                                                     Value Fund, LP, Biomedical
                                                                                                     Offshore Value Fund, Ltd.,
                                                                                                     Biomedical Institutional
                                                                                                     Value Fund, LP, GEF-SMA,
                                                                                                     LP and Class D Series of
                                                                                                     GEF-PS, LP.</FONT></TD></TR>                    <TR STYLE="vertical-align: top">
<TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
<TD><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><SUP>4</SUP></FONT></TD><TD STYLE="text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Based on a total of
                     72,513,144 shares of Common Stock outstanding, as reported by the Issuer on a Form 10-Q filed with the SEC
                     on November 14, 2014.</FONT></TD></TR>
</TABLE>
<!-- Field: Page; Sequence: 7 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="width: 23%; border: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 12pt">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="width: 59%; border-right: black 1px solid; font: bold 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 16pt">13G/A</FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top">Page
    8 of 9  Pages</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>(b)</TD>
<TD COLSPAN="2">Percent of class: 9.97%<FONT STYLE="font: 10pt Times New Roman, Times, Serif"><SUP>4</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>(c)</TD>
<TD COLSPAN="2">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="width: 9%; text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD STYLE="width: 4%">&nbsp;</TD>
<TD STYLE="width: 4%">(i)</TD>
<TD STYLE="width: 83%">Sole power to vote or to direct the vote: 0.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(ii)</TD>
<TD>Shared power to vote or to direct the vote: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(iii)</TD>
<TD>Sole power to dispose or to direct the disposition of: 0.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>(iv)</TD>
<TD>Shared power to dispose or to direct the disposition of: 7,588,341<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD>
<TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">Item 5.</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">Ownership of Five Percent or Less of a Class</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: justify; text-indent: 13%">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: justify">If this statement is being filed to report the fact that as of the date hereof each
of the Reporting Persons has ceased to be the beneficial owner of more than five percent of the class of securities, check the
following <FONT STYLE="font: 10pt Wingdings">&#0111;</FONT>.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">Item 6.</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">Ownership of More than Five Percent on Behalf of Another Person:</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">See Item 4.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">Item 7.</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">Not Applicable.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">Item 8.</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">Identification and Classification of Members of the Group</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">Not Applicable.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">Item 9.</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">Notice of Dissolution of Group</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">Not Applicable.</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">Item 10.</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">Certification</TD></TR>
<TR STYLE="vertical-align: top">
<TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
<TD COLSPAN="3" STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
<TD COLSPAN="4" STYLE="text-indent: 0pt; font-weight: normal; text-align: justify">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as participant in any transaction having that purpose or effect.</TD></TR>
</TABLE>


<!-- Field: Page; Sequence: 8 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD NOWRAP STYLE="width: 23%; border: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top"><FONT STYLE="font-size: 12pt">CUSIP
    No. 87164U102</FONT></TD>
    <TD STYLE="width: 59%; border-right: black 1px solid; font: bold 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 16pt">13G/A</FONT></TD>
    <TD STYLE="width: 18%; border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; font: 10pt Arial, Helvetica, Sans-Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: left; vertical-align: top">Page
    9 of 9  Pages</TD></TR>
</TABLE>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>SIGNATURE</U></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0pt; text-align: justify; text-indent: 0in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">Date: February 17, 2015</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">GREAT POINT PARTNERS, LLC</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 45%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 3%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 42%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 10%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="vertical-align: bottom; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay, M.D.</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, M.D.,</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; padding-left: 10pt"><FONT STYLE="font-size: 10pt">as senior managing member</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay, M.D.</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">DR. JEFFREY R. JAY, M.D.</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Mr. David Kroin</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
</TABLE>
<!-- Field: Page; Sequence: 9 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><U>Exhibit A</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13G/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(i) Each of them
is individually eligible to use the Schedule 13G/A to which this Exhibit is attached, and such Schedule 13G/A is filed on
behalf of each of them; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(ii) Each
of them is responsible for the timely filing of such Schedule 13G/A and any amendments thereto, and for the completeness and accuracy
of the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy
of the information concerning the other persons making the filing, unless such person knows or has reason to believe that such
information is inaccurate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Date: February 17, 2015</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">GREAT POINT PARTNERS, LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 45%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 42%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay, M.D.</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Dr. Jeffrey R. Jay, M.D.,</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 10pt"><FONT STYLE="font-size: 10pt">as senior managing member</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Dr. Jeffrey R. Jay, M.D.</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">DR. JEFFREY R. JAY, M.D.</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid"><FONT STYLE="font-size: 10pt">/s/ Mr. David Kroin</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">Mr. David Kroin</FONT></TD>
    <TD>&nbsp;</TD></TR>

</TABLE>

<!-- Field: Page; Sequence: 10 -->
    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

</BODY>
</HTML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
