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Stock-Based Compensation (Details Textual) - USD ($) |  | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Oct. 10, 2014 | Oct. 25, 2012 | Mar. 20, 2007 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2001 | May. 15, 2015 | Oct. 22, 2013 | Nov. 02, 2010
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options |  |  |  | $ 8,300,000 |  |  |  |  |  |
Employee Service Share-based Compensation, Cash Received from Exercise of Stock Options |  |  |  | 41,000 | $ 4,000 | $ 232,000 |  |  |  |
Proceeds from Issuance of Common Stock |  |  |  | 46,000,000 | 20,668,000 | 13,224,000 |  |  |  |
Change in fair value of warrant liabilities |  |  |  | 3,811,000 | (620,000) | 0 |  |  |  |
Warrant liabilities |  |  |  | $ 10,567,000 | $ 6,756,000 | $ 0 |  |  |  |
Class of Warrant or Right, Outstanding |  |  |  | 311,834 |  |  |  |  |  |
Warrant [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Issuance of Warrants to Purchase of Common Stock |  | 635,855 |  |  |  |  |  |  |  |
Warrants Exercise Price Per Share |  | $ 1.60 |  |  |  |  |  |  |  |
Investment Warrants Expiration Date |  | Oct. 25, 2017 |  |  |  |  |  |  |  |
Epitope [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Stock Options Expiration Term |  |  |  | Jun 30, 2018 |  |  |  |  |  |
Employees And Directors [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  | 3,781,666 | 2,382,500 | 222,500 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Fair Value |  |  |  | $ 8,000,000 | $ 5,000,000 | $ 350,000 |  |  |  |
Employee [Member] | General and Administrative Expenses and Research and Development Expense [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  |  |  | 2,300,000 | 2,100,000 | 1,300,000 |  |  |  |
Consultant [Member] | General and Administrative Expenses and Research and Development Expense [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  |  |  | $ 888,000 | 380,000 | $ 324,000 |  |  |  |
2001 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  | 671,607 |  |  |  |  |  |
2001 Stock Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  | 250,000 |  |  |
2007 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  | 2,500,000 | 428,657 |  |  |  |  |  |
2007 Stock Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  | 250,000 |  |  |  |  |  |  |
2010 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  | 7,841,666 |  |  |  |  |  | 3,000,000
2010 Stock Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  | 8,000,000 | 6,000,000 |
2010 Stock Plan [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  | 6,000,000 | 3,000,000 |
Stock Warrants [Member] |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |
Issuance of Warrants to Purchase of Common Stock | 0.5 |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Warrants, Vested and Expected to Vest Outstanding, Number | 1.75 |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number | 7,029,808 |  |  |  |  |  |  |  |  |
Sale of Stock, Number of Shares Issued in Transaction | 14,059,616 |  |  |  |  |  |  |  |  |
Sale of Stock, Price Per Share | $ 1.47 |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock | $ 19,100,000 |  |  |  |  |  |  |  |  |
Change in fair value of warrant liabilities | $ 7,400,000 |  |  | $ 3,800,000 | 620,000 |  |  |  |  |
Warrant liabilities |  |  |  | $ 10,600,000 | $ 6,800,000 |  |  |  |  |

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