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Consolidated Statements of Equity - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Noncontrolling Interest [Member]
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2012 | $ 13,028 | $ 44 | $ 81,925 | $ (68,941) | $ 0
Balance (in shares) at Dec. 31, 2012 |  | 44,362,748 |  |  |
Stock-based compensation | 1,669 | $ 0 | 1,669 | 0 | 0
Issuance of common stock, net of issuance costs | 12,193 | $ 13 | 12,180 | 0 | 0
Issuance of common stock, net of issuance costs (in shares) |  | 13,225,000 |  |  |
Issuance of common stock for exercise of stock options | 232 | $ 1 | 231 | 0 | 0
Issuance of common stock for exercise of stock options (in shares) |  | 291,667 |  |  |
Issuance of common stock for license agreement | 425 | $ 0 | 425 | 0 | 0
Issuance of common stock for license agreement (in shares) |  | 334,911 |  |  |
Issuance of stock | 1 | $ 0 | 0 | 0 | 1
Issuance of stock (in shares) |  | 0 |  |  |
Net loss | (12,317) | $ 0 | 0 | (12,317) | (1)
Non-controlling interest | (1) |  |  |  |
Balance at Dec. 31, 2013 | 15,230 | $ 58 | 96,430 | (81,258) | 0
Balance (in shares) at Dec. 31, 2013 |  | 58,214,326 |  |  |
Stock-based compensation | 2,459 | $ 0 | 2,459 | 0 | 0
Issuance of common stock, net of issuance costs | 11,647 | $ 14 | 11,633 | 0 | 0
Issuance of common stock, net of issuance costs (in shares) |  | 14,059,616 |  |  |
Issuance of common stock for exercise of stock options | 4 | $ 0 | 4 | 0 | 0
Issuance of common stock for exercise of stock options (in shares) |  | 6,583 |  |  |
Issuance of common stock for cashless exercise of warrants | 0 | $ 0 | 0 | 0 | 0
Issuance of common stock for cashless exercise of warrants (in shares) |  | 232,619 |  |  |
Net loss | (19,784) | $ 0 | 0 | (19,784) | 0
Non-controlling interest | 0 |  |  |  |
Balance at Dec. 31, 2014 | 9,556 | $ 72 | 110,526 | (101,042) | 0
Balance (in shares) at Dec. 31, 2014 |  | 72,513,144 |  |  |
Stock-based compensation | 3,198 | $ 0 | 3,198 | 0 | 0
Issuance of common stock, net of issuance costs | 42,643 | $ 16 | 42,627 | 0 | 0
Issuance of common stock, net of issuance costs (in shares) |  | 15,333,333 |  |  |
Stock issued for milestone payments | 1,350 | $ 2 | 1,348 | 0 | 0
Stock issued for milestone payments (in Shares) |  | 2,005,321 |  |  |
Issuance of common stock for exclusive channel collaboration agreement | 3,000 | $ 1 | 2,999 | 0 | 0
Issuance of common stock for exclusive channel collaboration agreement (in shares) |  | 937,500 |  |  |
Issuance of common stock for exercise of stock options | 41 | $ 0 | 41 | 0 | 0
Issuance of common stock for exercise of stock options (in shares) |  | 35,008 |  |  |
Issuance of common stock for cashless exercise of warrants | 0 | $ 0 | 0 | 0 | 0
Issuance of common stock for cashless exercise of warrants (in shares) |  | 2,446 |  |  |
Net loss | (43,737) | $ 0 | 0 | (43,737) | 0
Non-controlling interest | (1,048) | 0 | 0 | 0 | (1,048)
Balance at Dec. 31, 2015 | $ 15,003 | $ 91 | $ 160,739 | $ (144,779) | $ (1,048)
Balance (in shares) at Dec. 31, 2015 |  | 90,826,752 |  |  |

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