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License, Collaborative and Employment Agreements and Commitments (Details Textual) - USD ($) |  |  | 1 Months Ended | 12 Months Ended
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Dec. 04, 2015 | Aug. 10, 2015 | Aug. 31, 2015 | Aug. 29, 2015 | Aug. 10, 2015 | Apr. 28, 2015 | Mar. 18, 2015 | Feb. 29, 2012 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  | $ 32,906,000 | $ 14,489,000 | $ 6,507,000 |
Operating Leases, Rent Expense |  |  |  |  |  |  |  |  | 108,000 | 77,000 | 68,000 |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  | 148,000 |  |  |
Prepaid Expense and Other Assets, Current |  |  |  |  |  |  |  |  | 9,519,000 | 1,548,000 |  |
Payments to Acquire in Process Research and Development |  |  |  |  |  |  |  |  | $ 424,000 | $ 293,000 | $ 1,000,000 |
Exchange percentage of unregistered common stock |  |  |  |  |  |  |  |  | 50.00% |  |  |
Proceeds from (Repurchase of) Equity, Total |  |  |  |  |  |  |  |  | $ 3,000,000 |  |  |
Stock Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  | 1,350,000 |  |  |  |  |  |  |  |
Conversion of Stock, Shares Issued |  |  | 1,350,000 | 1,350,000 |  |  |  |  |  |  |  |
Channel Collaboration Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Shares, Issued |  | 937,500 |  |  | 937,500 |  |  |  |  |  |  |
Stock Issued |  | $ 3,000,000 |  |  | $ 3,000,000 |  |  |  |  |  |  |
Mark Pimentel [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock Outstanding Percentage |  |  |  |  |  |  |  |  | 8.50% |  |  |
Licensing Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payments for Fees |  |  |  |  |  |  |  |  | $ 150,000 |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  |  | 334,911 |  |  |
Patents [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Payments for Fees |  |  |  |  |  |  |  |  | $ 220,000 |  |  |
Riley Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense | $ 550,000 |  |  |  |  |  | $ 385,000 |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  | 75.00% |  |  |  |  |
Shallcross Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value |  |  |  |  |  |  |  |  | 1,900,000 |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  | 900,000 |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  |  |  |  |  | $ 315,000 |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  | 75.00% |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Maximum Contractual Term |  |  |  |  |  | 2 years |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent |  |  |  |  |  | 50.00% |  |  |  |  |  |
Ballantyne Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  |  |  |  |  |  | $ 335,000 |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  | 75.00% |  |  |  |  |
Jeffrey Riley [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value |  |  |  |  |  |  |  | $ 1,700,000 |  |  |  |
Officers Compensation |  |  |  |  |  |  |  | $ 348,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  | 750,000 |  |  |  |
C. Evan Ballantyne [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value |  |  |  |  |  |  |  | $ 1,000,000 |  |  |  |
Officers Compensation |  |  |  |  |  |  |  | $ 298,000 |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  | 425,000 |  |  |  |
Intrexon [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  | $ 7,800,000
Milestone Payment |  | 27,000,000 |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Acquisitions |  |  |  |  |  |  |  |  |  |  |  | 3,552,210
Prepaid Expense and Other Assets, Current |  |  |  |  |  |  |  |  | 2,500,000 |  |  |
Shares Issued, Price Per Share |  |  |  |  |  |  |  |  |  |  |  | $ 0.001
Milestone Payment upon First Dosing |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |
Intrexon [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Royalty Revenue, Total |  |  |  |  |  |  |  |  | 100,000,000 |  |  |
Intrexon [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Royalty Revenue, Total |  |  |  |  |  |  |  |  | 750,000,000 |  |  |
Intrexon [Member] | Research and Development Arrangement [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Prepaid Expense and Other Assets, Current |  |  |  |  |  |  |  |  | $ 643,000 |  |  |
Prev Abr Llc [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Additional Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  | $ 235,000
Unregistered Shares Issued to License Agreement |  |  |  |  |  |  |  |  |  |  |  | 625,000
Additional Consideration Payable |  |  |  |  |  |  |  |  |  |  |  | 50% in cash and 50% in our stock
Options To Be Received Common Stock Shares |  |  |  |  |  |  |  |  | 655,321 |  |  |
Cedars-Sinai Medical Center [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common stock Outstanding Percentage |  |  |  |  |  |  |  |  | 11.50% |  |  |
Office Space In Ann Arbor [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Operating Lease Leasing Term |  |  |  |  |  |  |  |  |  |  |  | extend the term of the lease to December 31, 2016
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  | $ 40,000
Office Space In Rockville [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Operating Lease Leasing Term |  |  |  |  |  |  |  |  |  |  |  | sixty-six month operating lease that may be renewed for one additional term of five years
Operating Annual Lease Payments |  |  |  |  |  |  |  |  |  |  |  | $ 142,172
December 31, 2014 [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  | 50,000
December 31, 2015 [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  | 25,000
Phase I Clinical Trials [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  | 50,000
Phase III Clinical Trials [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  | 100,000
NDA Submission In US [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  | 250,000
European Medicines Agency Approval [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  | 100,000
Regulatory Approval In Asian Country [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  | $ 100,000
IND Milestone Event [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Registration Payment Arrangement, Settlement Alternatives |  |  |  |  |  |  |  |  |  |  |  | The Company also agreed upon the filing of an IND application with the FDA for a Synthetic Product, or alternatively the filing of the first equivalent regulatory filing with a foreign regulatory agency (both as applicable, the IND Milestone Event), to pay Intrexon either (i) $2.0 million in cash, or (ii) that number of shares of Common Stock (the IND Milestone Shares) having a fair market value equaling $2.0 million where such fair market value is determined using published market data of the share price for Common Stock at the close of market on the business day immediately preceding the date of public announcement of attainment of the IND Milestone Event.
Approval Milestone Event [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Registration Payment Arrangement, Settlement Alternatives |  |  |  |  |  |  |  |  |  |  |  | Upon the first to occur of either first commercial sale of a Synthetic Product in a country or the granting of the regulatory approval of that Synthetic Product (both as applicable, the Approval Milestone Event), the Company agreed to pay to Intrexon either (i) $3.0 million in cash, or (ii) that number of shares of Common Stock (the Approval Milestone Shares) having a fair market value equaling $3.0 million where such fair market value is determined using published market data of the share price for Common Stock at the close of market on the business day immediately preceding the date of public announcement of attainment of the Approval Milestone Event.
Field Expansion Fee [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Registration Payment Arrangement, Settlement Alternatives |  |  |  |  |  |  |  |  |  |  |  | The Field Expansion Fee must be paid completely in either Common Stock or cash, and will comprise either (i) $2.0 million in cash for each target in excess of three total that the Company elects, or (ii) that number of shares of Common Stock (the Field Expansion Fee Shares) having a fair market value equaling $2.0 million for each such target that the Company elects in excess of three where such fair market value is determined using published market data establishing the volume-weighted average price for a share of Common Stock over the 30 day period immediately preceding the date of the Field Expansion Fee Closing.
First Year [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  | $ 303,287 |  |  |
Second Year [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  | 316,438 |  |  |
Third Year [Member] |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  | $ 328,758 |  |  |

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