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v3.3.1.900

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Cash Flows From Operating Activities: |  |  |
Net Loss | $ (44,785) | $ (19,784) | $ (12,318)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 3,198 | 2,459 | 1,669
Stock issued for milestone payments | 1,350 | 0 | 0
Stock issued for exclusive channel collaboration agreement | 3,000 | 0 | 0
Stock issued for license agreement | 0 | 0 | 425
Change in fair value of warrant liabilities | 3,811 | (620) | 0
Depreciation and amortization | 72 | 20 | 43
Provision for uncollectible note and interest receivables | 0 | 0 | 763
Loss on sale of equipment | 0 | 0 | 58
Changes in operating assets and liabilities: |  |  |
Prepaid expenses and other current assets | (7,971) | 43 | 855
Deposits and other assets | (8) | (2) | 33
Accounts payable | 3,417 | 854 | (253)
Accrued expenses | (1,001) | 416 | 885
Accrued employee benefits | (261) | 535 | 0
Deferred rent | 288 | 0 | 0
Impairment loss on equipment | 0 | 0 | 121
Net Cash Used In Operating Activities | (38,890) | (16,079) | (7,719)
Cash Flows From Investing Activities: |  |  |
Purchases of property and equipment | (501) | (48) | (36)
Net Cash Used In Investing Activities | (501) | (48) | (36)
Cash Flows From Financing Activities: |  |  |
Proceeds from issuance of common stock | 46,000 | 20,668 | 13,224
Cash paid as direct offering costs | (3,357) | (1,645) | (1,031)
Proceeds from issuance of common stock for stock option exercises | 41 | 4 | 232
Cash received from issuance of stock to non-controlling interest | 0 | 0 | 1
Net Cash Provided By Financing Activities | 42,684 | 19,027 | 12,426
Net increase in cash | 3,293 | 2,900 | 4,671
Cash at beginning of year | 17,525 | 14,625 | 9,954
Cash at end of year | 20,818 | 17,525 | 14,625
Supplemental disclosures of cash flow information: |  |  |
Cash paid for interest | 0 | 0 | 0
Cash paid for taxes | $ 0 | $ 0 | $ 0

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