    <SEC-DOCUMENT>0001144204-16-075008-index.html : 20160111
    <SEC-HEADER>0001144204-16-075008.hdr.sgml : 20160111
    <ACCEPTANCE-DATETIME>20160111100031
    ACCESSION NUMBER:		0001144204-16-075008
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		40
    CONFORMED PERIOD OF REPORT:	20160111
    ITEM INFORMATION:		Regulation FD Disclosure
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20160111
    DATE AS OF CHANGE:		20160111

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Synthetic Biologics, Inc.
    		CENTRAL INDEX KEY:			0000894158
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				133808303
    		STATE OF INCORPORATION:			NV
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-12584
    		FILM NUMBER:		161335361

    	BUSINESS ADDRESS:
    		STREET 1:		617 DETROIT STREET, SUITE 100
    		CITY:			ANN ARBOR
    		STATE:			MI
    		ZIP:			48104
    		BUSINESS PHONE:		(734) 332-7800

    	MAIL ADDRESS:
    		STREET 1:		155 GIBBS STREET
    		STREET 2:		SUITE 412
    		CITY:			ROCKVILLE
    		STATE:			MD
    		ZIP:			20850

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ADEONA PHARMACEUTICALS, INC.
    		DATE OF NAME CHANGE:	20081027

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
    		DATE OF NAME CHANGE:	20061214

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19970730
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>8-K
    <SEQUENCE>1
    <FILENAME>v428741_8k.htm
    <DESCRIPTION>CURRENT REPORT
    <TEXT>
    Document 1 - file: v428741_8k.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-99.1
    <SEQUENCE>2
    <FILENAME>v428741_ex99-1.htm
    <DESCRIPTION>EXHIBIT 99.1
    <TEXT>
    Document 2 - file: v428741_ex99-1.htm

    </DOCUMENT>
    <DOCUMENT>
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    <SEQUENCE>3
    <FILENAME>ex99-1pg01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: ex99-1pg01.jpg

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    <DOCUMENT>
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    <SEQUENCE>4
    <FILENAME>ex99-1pg02.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: ex99-1pg02.jpg

    </DOCUMENT>
    <DOCUMENT>
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    <SEQUENCE>5
    <FILENAME>ex99-1pg03.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: ex99-1pg03.jpg

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    <DOCUMENT>
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    <SEQUENCE>6
    <FILENAME>ex99-1pg04.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: ex99-1pg04.jpg

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    <DOCUMENT>
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    <SEQUENCE>7
    <FILENAME>ex99-1pg05.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: ex99-1pg05.jpg

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    <DOCUMENT>
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    <SEQUENCE>8
    <FILENAME>ex99-1pg06.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: ex99-1pg06.jpg

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    <DOCUMENT>
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    <SEQUENCE>9
    <FILENAME>ex99-1pg07.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: ex99-1pg07.jpg

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    <DOCUMENT>
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    <SEQUENCE>10
    <FILENAME>ex99-1pg08.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: ex99-1pg08.jpg

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    <DOCUMENT>
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    <SEQUENCE>11
    <FILENAME>ex99-1pg09.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: ex99-1pg09.jpg

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    <SEQUENCE>12
    <FILENAME>ex99-1pg10.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: ex99-1pg10.jpg

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    <SEQUENCE>13
    <FILENAME>ex99-1pg11.jpg
    <DESCRIPTION>GRAPHIC
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    Document 13 - file: ex99-1pg11.jpg

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    <SEQUENCE>14
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    <DESCRIPTION>GRAPHIC
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    Document 14 - file: ex99-1pg12.jpg

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    <DOCUMENT>
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    <SEQUENCE>15
    <FILENAME>ex99-1pg13.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: ex99-1pg13.jpg

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    <DOCUMENT>
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    <SEQUENCE>16
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    <DESCRIPTION>GRAPHIC
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    <DOCUMENT>
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    <SEQUENCE>17
    <FILENAME>ex99-1pg15.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: ex99-1pg15.jpg

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    <DOCUMENT>
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    <SEQUENCE>18
    <FILENAME>ex99-1pg16.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: ex99-1pg16.jpg

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    <DOCUMENT>
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    <SEQUENCE>19
    <FILENAME>ex99-1pg17.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: ex99-1pg17.jpg

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    <DOCUMENT>
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    <SEQUENCE>20
    <FILENAME>ex99-1pg18.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 20 - file: ex99-1pg18.jpg

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    <SEQUENCE>21
    <FILENAME>ex99-1pg19.jpg
    <DESCRIPTION>GRAPHIC
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    <SEQUENCE>22
    <FILENAME>ex99-1pg20.jpg
    <DESCRIPTION>GRAPHIC
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    <DOCUMENT>
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    <SEQUENCE>23
    <FILENAME>ex99-1pg21.jpg
    <DESCRIPTION>GRAPHIC
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    Document 23 - file: ex99-1pg21.jpg

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    <DOCUMENT>
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    <SEQUENCE>24
    <FILENAME>ex99-1pg22.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 24 - file: ex99-1pg22.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>25
    <FILENAME>ex99-1pg23.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 25 - file: ex99-1pg23.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>26
    <FILENAME>ex99-1pg24.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 26 - file: ex99-1pg24.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>27
    <FILENAME>ex99-1pg25.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 27 - file: ex99-1pg25.jpg

    </DOCUMENT>
    <DOCUMENT>
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    <SEQUENCE>28
    <FILENAME>ex99-1pg26.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 28 - file: ex99-1pg26.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>29
    <FILENAME>ex99-1pg27.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 29 - file: ex99-1pg27.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>30
    <FILENAME>ex99-1pg28.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 30 - file: ex99-1pg28.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>31
    <FILENAME>ex99-1pg29.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 31 - file: ex99-1pg29.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>32
    <FILENAME>ex99-1pg30.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
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    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>33
    <FILENAME>ex99-1pg31.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 33 - file: ex99-1pg31.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>34
    <FILENAME>ex99-1pg32.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 34 - file: ex99-1pg32.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>35
    <FILENAME>ex99-1pg33.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>36
    <FILENAME>ex99-1pg34.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 36 - file: ex99-1pg34.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>37
    <FILENAME>ex99-1pg35.jpg
    <DESCRIPTION>GRAPHIC
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    Document 37 - file: ex99-1pg35.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>38
    <FILENAME>ex99-1pg36.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 38 - file: ex99-1pg36.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>39
    <FILENAME>ex99-1pg37.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 39 - file: ex99-1pg37.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>40
    <FILENAME>ex99-1pg38.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 40 - file: ex99-1pg38.jpg

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