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Stock-Based Compensation and Warrants (Details Textual) - USD ($) |  | 1 Months Ended | 12 Months Ended |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Oct. 10, 2014 | Nov. 18, 2016 | Oct. 25, 2012 | Mar. 20, 2007 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Sep. 07, 2017 | Aug. 25, 2016 | May 15, 2015 | Oct. 22, 2013 | Nov. 02, 2010
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options |  |  |  |  | $ 2,900,000 |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock |  | $ 300,000 |  |  | 0 | $ 25,000,000 | $ 46,000,000 |  |  |  |  |
Change in fair value of warrant liabilities |  |  |  |  | (10,738,000) | (11,412,000) | 3,811,000 |  |  |  |  |
Proceeds from Stock Options Exercised |  |  |  |  | 166,000 | 814,000 | $ 41,000 |  |  |  |  |
IPO [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Sale of Stock, Price Per Share |  | $ 1.00 |  |  |  |  |  |  |  |  |  |
Change in fair value of warrant liabilities |  |  |  |  | 9,000,000 | 3,000,000 |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  | 25,000,000 |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights |  | 50,000,000 |  |  |  |  |  |  |  |  |  |
Warrants Not Settleable in Cash, Fair Value Disclosure |  | $ 15,700,000 |  |  | $ 3,700,000 | $ 12,700,000 |  |  |  |  |  |
Series A Warrants [Member] | IPO [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  | $ 1.43 |  |  |  |  |  |  |  |  |  |
Series B Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Investment Warrants Expiration Date |  | Dec. 31, 2017 |  |  | Dec. 31, 2017 |  |  |  |  |  |  |
Series B Warrants [Member] | IPO [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Investment Warrants Expiration Date |  | Dec. 31, 2017 |  |  |  |  |  |  |  |  |  |
Class of Warrant or Right, Exercise Price of Warrants or Rights |  | $ 1.72 |  |  |  |  |  |  |  |  |  |
Warrant [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Warrants to Purchase of Common Stock |  |  | 635,855 |  |  |  |  |  |  |  |  |
Warrants Exercise Price Per Share |  |  | $ 1.60 |  |  |  |  |  |  |  |  |
Employees And Directors [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  | 3,159,177 | 3,861,425 | 3,781,666 |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Fair Value |  |  |  |  | $ 1,800,000 | $ 3,100,000 | $ 8,000,000 |  |  |  |  |
Employee [Member] | General and Administrative Expenses and Research and Development Expense [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  |  |  |  | 3,000,000 | 3,400,000 | 2,300,000 |  |  |  |  |
Consultant [Member] | General and Administrative Expenses and Research and Development Expense [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  |  |  |  | $ 434,000 | 603,000 | $ 888,000 |  |  |  |  |
2007 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  | 2,500,000 | 712,258 |  |  |  |  |  |  |
2007 Stock Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  | 250,000 |  |  |  |  |  |  |  |
2010 Stock Plan [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  |  | 11,851,840 |  |  |  |  |  |  | 3,000,000
2010 Stock Plan [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  | 17,500,000 | 14,000,000 | 8,000,000 | 6,000,000 |
2010 Stock Plan [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Common Stock, Capital Shares Reserved for Future Issuance |  |  |  |  |  |  |  | 8,000,000 | 8,000,000 | 6,000,000 | 3,000,000 |
Stock Warrants [Member] |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Issuance of Warrants to Purchase of Common Stock | 0.5 |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Warrants, Exercisable Number | 7,029,808 |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Warrants, Vested and Expected to Vest Outstanding, Number | 1.75 |  |  |  |  |  |  |  |  |  |  |
Sale of Stock, Number of Shares Issued in Transaction | 14,059,616 |  |  |  |  |  |  |  |  |  |  |
Sale of Stock, Price Per Share | $ 1.47 |  |  |  |  |  |  |  |  |  |  |
Proceeds from Issuance of Common Stock | $ 19,100,000 |  |  |  |  |  |  |  |  |  |  |
Change in fair value of warrant liabilities | $ 7,400,000 |  |  |  | $ 1,700,000 | 8,500,000 |  |  |  |  |  |
Warrants Not Settleable in Cash, Fair Value Disclosure |  |  |  |  | $ 416,000 | $ 2,100,000 |  |  |  |  |  |

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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