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Consolidated Statements of (Deficit) Equity - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Noncontrolling Interest [Member]
--- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2014 | $ 9,556 | $ 72 | $ 110,526 | $ (101,042) | $ 0
Balance (in shares) at Dec. 31, 2014 |  | 72,513,144 |  |  |
Stock-based compensation | 3,198 | $ 0 | 3,198 | 0 | 0
Issuance of common stock, net of issuance costs | 42,643 | $ 16 | 42,627 | 0 | 0
Issuance of common stock, net of issuance costs (in shares) |  | 15,333,333 |  |  |
Stock issued for milestone payments | 1,350 | $ 2 | 1,348 | 0 | 0
Stock issued for milestone payments (in Shares) |  | 2,005,321 |  |  |
Stock issued for exclusive channel collaboration agreement | 3,000 | $ 1 | 2,999 | 0 | 0
Stock issued for exclusive channel collaboration agreement (in shares) |  | 937,500 |  |  |
Stock issued for exercise of stock options | 41 | $ 0 | 41 | 0 | 0
Stock issued for exercise of stock options (in shares) |  | 35,006 |  |  |
Stock issued for cashless exercise of warrants | 0 | $ 0 | 0 | 0 | 0
Stock issued for cashless exercise of warrants (in shares) |  | 2,448 |  |  |
Net Loss | (43,737) | $ 0 | 0 | (43,737) | 0
Non-controlling interest | (1,048) | 0 | 0 | 0 | (1,048)
Balance at Dec. 31, 2015 | 15,003 | $ 91 | 160,739 | (144,779) | (1,048)
Balance (in shares) at Dec. 31, 2015 |  | 90,826,752 |  |  |
Stock-based compensation | 4,009 | $ 0 | 4,009 | 0 | 0
Issuance of common stock, net of issuance costs | 24,384 | $ 25 | 24,359 | 0 | 0
Issuance of common stock, net of issuance costs (in shares) |  | 25,000,000 |  |  |
Fair value of warrants issued with financing | (15,667) | $ 0 | (15,667) | 0 | 0
Stock issued under “at-the-market” offering | 1,509 | $ 1 | 1,508 | 0 | 0
Stock issued under “at-the-market” offering (in shares) |  | 900,628 |  |  |
Stock issued for exercise of stock options | 814 | $ 0 | 814 | 0 | 0
Stock issued for exercise of stock options (in shares) |  | 445,334 |  |  |
Net Loss | (27,255) | $ 0 | 0 | (27,255) | 0
Non-controlling interest | (548) | 0 | 0 | 0 | (548)
Balance at Dec. 31, 2016 | 2,249 | $ 117 | 175,762 | (172,034) | (1,596)
Balance (in shares) at Dec. 31, 2016 |  | 117,172,714 |  |  |
Stock-based compensation | 3,409 | $ 0 | 3,409 | 0 | 0
Stock issued under “at-the-market” offering | 6,358 | $ 12 | 6,346 | 0 | 0
Stock issued under “at-the-market” offering (in shares) |  | 10,975,399 |  |  |
Stock issued for exercise of stock options | 166 | $ 0 | 166 | 0 | 0
Stock issued for exercise of stock options (in shares) |  | 418,773 |  |  |
Series A preferred stock beneficial conversion feature discount | 0 | $ 0 | 6,889 | (6,889) | 0
Series A preferred stock issue costs | (27) | 0 | (27) | 0 | 0
Series A preferred stock dividends | (73) | 0 | 0 | (73) | 0
Net Loss | (15,174) | 0 | 0 | (15,174) | 0
Non-controlling interest | (318) | 0 | 0 | 0 | (318)
Balance at Dec. 31, 2017 | $ (3,410) | $ 129 | $ 192,545 | $ (194,170) | $ (1,914)
Balance (in shares) at Dec. 31, 2017 |  | 128,566,886 |  |  |

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