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v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Cash Flows From Operating Activities: |  |  |
Net Loss | $ (15,492) | $ (27,803) | $ (44,785)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Stock-based compensation | 3,409 | 4,009 | 3,198
Stock issued for milestone payments | 0 | 0 | 1,350
Stock issued for exclusive channel collaboration agreement | 0 | 0 | 3,000
Change in fair value of warrant liabilities | (10,738) | (11,412) | 3,811
Depreciation | 245 | 157 | 72
Changes in operating assets and liability: |  |  |
Prepaid expenses and other current assets | 1,688 | 7,004 | (7,971)
Deposits and other assets | 0 | (9) | (8)
Accounts payable | 27 | (2,420) | 3,417
Accrued expenses | (1,101) | 2,330 | (1,001)
Accrued employee benefits | 1,761 | 36 | (261)
Deferred rent | (3) | 207 | 288
Net Cash Used In Operating Activity | (20,204) | (27,901) | (38,890)
Cash Flows From Investing Activity: |  |  |
Purchases of property and equipment | (212) | (569) | (501)
Net Cash Used In Investing Activity | (212) | (569) | (501)
Cash Flows From Financing Activities: |  |  |
Proceeds from sale of Series A Preferred Stock, net of issuance costs | 11,953 | 0 | 0
Proceeds from the exercise of stock options | 166 | 814 | 41
Proceeds from “at the market” stock issuances | 6,358 | 1,509 | 0
Proceeds from issuance of common stock | 0 | 25,000 | 46,000
Cash paid as direct offering costs | 0 | (616) | (3,357)
Net Cash Provided By Financing Activities | 18,477 | 26,707 | 42,684
Net (decrease) increase in cash | (1,939) | (1,763) | 3,293
Cash and cash equivalents at beginning of period | 19,055 | 20,818 | 17,525
Cash and cash equivalents at end of period | $ 17,116 | $ 19,055 | $ 20,818

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