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Non-controlling Interest (Details Textual) - USD ($) |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 05, 2018 | Aug. 31, 2015 | Aug. 29, 2015 | Dec. 31, 2018 | Dec. 31, 2017
Noncontrolling Interest [Line Items] |  |  |  |  |
Equity Method Investment, Ownership Percentage |  |  |  | 83.00% |
Net Loss Attributable to Non-controlling Interest |  |  |  | $ (54,000) | $ (318,000)
Stockholders' Equity Attributable to Noncontrolling Interest |  |  |  | (2,909,000) | (1,914,000)
Related Party Transaction, Expenses from Transactions with Related Party | $ 321,000 |  |  |  |
Research and Development Expense | 102,000 |  |  | $ 11,844,000 | 18,784,000
Fair Value Of Shares Issued | $ 285,000 |  |  |  |
Synthetic Biomics Inc [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Additional Number Of Common Stock To Be Issued | 2,420,000 |  |  |  |
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners | (17.00%) |  |  |  |
SYN Biomics [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Equity Method Investment, Ownership Percentage | 88.50% |  |  | 83.00% |
Net Loss Attributable to Non-controlling Interest |  |  |  | $ 2,900,000 | 1,900,000
Noncontrolling Interest, Ownership Percentage by Parent | 11.50% |  | 8.50% | 17.00% |
Consolidation, Eliminations [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Net Loss Attributable to Non-controlling Interest |  |  |  |  | 54,000
Dr. Pimentels [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Net Loss Attributable to Non-controlling Interest |  |  |  |  | 1,600,000
Dr. Pimentels [Member] | Consolidation, Eliminations [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Stockholders' Equity Attributable to Noncontrolling Interest |  |  |  |  | $ 505,000
Cedars-Sinai Medical Center [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Number Of Common Stock To Be Issued | 50,000 |  |  |  |
Cedars-Sinai Medical Center [Member] | Synthetic Biomics Inc [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Additional Number Of Common Stock To Be Issued | 2,420,000 |  |  |  |
Number Of Common Stock To Be Held By Related Party | 7,480,000 |  |  |  |
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners | (17.00%) |  |  |  |
Stock Purchase Agreement [Member] |  |  |  |  |
Noncontrolling Interest [Line Items] |  |  |  |  |
Conversion of Stock, Shares Issued |  | 38,572 | 38,572 |  |
Research and Development Expense | $ 36,000,000 |  |  |  |

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