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Consolidated Statements of Equity (Deficit) - USD ($) $ in Thousands | Total | Series B Preferred Stock [Member] | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Noncontrolling Interest [Member]
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2016 | $ 2,261 | $ 0 | $ 4 | $ 175,887 | $ (172,034) | $ (1,596)
Balance (in shares) at Dec. 31, 2016 |  | 0 | 3,345,466 |  |  |
Stock-based compensation | 3,409 | $ 0 | $ 0 | 3,409 | 0 | 0
Stock issued under "at-the-market" offering | 6,346 | $ 0 | $ 0 | 6,346 | 0 | 0
Stock issued under "at-the-market" offering (in shares) |  | 0 | 313,583 |  |  |
Stock issued for exercise of stock options | $ 166 | $ 0 | $ 0 | 166 | 0 | 0
Stock issued for exercise of stock options (in shares) | 11,965 | 0 | 11,965 |  |  |
Series A preferred stock issue costs | $ (27) | $ 0 | $ 0 | (27) | 0 | 0
Series A preferred stock dividends | (73) | 0 | 0 | 0 | (73) | 0
Series A and B preferred stock beneficial conversion feature discount | 0 | 0 | 0 | 6,889 | (6,889) | 0
Net Loss | (15,174) | 0 | 0 | 0 | (15,174) | 0
Non-controlling interest | (318) | 0 | 0 | 0 | 0 | (318)
Balance at Dec. 31, 2017 | (3,410) | $ 0 | $ 4 | 192,670 | (194,170) | (1,914)
Balance (in shares) at Dec. 31, 2017 |  | 0 | 3,671,014 |  |  |
Stock-based compensation | 2,074 | $ 0 | $ 0 | 2,074 | 0 | 0
Stock issued under "at-the-market" offering | 12,172 | $ 0 | $ 3 | 12,169 | 0 | 0
Stock issued under "at-the-market" offering (in shares) |  | 0 | 3,534,982 |  |  |
Common stock and warrants issued to vendors | 35 | $ 0 | $ 0 | 35 | 0 | 0
Common stock and warrants issued to vendors (in Shares) |  | 0 | 50,000 |  |  |
Series A preferred stock dividends | (243) | $ 0 | $ 0 | 0 | (243) | 0
Series A and B preferred stock beneficial conversion feature discount | 0 | 9,161 | 0 | 0 | (9,161) | 0
Issuance of Common Stock, preferred Stock and Warrants in Units Offering, net of issuance costs | 16,916 | $ 641 | $ 2 | 16,273 | 0 | 0
Issuance of Common Stock, preferred Stock and Warrants in Units Offering, net of issuance costs (in shares) |  | 15,723 | 2,520,000 |  |  |
Issuance of SYN Biomics Stock | 36 | $ 0 | $ 0 | 977 | 0 | (941)
Conversion of Series B Preferred Stock to Common | 0 | $ (4,042) | $ 6 | 6,556 | (2,520) | 0
Conversion of Series B Preferred Stock to Common (in shares) |  | (6,562) | 5,706,087 |  |  |
Net Loss | (13,367) | $ 0 | $ 0 | 0 | (13,367) | 0
Non-controlling interest | (54) | 0 | 0 | 0 | 0 | (54)
Balance at Dec. 31, 2018 | $ 14,159 | $ 5,760 | $ 15 | $ 230,754 | $ (219,461) | $ (2,909)
Balance (in shares) at Dec. 31, 2018 |  | 9,161 | 15,482,083 |  |  |

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