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License, Collaborative and Employment Agreements and Commitments (Details Textual) - USD ($) |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended |
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Sep. 05, 2018 | Dec. 04, 2017 | Dec. 04, 2015 | Aug. 10, 2015 | Dec. 05, 2013 | Oct. 05, 2012 | Dec. 06, 2018 | Nov. 30, 2017 | Jan. 17, 2017 | Nov. 30, 2016 | Aug. 31, 2015 | Aug. 29, 2015 | Apr. 28, 2015 | Dec. 19, 2012 | Nov. 28, 2012 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2012 | Oct. 15, 2018
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Line of Credit Facility, Periodic Payment, Interest |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 381,150 |  |  |  |  |
Research and Development Expense | $ 102,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,844,000 | $ 18,784,000 |  |  |  |
Operating Leases, Rent Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 201,000 | 199,000 |  |  |  |
Salary and Wage, Officer, Excluding Cost of Good and Service Sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 385,000 |  |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 300,000 |  |  |  |  |
Payments for Other Fees |  |  |  |  |  |  |  | $ 4,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Payments to Acquire in Process Research and Development | 321,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 643,000 | $ 424,000 |  |
Exchange percentage of unregistered common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50.00% |  |  |  |  |
Proceeds from (Repurchase of) Equity |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,000,000 | $ 3,000,000 |  |  |  |
Options To Be Received Common Stock Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 |  |  |  |  |
Shares Issued, Price Per Share |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1.15
Fair Value Of Shares Issued | $ 285,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Synthetic Biomics Inc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Number Of Common Stock To Be Issued | 2,420,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners | (17.00%) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense | $ 36,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  |  |  |  | 38,572 |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Issued |  |  |  |  |  |  |  |  |  |  | 38,572 | 38,572 |  |  |  |  |  |  |  |  |
Channel Collaboration Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares, Issued |  |  |  | 26,786 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued |  |  |  | $ 3,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Licensing Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Other Fees |  |  |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  | 9,569 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Patents [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Other Fees |  |  |  |  | $ 220,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Riley Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Salary and Wage, Officer, Excluding Cost of Good and Service Sold |  | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  |  | $ 550,000 |  |  |  |  |  | $ 385,000 |  |  |  |  |  |  | $ 5,397 |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  | 75.00% |  |  |  |  |  | 75.00% |  |  |  |  |  |  |  |  |  |  |  |
Shallcross Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (8,000) |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  |  |  |  |  |  | $ 550,000 |  |  |  |  |  | $ 315,000 |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  | 75.00% |  |  |  |  |  | 75.00% |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  |  |  |  |  |  |  |  |  |  |  |  | 25,714 |  |  |  |  |  |  |  |
Jeffrey Riley [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 75.00% |  |
Steven A. Shallcross [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 1,900,000 |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  |  |  |  |  |  |  |  |  | $ 346,500 |  |  |  |  |  |  |  |  |  |  |
Intrexon [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research and Development Expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 7,800,000 |
Stock Issued During Period, Shares, Acquisitions |  |  |  |  |  | 101,492 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share |  |  |  |  |  | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment upon First Dosing |  |  |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 |  |  |  |  |
Prev Abr Llc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 235,000 |  |  |  |  |  |
Unregistered Shares Issued to License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 17,858 |  |  |  |  |  |
Additional Consideration Payable |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50% in cash and 50% in our stock |  |  |  |  |  |
Options To Be Received Common Stock Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 18,724 |  |
Cedars-Sinai Medical Center [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number Of Common Stock To Be Issued | (50,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cedars-Sinai Medical Center [Member] | Synthetic Biomics Inc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Number Of Common Stock To Be Issued | (2,420,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Number Of Common Stock To Be Held By Related Party | (7,480,000) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
December 31, 2014 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 |  |  |  |  |  |  |
December 31, 2015 [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Leases, Future Minimum Payments Due, Next Twelve Months |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000 |  |  |  |  |  |  |
Phase I Clinical Trials [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 50,000 |  |  |  |  |  |  |
Phase III Clinical Trials [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |
NDA Submission In US [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 250,000 |  | $ 2,500,000 |  |  |  |  |
European Medicines Agency Approval [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |
Regulatory Approval In Asian Country [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |  |  |  |
First Year [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  | 303,287 |  |  |  |  |  |  |
Second Year [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  | 316,438 |  |  |  |  |  |  |
Third Year [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 328,758 |  |  |  |  |  |  |

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- Definition A milestone payment is an authority payment made to a contractor which is linked to the contractor delivering a service or commodity such that, should the agreement be terminated at the point of payment. + References No definition available. + Details
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- Definition The number of shares converted in a noncash (or part noncash) transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4313-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4304-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4332-108586 + Details
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