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License, Collaborative and Employment Agreements and Commitments - Additional Information (Details) - USD ($) |  |  |  |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
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Dec. 05, 2019 | Dec. 04, 2019 | Aug. 07, 2019 | Sep. 05, 2018 | Sep. 05, 2018 | Dec. 04, 2017 | Aug. 31, 2015 | Aug. 29, 2015 | Aug. 10, 2015 | Dec. 05, 2013 | Oct. 05, 2012 | Dec. 06, 2018 | Jan. 17, 2017 | Aug. 31, 2015 | Aug. 29, 2015 | Dec. 19, 2012 | Dec. 19, 2012 | Nov. 28, 2012 | Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2015
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Line of Credit Facility, Periodic Payment, Interest |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 381,150 |  |
Salary and Wage, Officer, Excluding Cost of Good and Service Sold |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 385,000
Payments for Other Fees |  |  |  |  |  | $ 4,500,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments to Acquire in Process Research and Development |  |  |  | $ 441,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exchange percentage of unregistered common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50.00% |  |
Proceeds from (Repurchase of) Equity |  |  |  |  | $ 3,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 3,000,000 |  |
Options To Be Received Common Stock Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,000,000 |  |
Fair Value Of Shares Issued |  |  |  | $ 285,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Operating Lease, Cost |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 201,000 | $ 201,000 |
Operating Lease, Payments |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 300,000 |  |
Non Cash Addition of Right of Use Assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 537,000 |  |
Operating Lease, Weighted Average Discount Rate, Percent |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 9.90% |  |
Licensing Agreements [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Annual payments due under license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 |  |  |  |  |
Final payment due under license agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 25,000 |  |  |  |  |
Payments for Other Fees |  |  |  |  |  |  |  |  |  | $ 150,000 |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, New Issues |  |  |  |  |  |  |  |  |  | 9,569 |  |  |  |  |  |  |  |  |  |  |
Patents [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payments for Other Fees |  |  |  |  |  |  |  |  |  | $ 220,000 |  |  |  |  |  |  |  |  |  |  |
Riley Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Salary and Wage, Officer, Excluding Cost of Good and Service Sold |  |  |  |  |  | $ 200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  |  |  |  |  |  |  |  |  |  |  |  | $ 550,000 |  |  |  |  |  | $ 5,397 |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  |  |  |  |  |  |  | 75.00% |  |  |  |  |  |  |  |
Shallcross Employment Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 8,000 |  |
Deferred Compensation Arrangement with Individual, Compensation Expense |  | $ 565,000 |  |  |  |  |  |  |  |  |  | $ 550,000 |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  |  |  |  |  |  | 75.00% |  |  |  |  |  |  |  |  |
Jeffrey Riley [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 75.00%
Steven A. Shallcross [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share |  | $ 0.418 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cost of Living Adjustments Percentage | 3.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Compensation Expense | $ 565,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deferred Compensation Arrangement with Individual, Cash Awards Granted, Percentage |  | 75.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross |  | 450,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Intrexon [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued During Period, Shares, Acquisitions |  |  |  |  |  |  |  |  |  |  | 101,492 |  |  |  |  |  |  |  |  |  |
Shares Issued, Price Per Share |  |  |  |  |  |  |  |  |  |  | $ 0.001 |  |  |  |  |  |  |  |  |  |
Milestone Payment upon First Dosing |  |  |  |  |  |  |  |  | $ 2,000,000 |  |  |  |  |  |  |  |  |  | $ 2,000,000 |  |
Prev Abr Llc [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Additional Cash Payment for License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 235,000 |  |  |
Unregistered Shares Issued to License Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 17,858 |  |  |
Additional Consideration Payable |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 50% in cash and 50% in our stock |  |  |
Options To Be Received Common Stock Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 18,724
Phase I Clinical Trials [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000 |  |  |  |
Phase III Clinical Trials [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |
NDA Submission In US [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 250,000 |  |  |  |
European Medicines Agency Approval [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |
Regulatory Approval In Asian Country [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone Payment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 100,000 |  |  |  |
PKU ECC [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares, Issued |  |  |  |  |  |  |  |  | 26,786 |  |  |  |  |  |  |  |  |  |  |  |
Stock Issued |  |  |  |  |  |  |  |  | $ 3,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Stock Purchase Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion of Stock, Shares Converted |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 38,572 |  |  |  |  |  |
Conversion of Stock, Shares Issued |  |  |  |  |  |  | 38,572 | 38,572 |  |  |  |  |  | 38,572 |  |  |  |  |  |  |
Clinical Trial Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Estimated Research Costs |  |  | $ 3,200,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
First Year [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 303,287 | 303,287 |  |  |  |
Second Year [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 316,438 | 316,438 |  |  |  |
Third Year [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Research Agreement Fixed Fee |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 328,758 | $ 328,758 |  |  |  |

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- Definition The number of shares converted in a noncash (or part noncash) transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4313-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4304-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=98513485&loc=d3e4332-108586 + Details
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