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License, Collaborative and Employment Agreements and Commitments - Maturity analysis of operating leases (Details) - USD ($) | Dec. 31, 2019 | Jan. 01, 2019 | Dec. 31, 2018
--- | --- | --- | ---
Commitments and Contingencies |  |  |
2020 | $ 309,000 |  |
2021 | 321,000 |  |
2022 | 192,000 |  |
Total | 822,000 |  |
Discount factor | (100,000) |  |
Lease liability | 722,000 |  |
Amount due within 12 months | (249,000) | $ (939,000) | $ 0
Non-current lease liability | $ 473,000 |  | $ 0
Operating Lease, Liability, Statement of Financial Position [Extensible List] | us-gaap:OperatingLeaseLiabilityCurrent us-gaap:OperatingLeaseLiabilityNoncurrent |  |

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