<SEC-DOCUMENT>0000930413-20-000372.txt : 20200214
<SEC-HEADER>0000930413-20-000372.hdr.sgml : 20200214
<ACCEPTANCE-DATETIME>20200214103658
ACCESSION NUMBER:		0000930413-20-000372
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20200214
DATE AS OF CHANGE:		20200214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Synthetic Biologics, Inc.
		CENTRAL INDEX KEY:			0000894158
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				133808303
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-50777
		FILM NUMBER:		20615334

	BUSINESS ADDRESS:	
		STREET 1:		9605 MEDICAL CENTER DRIVE
		STREET 2:		SUITE 270
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850
		BUSINESS PHONE:		(734) 332-7800

	MAIL ADDRESS:	
		STREET 1:		9605 MEDICAL CENTER DRIVE
		STREET 2:		SUITE 270
		CITY:			ROCKVILLE
		STATE:			MD
		ZIP:			20850

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ADEONA PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20081027

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
		DATE OF NAME CHANGE:	20061214

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19970730

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Iroquois Capital Management, LLC
		CENTRAL INDEX KEY:			0001481867
		IRS NUMBER:				010786483
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		641 LEXINGTON AVENUE
		STREET 2:		26TH FLOOR
		CITY:			NEW YORK,
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212.974.3070

	MAIL ADDRESS:	
		STREET 1:		641 LEXINGTON AVENUE
		STREET 2:		26TH FLOOR
		CITY:			NEW YORK,
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>c95258_sc13ga.htm
<TEXT>
<HTML>
<HEAD>
<TITLE></TITLE>
</HEAD>
<BODY>


<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0 0 0 3pt; text-align: center; border-top: Black 1px solid">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0 0 0 0.7pt; text-align: center"><B>SECURITIES AND EXCHANGE<BR>
COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 0.7pt; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; background-color: gray; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE 13G</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Rule 13d-102)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>INFORMATION TO BE INCLUDED IN STATEMENTS
FILED PURSUANT<BR>
TO &sect; 240.13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED<BR>
PURSUANT TO &sect; 240.13d-2.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>(Amendment No.&nbsp;2)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1px solid"><B>Synthetic
Biologics, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1px solid"><B>Common Stock,
par value $0.001 per share</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1px solid"><B>87164U102</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; border-bottom: black 1px solid"><B>December
31, 2019</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Date of Event Which Requires Filing of this
Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the appropriate box to designate the rule pursuant to which
this Schedule is filed:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD STYLE="width: 18pt">&nbsp;</TD>
    <TD STYLE="width: 25pt; padding: 3pt; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding: 3pt">Rule 13d-1(b)</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 3pt; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD STYLE="padding: 3pt; font: 10pt Times New Roman, Times, Serif">Rule 13d-1(c)</TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="padding: 3pt; font: 10pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="padding: 3pt; font: 10pt Times New Roman, Times, Serif">Rule 13d-1(d)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; background-color: gray; border-collapse: collapse">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">*The remainder of this cover page&nbsp;shall be filled out for a
reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">The information required in the remainder of this cover page&nbsp;shall
not be deemed to be &#8220;filed&#8221; for purposes of Section&nbsp;18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however,
see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
</TABLE>

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<TR>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-bottom: 3pt; padding-left: 5pt">CUSIP No:&nbsp;87164U102</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(1)</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1px solid; padding: 3pt">Names of Reporting Persons<BR>
    Iroquois Capital Management L.L.C.</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(2)</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt">Check the Appropriate Box if a Member of a Group (See Instructions)</TD></TR>
<TR>
    <TD STYLE="padding: 3pt; width: 18pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 36pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt; width: 18pt">(a)</TD>
    <TD STYLE="border-bottom: black 1px solid; padding: 3pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt">(b)</TD>
    <TD STYLE="border-bottom: black 1px solid; padding: 3pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(3)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">SEC Use Only </TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(4)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Citizenship or Place of Organization
    <BR>
    Delaware</TD></TR>

<TR>

    <TD colspan=2 ROWSPAN="7" STYLE="padding: 3pt; width: 54pt">Number of<BR>
    Shares<BR>
    Beneficially<BR>
    Owned by<BR>
    Each<BR>
    Reporting<BR>
    Person With</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 18pt; text-align: left">(5)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Sole Voting Power <BR>
    0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt; text-align: left">(6)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Shared Voting Power<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P>
        <P STYLE="margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt; text-align: left">(7)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Sole Dispositive Power <BR>
    0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt; text-align: left">(8)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Shared Dispositive Power<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P>
        <P STYLE="margin: 0">&nbsp;</P></TD></TR>

<TR>
    <TD STYLE="padding: 3pt; width: 18pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 36pt">(9)</TD>
    <TD colspan=2 STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P>
        <P STYLE="margin: 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(10)</TD>
    <TD colspan=2  STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Check Box if the Aggregate Amount in Row
    (9) Excludes Certain Shares (See Instructions)&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT> </TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(11)</TD>
    <TD colspan=2  STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Percent of Class Represented by Amount in
    Row (9)<BR>
    9.99%</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(12)</TD>
    <TD colspan=2 STYLE="vertical-align: top; border-bottom: black 1px solid; padding: 3pt">Type of Reporting Person (See Instructions)<BR>
    OO</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* As more fully described in Item 4, the
shares of Preferred Stock are subject to a 9.99% blocker and the Warrants are subject to a 9.99% blocker, and the percentage set
forth in row (11) gives effect to such blockers. However, as more fully described in Item 4, the securities reported in rows (6),
(8) and (9) show the number of shares of Common Stock that would be issuable upon full conversion and exercise of such reported
securities and do not give effect to such blockers. Therefore, the actual number of shares of Common Stock beneficially owned by
such Reporting Person, after giving effect to such blockers, is less than the number of securities reported in rows (6), (8) and
(9).</P>


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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-bottom: 3pt; padding-left: 5pt">CUSIP No:&nbsp;87164U102</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(1)</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1px solid; padding: 3pt">Names of Reporting Persons<BR>
    Richard Abbe</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(2)</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt">Check the Appropriate Box if a Member of a Group (See Instructions)</TD></TR>
<TR>
    <TD STYLE="padding: 3pt; width: 18pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 36pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt; width: 18pt">(a)</TD>
    <TD STYLE="border-bottom: black 1px solid; padding: 3pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt">(b)</TD>
    <TD STYLE="border-bottom: black 1px solid; padding: 3pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(3)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">SEC Use Only </TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(4)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Citizenship or Place of Organization
    <BR>
    United States of America</TD></TR>

<TR>
    <TD colspan=2 ROWSPAN="7" STYLE="padding: 3pt; width: 54pt">Number of<BR>
    Shares<BR>
    Beneficially<BR>
    Owned by<BR>
    Each<BR>
    Reporting<BR>
    Person With</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 18pt">(5)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Sole Voting Power<BR>
        9,073 shares of Common Stock</P>
        <P STYLE="margin: 0">955,652 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,478,501 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt">(6)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Shared Voting Power<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt">(7)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Sole Dispositive Power<BR>
        9,073 shares of Common Stock</P>
        <P STYLE="margin: 0">955,652 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,478,501 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt">(8)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Shared Dispositive Power<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P></TD></TR>

<TR>
    <TD STYLE="padding: 3pt; font-size: 12pt; width: 18pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; font-size: 10pt; width: 36pt"><FONT STYLE="font-size: 10pt">(9)</FONT></TD>
    <TD colspan=2 STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
        15,271 shares of Common Stock</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">1,686,956 shares of Common Stock issuable upon conversion of Preferred
        Stock (See Item 4)*</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">2,608,696 shares of Common Stock issuable upon exercise of Warrants
        (See Item 4)*</P></TD></TR>
<TR>
    <TD STYLE="padding: 3pt; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(10)</FONT></TD>
    <TD colspan=2  STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(11)</FONT></TD>
    <TD  colspan=2 STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Percent of Class Represented by Amount in Row (9)</FONT><BR>
<FONT STYLE="font-size: 10pt">9.99%</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt; font-size: 12pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(12)</FONT></TD>
    <TD  colspan=2 STYLE="vertical-align: top; border-bottom: black 1px solid; padding: 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Type of Reporting Person (See Instructions)</FONT><BR>
<FONT STYLE="font-size: 10pt">IN; HC</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* As more fully described in Item 4, the shares of Preferred Stock
are subject to a 9.99% blocker and the Warrants are subject to a 9.99% blocker, and the percentage set forth in row (11) gives
effect to such blockers. However, as more fully described in Item 4, the securities reported in rows (6), (8) and (9) show the
number of shares of Common Stock that would be issuable upon full conversion and exercise of such reported securities and do not
give effect to such blockers. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person,
after giving effect to such blockers, is less than the number of securities reported in rows (6), (8) and (9).</P>


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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding: 3pt 3pt 3pt 5pt">CUSIP No:&nbsp;87164U102</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(1)</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1px solid; padding: 3pt">Names of Reporting Persons<BR>
    Kimberly Page</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(2)</TD>
    <TD COLSPAN="2" STYLE="padding: 3pt">Check the Appropriate Box if a Member of a Group (See Instructions)</TD></TR>
<TR>
    <TD STYLE="padding: 3pt; width: 18pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 36pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt; width: 18pt">(a)</TD>
    <TD STYLE="border-bottom: black 1px solid; padding: 3pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">&nbsp;</TD>
    <TD STYLE="padding: 3pt">(b)</TD>
    <TD STYLE="border-bottom: black 1px solid; padding: 3pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(3)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">SEC Use Only </TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(4)</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Citizenship or Place of Organization
    <BR>
    United States of America</TD></TR>

<TR>
    <TD  colspan=2 ROWSPAN="7" STYLE="padding: 3pt; width: 54pt">Number of<BR>
    Shares<BR>
    Beneficially<BR>
    Owned by<BR>
    Each<BR>
    Reporting<BR>
    Person With</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 18pt">(5)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Sole Voting Power <BR>
    0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt">(6)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Shared Voting Power<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P>
        <P STYLE="margin: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt">(7)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Sole Dispositive Power <BR>
    0</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="padding-right: 3pt; padding-left: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding: 3pt">(8)</TD>
    <TD STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Shared Dispositive Power<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P>
        <P STYLE="margin: 0">&nbsp;</P></TD></TR>

<TR>
    <TD>&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR>
    <TD STYLE="padding: 3pt; width: 18pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt; width: 36pt">(9)</TD>
    <TD  colspan=2 STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt"><P STYLE="margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
        6,198 shares of Common Stock</P>
        <P STYLE="margin: 0">731,304 shares of Common Stock issuable upon conversion of Preferred Stock (See Item 4)*</P>
        <P STYLE="margin: 0">1,130,195 shares of Common Stock issuable upon exercise of Warrants (See Item 4)*</P>
        <P STYLE="margin: 0">&nbsp;</P></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(10)</TD>
    <TD  colspan=2 STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Check Box if the Aggregate Amount in Row
    (9) Excludes Certain Shares (See Instructions)&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(11)</TD>
    <TD  colspan=2 STYLE="vertical-align: bottom; border-bottom: black 1px solid; padding: 3pt">Percent of Class Represented by Amount in
    Row (9)<BR>
    9.99%</TD></TR>
<TR>
    <TD STYLE="padding: 3pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 3pt">(12)</TD>
    <TD  colspan=2 STYLE="vertical-align: top; border-bottom: black 1px solid; padding: 3pt">Type of Reporting Person (See Instructions)<BR>
    IN</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">* As more fully described in Item 4, the shares of Preferred Stock
are subject to a 9.99% blocker and the Warrants are subject to a 9.99% blocker, and the percentage set forth in row (11) gives
effect to such blockers. However, as more fully described in Item 4, the securities reported in rows (6), (8) and (9) show the
number of shares of Common Stock that would be issuable upon full conversion and exercise of such reported securities and do not
give effect to such blockers. Therefore, the actual number of shares of Common Stock beneficially owned by such Reporting Person,
after giving effect to such blockers, is less than the number of securities reported in rows (6), (8) and (9).</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">This Amendment No. 2 (this &#8220;Amendment&#8221;) amends the statement
on Schedule 13G filed on October 18, 2018, as amended on February 14, 2019 (the &#8220;Original Schedule 13G&#8221;) with respect
to the Common Stock, $0.001 par value (the &#8220;Common Stock&#8221;) of Synthetic Biologics, Inc., a Nevada corporation (the
&#8220;Company&#8221;). Capitalized terms used herein and not otherwise defined in this Amendment have the meanings set forth in
the Original Schedule 13G. This Amendment amends and restates Item 4 in its entirety as set forth below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 10%"><B>Item 4.</B></TD>
    <TD STYLE="width: 90%"><B>Ownership</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Provide the following information regarding the aggregate number
and percentage of the class of securities of the issuer identified in Item 1.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">The information as of the date of the event which requires filing
of this statement required by Items 4(a) &#8211; (c) is set forth in Rows 5 &#8211; 11 of the cover page for each Reporting Person
hereto and is incorporated herein by reference for each such Reporting Person. The percentage set forth in Row 11 of the cover
page for each Reporting Person is based on 16,806,430 shares of Common Stock outstanding as of October 31, 2019 as reported in
the Company's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2019 filed with the Securities and Exchange
Commission on November 4, 2019, and assumes the exercise of the Company's reported warrants (the &#8220;Reported Warrants&#8221;)
and the conversion of the Company&#8217;s reported preferred stock (the &#8220;Reported Preferred Stock&#8221;), subject to the
Blockers (as defined below).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Pursuant to the terms of (i) the certificate of designations containing
the terms of the Reported Preferred Stock, the Reporting Persons cannot convert the Reported Preferred Stock to the extent the
Reporting Persons would beneficially own, after any such conversion, more than 9.99% of the outstanding shares of Common Stock
(the &#8220;Preferred Stock Blockers&#8221;) and (ii) the Reported Warrants, the Reporting Persons cannot exercise the Reported
Warrants to the extent the Reporting Persons would beneficially own, after any such exercise, more than 9.99% of the outstanding
shares of Common Stock (the &#8220;Warrant Blockers&#8221; and collectively with the Preferred Stock Blockers, the &#8220;Blockers&#8221;),
and the percentage set forth in Row 11 of the cover page for each Reporting Person gives effect to the Blockers. Consequently,
as of the date of the event which requires the filing of this statement, the Reporting Persons were not able to exercise all of
the Reported Preferred Stock or any of the Reported Warrants due to the Blockers.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">As of the date of the event which requires filing of this statement,
Iroquois Master Fund Ltd. (&#8220;Iroquois Master Fund&#8221;) held 6,198 shares of Common Stock, 841 shares of Reported Preferred
Stock convertible into 731,304 shares of Common Stock and warrants to purchase 1,130,195 shares of Common Stock and Iroquois Capital
Investment Group LLC (&#8220;ICIG&#8221;) held 9,073 shares of Common Stock, 1,099 shares of Reported Preferred Stock convertible
into 955,652 shares of Common Stock and warrants to purchase 1,478,501 shares of Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Mr. Abbe shares authority and responsibility for the investments
made on behalf of Iroquois Master Fund with Ms. Kimberly Page, each of whom is a director of the Iroquois Master Fund. As such,
Mr. Abbe and Ms. Page may each be deemed to be the beneficial owner of all shares of Common Stock held by, and underlying the Reported
Preferred Stock and Reported Warrants (each subject to the Blockers) held by, Iroquois Master Fund. Iroquois Capital is the investment
advisor for Iroquois Master Fund and Mr. Abbe is the President of Iroquois Capital. Mr. Abbe has the sole authority and responsibility
for the investments made on behalf of ICIG. As such, Mr. Abbe may be deemed to be the beneficial owner of all shares of Common
Stock held by, and underlying the Reported Preferred Stock and Reported Warrants (each subject to the Blockers) held by, Iroquois
Master Fund and ICIG. The foregoing should not be construed in and of itself as an admission by any Reporting Person as to beneficial
ownership of shares of Common Stock owned by another Reporting Person. Each of the Reporting Persons hereby disclaims any beneficial
ownership of any such shares of Common Stock except to the extent of their pecuniary interest therein.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 10%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 10.</B></FONT></TD>
    <TD STYLE="font-size: 10pt; width: 90%"><FONT STYLE="font-size: 10pt"><B>Certification</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">By signing below each of the undersigned certifies that, to the
best of its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with
the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.</P>


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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SIGNATURES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 36pt">After reasonable inquiry and to the best of my
knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Date: February 14, 2020</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 216pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">IROQUOIS CAPITAL MANAGEMENT L.L.C.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 37%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>By:</TD>
    <TD STYLE="border-bottom: Black 1px solid; padding-left: 3pt">/s/ Richard Abbe </TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 16pt">Richard Abbe, President</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; padding-left: 3pt">/s/ Richard Abbe </TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Richard Abbe</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></TD>
    <TD><FONT STYLE="text-transform: uppercase">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; padding-left: 3pt">/s/ Kimberly Page </TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">Kimberly Page</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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