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Stock-Based Compensation - Stock incentive plan and other information (Details) - USD ($) |  | 3 Months Ended | 6 Months Ended |  |
--- | --- | --- | --- | --- | ---
Mar. 20, 2007 | Jun. 30, 2021 | Jun. 30, 2020 | Jun. 30, 2021 | Jun. 30, 2020 | Sep. 17, 2020 | Nov. 02, 2010
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options |  | $ 483,000 |  | $ 483,000 |  |  |
General and Administrative Expenses and Research and Development Expense [Member] | Employees [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  | 34,000,000 | $ 40,000,000 | 67,000,000 | $ 79,000,000 |  |
Research and Development Expense | Employees [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  | 16,000,000 | 15,000,000 | 31,000,000 | 31,000,000 |  |
Consultant [Member] | General and Administrative Expenses and Research and Development Expense [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  | 49,000 | 27,000 | 98,000 | 53,000 |  |
Consultant [Member] | Research and Development Expense |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Allocated Share-based Compensation Expense |  | $ 3,000,000 | $ 4,000,000 | $ 7,000,000 | $ 6,000,000 |  |
2007 Stock Plan [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number | 71,429 | 5,145 |  | 5,145 |  |  |
2007 Stock Plan [Member] | Maximum [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | 7,143 |  |  |  |  |  |
2010 Stock Plan [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  | 1,540,000 |  | 1,540,000 |  |  | 85,714
2010 Stock Plan [Member] | Board of Directors [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  | 2,452,273 |  | 2,452,273 |  |  |
2020 Stock Plan [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number |  |  |  |  |  | 4,000,000 |

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