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Summary of Significant Accounting Policies - Additional Information (Details) - USD ($) |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | ---
Nov. 16, 2020 | Dec. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2018 | Sep. 05, 2018
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Depreciation, Depletion and Amortization |  |  | $ 87,000 | $ 201,000 |  |
Cash and Cash Equivalents, at Carrying Value. |  | $ 6,227,000 | $ 67,325,000 | 6,227,000 |  |
Equity Method Investment, Ownership Percentage |  |  | 83.00% |  |  |
Accrued Liabilities |  |  | $ 700,000 |  |  |
Prepaid Expense |  | 500,000 | 500,000 | 500,000 |  |
Effect of Warrant exercise price adjustment |  | 900,000 | 0 | 880,000 |  |
Net Loss Attributable to Non-controlling Interest |  |  | $ (1,000) | $ (73,000) |  |
Preferred Stock Shares Converted | 1.38 |  | 3,973 | 3,665 |  |
Right of use asset |  | 279,000 | $ 1,383,000 | $ 279,000 |  |
Operating Lease Liability |  | 287,000 | 124,000 | 287,000 |  |
Preferred stock price adjustment |  |  | 7,402,000 | $ 0 |  |
Series A and Series B Preferred Stock [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Net Loss Attributable to Non-controlling Interest |  |  | 100,000 |  |  |
Series B Preferred Stock [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  | 3,454,783 |  |
Preferred stock accrued dividends |  |  | 1,496,000 | $ 1,380,000 |  |
Accretion of preferred discount | $ 900,000 | 1,400,000 | 1,500,000 | $ 1,400,000 |  |
Series A Preferred Stock [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  |  | 678,258 |  |
Preferred stock accrued dividends |  |  | 24,000 | $ 254,000 |  |
Effect of Warrant exercise price adjustment |  |  |  | 1,000,000.0 |  |
Accretion of Preferred Stock Deemed Dividend |  |  |  | 300,000 |  |
Accretion of preferred discount |  |  | 100,000 |  | $ 6,900,000 |
Preferred stock price adjustment |  |  | $ 7,402,000 | $ 0 |  |
Warrant [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  | 6,344,966 | 18,000,713 |  |
Options [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount |  |  | 6,255,275 | 3,997,418 |  |
Money Market Accounts [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Cash and Cash Equivalents, at Carrying Value. |  | $ 114,000,000 | $ 193,000,000 | $ 114,000,000 |  |
SYN Biomics [Member] |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |
Equity Method Investment, Ownership Percentage |  |  | 100.00% |  |  | 88.50%
Noncontrolling Interest, Ownership Percentage by Parent |  |  |  |  |  | 11.50%
Net Loss Attributable to Non-controlling Interest |  |  |  | $ 2,800,000 |  |

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