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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash Flows from Operating Activities: |  |
Net loss | $ (14,268,000) | $ (10,116,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation | 416,000 | 350,000
Subsidiary stock issuances to vendor | 0 | 178,000
Depreciation | 87,000 | 201,000
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 174,000 | (326,000)
Right of use asset | 166,000 | 141,000
Accounts payable | (363,000) | (1,429,000)
Accrued expenses | 1,004,000 | (851,000)
Accrued employee benefits | 110,000 | (67,000)
Lease liability | (216,000) | (249,000)
Net Cash Used in Operating Activities | (12,890,000) | (12,168,000)
Cash Flows from Investing Activities |  |
Purchases of property and equipment | (14,000) | (9,000)
Net Cash Used in Investing Activities | (14,000) | (9,000)
Cash Flows from Financing Activities |  |
Proceeds from "at the market" stock issuance | 65,960,000 | 3,359,000
Proceeds from issuance of common stock for warrant exercises | 8,042,000 | 0
Net Cash Provided by Financing Activities | 74,002,000 | 3,359,000
Net increase (decrease) in cash and cash equivalents | 61,098,000 | (8,818,000)
Cash and cash equivalents at beginning of year | 6,227,000 | 15,045,000
Cash and cash equivalents at end of year | 67,325,000 | 6,227,000
NONCASH FINANCING ACTIVITIES: |  |
Preferred stock price adjustment | 7,402,000 | 0
Return of SYN Biomics Stock | 2,774,000 | 0
Deemed dividends for accretion of Series B Preferred Stock discount | 1,496,000 | 1,380,000
Right of use assets from operating lease | 1,270,000 | 0
In-kind dividends paid in preferred stock | 24,000 | 254,000
Effect of Warrant exercise price adjustment | 0 | 880,000
Series A Preferred Stock [Member] |  |
NONCASH FINANCING ACTIVITIES: |  |
Conversion of Stock | 12,822,000 | 0
Preferred stock price adjustment | 7,402,000 | 0
Effect of Warrant exercise price adjustment |  | 1,000,000.0
Series B Preferred Stock [Member] |  |
NONCASH FINANCING ACTIVITIES: |  |
Conversion of Stock | 2,477,000 | 2,284,000
Series B Preferred Stock [Member] | Preferred Stock [Member] |  |
Cash Flows from Operating Activities: |  |
Net loss | $ 0 | $ 0

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