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Consolidated Statements of Stockholders (Deficit) Equity - USD ($) $ in Thousands | Common Stock Series B Preferred | Common Stock Series A Preferred Stock [Member] | Common Stock | APIC Series B Preferred | APIC Series A Preferred Stock [Member] | APIC | Accumulated Deficit Series B Preferred | Accumulated Deficit Series A Preferred Stock [Member] | Accumulated Deficit | Non-Controlling InterestAccumulated Non-Controlling Stockholders' Series B Preferred | Non-Controlling InterestAccumulated Non-Controlling Stockholders' Series A Preferred Stock [Member] | Non-Controlling InterestAccumulated Non-Controlling Stockholders' | Preferred Stock [Member] Series B Preferred | Preferred Stock [Member] Series A Preferred Stock [Member] | Series B Preferred | Series A Preferred Stock [Member] | Total
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Stock-based compensation |  |  | $ 0 |  |  | $ 350 |  |  | $ 0 |  |  | $ 0 | $ 0 |  |  |  | $ 350
Stock issued under "at-the-market" offering |  |  | $ 9 |  |  | 3,350 |  |  | 0 |  |  | 0 | 0 |  |  |  | 3,359
Stock issued under "at-the-market" offering (in shares) |  |  | 9,256,535 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series A Preferred Stock Dividends |  |  | $ 0 |  |  | 0 |  |  | 254 |  |  | 0 | 0 |  |  |  | 254
Issuance of SYN Biomics Stock |  |  | 0 |  |  | 0 |  |  | 0 |  |  | 178 | 0 |  |  |  | 178
Effect of Warrant exercise price adjustment |  |  | 0 |  |  | 880 |  |  | (880) |  |  | 0 | 0 |  |  |  | 0
Conversion of Series B Preferred Stock to Common |  |  | $ 3 |  |  | 3,661 |  |  | (1,380) |  |  | 0 | $ (2,284) |  |  |  | 0
Conversion of Series B Preferred Stock to Common (in shares) |  |  | 3,186,960 |  |  |  |  |  |  |  |  |  | (3,665) |  |  |  |
Net Loss |  |  | $ 0 |  |  | 0 |  |  | (10,043) |  |  | (73) | $ 0 |  |  |  | (10,116)
Non-controlling interest |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (73)
Balance at Dec. 31, 2020 |  |  | 29 |  |  | 240,821 |  |  | (248,094) |  |  | (2,773) | 2,477 |  |  |  | (7,540)
Balance at Dec. 31, 2019 |  |  | $ 17 |  |  | 232,580 |  |  | (235,537) |  |  | (2,878) | $ 4,761 |  |  |  | (1,057)
Balance (in shares) at Dec. 31, 2020 |  |  | 29,249,925 |  |  |  |  |  |  |  |  |  | 3,973 |  |  |  |
Balance (in shares) at Dec. 31, 2019 |  |  | 16,806,430 |  |  |  |  |  |  |  |  |  | 7,638 |  |  |  |
Stock-based compensation |  |  | $ 0 |  |  | 416 |  |  | 0 |  |  | 0 | $ 0 |  |  |  | 416
Stock issued under "at-the-market" offering |  |  | $ 79 |  |  | 65,881 |  |  | 0 |  |  | 0 | 0 |  |  |  | 65,960
Stock issued under "at-the-market" offering (in shares) |  |  | 78,685,315 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Series A Preferred Stock Dividends |  |  | $ 0 |  |  | 0 |  |  | 24 |  |  | 0 | 0 |  |  |  | 24
Conversion of Series B Preferred Stock to Common | $ 3 |  |  | $ 3,971 |  |  | $ (1,497) |  |  | $ 0 |  |  | $ (2,477) |  | $ 0 |  |
Conversion of Series B Preferred Stock to Common (in shares) | 3,454,783 |  |  |  |  |  |  |  |  |  |  |  | (3,973) |  |  |  |
Net Loss |  |  | 0 |  |  | 0 |  |  | (14,267) |  |  | (1) | $ 0 |  |  |  | (14,268)
Reversal of noncontrolling interest due to return of Syn Biomics shares |  |  | 0 |  |  | (2,774) |  |  | 0 |  |  | 2,774 | 0 |  |  |  | 0
Warrants Exercised |  |  | $ 12 |  |  | 8,030 |  |  | 0 |  |  | 0 | 0 |  |  |  | 8,042
Warrants Exercised (In shares) |  |  | 11,655,747 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Effect of Series A Preferred Stock price adjustment |  |  | $ 0 |  |  | 7,402 |  |  | (7,402) |  |  | 0 | 0 |  |  |  | 0
Conversion of Series A Preferred Stock to Common |  | $ 9 |  |  | $ 12,813 |  |  | $ 0 |  |  | $ 0 |  |  | $ 0 |  | $ 12,822 |
Conversion of Series A Preferred Stock to Common (in shares) |  | 8,996,768 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Non-controlling interest |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (1)
Balance at Dec. 31, 2021 |  |  | 132 |  |  | 336,560 |  |  | (271,284) |  |  | 0 | 0 |  |  |  | 65,408
Balance at Dec. 31, 2020 |  |  | $ 29 |  |  | $ 240,821 |  |  | $ (248,094) |  |  | $ (2,773) | $ 2,477 |  |  |  | $ (7,540)
Balance (in shares) at Dec. 31, 2021 |  |  | 132,042,538 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Balance (in shares) at Dec. 31, 2020 |  |  | 29,249,925 |  |  |  |  |  |  |  |  |  | 3,973 |  |  |  |

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