    <SEC-DOCUMENT>0001104659-22-091820-index.html : 20220816
    <SEC-HEADER>0001104659-22-091820.hdr.sgml : 20220816
    <ACCEPTANCE-DATETIME>20220816170657
    ACCESSION NUMBER:		0001104659-22-091820
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		5
    CONFORMED PERIOD OF REPORT:	20220930
    FILED AS OF DATE:		20220816
    DATE AS OF CHANGE:		20220816

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Synthetic Biologics, Inc.
    		CENTRAL INDEX KEY:			0000894158
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				133808303
    		STATE OF INCORPORATION:			NV
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-12584
    		FILM NUMBER:		221170993

    	BUSINESS ADDRESS:
    		STREET 1:		9605 MEDICAL CENTER DRIVE
    		STREET 2:		SUITE 270
    		CITY:			ROCKVILLE
    		STATE:			MD
    		ZIP:			20850
    		BUSINESS PHONE:		(734) 332-7800

    	MAIL ADDRESS:
    		STREET 1:		9605 MEDICAL CENTER DRIVE
    		STREET 2:		SUITE 270
    		CITY:			ROCKVILLE
    		STATE:			MD
    		ZIP:			20850

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ADEONA PHARMACEUTICALS, INC.
    		DATE OF NAME CHANGE:	20081027

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	PIPEX PHARMACEUTICALS, INC.
    		DATE OF NAME CHANGE:	20061214

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	SHEFFIELD PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19970730
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>tm2222180-2_def14a.htm
    <DESCRIPTION>DEF 14A
    <TEXT>
    Document 1 - file: tm2222180-2_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>lg_synthetic-4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: lg_synthetic-4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>tm2222180d2-px_01page4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: tm2222180d2-px_01page4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>tm2222180d2-px_02page4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: tm2222180d2-px_02page4clr.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>tm2222180d2-px_03page4clr.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: tm2222180d2-px_03page4clr.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>