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v3.23.1

License, Collaborative and Employment Agreements and Commitments (Details) - USD ($) |  |  |  |  |  |  |  |  | 1 Months Ended | 12 Months Ended
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Dec. 15, 2022 | Mar. 22, 2022 | Dec. 23, 2021 | Dec. 23, 2020 | Aug. 07, 2019 | Dec. 19, 2012 | Dec. 09, 2012 | Nov. 28, 2012 | Nov. 30, 2017 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2015
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Annual base salary | $ 614,250 |  |  |  |  |  |  |  |  |  |  |
Operating Lease weighted average discount rate |  |  |  |  |  |  |  |  |  | 8.50% |  |
Operating lease cost |  |  |  |  |  |  |  |  |  | $ 569,000 | $ 280,000 |
Payments for other fees |  |  |  |  |  |  |  |  | $ 4,500,000 |  |  |
Licensing Agreements |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Annual payments due under license agreement |  |  |  |  |  | $ 50,000 |  |  |  |  |  |
Final payment due under license agreement |  |  |  |  |  | 25,000 |  |  |  |  |  |
Steven A. Shallcross |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Annual cash performance bonus |  |  |  | 62.00% |  |  |  |  |  |  |  |
Share-based payment award, options, grants in period, gross | 475,000 |  |  | 450,000 |  |  |  |  |  |  |  |
Cash bonus paid as per employee agreement | $ 385,000 |  |  |  |  |  |  |  |  |  |  |
Dr. Sliman |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Annual cash performance bonus |  |  | 62.50% |  |  |  |  |  |  |  |  |
Share-based payment award, options, grants in period, gross |  |  | 650,000 |  |  |  |  |  |  |  |  |
Frank Tufaro |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Annual cash performance bonus |  | 40.00% |  |  |  |  |  |  |  |  |  |
Annual base salary |  | $ 375,000 |  |  |  |  |  |  |  |  |  |
Francis Tufaro |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Annual cash performance bonus | 23.00% |  |  |  |  |  |  |  |  |  |  |
Share-based payment award, options, grants in period, gross | 100,000 |  |  |  |  |  |  |  |  |  |  |
Annual base salary | $ 393,750 |  |  |  |  |  |  |  |  |  |  |
Prev Abr Llc |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Additional cash payment for license agreement |  |  |  |  |  |  |  | $ 235,000 |  |  |  |
Unregistered shares issued to license agreement |  |  |  |  |  |  |  | 17,858 |  |  |  |
Additional consideration payable |  |  |  |  |  |  |  | 50% in cash and 50% in our stock |  |  |  |
Options to be received common stock shares |  |  |  |  |  |  |  |  |  |  |  | 18,724
Phase I Clinical Trials |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  | 50,000 |  |  |  |  |  |
Phase III Clinical Trials |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  | 100,000 |  |  |  |  |  |
NDA Submission In US |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  |  | $ 250,000 |  |  |  |  |
European Medicines Agency Approval |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  | 100,000 |  |  |  |  |  |
Regulatory Approval In Asian Country |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Milestone payment |  |  |  |  |  | 100,000 |  |  |  |  |  |
Clinical Trial Agreement |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Estimated research costs |  |  |  |  | $ 3,200,000 |  |  |  |  |  |  |
First Year |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Research agreement fixed fee |  |  |  |  |  | 303,287 |  |  |  |  |  |
Second Year |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Research agreement fixed fee |  |  |  |  |  | 316,438 |  |  |  |  |  |
Third Year |  |  |  |  |  |  |  |  |  |  |  |
License, Collaborative and Employment Agreements and Commitments |  |  |  |  |  |  |  |  |  |  |  |
Research agreement fixed fee |  |  |  |  |  | $ 328,758 |  |  |  |  |  |

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