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Income Taxes (Details Narrative) - USD ($)
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Effective tax rate of expected statutory rate 21.00% 21.00%
Valuation allowance on deferred tax assets $ 24,595,000 $ 23,740,000
Increase in valuation allowance 855,000  
Net operating loss carry-forwards $ 76,070,000  
Operating loss carry-forwards expiration years Expire between 2026 and 2040.  
Net operating loss due to ownership changes $ 765,000  
Research and development tax credit carry-forwards 1,795,000 $ 1,795,000
Annual limitation due to ownership changes $ 1,151,000  
Tax credit carry-forwards, expiration date Expire between 2023 and 2037.  
Percentage of income tax benefit Greater than 50% likely  
Effective tax rate expected statutory valuation allowance on net deferred tax assets 100.00% 100.00%
Research And Development [Member]    
Tax credit carryforwards $ 1,795,000