Below is a summary of the Company’s options activity and related information with respect to options granted to employees during the years ended December 31, 2024 and 2023:

	Year ended December 31,					Year ended December 31,
	2024					2023
	Amount of options			Weighted average exercise price		Amount of options			Weighted average exercise price

Outstanding - beginning of the year		18,184		$	62.16		12,353		$	45.04
Granted		**4,187		$	21.76		*5,894		$	97.92
Exercised		-		$	-		-		$	-
Expired or forfeited		(62	)	$	105.60		(62	)	$	53.12

Outstanding - end of the year		22,309		$	54.48		18,184		$	62.16

Exercisable at end of year		18,082		$	46.56		11,114		$	48.96

*

Including the grant of 1,500 options to purchase up to 1,500 ordinary shares to directors, as approved by the Company’s shareholders on November 30, 2023, with an exercise price of $105.60 per share. The options will expire at the earlier of (i) ten years from the date of grant or (ii) 90 days following a termination of employment or service. The fair value of each option as of the grant date was $9.60, determined using the Black-Scholes option pricing model and the total expenses of $15 thousand will be expensed over the option vesting periods of three years.

**

Including the grant of 1,250 options to purchase up to 1,250 ordinary shares to the Company’s Chief Executive Officer and Chief Scientific Officer, as approved by the Company’s shareholders on September 26, 2024, with an exercise price of $34.40 per share. The options will expire at the earlier of (i) ten years from the date of grant or (ii) 90 days following a termination of employment or service. The fair value of each option as of the grant date was $15.60, determined using the Black-Scholes option pricing model and the total expenses of $19 thousand will be expensed over the option vesting periods of three years.

Schedule of Options to Consultants

The Company’s outstanding options to consultants as of December 31, 2024 were as follows:

Issuance date	In connection with	No. of options issued		Exercise price		No. of options exercisable
2015	Rendered services		1,383	$	0.24		1,383
2017	Rendered services		461	$	0.24		461
2021	Rendered services		863	$	0.24-$180.00		863
2023*	Rendered services		1,250	$	43.68		555

*

On April 27, 2023, the Company’s Board of Directors approved the additional grant of options to purchase up to 1,250 ordinary shares to a consultant, with an exercise price of $43.68 per share. The options will expire at the earlier of (i) ten years from the date of grant or (ii) 90 days following a termination of services. The fair value of each option as of the grant date was $20.80, determined using the Black-Scholes option pricing model and the total expenses of $26 thousand will be expensed over the option vesting periods of three years.

Schedule of Issuance of Equity Warrants to Investors and Associate

Equity Warrants to investors and associated with the IPO and follow on fund raising, as of December 31, 2024:

Number of warrants/ options

Issuance date

Exercise price

Exercise ratio

Expiration date

Notes

98,261

September 13, 2022

$

160.00

Each warrant is exercisable into 1 ordinary share

5 years following the issuance date

Registered for trading (*)

2,344

September 15, 2022

$

424.80

Each warrant is exercisable into 1 ordinary share

5 years following the issuance date

Owned by underwriter

295

September 15, 2022

$

338.40

Each warrant is exercisable into 1 ordinary share

10 years following the issuance date

Owned by the legal advisor

205,500

November 27, 2024

$

10.00

(**)

Each warrant is exercisable into 1 ordinary share

5 years following the issuance date

Owned by an investor

78,000

November 27, 2024

$

0.0004

Each pre funded warrant is exercisable into 1 ordinary share

Until exercised in full

Owned by an investor

(*)

The warrants are exercisable at any time after their original issuance and at any time up to the date that is five years after their original issuance. The warrants will be exercisable, at the option of each holder, in whole or in part by delivering to us a duly executed exercise notice and, at any time a registration statement registering the issuance of the ordinary shares underlying the warrants under the Securities Act of 1933, as amended, is effective and available for the issuance of such shares, by payment in full in immediately available funds for the number of ordinary shares purchased upon such exercise.

The exercise price per whole ordinary share purchasable upon exercise of the warrants $320.00 per share (the “Initial Exercise Price”). The exercise price is subject to appropriate adjustment in the event of certain stock dividends and distributions, stock splits, stock combinations, reclassifications or similar events affecting ordinary shares and also upon any distributions of assets, including cash, stock or other property to the Company’s shareholders. Subject to certain exemptions outlined in the warrant, for a period until two years from the date of issuance of the warrant, if the Company shall sell, enter into an agreement to sell and subsequently sells, or grant any option to purchase, or sell, enter into an agreement to sell and subsequently sells, or grant any right to reprice, or otherwise dispose of or issue (or announce any offer, sale, grant or any option to purchase or other disposition the subsequently closes) any ordinary shares or convertible security, at an effective price per share less than the exercise price of the warrant then in effect, the exercise price of the warrant shall be reduced to equal the effective price per share in such Dilutive Issuance; provided, however, that in no event shall the exercise price of the warrant be reduced to an exercise price lower than 50% of the Initial Exercise Price. On the date that is 90 calendar days immediately following the initial issuance date of the warrants, the exercise price of the warrants will adjust (the “Reset Price”), provided that such value is less than the exercise price in effect on that date. The Reset Price is equal to the greater of (a) 50% of the Initial Exercise Price of the warrants on the issuance date or (b) 100% of the lowest volume weighted average price per ordinary share occurring on any day between the initial exercise date of the warrants and 90 calendar days following the issuance date of the warrants. The lowest Reset Price is $160.00, which is 50% of the Initial Exercise Price.

(**)	On January 30, 2025, the exercise price of the warrants pursuant to a November 2024 private placement was adjusted to $4.00 per share following the closing of an additional offering.