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Stock-based compensation - Summary of stock option activity (Details)
 9 Months Ended
Sep. 30, 2016
USD ($)
$ / shares
shares
Shares  
Shares outstanding, Beginning Balance | shares 1,824,973
Shares granted | shares 759,820
Shares exercised | shares (8,516)
Shares canceled or forfeited | shares (256,030)
Shares outstanding, Ending Balance | shares 2,320,247
Shares exercisable | shares 773,252
Shares vested or expected to vest | shares 2,161,668
Weighted-Average Exercise Price  
Shares outstanding, weighted-average exercise price, Beginning Balance (in usd per share) | $ / shares $ 8.34
Shares granted, weighted-average exercise price (in usd per share) | $ / shares 10.04
Shares exercised, weighted-average exercise price (in usd per share) | $ / shares 2.59
Shares canceled or forfeited, weighted-average exercise price (in usd per share) | $ / shares 11.99
Shares outstanding, weighted-average exercise price, Ending Balance (in usd per share) | $ / shares 8.51
Shares exercisable, weighted-average exercise price (in usd per share) | $ / shares 7.31
Shares vested or expected to vest, weighted-average exercise price (in usd per share) | $ / shares $ 8.69
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract]  
Outstanding, weighted-average remaining contractual term (in years) 8 years 4 months 13 days
Exercisable, weighted-average remaining contractual term (in years) 8 years 18 days
Vested or expected to vest, weighted-average remaining contractual term (in years) 7 years 11 months 27 days
Outstanding, aggregate intrinsic value | $ $ 9,167,034
Exercisable, aggregate intrinsic value | $ 4,216,112
Vested or expected to vest, aggregate intrinsic value | $ $ 8,229,864