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Research and development expenses | 12 Months Ended
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Dec. 31, 2018
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Research and development expenses | NOTE 11. RESEARCH AND DEVELOPMENT EXPENSES The following table shows the major classes of research and development expenses for fiscal years 2018 and 2017:
|  | Fiscal years |
|  | 2018 |  |  | 2017 |
Manufacturing costs |  | $ | 283,830 |  |  | $ | 721,413 |
Pre-clinical costs |  |  | 704,744 |  |  |  | 1,403,436 |
Clinical trial costs |  |  | 299,047 |  |  |  | 4,823 |
Total research and development expenses |  | $ | 1,287,621 |  |  | $ | 2,129,672 |

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