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Research and development expenses (Tables)
12 Months Ended
Dec. 31, 2018
Text Block [Abstract]  
Schedule of major classes of research and development expenses

The following table shows the major classes of research and development expenses for fiscal years 2018 and 2017:

 

     Fiscal years  
     2018      2017  

Manufacturing costs

   $ 283,830    $ 721,413

Pre-clinical costs

     704,744      1,403,436

Clinical trial costs

     299,047      4,823
  

 

 

    

 

 

 

Total research and development expenses

   $ 1,287,621    $ 2,129,672