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Note 1 - The Company and Summary of Significant Accounting Policies (Details Narrative) - USD ($) | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | ---
Jun. 30, 2016 | Jun. 30, 2015 | Jun. 30, 2016 | Jun. 30, 2015 | Dec. 31, 2015 | Dec. 31, 2014 | Dec. 31, 2013
Accumulated deficit | $ (118,190,000) |  | $ (118,190,000) |  | $ (145,682,000) | $ (112,956,000) | $ (89,467,000)
Cash and cash equivalent | 355,000 | $ 125,000 | $ 355,000 | $ 125,000 | $ 47,000 | $ 855,000 | $ 43,000
Stock options granted |  |  |  |  | 52,000 | 321,833 |
Expected volatility |  |  |  |  | 90.00% |  |
Risk free interest rate |  |  |  |  | 1.50% |  |
Expected life |  |  |  |  | 5 years |  |
Expected dividend yield |  |  |  |  | $ 0.00 |  |
Share based compensation expense |  |  |  |  | $ 221,000 | $ 162,000 |
Diluted shares excluded from calcuation of EPS |  |  | 12,900,521 | 1,677,144 | 12,525,721 | 3,092,737 |
Research and development costs | $ 250,000 | $ 0 | $ 475,000 | $ 250,000 | $ 1,000,000 | $ 0 |
Minimum |  |  |  |  |  |  |
Amortized over vesting period |  |  |  |  |  | 1 year |
Maximum |  |  |  |  |  |  |
Amortized over vesting period |  |  |  |  |  | 4 years |

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB TOPIC 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Staff Accounting Bulletin (SAB) -Number Topic 14 -Section F + Details
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