    <SEC-DOCUMENT>0000939798-16-000149-index.html : 20161003
    <SEC-HEADER>0000939798-16-000149.hdr.sgml : 20161003
    <ACCEPTANCE-DATETIME>20160930175133
    ACCESSION NUMBER:		0000939798-16-000149
    CONFORMED SUBMISSION TYPE:	S-1/A
    PUBLIC DOCUMENT COUNT:		53
    FILED AS OF DATE:		20161003
    DATE AS OF CHANGE:		20160930

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			OXIS INTERNATIONAL INC
    		CENTRAL INDEX KEY:			0000109657
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				941620407
    		STATE OF INCORPORATION:			FL
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		S-1/A
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-213270
    		FILM NUMBER:		161913884

    	BUSINESS ADDRESS:
    		STREET 1:		100 SOUTH ASHLEY DRIVE
    		STREET 2:		SUITE 600
    		CITY:			TAMPA
    		STATE:			FL
    		ZIP:			33602
    		BUSINESS PHONE:		(800) 304-9888

    	MAIL ADDRESS:
    		STREET 1:		100 SOUTH ASHLEY DRIVE
    		STREET 2:		SUITE 600
    		CITY:			TAMPA
    		STATE:			FL
    		ZIP:			33602

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	DDI PHARMACEUTICALS INC
    		DATE OF NAME CHANGE:	19920703

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	DIAGNOSTIC DATA INC /DE/
    		DATE OF NAME CHANGE:	19850312
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>S-1/A
    <SEQUENCE>1
    <FILENAME>oxissoneamendtwo.htm
    <DESCRIPTION>OXIS S-1 AMENDMENT NO. 2
    <TEXT>
    Document 1 - file: oxissoneamendtwo.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5
    <SEQUENCE>2
    <FILENAME>opinionreshares.htm
    <DESCRIPTION>OPINION LETTER REGARDING LEGALITY OF SHARES
    <TEXT>
    Document 2 - file: opinionreshares.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.3
    <SEQUENCE>3
    <FILENAME>exhibittenpointthree.htm
    <DESCRIPTION>LICENSE AGREEMENT WITH ID4 PHARMA LLC
    <TEXT>
    Document 3 - file: exhibittenpointthree.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.4
    <SEQUENCE>4
    <FILENAME>extenpointfour.htm
    <DESCRIPTION>LICENSE AGREEMENT WITH THE UNIVERSITY OF MINNESOTA
    <TEXT>
    Document 4 - file: extenpointfour.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.5
    <SEQUENCE>5
    <FILENAME>extenpointfive.htm
    <DESCRIPTION>LICENSE AGREEMENT WITH DANIEL A. VALLERA, PH.D.
    <TEXT>
    Document 5 - file: extenpointfive.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.6
    <SEQUENCE>6
    <FILENAME>extenpointsix.htm
    <DESCRIPTION>LICENSE AGREEMENT WITH MULTICELL IMMUNOTHERAPEUTICS, INC
    <TEXT>
    Document 6 - file: extenpointsix.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.7
    <SEQUENCE>7
    <FILENAME>extenpointseven.htm
    <DESCRIPTION>NOTE CONVERSION AGREEMENT
    <TEXT>
    Document 7 - file: extenpointseven.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.8
    <SEQUENCE>8
    <FILENAME>extenpointeight.htm
    <DESCRIPTION>WARRANT CONVERSION AGREEMENT
    <TEXT>
    Document 8 - file: extenpointeight.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.9
    <SEQUENCE>9
    <FILENAME>extenpointnine.htm
    <DESCRIPTION>PREFERRED STOCK EXCHANGE AGREEMENT
    <TEXT>
    Document 9 - file: extenpointnine.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.10
    <SEQUENCE>10
    <FILENAME>extenpointten.htm
    <DESCRIPTION>FORM OF SERIES A WARRANT
    <TEXT>
    Document 10 - file: extenpointten.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.11
    <SEQUENCE>11
    <FILENAME>extenpointeleven.htm
    <DESCRIPTION>PLACEMENT AGREEMENT
    <TEXT>
    Document 11 - file: extenpointeleven.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>12
    <FILENAME>extwentythree.htm
    <DESCRIPTION>AUDITOR CONSENT
    <TEXT>
    Document 12 - file: extwentythree.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.INS
    <SEQUENCE>13
    <FILENAME>oxis-20160630.xml
    <TEXT>
    Document 13 - file: oxis-20160630.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.SCH
    <SEQUENCE>14
    <FILENAME>oxis-20160630.xsd
    <TEXT>
    Document 14 - file: oxis-20160630.xsd

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.CAL
    <SEQUENCE>15
    <FILENAME>oxis-20160630_cal.xml
    <TEXT>
    Document 15 - file: oxis-20160630_cal.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.DEF
    <SEQUENCE>16
    <FILENAME>oxis-20160630_def.xml
    <TEXT>
    Document 16 - file: oxis-20160630_def.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.LAB
    <SEQUENCE>17
    <FILENAME>oxis-20160630_lab.xml
    <TEXT>
    Document 17 - file: oxis-20160630_lab.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.PRE
    <SEQUENCE>18
    <FILENAME>oxis-20160630_pre.xml
    <TEXT>
    Document 18 - file: oxis-20160630_pre.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>20
    <FILENAME>image00003.jpg
    <TEXT>
    Document 20 - file: image00003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>21
    <FILENAME>image00004.jpg
    <TEXT>
    Document 21 - file: image00004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>22
    <FILENAME>R1.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 22 - file: R1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>23
    <FILENAME>R2.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 23 - file: R2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>24
    <FILENAME>R3.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 24 - file: R3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>25
    <FILENAME>R4.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 25 - file: R4.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>26
    <FILENAME>R5.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 26 - file: R5.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>27
    <FILENAME>R6.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 27 - file: R6.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>28
    <FILENAME>R7.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 28 - file: R7.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>29
    <FILENAME>R8.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 29 - file: R8.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>30
    <FILENAME>R9.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 30 - file: R9.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>31
    <FILENAME>R10.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 31 - file: R10.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>32
    <FILENAME>R11.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 32 - file: R11.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>33
    <FILENAME>R12.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 33 - file: R12.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>34
    <FILENAME>R13.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 34 - file: R13.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>35
    <FILENAME>R14.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 35 - file: R14.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>36
    <FILENAME>R15.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 36 - file: R15.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>37
    <FILENAME>R16.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 37 - file: R16.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>38
    <FILENAME>R17.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 38 - file: R17.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>39
    <FILENAME>R18.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 39 - file: R18.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>40
    <FILENAME>R19.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 40 - file: R19.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>41
    <FILENAME>R20.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 41 - file: R20.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>42
    <FILENAME>R21.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 42 - file: R21.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>43
    <FILENAME>R22.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 43 - file: R22.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>44
    <FILENAME>R23.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 44 - file: R23.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>45
    <FILENAME>R24.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 45 - file: R24.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>46
    <FILENAME>R25.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 46 - file: R25.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>47
    <FILENAME>R26.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 47 - file: R26.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>48
    <FILENAME>R27.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 48 - file: R27.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>49
    <FILENAME>R28.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 49 - file: R28.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EXCEL
    <SEQUENCE>50
    <FILENAME>Financial_Report.xlsx
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 50 - file: Financial_Report.xlsx

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>51
    <FILENAME>Show.js
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 51 - file: Show.js

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>52
    <FILENAME>report.css
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 52 - file: report.css

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>54
    <FILENAME>FilingSummary.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 54 - file: FilingSummary.html

    Document 54 - RAW XML: FilingSummary.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>ZIP
    <SEQUENCE>56
    <FILENAME>0000939798-16-000149-xbrl.zip
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 56 - file: 0000939798-16-000149-xbrl.zip

    </DOCUMENT>
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