<SEC-DOCUMENT>0001654954-17-005850.txt : 20170626
<SEC-HEADER>0001654954-17-005850.hdr.sgml : 20170626
<ACCEPTANCE-DATETIME>20170626080020
ACCESSION NUMBER:		0001654954-17-005850
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20170626
ITEM INFORMATION:		Regulation FD Disclosure
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20170626
DATE AS OF CHANGE:		20170626

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			OXIS INTERNATIONAL INC
		CENTRAL INDEX KEY:			0000109657
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				941620407
		STATE OF INCORPORATION:			FL
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-08092
		FILM NUMBER:		17928895

	BUSINESS ADDRESS:	
		STREET 1:		100 SOUTH ASHLEY DRIVE
		STREET 2:		SUITE 600
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33602
		BUSINESS PHONE:		(800) 304-9888

	MAIL ADDRESS:	
		STREET 1:		100 SOUTH ASHLEY DRIVE
		STREET 2:		SUITE 600
		CITY:			TAMPA
		STATE:			FL
		ZIP:			33602

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DDI PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19920703

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	DIAGNOSTIC DATA INC /DE/
		DATE OF NAME CHANGE:	19850312
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>oxiseightk.htm
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
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STATES</font></div>
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D. C. 20549</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 24px"><font style="font-weight: bold; font-family: Times New Roman;">FORM
8-K</font></font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">CURRENT
REPORT</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Securities
Exchange Act of 1934</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Date of Report
(Date of earliest event reported): June 26, 2017</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<font style="font-size: 24px">OXIS INTERNATIONAL,
INC.</font></font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Exact name of
Registrant as specified in its charter)</font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Delaware</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(State or other
Jurisdiction of<br>
Incorporation or organization)</font></div>
</td>
<td style="width: 33%; vertical-align: top; border-bottom: 2px solid black">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">000-08092</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Commission File
Number)</font></div>
</td>
<td style="width: 33%; vertical-align: top; border-bottom: 2px solid black">
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">94-1620407</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(IRS Employer I.D.
No.)</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">100
South Ashley Drive,</font> <font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Suite
600</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Tampa,
FL 33602</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman"><font style="text-decoration: underline">
Phone: (800) 304-9888</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Address, including
zip code, and telephone number, including area code,
of</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">registrant's
principal executive offices)</font></div>
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N/A</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Former name,
former address and former fiscal year, if changed since last
report)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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under any of the following provisions (see General Instruction A.2.
below):</font></div>
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communications pursuant to Rule 425 under the Securities Act (17
CFR 230.425)</font></div>
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pursuant to Rule l 4a- l 2 under the Exchange Act ( 17 CFR 240. l
4a- l 2)</font></div>
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communications pursuant to Rule l 4d-2(b) under the Exchange Act
(17 CFR 240. l 4d-2(b))</font></div>
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communications pursuant to Rule 13e-4(c) under the Exchange Act (17
CFR 240. l 3e-4(c))</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
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<font style="color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
Item&#xA0;7.01&#xA0;Regulation FD Disclosure.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
On June 26, 2017, Oxis International, Inc. (the
&#x201C;Company&#x201D;) issued a press release announcing that the
Company agrees to acquire Georgetown Translational Pharmaceuticals,
Inc. and hire a new Chief Executive Officer and Chief Medical
Officer. A copy of the press release is attached hereto as
Exhibit&#xA0;99.1 and is incorporated herein by
reference.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="color: #000000; font-family: Times New Roman; font-size: 13px">
The information contained in this Item 7.01, and in Exhibit 99.1,
referenced herein is being furnished and shall not be deemed
"filed" for the purposes of Section 18 of the Securities Exchange
Act or incorporated by reference in any filing under the Securities
Act, unless the Company expressly so incorporates such information
by reference.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; background-color: #ffffff"><font style="font-weight: bold; color: #000000; font-size: 13px; font-family: Times New Roman">
Item 9.01 Financial Statements and Exhibits.</font></div>
<br>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(d)
Exhibits:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
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<table cellpadding="0" cellspacing="0" style="text-align: left; width: 100%; font-size: 13px; font-family: Times New Roman">
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<td style="vertical-align: middle; width: 10%; border-bottom: 2px solid #000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Exhibit
No.</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 89%; border-bottom: 2px solid #000">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Description</font></div>
</td>
</tr><tr>
<td style="vertical-align: middle; width: 10%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 89%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
</tr><tr style="background-color: #cceeff">
<td style="vertical-align: middle; width: 10%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><a href="a6-23oxisgtpacquisitionpr.htm"><font style="font-size: 13px; font-family: Times New Roman">99.1</font></a></div>
</td>
<td style="vertical-align: middle; width: 1%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
</td>
<td style="vertical-align: middle; width: 89%">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Press Release
issued by the Company on June&#xA0; 26, 2017.</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; background-color: #ffffff"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
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<div id="ftr">
<div style="text-align: left; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
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<div id="hdr">
<div style="text-align: right; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px; background-color: #ffffff"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">SIGNATURE
PAGE</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Pursuant to the
requirement of the Securities and Exchange Act of 1934, the
Registrant has duly caused this report to be signed on its behalf
by the undersigned hereunto duly authorized.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
<div>
<table cellpadding="0" cellspacing="0" id="6f1d2e46049d4805b513ecad952d7a4f" style="width: 100%; font-size: 13px; font-family: Times New Roman">
<tr>
<td style="width: 52%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td colspan="3" style="width: 42%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">Oxis
International, Inc.</font></div>
</td>
<td style="width: 6%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 52%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 4%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 3%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 35%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 6%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 52%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Dated: June 26,
2017</font></div>
</td>
<td style="width: 4%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 3%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">By:</font></div>
</td>
<td style="width: 35%; vertical-align: top; border-bottom: 2px solid #000000">
<div style="text-align: left; margin-left: 36px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">/s/ Steven
Weldon</font></div>
</td>
<td style="width: 6%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr>
<td style="width: 52%; vertical-align: top">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>a6-23oxisgtpacquisitionpr.htm
<DESCRIPTION>ADDITIONAL EXHIBITS
<TEXT>
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<title>Blueprint</title>
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<font style="font-weight: bold"><font style="font-family: Times New Roman; font-size: 13px">OXIS AGREES TO
ACQUIRE GEORGETOWN TRANSLATIONAL PHARMACEUTICALS, APPOINTS NEW
CHIEF EXECUTIVE OFFICER AND CHIEF MEDICAL
OFFICER</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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<font><font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">LOS ANGELES, CA / ACCESSWIRE / June 26, 2017
/</font></font> Oxis International Inc. (OTCQB: <font style="font-weight: bold">OXIS</font> and Euronext Paris <font style="font-weight: bold">OXI.PA</font>) announced today that it has
executed a binding LOI agreement to acquire Georgetown
Translational Pharmaceuticals, Inc. (GTP), a deal that will add new
management and a class of close-to-market Central Nervous Systems
(CNS) products that will add significant value to the Oxis business
model.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Oxis
has agreed to pay 33 percent of its outstanding shares to GTP to
complete the transaction, which is expected to close on or before
90 days as per the agreement.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">GTP,
founded by Kathleen Clarence-Smith, MD, PhD, and Mark J. Silverman,
JD, was incorporated in Delaware in 2015.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Dr.
Clarence-Smith will become Chief Executive Officer of Oxis as part
of the acquisition and will be appointed to the Oxis Board of
Directors. Also joining the company&#x2019;s executive management
team as part of the merger will be a Chief Medical Officer (name to
be disclosed upon closing), who was formerly Vice President and
Chief Medical Officer and Medical Director, Oncology Clinical
R&amp;D of Pfizer, Inc. (NYSE: PFE).</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Anthony
J. Cataldo, who has served as Chief Executive Officer of Oxis since
July 2014, will become Executive Chairman of the company. Steven
Weldon will continue as Chief Financial Officer.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Prior
to founding GTP, Dr. Clarence-Smith co-founded Chase
Pharmaceuticals Corporation in Washington D.C. and served as
Chairman of the company&#x2019;s Board from 2008 to 2014. Chase
Pharmaceuticals was acquired by Allergan, PLC (NYSE: AGN) in
2016.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Under
the deal, Allergan agreed to pay $125 million upfront along with
potential Regulatory and commercial milestones of up to $875
million to the shareholders of Chase.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #0563C1; font-family: Times New Roman; font-size: 13px">
http://asia.nikkei.com/Business/AC/Cipla-sells-Chase-Pharma-stake-to-Allergan</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Dr.
Clarence-Smith also held executive management positions with
Sanofi, Roche, Otsuka Pharmaceutical and Prestwick Scientific
Capital. She is co-founder and a managing member of KM
Pharmaceutical Consulting in Washington, D. C.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000; background-color: #FFFFFF">
"The merger of Oxis</font><font style="color: #000000">&#xA0;</font><font style="color: #000000; background-color: #FFFFFF">and GTP will greatly
accelerate the clinical development of exciting new treatments to
meet the medical needs of those suffering from cancer and
neurologic disease,&#x201D; said Dr. Clarence-Smith.
&#x201C;Harnessing the immune system to fight cancer has the
potential to soon bring the cure for certain cancers within our
reach, and our CNS pipeline includes drugs that have the potential
to improve the quality of life of many
patients."</font></font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Oxis&#x2019;
incoming CMO said: &#x201C;The drugs in the Oxis pipeline are at the
forefront of targeted immunotherapeutics and represent the wave of
the future. The non-clinical and clinical data is impressive and
validates this approach to cancer therapy. Once approved, these
agents will herald a major breakthrough in the field of
immunotherapy and offer patients hope against some of the most
difficult diseases to treat.&#x201D;</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Mr.
Cataldo said: "The addition of Dr. Clarence-Smith as CEO and our
new incoming CMO will be instrumental in completing Oxis&#x2019; FDA
phase 2 clinical trial of OXS-1550 and our plans to advance the
highly-valued TriKE platform oncology assets, which are set to go
into FDA clinical trials soon. Further, we are very excited with
the incoming GTP product pipeline, which will add significant value
as they continue to move towards a commercial
license."</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Oxis'
lead drug candidate, OXS-1550 (DT2219ARL), is a novel drug that
binds to targets and destroys cancer cells, due to the action of
the drug's cytotoxic payload. OXS-1550 has demonstrated success in
early human clinical trials in patients with relapsed/refractory
B-cell lymphoma or leukemia. It is currently in a FDA-approved
Phase 2 trial at the University of Minnesota.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">In
addition, Oxis holds the rights to commercialize OXS-3550, also
known as TriKE, a targeted immunotherapy platform drug that directs
Natural Killer (NK) cells to kill cancer cells without drug-related
toxicity. &#x201C;The first molecule called 161533 TriKE will target
the CD33 antigen on acute myeloid leukemia cells. The 161533 TriKE
will enable NK cells to become antigen specific and also drive the
immune response through its IL-15 linker&#x201C;. Our existing
Oncology products have now reached the point where Dr.
Clarence-Smith&#x2019;s experience in taking drugs through FDA
approvals and into the market, will bring significant value to our
shareholders,&#x201D; Mr. Cataldo said.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
agreement to acquire GTP marks another major value-added inflection
point for the shareholders of Oxis. The company continues to
progress with recently announced partnership and milestone
accomplishments.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
About Oxis Biotech, Inc.</font>:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Oxis
Biotech is an immuno-oncology focused company developing innovative
drugs focused on the treatment of cancer and other unmet medical
needs. Oxis' lead drug candidate, OXS-1550 (DT2219ARL) is a novel
bispecific scFv recombinant fusion protein-drug conjugate composed
of the variable regions of the heavy and light chains of anti-CD19
and anti-CD22 antibodies and a modified form of diphtheria toxin as
its cytotoxic drug payload. OXS-1550 targets cancer cells
expressing the CD19 receptor or CD22 receptor or both receptors.
When OXS-1550 binds to cancer cells, the cancer cells internalize
the drug and are killed due to the action of drug's cytotoxic
payload. OXS-1550 has demonstrated success in early human clinical
trials in patients with relapsed/refractory B-cell lymphoma or
leukemia. OXS-3550 TriKE technology was developed by researchers at
the University of Minnesota Masonic Cancer Center. As demonstrated
in non-clinical models, this targeted immunotherapy directs immune
cells to kill cancer cells while diminishing drug-related
toxicity.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
About GTP Inc</font>.:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">GTP is
a privately-owned biotechnology company focused on acquiring or
discovering and patenting late-stage, de-risked, and
close-to-market improved treatments for CNS disease (Neurology and
Pain) and shepherding the products through the FDA approval process
to the NDA. GTP products currently include treatment for
neuropathic pain, refractory epilepsies, the symptoms of myasthenia
gravis, and motion sickness.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
Forward-Looking Statements:</font>&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Except
for historical information contained herein, the statements in this
release are forward-looking and made pursuant to the safe harbor
provisions of the Private Securities Litigation Reform Act of 1995.
Forward-looking statements are inherently unreliable and actual
results may differ materially. Examples of forward-looking
statements in this news release include statements regarding the
payment of dividends, marketing and distribution plans, development
activities and anticipated operating results. Factors which could
cause actual results to differ materially from these
forward-looking statements include such factors as the Company's
ability to accomplish its business initiatives, significant
fluctuations in marketing expenses and ability to achieve and
expand significant levels of revenues, or recognize net income,
from the sale of its products and services, as well as the
introduction of competing products, or management's ability to
attract and maintain qualified personnel necessary for the
development and commercialization of its planned products, and
other information that may be detailed from time to time in the
Company's filings with the United States Securities and Exchange
Commission. The Company undertakes no obligation to publicly update
or revise any forward-looking statements, whether as a result of
new information, future events or otherwise.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">
Media Contact:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Wendy
Tanaka, Sitrick &amp; Co.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">(415)
369-8447, or&#xA0;<font style="font-style: italic; text-decoration: underline; color: #000000">wtanaka@sitrick.com</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold">
SOURCE:</font>&#xA0;Oxis International Inc.</font></div>
<div><font style="font-family: Times New Roman; font-size: 10">&#xA0;</font></div>
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