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Note 7 - Stockholders' Equity (Details 2) - $ / shares | 12 Months Ended |  |  |
--- | --- | --- | --- | ---
Dec. 31, 2018 | Mar. 31, 2019 | Dec. 31, 2017 | Dec. 31, 2016
Stock Options And Warrants Details |  |  |  |
Exercise price range | $750.00 to $2,225.00 |  |  |
Number of options outstanding, ending | 1,113 |  | 1,246 | 1,246
Weighted average remaining contractual life | 5 months 26 days |  |  |
Weighted average exercise price, outstanding | $ 1,320.00 | $ 1,320.00 | $ 1,428.00 |
Number of options exercisable | 1,113 | 1,133 | 1,246 |
Weighted average exercise price, exercisable | $ 1,320.00 | $ 1,320.00 | $ 1,428.00 |

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