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v3.22.1

Consolidated Statements Of Stockholders' Equity (Deficit) - USD ($) shares in Thousands | Preferred Stock [Member] | Common Stock [Member] | Common Shares Issuable [Member] | Additional Paid-in Capital [Member] | Retained Earnings [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Beginning balance, value at Dec. 31, 2019 | $ 3,000 | $ 4,000 |  | $ 548,184,000 | $ (567,501,000) | $ (19,310,000)
Beginning balance, shares at Dec. 31, 2019 | 2,450 | 4,105 |  |  |  |
Fair value of amended convertible notes and warrants |  |  |  | 8,643,000 |  | 8,643,000
Issuance of common and warrants for settlement of litigation |  |  |  | 2,246,000 |  | 2,246,000
Issuance of common and warrants for settlement of litigation, shares |  | 262 |  |  |  |
Beneficial conversion feature on convertible notes payable |  |  |  | 5,274,000 |  | 5,274,000
Common shares issued upon conversion of notes payable |  | $ 1,000 |  | 1,740,000 |  | 1,741,000
Common shares issued upon conversion of notes payable, shares |  | 512 |  |  |  |
Common shares issued upon exercise of warrants |  |  |  |  |  |
Common shares issued upon exercise of warrants, shares |  | 240 |  |  |  |
Issuance of common stock for compensation |  |  |  | 269,000 |  | 269,000
Issuance of common stock for compensation, shares |  | 99 |  |  |  |
Net loss |  |  |  |  | (28,296,000) | (28,296,000)
Ending balance, value at Dec. 31, 2020 | $ 3,000 | $ 5,000 |  | 566,356,000 | (595,797,000) | (29,433,000)
Ending balance, shares at Dec. 31, 2020 | 2,450 | 5,218 |  |  |  |
Extinguishment of debt discount upon adoption of ASU 2020-06 |  |  |  | (4,745,000) | 226,000 | (4,519,000)
Conversion of Preferred Series J-1 to common stock | $ (2,000) | $ 1,000 |  | 1,000 |  |
Conversion of Preferred Series J-1 to common stock, shares | (2,354) | 692 |  |  |  |
Common shares issued upon mandatory conversion of notes payable and accrued interest |  | $ 11 | $ 1,113 | 37,675 |  | 38,799
Common shares issued upon mandatory conversion of notes payable and accrued interest, shares |  | 11,086 | 327 |  |  |
Common shares issued upon exercise of warrants |  | $ 3,000 |  | 16,430,000 |  | 16,433,000
Common shares issued upon exercise of warrants, shares |  | 3,074 |  |  |  |
Issuance of common stock in public offering, net of cost |  | $ 5,000 |  | 24,674,000 |  | 24,679,000
Issuance of common stock in public offering, net of cost, shares |  | 4,945 |  |  |  |
Issuance of common stock for research and development agreement |  |  |  | 1,355,000 |  | 1,355,000
Issuance of common stock for research and development agreement, shares |  | 190 |  |  |  |
Issuance of common stock for services |  | $ 3,000 |  | 15,337,000 |  | 15,340,000
Issuance of common stock for services, shares |  | 3,082 |  |  |  |
Equity compensation to officers, board of directors and employees |  | $ 4,000 |  | 17,230,000 |  | 17,234,000
Equity compensation to officers and board of directors, shares |  | 3,775 |  |  |  |
Extinguishment of derivative liability |  |  |  | 35,000 |  | 35,000
Net loss |  |  |  |  | (58,013,000) | (58,013,000)
Ending balance, value at Dec. 31, 2021 | $ 1,000 | $ 32,000 | $ 1,113,000 | $ 674,348,000 | $ (653,584,000) | $ 21,910,000
Ending balance, shares at Dec. 31, 2021 | 96 | 32,062 | 327 |  |  |

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