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v3.23.1

Commitments and Contingencies (Details Narrative) - USD ($) |  |  |  | 12 Months Ended
--- | --- | --- | --- | ---
Mar. 04, 2022 | Aug. 06, 2021 | Mar. 26, 2021 | Dec. 31, 2022 | Dec. 31, 2021
Loss Contingencies [Line Items] |  |  |  |  |
Litigation settlement expense | $ 425,000 |  |  |  |
Project fee |  |  |  | $ 2,100,000 |
Project fee incurred |  |  |  | 1,700,000 |
Research and development expense |  |  |  | 8,811,000 | $ 9,591,000
Scientific Research Agreement [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Research and development expense |  |  |  | 766,000 | 964,000
2016 Patent Exclusive License Agreement [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Research and development expense |  |  |  | 0 |
Proceeds from upfront amount |  |  |  | 200,000 |
Maintenance fee |  |  |  | 100,000 |
Performance milestone payments |  |  |  | 3,100,000 |
Sales milestone payments |  |  |  | 1,000,000.0 |
Gross sales |  |  |  | 250,000,000 |
Sales revenue |  |  |  | 5,000,000.0 |
Cumulative gross sales |  |  |  | $ 500,000,000 |
2016 Patent Exclusive License Agreement [Member] | Minimum [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Net sales percentage |  |  |  | 4.00% |
Annual royalty payments |  |  |  | $ 250,000 |
2016 Patent Exclusive License Agreement [Member] | Maximum [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Net sales percentage |  |  |  | 6.00% |
Annual royalty payments |  |  |  | $ 5,000,000.0 |
2021 Patent License Agreement [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Research and development expense |  |  |  | $ 0 | $ 0
Maintenance fee |  |  | $ 2,000,000.0 |  |
Annual royalty payments |  |  | 250,000 |  |
Performance milestone payments |  |  | 3,100,000 |  |
Sales milestone payments |  |  | 1,000,000.0 |  |
Gross sales |  |  | 250,000,000 |  |
Sales revenue |  |  | 5,000,000.0 |  |
Cumulative gross sales |  |  | 500,000,000 |  |
Upfront license fee |  |  | 20,000 |  |
License maintenance fee, receivable |  |  | $ 5,000 |  |
2021 Patent License Agreement [Member] | Minimum [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Net sales percentage |  |  | 2.50% |  |
2021 Patent License Agreement [Member] | Maximum [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Net sales percentage |  |  | 5.00% |  |
Sheffield Properties [Member] |  |  |  |  |
Loss Contingencies [Line Items] |  |  |  |  |
Litigation settlement expense |  | $ 100,000 |  |  |

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